CA2151142C - Ligand glycoproteique pour la p-selectine et ses modes d'utilisation - Google Patents

Ligand glycoproteique pour la p-selectine et ses modes d'utilisation Download PDF

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Publication number
CA2151142C
CA2151142C CA002151142A CA2151142A CA2151142C CA 2151142 C CA2151142 C CA 2151142C CA 002151142 A CA002151142 A CA 002151142A CA 2151142 A CA2151142 A CA 2151142A CA 2151142 C CA2151142 C CA 2151142C
Authority
CA
Canada
Prior art keywords
selectin
ligand
cells
binding
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002151142A
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English (en)
Other versions
CA2151142A1 (fr
Inventor
Richard D. Cummings
Kevin L. Moore
Rodger P. Mcever
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Publication of CA2151142A1 publication Critical patent/CA2151142A1/fr
Application granted granted Critical
Publication of CA2151142C publication Critical patent/CA2151142C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CA002151142A 1992-11-16 1993-11-16 Ligand glycoproteique pour la p-selectine et ses modes d'utilisation Expired - Fee Related CA2151142C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97655292A 1992-11-16 1992-11-16
US976,552 1992-11-16
PCT/US1993/011129 WO1994011498A1 (fr) 1992-11-16 1993-11-16 Ligand clycoproteique pour la p-selectine et son procede d'utilisation

Publications (2)

Publication Number Publication Date
CA2151142A1 CA2151142A1 (fr) 1994-05-26
CA2151142C true CA2151142C (fr) 2001-10-02

Family

ID=25524217

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002151142A Expired - Fee Related CA2151142C (fr) 1992-11-16 1993-11-16 Ligand glycoproteique pour la p-selectine et ses modes d'utilisation

Country Status (4)

Country Link
EP (1) EP0668907A1 (fr)
AU (1) AU681369B2 (fr)
CA (1) CA2151142C (fr)
WO (1) WO1994011498A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464778A (en) * 1989-03-08 1995-11-07 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for P-selectin and methods of use thereof
US6124267A (en) * 1991-02-05 2000-09-26 Southpac Trust Internationals, Inc. O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1
US6309639B1 (en) 1991-02-05 2001-10-30 The Board Of Regents Of The University Of Oklahoma Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand
US5648458A (en) * 1992-05-06 1997-07-15 Affymax Technologies N.V. Peptides and compounds that bind to ELAM-1
US5728802A (en) * 1992-05-06 1998-03-17 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1)
US5643873A (en) * 1992-05-06 1997-07-01 Affymax Technologies N.V. Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1
US5843707A (en) * 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
JPH08502886A (ja) * 1992-10-23 1996-04-02 ジェネティックス・インスティテュート・インコーポレイテッド 新規ｐ−セレクチンリガンド蛋白質
US6277975B1 (en) 1992-10-23 2001-08-21 Genetics Institute, Inc. Fusions of P-selectin ligand protein and polynucleotides encoding same
WO1995030001A2 (fr) * 1994-04-28 1995-11-09 Genetics Institute, Inc. Nouvelle proteine ligand de p-selectine
AU6272996A (en) * 1995-06-14 1997-01-15 General Hospital Corporation, The P-selectin ligands and related molecules and methods
EP1428832A3 (fr) * 1995-08-03 2004-09-22 The Board of Regents for the University of Oklahoma Peptides et O-glycanes inhibiteurs de l'inflammation induite par la sélectine
KR100523506B1 (en) * 1995-08-03 2005-10-24 Peptide and O-glycan inhibitors of selectin mediated inflammation
US6841543B1 (en) 1996-01-31 2005-01-11 President And Fellows Of Harvard College Methods of inhibiting production of T helper type 2 cytokines in human immune cells
WO1999043834A2 (fr) * 1998-02-27 1999-09-02 Genetics Institute, Inc. Proteine constituant un ligand de la p-selectine et proteines de fusion tetrameriques
US20030143662A1 (en) 1998-06-16 2003-07-31 Cummings Richard D. Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof
AU773542B2 (en) 1998-06-16 2004-05-27 Board Of Regents Of The University Of Oklahoma, The Glycosulfopeptides and methods of synthesis and use thereof
US7223845B2 (en) 1998-06-16 2007-05-29 The Board Of Regents Of The University Of Oklahoma Synthetic glycosulfopeptides and methods of synthesis thereof
EP1131084A4 (fr) * 1998-10-30 2001-12-19 Genetics Inst Inhibition de la differentiation des lymphocytes t cytotoxiques par des antagonistes du ligand de p-selectine (psgl)
DE60118362T2 (de) * 2000-05-19 2007-05-24 The Center for Blood Research, Inc., Boston VERFAHREN ZUR BEHANDLUNG VON HÄMOSTATISCHEN STÖRUNGEN DURCH LöSLICHES P-SELECTIN
WO2002089819A1 (fr) * 2001-05-07 2002-11-14 Vereniging Voor Christelijk Wetenschappelijk Onderwijs Glycoconjugues et utilisations de ceux-ci
CN111201038A (zh) 2017-01-11 2020-05-26 戊瑞治疗有限公司 Psgl-1拮抗剂及其用途
AU2018236218A1 (en) 2017-03-14 2019-09-12 Bristol-Myers Squibb Company Antibodies binding to vista at acidic pH

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05504470A (ja) * 1989-10-20 1993-07-15 ニューイングランド・メディカル・センター・ホスピタルズ・インコーポレーテッド Ｐａｄｇｅｍを介した細胞結合の阻害
WO1992001718A2 (fr) * 1990-07-17 1992-02-06 Board Of Regents Of The University Of Oklahoma Peptides fonctionnellement actifs derives de la selectine et ligand pour selectine gmp 140
EP0575557A1 (fr) * 1991-03-11 1993-12-29 New England Medical Center Procede d'inhibition d'interactions induites par padgem au moyen d'un inhibiteur comprenant un constituant d'acide 2,6 sialique

Also Published As

Publication number Publication date
AU5727594A (en) 1994-06-08
CA2151142A1 (fr) 1994-05-26
AU681369B2 (en) 1997-08-28
EP0668907A1 (fr) 1995-08-30
WO1994011498A1 (fr) 1994-05-26

Similar Documents

Publication Publication Date Title
CA2151142C (fr) Ligand glycoproteique pour la p-selectine et ses modes d'utilisation
US5880091A (en) Glycoprotein ligand for P-selectin and methods of use thereof
US6309639B1 (en) Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand
AU660627B2 (en) Functionally active selectin-derived peptide for GMP-140
US5198424A (en) Functionally active selectin-derived peptides
US6124267A (en) O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1
Moore et al. Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells.
AU723262B2 (en) Peptide and O-glycan inhibitors of selectin mediated inflammation
EP0602194A1 (fr) Inhibiteurs peptidiques d'inflammation presentant une mediation par les selectines
WO1994014836A1 (fr) Inhibiteurs peptidiques de liaison de selectine
WO1992016612A2 (fr) Procede d'inhibition d'interactions induites par padgem au moyen d'un inhibiteur comprenant un constituant d'acide 2,6 sialique
WO1994005269A1 (fr) Inhibiteurs peptidiques de fixation de la selectine
WO1994005314A1 (fr) Inhibiteurs peptidiques de l'adhesion des leucocytes
EP0656904A1 (fr) Peptides inhibiteurs de la liaison de selectine
EP1245575A2 (fr) Peptides fonctionellement actifs dérivés de sélectine et ligand pour GMP140
EP1428832A2 (fr) Peptides et O-glycanes inhibiteurs de l'inflammation induite par la sélectine

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