CA2187030C - Improved anti-dandruff shampoo - Google Patents

Abstract

A shampoo that contains ketoconazole or elubiol, a surfactant, a foaming age nt, thickener sufficient to give the final formulation a viscosity in the range of about 4,000 to about 9,000 cps (mPa.s) at room t emperature (i.e., about 20-25 .degree.C), preservative, butylated hydroxytoluene or butylated hydroxyanisole in an amount sufficient to retard degradation of the ketoconazole or elubiol, and acid, b ase or buffer sufficient to give the final composition a pH in the range of from ab out 4 to about 10.

Description

?7315-3?
The invention relates to an improved anti-dandruff shampoo containing ketoconazole or elubiol.
Background of the Invention Ketoconazole is the generic name for the compound (~) -cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine, having the formula:
N
N CI CI
I
CHZ ~ , / ~ ~

U
Ketoconazole was originally described by Heeres et al., for instance, in U.S. Patent No. 4,335,125, in which its principal utility was Asian antifungal compound. Ketoconazole was also disclosed by Rosenberg et al. in U.S. Patent No. 4,569,935 to be useful in the topical treatment of psoriasis and seborrheic dermatitis.
Elubiol is the generic name for the compound (~)-ethyl cis-4-[4-[[2-(2,4-dichlorophenyl)-2-(1~-imidazol-1-ylmethyl)-1,3--i-WO 95127471 218 7 0 3 0 pCT/US95103197 dioxolan-4-yl]methoxy]phenyl]-1-piperazinecarboxylate, having the formula:
N
~~ CI CI , CHZ
o 'o CH2-0 ~ ~ N N-CO-0-CHz-CH3 L
Elubiol was also originally described by Heeres et al., for instance, in U.S. Patent No. 4,335,125, in which its principal utility was as an antifungal compound.
Retoconazole has been marketed in a 2% shampoo formulation (available in the United States by prescription only) for the treatment of scaling due to dandruff. The components of this shampoo include coconut fatty acid diethanolamide, disodium monolauryl ether sulphosuccinate, colorant such as F.D. & C. Red No. 40, hydrochloric acid and/or sodium hydroxide to control pH, imidurea, laurdimonium hydrolyzed animal collagen, macrogol 120 methyl glucose dioleate, perfume bouquet, purified water, sodium lauryl ether sulphate, and ketoconazole (2%).
Although the above-described shampoo is efficacious for dandruff treatment, it was desired to improve its cosmetic attributes such as lathering and conditioning, and to develop an efficacious formulation that, if desired, could contain less than 2% of the active agent, i.e., ketoconazole or elubiol. However, , since ketoconazole and elubiol are subject to slow degradation by oxidation and hydrolysis, any formulation that contains significantly less than 2% of the active agent must be effective 1y stabilized in order to have an acceptable shelf life. The -a-present invention is based on the discovery of a formulation for a ketoconazole-containing or elubiol-containing shampoo that exhibits excellent cosmetic attributes such as lathering and conditioning, and is acceptably stable to degradation so that, if desired, the shampoo can be formulated to contain less than 2% ketoconazole.
Brief Summary of the Invention The present invention provides an aqueous shampoo that contains ketoconazole or elubiol, a surfactant, a foaming agent, thickener sufficient to give the final formulation a viscosity in the range of about 4,000 to about 9,000 cps (mPa.s) at room temperature (i.e., about 20-25°C), preservative, an antioxidant selected from the group consisting of butylated hydroxytoluene and butylated hydroxy anisole in an amount sufficient to retard degradation of the ketoconazole or elubiol, and acid, base or buffer sufficient to give the final composition a pH in the range of from about 4 to about 10, preferably from about 6.5 to about 8, and more preferably from 6.9 to 7.4.
According to one aspect of the present invention, there is provided an aqueous shampoo that comprising active agent selected from the group consisting of ketoconazole and elubiol in an amount effective to combat scaling due to dandruff, one or more surfactants, a foaming agent, thickener sufficient to give the final formulation a viscosity in the range of about 4,000 to about 9,000 cps (mPa.s) at room temperature, preservative, an antioxidant selected from the group consisting of butylated hydroxytoluene and butylated hydroxyanisole in an amount sufficient to retard degradation of the active agent, and acid, base or buffer sufficient to give the shampoo a pH in the range of from about 4 to about 10.

According to another aspect of the present invention, there is provided a process of preparing a shampoo formulation as defined herein comprising the steps of: (a) heating a solution of thickener and deionized water, (b) mixing the surfactants, the foaming agent and optionally the pearlizing agent with the solution of (a), (c) mixing the BHT or BHA with the solution of (b), (d) mixing the active agent with the solution of (c), (e) allowing the solution of (d) to cool somewhat and mixing therewith the preservatives) and the sodium chloride for thickening, and optionally the conditioner, the fragrances) and colorant(s), (f) adding acid, base or buffer to the solution of (e) to yield a pH in the range of 4 to 10, and (g) adding deionized water to the solution of (f) to 100%.
The Prior Art Butylated hydroxytoluene, whose proper chemical name is 2,6-bis(1,1-dimethylethyl)-4-methylphenol, also 2,6-di-tert-butyl-p-cresol or 2,6-di-tert-butyl-4-methylphenol, is marketed as an antioxidant for food, animal feed, petroleum products, synthetic rubbers, plastics, animal and vegetable oils, and soaps, and as an antiskinning agent in paints and inks. (Ref. - Page 238 of the Merck Index, Eleventh Edition.) Butylated hydroxyanisole, whose proper chemical name is 2(3)-tert-butyl-4-methoxyphenol, is marketed as an antioxidant, especially for food. (Ref. - Page 1547 of the Merck Index, Eleventh Edition.) -3a-g~ta~lPd Description of the Invention The shampoo of the invention contains ketoconazole or elubiol, at least one surfactant, a foaming agent, thickeners sufficient to give the final formulation a viscosity in the range of about 4,000 to about 9,000 cps (mPa.s) at room temperature, preservatives including butylated hydroxytoluene sufficient to prevent degradation of the final composition, and acid, base or buffer sufficient to give the final composition a pH in the range of from about 4 to about 10. Each class of ingredients will be discussed in turn.
The active agent, i.e. , ketoconazole or elubiol, is employed in the shampoo in an amount effective to combat scaling due to dandruff. An effective amount will usually be found within the range of from about 0.3 weight percent up to about 3 weight percent of active agent, based on weight of the entire shampoo formulation. Preferred amounts are usually found within the range of from about 0.4 to 2 weight percent, and more preferably from about 0.5 to about 1.1 weight percent. At concentrations below the indicated range, the effectiveness begins to diminish to unacceptable levels, and at concentrations higher than about 3 weight percent, the limited solubility of ketoconazole or elubiol in aqueous media, even with surfactants present, becomes a significant factor.
The shampoo of the invention contains one or more surfactants, which are employed principally as cleansing agents.
Specific illustrations of surfactants that have been found to be useful include the following compositions:
Sodium laureth sulfate, a composition having the formula CH3(CH2)10CH2(OCH2CH2)n0503Na, wherein n represents a number having an average value of from 1 to 4; and Sodium cocoyl sarcosinate, which is the sodium salt of cocoyl sarcosine. Cocoyl sarcosine is the coconut oil fatty acid amide of sarcosine (N-methylglycine or methylaminoethanoic acid).
Coconut fatty acid is a mixture of myristic acid, lauric acid, palmitic acid and stearic acid.
Other surfactants that can be employed in the shampoo of the invention include sodium C14.i6 olefin sulfonates, sodium lauryl sulfate, cocamidopropylamine oxide, lauramido DEA (lauramido diethanolamine), cocamidopropyl betaine, disodium oleamido MIPA
sulfosuccinate, disodium cocamido MIPA sulfosuccinate, disodium laureth sulfosuccinate, cocoamphocarboxy-glycinate, and disodium oleamido MFJ~ sulfosuccinate. These surfactants are all known in the shampoo and cosmetic arts.
The shampoo of the invention also contains foaming agents such as fatty acid mono- and di-alkanolamides, for instance, cocamide MEA (a mixture of coconut acid monoethanolamides of the formula R-CO-NHCH2CH2oH wherein R represents the residue after removal of the carboxyl group of coconut fatty acid), cocamide DEA [a mixture of diethanolamides of the formula R-CO-N(CH2CHZOH)2 wherein R is as defined above], oleamide MEA and oleamide DEA.
The shampoo of the invention contains a thickener to impart a viscosity to the formulation in the range of from about 4,000 to about 9,000 cps (mPa.s) at room temperature. Such thickeners include CarbopolTM 1342, which is a copolymer of Clo~3oalkyl acrylates, acrylic acid and/or methacrylic acid, cross-linked with an allyl ether of sucrose. Other thickeners that can be used include cellulose derivatives such as hydroxypropyl methylcellulose, hydroxyethyl cellulose, carboxymethyl cellulose, and the like. The addition of a small amount of salt (NaCl) also serves to control the viscosity of the final fonaulation.
Usually, the amount of salt added will be within the range of from about 0.25 to 0.6 weight percent.

The preservatives that can be used in the shampoo of the invention include tetrasodium EDTA (the tetrasodium salt of ethylenediamine tetraacetic acid - used as a chelating agent to protect against degradation caused by metal ions and also to enhance anti-bacterial activity) and quaternium-15 [1-(3-chloro allyl)-3,5,7-triaza-1-azonia-adamantane chloride - used as an anti-microbial agent]. Other preservatives that can be used include paraben, KathonT""CG biocide (a mixture of 5-chloro-2 methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one), phenoxyethanol, benzyl alcohol, and the like.
The shampoo of the invention may also contain other therapeutically active agents, such as the antiseborrheic agent octopirox, a trade name for piroctone, a compound whose chemical name is 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1~)-pyridinone.
An important feature of the present invention is the discovery that a carefully controlled amount of an antioxidant selected from the group consisting of butylated hydroxytoluene ("BHT") and butylated hydroxyanisole ("BHA") is effective to stabilize the ketoconazole or elubiol present in the shampoo against degradation during accelerated aging for 13 weeks at 50°C, which is considered to be predictive of performance during storage at ambient temperatures for two years. Effective stability is considered to be a loss of active ingredient during storage of not more than about 10 percent. The proportion of BHT
or BHA that has been found to be most effective is within the range of from about 0.01 to about 1, and preferably 0.1 ~ 0.025, weight percent, based on weight of the entire shampoo formulation (See Table 1, below). Surprisingly, proportions greater than this amount do not stabilize as effectively for the 13-week accelerated aging period, although if one extends the accelerated aging period longer than 13 weeks, greater proportions of BHT or BHA tend to.be more effective, since the BHT or B~iA itself is W O 95127471 218 7 0 3 0 PCT~S95/03197 also subject to degradation (see Table 2, below). However, it is well recognized by government regulatory agencies and in the ' pharmaceutical and cosmetic industries that stability testing for 13 weeks at 5o°C is quite sufficient to predict product stability during normal shelf life storage for two (2) years at room temperature. It is also equally important that, for safety reasons (that is, to minimize the potential for skin sensitiza-tion), it is desired to use as small an amount as possible of BHT
or BHA.
The shampoo of the invention can contain other materials such as fragrances, colorants, opacifiers, conditioners such as polyquaternium-7 [the polymeric quaternary ammonium salt of acrylamide and dimethyl diallyl ammonium chloride], pearlizing agents such as ethylene glycol distearate and ethylene glycol monostearate, etc., that are standard in shampoo formulations:
The shampoo contains acids, bases, and buffers, as needed to maintain a pH of from 4 to 10, and preferably from about 6.5 to 8, and more preferably from 6.9 to 7.4. (A neutral pH is desired in order to minimize the potential for skin sensitiza-tion.) The nature and mode of use of such materials are known in the art.
The components of the shampoo are employed in conventional amounts, for example:
(a) 36% to 45% surfactants, (b) 2% to 6% foaming agent, (c) 0.3% to 3% ketoconazole or elubiol, (d) 0.2% to 1.3% thickener, (e) 0.01% to 1% BHT or BHA;
(f) preservatives sufficient to retard degradation of the final composition in order to give adequate shelf life, (g) acid, base or buffer to yield a pH in the desired range, and (h) water QS ad 100% (that is, sufficient water to make 100%).

W0 95/27471 PCTIUS95l03197 st:..,r~rrd preparatl on of Shampoo A vessel was charged with a 1.64% stock solution of Carbopol ' 1342 (prepared using a Quadro disperser which functions by keeping the powdered polymer evenly divided and pulling the powder by a vacuum into a stream of water) and deionized water, and heated to about 70°C. Both surfactants, i.e. sodium laureth sulfate and sodium cocoyl sarcosinate, were added, followed by the foaming agent, cocamide MEA, and a pearlizing agent (ethylene glycol distearate) and mixed until complete dissolution. Then the BHT was added and the mixture was stirred until complete dissolution thereof. The solution was allowed to cool slightly, whereupon the antifungal ingredient ketoconazole was added while stirring well. (The ketoconazole is added while the pH is slightly acidic, to facilitate dissolution.) Themixture was allowed to cool to about 40°C, at which temperature there were added the conditioner (polyquaternium-7), the preservatives quaternium-15 and tetrasodium EDTA, the colorants and fragrances, and the NaCl for thickening the solution. The pH of the solution was adjusted to 6.9-7.4 with a 25% aq. solution of NaOH and deionized water was added to the final volume.
Using the general procedure described above, the following shampoo formulations were made: -Example 1: Shampoo formulations for normal hair Parts. by wt.
Ingredients (a) (b) sodium laureth sulfate 30 30 sodium cocoyl sarcosinate 10 l0 cocamide NEA 4 4 ketoconazole USP 1 2 glycol distearate 1.25 1.25 .

polyquaternium-7 1 1 Carbopol 1342 0.6 0.6 -S-tetrasodium EDTA 0.5 0.5 perfume oil 0.5 0.5 sodium chloride 0.3 0.3 sodium hydroxide 25% 0.92 0.9 butylated hydroxytoluene 0.1 0.1 quaternium-15 0.05 0.05 colorants 0.001 0.001 deionized water QS ad 100 100 Example 2: Shampoo formulations for oily hair Parts by weigh t Ingredients (a) (b) (c) sodium laureth sulfate 33.33 33.33 33.33 sodium cocoyl sarcosinate 11 11 11 cocamide MEA 4 4 4 ketoconazole USP 1 1 2 glycol distearate 1.25 1.25 1.25 polyquaternium-7 0.6 0.6 0.6 Carbopol 1342 0.75 0.75 0.75 tetrasodium EDTA 0.5 0.5 0.5 perfume oil 0.5 0.5 0.5 sodium chloride 0.3 0.3 0.3 sodium hydroxide 25% 1.18 1.243 1.18 butylated hydroxytoluene 0.1 0.1 0.1 quaternium-15 0.05 0.05 0.05 colorants 0.0053 0.0053 0.0053 deionized water QS ad 100 100 100 Example 3: Shampoo formulations for dry or damaged hair Parts by weight Ingredients (a) (b) (c) sodium laureth sulfate 30 30 30 sodium cocoyl sarcosinate 10 10 10 cocamide MEA 4 4 4 ketoconazole USP 1 1 2 _g-glycol distearate 1.25 1.25 1.25 polyquaternium-7 5 5 5 Carbopol 1342 0.5 0.5 0.5 tetrasodium EDTA 0.5 0.5 0.5 perfume oil 0.5 0.5 0.5 E

sodium chloride 0.4 0.4 0.3 sodium hydroxide 25% 0.7333 0.733 1.19 butylated hydroxytoluene 0.1 0.1 0.1 quaternium-15 0.05 0.05 0.05 l0 colorants 0.0018 0.0018 0.0018 deionized water QS ad 100 100 100 In all- the formulations given above in Examples 1-3, the proportion of sodium hydroxide may vary slightly, to arrive at the more preferred pH level of 6.9 to 7.4, and the proportion of salt (NaCl) may vary, to arrive at the desired viscosity.
Example 4: Stability Studies The formulation described above as Example 1 (a) [Shampoo formulation for normal hair containing 1% ketoconazole] was subjected to stability studies, as follows:
Shampoo formulations containing 0, 0.01, 0.1, 0.4, 0.7 and 1.0 weight % BHT were stored at 50°C for 24 weeks. At 0, 4, 8, 12, 16, 20 and 24 weeks, samples were taken from each formulation and analyzed for ketoconazole content. The table below reports the percentage of ketoconazole remaining for each sample after the indicated number of weeks:

pPrePnt of nr;Q;nai pxouortion of ketoconazole remainsn~
' Stability analyses at 50°C for the 24 weeks is indicated as follows:
Week 0.0%1 0.01% 0.1% 0.4% 0.7% 1.0%

4 97.98 99.01 101.12 102.00 101.23 101.89 8 97.18 97.75 98.84 101.07 100.78 102.77 12 85.61 92.30 99.48 96.35 94.49 95.91 16 88.49 88.80 95.93 93.01 93.24 93.27 82.22 84.75 87.17 90.29 89.91 93.27 24 82.12 84.13 86.44 89.46 92.82 90.68 15 Note - the relative standard deviation for all but two samples was less than 2%.
The samples were also analyzed for BHT content after storage for 24 weeks at 4°C and at 50°C. The results are displayed 20 in the following table:

BHT analysis FORMULATED % BHT 4C 24 wks. 50C 24 wks.
% BHT % BHT

1.0% 0.940% 0.277%

0.7% 0.583% 0.218%

0.4% 0.352% 0.107%

0.1% 0.084% 0.023%

0.01% 0.009% 0.005 0.0% 0 p PLACEB01 0.0968% O.D631%

f Percent BHT in original sample.
'- Contained 0.1% BHT and no ketoconazole.

SUBSTITUTE SHEET (RULE 26~

WO 95127471 218 7 0 3 0 PCT/fTS95/03197 Example 5 - Elubiol-Containing Shampoo Stability study Shampoos were made from the formulations shown below in the Table:
Table: Shampoo Formulations with 0.1% and 0.5% BHT
Ingredients/Parts, by A (Normal B (Dry Hair) weight Hair) sodium laureth sulfate 30.00 30.00 sodium cocoyl sarcosinate 10.00 10.00 Cocamide MEA 4.00 4.00 elubiol 0.75 0.25 glycol distearate 1.25 1.25 polyquaternium-7 1.00 5.00 Carbopol 1342 NF (1.64%) 36.58 48.54 tetrasodium EDTA 0.50 0.50 octopirox 0.75 0.75 sodium hydroxide 25% 0.50 1.07 butylated hydroxytoluene 0.10 0.50 quaternium-15 0.05 0.05 colorants 1.0o kathon 0.05 perfume oil 0.5 sodium chloride 0-0.6 0-0.6 deionized water qs ad 100.00 100.00 * Formula A: more than 98% elubiol remained after 10 weeks at 50°C at 0.1% BHT.
* Formula B: more than 95% elubiol remained after 5 months at 40°C at 0.5% BHT.
Both Formula A&B can be extrapolated to 2 years shelf-life at room temperature. Although 0.5% BHT was added for Formula B, it is believed, based on the results from Formula A, that 0.1% BHT '-will be sufficient to stabilize the formulation to yield accept-able shelf life.

SUBSTITUTE SHEET (RULE 26) WO 95/27.771 218 7 0 3 0 PCT/US95103197 ~:
Example 6 - 0.5% Ketoconazole formulation The following table presents a formulation for a shampoo containing 0.5% ketoconazole:
Table: 0.5% Ketoconazole Shampoo with 0.1% BHT
Ingredients Parts, by wt.

sodium laureth sulfate 30.00 sodium cocoyl sarcosinate 10.00 Cocamide MEA 4.00 ketoconazole 0.50 glycol distearate 0.60 polyquaternium-7 1.00 Carbopol 1342 NF 0.50 tetrasodium EDTA 0.50 sodium hydroxide 25% 0.50 butylated hydroxytoluene 0.10 quaternium-15 0.05 colorants 1.00 perfume oil 0.30 deionized water qs ad 100.00 Stability: >92% after 2 months @ 49°C (@ pH 7) >95% after 2 months @ 49°C (@ pH 8) SUBSTITUTE SHEET (RULE 26~

Claims (22)

CLAIMS:

1. An aqueous shampoo comprising active agent selected from the group consisting of ketoconazole and elubiol in an amount effective to combat scaling due to dandruff, one or more surfactants, a foaming agent, thickener sufficient to give the final formulation a viscosity in the range of about 4,000 to about 9,000 cps (mPa.s) at room temperature, preservative, an antioxidant selected from the group consisting of butylated hydroxytoluene and butylated hydroxyanisole in an amount sufficient to retard degradation of the active agent, and acid, base or buffer sufficient to give the shampoo a pH in the range of from about 4 to about 10.

2. The shampoo of claim 1, wherein the pH is in the range of from about 6.5 to about 8.

3. The shampoo of claim 1, wherein the pH is in the range of from about 6.9 to 7.4.

4. The shampoo of any one of claims 1 to 3, wherein the antioxidant is butylated hydroxytoluene employed in an amount of 0.1 ~ 0.025 weight percent, based on weight of the shampoo.

5. The shampoo of any one of claims 1 to 4, wherein the active agent is employed in an amount within the range of from about 0.3 weight percent to about 3 weight percent, based on weight of the shampoo.

6. The shampoo of any one of claims 1 to 4, wherein the active agent is employed in an amount within the range of from about 0.4 weight percent to about 2.0 weight percent, based on weight of the shampoo.

7. The shampoo of any one of claims 1 to 4, wherein the active agent is employed in an amount within the range of from about 0.5 weight percent to about 1.1 weight percent, based on weight of the shampoo.

8. A shampoo according to any one of claims 1 to 7, wherein the one or more surfactants are selected from the group consisting of sodium C14-16 olefin sulfonates, sodium lauryl sulfate, sodium laureth sulfate, cocamidopropylamine oxide, lauramido DEA, cocamidopropyl betaine, sodium cocoyl sarcosinate, disodium oleamido MIPA sulfosuccinate, disodium cocamido MIPA sulfosuccinate, disodium laureth sulfosuccinate, cocoamphocarboxy-glycinate, and disodium oleamido MEA sulfosuccinate.

9. A shampoo according to any one of claims 1 to 8, wherein the foaming agent is selected from the group of fatty acid mono- and di-alkanolamides consisting of cocamide MEA, cocamide DEA, oleamide MEA and oleamide DEA.

10. A shampoo according to any one of claims 1 to 9, further comprising polyquaternium-7 as a conditioner.

11. A shampoo according to any one of claims 1 to 10, further comprising one or more pearlizing agents selected from the group consisting of ethylene glycol distearate and ethylene glycol monostearate.

12. A shampoo according to any one of claims 1 to 11, further comprising one or more fragrances and one or more colorants.

13. A shampoo according to claim 1 comprising by weight based on the total weight of the shampoo approximately:
(a) 36% to 45% surfactants, (b) 2% to 6% foaming agent, (c) 0.3% to 3% active agent, (d) 0.2% to 1.3% thickener, (e) 0.01% to 1% BHT antioxidant, (f) preservatives sufficient to retard degradation of the final composition, (g) acid, base or buffer to yield a pH in the range of from 6.9 to 7.4, and (h) water QS ad 100%.

14. A shampoo according to claim 1 comprising by weight based on the total weight of the shampoo approximately:
(a) 36% to 45% of the one or more surfactants, (b) 2% to 60 of the foaming agent, (c) 0.3% to 3% of the active agent, (d) 0.2% to 1.3% of the thickener, (e) 1% to 1.5% of a pearlizing agent, (f) 0.5% to 1% of the preservative(s), (g) 0.1 ~ 0.025% of the BHT antioxidant, and (h) acid, base or buffer to yield a pH in the range of 6.9 to 7.4, and further comprising (i) 0.4 to 8% of a conditioner, (j) one or more fragrance and one or more colorant, and (k) water QS ad 100%.

15. The shampoo of any one of claims 1 to 14, wherein the active agent is ketoconazole.

16. The shampoo of any one of claims 1 to 14, wherein the active agent is elubiol.

17. A process of preparing a shampoo as defined in claim 1 comprising the steps of:
(a) heating a solution of the thickener and deionized water, (b) mixing the one of more surfactant, the foaming agent with the solution of (a), (c) mixing the BHT or BHA with the solution of (b), (d) mixing the active agent with the solution of (c), (e) allowing the solution of (d) to cool somewhat and mixing therewith the preservative and sodium chloride for thickening, (f) adding the acid, base or buffer to the solution of (e) to yield a pH in the range of 4 to 10, and (g) adding deionized water to the solution of (f) to 100%.

18. The process of claim 17, wherein the shampoo further comprises one or more pearlizing agents and the one or more pearlizing agents are added in step (b).

19. The process of claim 18, wherein the one or more pearlizing agents are selected from ethylene glycol distearate and ethylene glycol monostearate.

20. The process of any one of claims 17 to 19, wherein the shampoo further comprises a conditioner and the conditioner is added in step (e) after the cooling.

21. The process of claim 20, wherein the conditioner is polyquaternium-7.

22. The process of any one of claims 17 to 21, wherein the shampoo further comprises one or more fragrances and one or more colorants and the one or more fragrances and one or more colorants are added in step (e) after the cooling.