CA2187741C - Systeme de liberation de medicament specifique au colon - Google Patents

Systeme de liberation de medicament specifique au colon Download PDF

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Publication number
CA2187741C
CA2187741C CA002187741A CA2187741A CA2187741C CA 2187741 C CA2187741 C CA 2187741C CA 002187741 A CA002187741 A CA 002187741A CA 2187741 A CA2187741 A CA 2187741A CA 2187741 C CA2187741 C CA 2187741C
Authority
CA
Canada
Prior art keywords
drug
polymer material
coated
organic acid
saccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002187741A
Other languages
English (en)
Other versions
CA2187741A1 (fr
Inventor
Shunsuke Watanabe
Hitoshi Kawai
Masataka Katsuma
Muneo Fukui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Priority claimed from PCT/JP1995/000766 external-priority patent/WO1995028963A1/fr
Publication of CA2187741A1 publication Critical patent/CA2187741A1/fr
Application granted granted Critical
Publication of CA2187741C publication Critical patent/CA2187741C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Abstract

L'invention concerne un système de libération d'un médicament dans le côlon d'un tractus gastro-intestinal. Ledit système comprend un médicament (b) enrobé d'une substance macromoléculaire organique soluble dans l'acide (a), et un saccharide (c) qui génère rapidement un acide organique sous l'action de bactéries intestinales dans un tractus gastro-intestinal inférieur. L'invention porte également sur une préparation de libération de médicament buvable spécifique au côlon comprenant une composition contenant un médicament (b) enrobé d'une substance macromoléculaire organique soluble dans l'acide, et d'un saccharide (c) qui génère rapidement un acide organique sous l'action de bactéries intestinales dans un tractus gastro-intestinal, ladite composition étant elle-même enrobée d'une substance macromoléculaire intestinale (d). Lesdits système et préparation utilisent des bactéries intestinales, ne produisent aucune substance nocive induite par le mécanisme de déclenchement de la libération, et ont une activité élevée spécifique au côlon.
CA002187741A 1994-04-22 1995-04-19 Systeme de liberation de medicament specifique au colon Expired - Fee Related CA2187741C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8511494 1994-04-22
JPHEI-6-85114 1994-04-22
PCT/JP1995/000766 WO1995028963A1 (fr) 1994-04-22 1995-04-19 Systeme de liberation de medicament specifique au colon

Publications (2)

Publication Number Publication Date
CA2187741A1 CA2187741A1 (fr) 1995-11-02
CA2187741C true CA2187741C (fr) 2007-06-19

Family

ID=38281730

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002187741A Expired - Fee Related CA2187741C (fr) 1994-04-22 1995-04-19 Systeme de liberation de medicament specifique au colon

Country Status (1)

Country Link
CA (1) CA2187741C (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160193154A1 (en) * 2013-07-24 2016-07-07 Novo Nordisk A/S Pharmaceutical Composition for Oral Insulin Administration Comprising a Tablet Core and an Anionic Copolymer Coating
EP3976188A1 (fr) * 2019-05-28 2022-04-06 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Compositions pour l'administration de ladostigil

Also Published As

Publication number Publication date
CA2187741A1 (fr) 1995-11-02

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MKLA Lapsed

Effective date: 20130419