CA2157874A1 - Anti-hiv monoclonal antibody - Google Patents
Anti-hiv monoclonal antibodyInfo
- Publication number
- CA2157874A1 CA2157874A1 CA002157874A CA2157874A CA2157874A1 CA 2157874 A1 CA2157874 A1 CA 2157874A1 CA 002157874 A CA002157874 A CA 002157874A CA 2157874 A CA2157874 A CA 2157874A CA 2157874 A1 CA2157874 A1 CA 2157874A1
- Authority
- CA
- Canada
- Prior art keywords
- region
- hiv
- monoclonal antibody
- antibody
- pnd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000036436 anti-hiv Effects 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 108700026220 vif Genes Proteins 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention is directed to a monoclonal antibody useful for clinical application which recognizes the conserved region of V3-PND region of glycoprotein antigen having a molecular weight of about 1.2 x 10 5 daltons (gp120) on a coating membrane of human immunodeficiency virus (HIV) and which has an ability to neutralize a broad range of various HIV variants, or a fragment thereof, and the chimeric and humanized antibodies derived therefrom. By using as an immunogen a plurality of peptides having PND-Tip region containing the highly conserved GPGR sequence within PND of HIV gp120, a monoclonal antibody having a neutralizing activity to many HIV variants can be prepared.
By transplanting the gene fragment coding for the variable region of said monoclonal antibody or complementarity determining region (CDR) of said region to a human antibody gene, a chimeric antibody or a reshaped antibody having an anti-HIV neutralizing activity which are effective for clinical applications can be obtained.
By transplanting the gene fragment coding for the variable region of said monoclonal antibody or complementarity determining region (CDR) of said region to a human antibody gene, a chimeric antibody or a reshaped antibody having an anti-HIV neutralizing activity which are effective for clinical applications can be obtained.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7891393 | 1993-03-11 | ||
| JP78913/93 | 1993-03-11 | ||
| PCT/JP1994/000371 WO1994020632A1 (en) | 1993-03-11 | 1994-03-09 | Anti-hiv monoclonal antibody |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2157874A1 true CA2157874A1 (en) | 1994-09-15 |
| CA2157874C CA2157874C (en) | 2006-04-18 |
Family
ID=36250865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002157874A Expired - Lifetime CA2157874C (en) | 1993-03-11 | 1994-03-09 | Anti-hiv monoclonal antibody |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2157874C (en) |
-
1994
- 1994-03-09 CA CA002157874A patent/CA2157874C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2157874C (en) | 2006-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20140310 |