CA2182967A1 - Production et utilisation de map-kinases phosphatases et acides nucleiques de codage prevus a cet effet - Google Patents

Production et utilisation de map-kinases phosphatases et acides nucleiques de codage prevus a cet effet

Info

Publication number
CA2182967A1
CA2182967A1 CA002182967A CA2182967A CA2182967A1 CA 2182967 A1 CA2182967 A1 CA 2182967A1 CA 002182967 A CA002182967 A CA 002182967A CA 2182967 A CA2182967 A CA 2182967A CA 2182967 A1 CA2182967 A1 CA 2182967A1
Authority
CA
Canada
Prior art keywords
polypeptide
nucleic acid
sequence
map kinase
encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002182967A
Other languages
English (en)
Inventor
Alan Ashworth
Brad Ozanne
Andrea King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9402573A external-priority patent/GB9402573D0/en
Priority claimed from PCT/GB1994/000694 external-priority patent/WO1994023039A1/fr
Application filed by Individual filed Critical Individual
Publication of CA2182967A1 publication Critical patent/CA2182967A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

Cette invention se rapporte à des MAP-kinases phosphatases, apparentées à CL100, qui assurent la déphosphorylation de l'enzyme MAP-kinase et qui interviennent dans le contrôle d'un certain nombre de mécanismes cellulaires, y compris la prolifération. Leur fonction de suppression des tumeurs peut être utilisée à des fins thérapeutiques. Des acides nucléiques codant les MAP-kinases phosphatases peuvent être utilisés pour produire les polypeptides codés, pour rechercher des anomalies génétiques, pour réaliser des traitements et pour obtenir d'autres éléments de cette famille, ainsi que des orthologues et des homologues provenant d'autres espèces. Un tel polypeptide peut être utilisé pour stimuler la formation d'anticorps, qui eux-mêmes peuvent servir à rechercher la présence de polypeptides normaux ou aberrants.
CA002182967A 1994-02-10 1995-02-10 Production et utilisation de map-kinases phosphatases et acides nucleiques de codage prevus a cet effet Abandoned CA2182967A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9402573.1 1994-02-10
GB9402573A GB9402573D0 (en) 1994-02-10 1994-02-10 Phosphatases
PCT/GB1994/000694 WO1994023039A1 (fr) 1993-04-07 1994-03-31 Procedes de criblage de substances a activite therapeutique et levure utilisee a cet effet
WOPCT/GB94/00694 1994-03-31

Publications (1)

Publication Number Publication Date
CA2182967A1 true CA2182967A1 (fr) 1995-08-17

Family

ID=26304171

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002182967A Abandoned CA2182967A1 (fr) 1994-02-10 1995-02-10 Production et utilisation de map-kinases phosphatases et acides nucleiques de codage prevus a cet effet

Country Status (5)

Country Link
EP (1) EP0742827A1 (fr)
JP (1) JPH09508795A (fr)
AU (1) AU696939B2 (fr)
CA (1) CA2182967A1 (fr)
WO (1) WO1995021923A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6281196A (en) * 1995-06-16 1997-01-15 Oregon Health Sciences University Mitogen-activated protein kinase phosphatase cdnas and their biologically active expression products
US6074862A (en) * 1995-12-20 2000-06-13 Signal Pharmaceuticals Inc. Mitogen-activated protein kinase kinase MEK6 and variants thereof
US5948885A (en) 1996-05-20 1999-09-07 Signal Pharmaceuticals, Inc. Mitogen-activated protein kinase p38-2 and methods of use therefor
US6677130B1 (en) 1996-05-20 2004-01-13 Signal Pharmaceuticals, Inc. Mitogen-activated protein kinase p38-2 and methods of use therefor
US6897019B1 (en) 1998-04-17 2005-05-24 Tufts College Methods for treating and preventing insulin resistance and related disorders
WO2000065068A1 (fr) 1999-04-23 2000-11-02 Ceptyr, Inc. Kinase phosphatase dsp-10 a double specificite activee par un mitogene
US6649391B1 (en) 1999-07-20 2003-11-18 Ceptyr, Inc. DSP-11 dual-specificity phosphatase
GB0102946D0 (en) * 2001-02-06 2001-03-21 Oxford Biomedica Ltd Enzyme

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5512434A (en) * 1992-12-14 1996-04-30 The United States Of America As Represented By The Department Of Health And Human Services Expression cloning of a human phosphatase

Also Published As

Publication number Publication date
EP0742827A1 (fr) 1996-11-20
AU696939B2 (en) 1998-09-24
AU1586195A (en) 1995-08-29
WO1995021923A1 (fr) 1995-08-17
JPH09508795A (ja) 1997-09-09

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Legal Events

Date Code Title Description
FZDE Discontinued