CA2184188A1 - Antithrombotic agents - Google Patents

Antithrombotic agents

Info

Publication number
CA2184188A1
CA2184188A1 CA002184188A CA2184188A CA2184188A1 CA 2184188 A1 CA2184188 A1 CA 2184188A1 CA 002184188 A CA002184188 A CA 002184188A CA 2184188 A CA2184188 A CA 2184188A CA 2184188 A1 CA2184188 A1 CA 2184188A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
amino
pro
hcl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002184188A
Other languages
English (en)
French (fr)
Inventor
Aaron Leigh Schacht
Robert Theodore Shuman
Gerald Floyd Smith
James Howard Wikel
Michael Robert Wiley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/318,600 external-priority patent/US5602101A/en
Application filed by Individual filed Critical Individual
Publication of CA2184188A1 publication Critical patent/CA2184188A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002184188A 1994-03-04 1995-03-03 Antithrombotic agents Abandoned CA2184188A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20650094A 1994-03-04 1994-03-04
US08/206,500 1994-03-04
US08/318,600 US5602101A (en) 1994-03-04 1994-10-05 Antithrombotic agents
US08/318,600 1994-10-05

Publications (1)

Publication Number Publication Date
CA2184188A1 true CA2184188A1 (en) 1995-09-08

Family

ID=26901406

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002184188A Abandoned CA2184188A1 (en) 1994-03-04 1995-03-03 Antithrombotic agents

Country Status (5)

Country Link
EP (1) EP0748333A4 (ja)
JP (1) JPH09509943A (ja)
AU (1) AU1884395A (ja)
CA (1) CA2184188A1 (ja)
WO (1) WO1995023809A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019919A1 (fr) * 1995-11-30 1997-06-05 C & C Research Laboratories Derives de sulfamides
DE19549118C2 (de) * 1995-12-29 2000-07-13 Thomas W Stief Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten
IL147696A0 (en) * 2001-01-25 2002-08-14 Pfizer Prod Inc Combination therapy
IL160488A0 (en) * 2001-08-21 2004-07-25 Ivax Inst For Drug Res Ltd Peptide arginals and methods for treating disseminated intravascular coagulation
AU2003264388A1 (en) * 2002-09-09 2004-03-29 Ono Pharmaceutical Co., Ltd. Process for producing 4-methyl-1,3-thiazol-2-ylsulfonyl halide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
US5430023A (en) * 1990-09-28 1995-07-04 Eli Lilly And Company Tripeptide antithrombotic agents
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5250660A (en) * 1991-11-12 1993-10-05 Eli Lilly And Company Peptide purification process
ZA928581B (en) * 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents

Also Published As

Publication number Publication date
EP0748333A4 (en) 2000-05-10
WO1995023809A1 (en) 1995-09-08
AU1884395A (en) 1995-09-18
JPH09509943A (ja) 1997-10-07
EP0748333A1 (en) 1996-12-18

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Legal Events

Date Code Title Description
FZDE Dead