CA2182105C - Intermediaires de la chloropyrimidine - Google Patents

Intermediaires de la chloropyrimidine Download PDF

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Publication number
CA2182105C
CA2182105C CA002182105A CA2182105A CA2182105C CA 2182105 C CA2182105 C CA 2182105C CA 002182105 A CA002182105 A CA 002182105A CA 2182105 A CA2182105 A CA 2182105A CA 2182105 C CA2182105 C CA 2182105C
Authority
CA
Canada
Prior art keywords
formula
compound
amino
preparation
diamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002182105A
Other languages
English (en)
Other versions
CA2182105A1 (fr
Inventor
Susan Mary Daluge
Michael Tolar Martin
Michelle Joanne Ferry Fugett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9402161A external-priority patent/GB9402161D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of CA2182105A1 publication Critical patent/CA2182105A1/fr
Application granted granted Critical
Publication of CA2182105C publication Critical patent/CA2182105C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur de nouveaux intermédiaires de la pyrimidine et leurs sels, ainsi que sur leur procédé de préparation et de conversion en 2-aminopurines substituées en 9, qui s'avèrent utiles en thérapie médicale
CA002182105A 1994-02-04 1995-02-03 Intermediaires de la chloropyrimidine Expired - Lifetime CA2182105C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9402161.5 1994-02-04
GB9402161A GB9402161D0 (en) 1994-02-04 1994-02-04 Chloropyrimidine intermediates
PCT/GB1995/000225 WO1995021161A1 (fr) 1994-02-04 1995-02-03 Intermediaires de la chloropyrimidine

Publications (2)

Publication Number Publication Date
CA2182105A1 CA2182105A1 (fr) 1995-08-10
CA2182105C true CA2182105C (fr) 2006-07-25

Family

ID=36707428

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002182105A Expired - Lifetime CA2182105C (fr) 1994-02-04 1995-02-03 Intermediaires de la chloropyrimidine

Country Status (1)

Country Link
CA (1) CA2182105C (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117050024B (zh) * 2023-10-13 2024-01-05 苏州开元民生科技股份有限公司 一种2-氨基-4,6-二氯-5-甲酰胺基嘧啶的合成方法

Also Published As

Publication number Publication date
CA2182105A1 (fr) 1995-08-10

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Effective date: 20150203