CA2139129A1 - Derives peptidyle et leur utilisation comme inhibiteur d'une metalloproteinase - Google Patents
Derives peptidyle et leur utilisation comme inhibiteur d'une metalloproteinaseInfo
- Publication number
- CA2139129A1 CA2139129A1 CA002139129A CA2139129A CA2139129A1 CA 2139129 A1 CA2139129 A1 CA 2139129A1 CA 002139129 A CA002139129 A CA 002139129A CA 2139129 A CA2139129 A CA 2139129A CA 2139129 A1 CA2139129 A1 CA 2139129A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- optionally substituted
- hydrogen atom
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9308695.7 | 1993-04-27 | ||
GB939308695A GB9308695D0 (en) | 1993-04-27 | 1993-04-27 | Peptidyl derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2139129A1 true CA2139129A1 (fr) | 1994-11-10 |
Family
ID=10734557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002139129A Abandoned CA2139129A1 (fr) | 1993-04-27 | 1994-04-27 | Derives peptidyle et leur utilisation comme inhibiteur d'une metalloproteinase |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0648206A1 (fr) |
JP (1) | JPH08500610A (fr) |
AU (1) | AU6575494A (fr) |
CA (1) | CA2139129A1 (fr) |
GB (1) | GB9308695D0 (fr) |
WO (1) | WO1994025435A1 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6037472A (en) | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
GB2300188B (en) * | 1994-01-22 | 1998-07-01 | British Biotech Pharm | Metalloproteinase inhibitors |
AU711047B2 (en) * | 1994-01-22 | 1999-10-07 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
DE69512891T2 (de) * | 1994-01-22 | 2000-02-24 | British Biotech Pharmaceuticals Ltd., Cowley | Metalloproteinaseinhibitoren |
GB9423914D0 (en) * | 1994-11-26 | 1995-01-11 | British Biotech Pharm | Polyether derivatives as metalloproteinase inhibitors |
US5917090A (en) * | 1995-06-30 | 1999-06-29 | British Biotech Pharmaceuticals Ltd. | Matrix metalloproteinase inhibitors |
US6127427A (en) | 1995-11-23 | 2000-10-03 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
JP2000502330A (ja) * | 1995-12-08 | 2000-02-29 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | メタロプロテイナーゼ阻害薬、それらを含有する薬剤組成物および薬剤としてのそれらの使用、ならびにそれらの製造に有用な方法および中間体 |
TW424083B (en) * | 1996-07-10 | 2001-03-01 | American Cyanamid Co | Mercaptoketones and mercaptoalcohols and a process for their prepartation |
US5852213A (en) * | 1996-07-10 | 1998-12-22 | American Cyanamid Company | Mercaptoketones and mercaptoalcohols and a process for their preparation |
ES2181021T3 (es) | 1996-09-10 | 2003-02-16 | British Biotech Pharm | Derivados citostaticos del acido hidroxamico. |
US6462023B1 (en) | 1996-09-10 | 2002-10-08 | British Biotech Pharmaceuticals, Ltd. | Cytostatic agents |
US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
ZA9818B (en) * | 1997-01-07 | 1998-07-02 | Abbott Lab | C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion |
RU2141483C1 (ru) * | 1997-07-04 | 1999-11-20 | Небольсин Владимир Евгеньевич | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
TR200001909T2 (tr) | 1998-01-09 | 2000-12-21 | Pfizer Inc. | Matris metaloprotez inhibitörleri. |
GB9803005D0 (en) | 1998-02-12 | 1998-04-08 | British Biotech Pharm | Anti-inflammatory agents |
US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
MXPA02009311A (es) | 2000-03-21 | 2003-03-12 | Procter & Gamble | Inhibidores de las metaloproteasas n-sustituidas que contienen cadenas laterales heterociclicas. |
IL151250A0 (en) | 2000-03-21 | 2003-04-10 | Procter & Gamble | Difluorobutyric acid metalloprotease inhibitors |
AU5101801A (en) * | 2000-03-27 | 2001-10-08 | Scripps Research Inst | Inhibition of angiogenesis and tumor growth |
AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
BR0210422A (pt) | 2001-06-15 | 2004-08-17 | Vicuron Pharm Inc | Compostos bicìclicos de pirrolidina |
RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
AU2008234380B2 (en) * | 2007-04-02 | 2013-01-24 | Merck Canada Inc. | Amidation process for the preparation of cathepsin K inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8919251D0 (en) * | 1989-08-24 | 1989-10-04 | British Bio Technology | Compounds |
HUT62263A (en) * | 1990-12-03 | 1993-04-28 | Celltech Ltd | Process for producing peptidyl derivatives and pharmaceutical compositions comprising such compounds as active ingredient |
-
1993
- 1993-04-27 GB GB939308695A patent/GB9308695D0/en active Pending
-
1994
- 1994-04-27 EP EP94913710A patent/EP0648206A1/fr not_active Withdrawn
- 1994-04-27 AU AU65754/94A patent/AU6575494A/en not_active Abandoned
- 1994-04-27 WO PCT/GB1994/000896 patent/WO1994025435A1/fr not_active Application Discontinuation
- 1994-04-27 CA CA002139129A patent/CA2139129A1/fr not_active Abandoned
- 1994-04-27 JP JP6524027A patent/JPH08500610A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPH08500610A (ja) | 1996-01-23 |
WO1994025435A1 (fr) | 1994-11-10 |
GB9308695D0 (en) | 1993-06-09 |
AU6575494A (en) | 1994-11-21 |
EP0648206A1 (fr) | 1995-04-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |