CA2149245C - Novel isoxazolines as antiinflammatory agents - Google Patents

Novel isoxazolines as antiinflammatory agents

Info

Publication number
CA2149245C
CA2149245C CA002149245A CA2149245A CA2149245C CA 2149245 C CA2149245 C CA 2149245C CA 002149245 A CA002149245 A CA 002149245A CA 2149245 A CA2149245 A CA 2149245A CA 2149245 C CA2149245 C CA 2149245C
Authority
CA
Canada
Prior art keywords
carbon atoms
alkyl
alkoxy
halosubstituted
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002149245A
Other languages
English (en)
French (fr)
Other versions
CA2149245A1 (en
Inventor
Akemi Ando
Rodney W. Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of CA2149245A1 publication Critical patent/CA2149245A1/en
Application granted granted Critical
Publication of CA2149245C publication Critical patent/CA2149245C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002149245A 1992-11-20 1993-10-20 Novel isoxazolines as antiinflammatory agents Expired - Fee Related CA2149245C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP312259/92 1992-11-20
JP4312259A JP2738486B2 (ja) 1992-11-20 1992-11-20 抗炎症剤としての新規なイソオキサゾリン類

Publications (2)

Publication Number Publication Date
CA2149245A1 CA2149245A1 (en) 1994-06-09
CA2149245C true CA2149245C (en) 1997-08-26

Family

ID=18027089

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002149245A Expired - Fee Related CA2149245C (en) 1992-11-20 1993-10-20 Novel isoxazolines as antiinflammatory agents

Country Status (9)

Country Link
US (1) US5552424A (ja)
EP (1) EP0669914A1 (ja)
JP (1) JP2738486B2 (ja)
KR (1) KR0163648B1 (ja)
CN (1) CN1035054C (ja)
AU (1) AU675256B2 (ja)
CA (1) CA2149245C (ja)
FI (1) FI935117A (ja)
WO (1) WO1994012481A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
KR100594544B1 (ko) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 이소옥사졸린 구조를 갖는 캐스파제 저해제
JP2007530598A (ja) * 2004-03-26 2007-11-01 サイトカイン・ファーマサイエンシズ・インコーポレーテッド マクロファージ遊走阻害因子の阻害に関する、化合物、組成物、作製プロセス、および使用方法
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
US20080262057A1 (en) * 2007-04-20 2008-10-23 Dow Agrosciences Llc Diarylisoxazolines
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA871860B (en) * 1986-03-14 1988-10-26 Syntex Inc Transglutaminase inhibitors
IE59813B1 (en) * 1986-05-09 1994-04-06 Warner Lambert Co Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
CA1334975C (en) * 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
GB9012252D0 (en) * 1990-06-01 1990-07-18 Lilly Industries Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
JPH06157485A (ja) 1994-06-03
CN1091132A (zh) 1994-08-24
US5552424A (en) 1996-09-03
CN1035054C (zh) 1997-06-04
KR0163648B1 (ko) 1998-12-01
KR950704273A (ko) 1995-11-17
JP2738486B2 (ja) 1998-04-08
EP0669914A1 (en) 1995-09-06
AU675256B2 (en) 1997-01-30
FI935117A (fi) 1994-05-21
FI935117A0 (fi) 1993-11-18
AU5359994A (en) 1994-06-22
WO1994012481A1 (en) 1994-06-09
CA2149245A1 (en) 1994-06-09

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