CA2135882A1 - Mode de preparation d'un agent diagnostic ayant la capacite de detecter les inflammations - Google Patents

Mode de preparation d'un agent diagnostic ayant la capacite de detecter les inflammations

Info

Publication number
CA2135882A1
CA2135882A1 CA002135882A CA2135882A CA2135882A1 CA 2135882 A1 CA2135882 A1 CA 2135882A1 CA 002135882 A CA002135882 A CA 002135882A CA 2135882 A CA2135882 A CA 2135882A CA 2135882 A1 CA2135882 A1 CA 2135882A1
Authority
CA
Canada
Prior art keywords
protein
kit
substance
purified
proteinaceous substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002135882A
Other languages
English (en)
Inventor
Ernest K. J. Pauwels
R. I .J. Feitsam
Mick W. Welling
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Publication of CA2135882A1 publication Critical patent/CA2135882A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/534Production of labelled immunochemicals with radioactive label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002135882A 1992-05-15 1993-04-15 Mode de preparation d'un agent diagnostic ayant la capacite de detecter les inflammations Abandoned CA2135882A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP92201390.9 1992-05-15
EP92201390 1992-05-15
PCT/US1993/003586 WO1993023743A1 (fr) 1992-05-15 1993-04-15 Procede de preparation d'un agent diagnostique pour deceler les inflammations

Publications (1)

Publication Number Publication Date
CA2135882A1 true CA2135882A1 (fr) 1993-11-25

Family

ID=8210610

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002135882A Abandoned CA2135882A1 (fr) 1992-05-15 1993-04-15 Mode de preparation d'un agent diagnostic ayant la capacite de detecter les inflammations

Country Status (5)

Country Link
EP (1) EP0640211A1 (fr)
JP (1) JPH07506830A (fr)
AU (1) AU4288493A (fr)
CA (1) CA2135882A1 (fr)
WO (1) WO1993023743A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19514088A1 (de) 1995-04-13 1996-10-17 Deutsches Krebsforsch Konjugat zur Behandlung von Entzünduns-, Infektions- und/oder Hauterkrankungen
RU2571486C1 (ru) * 2014-11-05 2015-12-20 Общество с ограниченной ответственностью "ДИАМЕД" Способ визуализации воспалений

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323546A (en) * 1978-05-22 1982-04-06 Nuc Med Inc. Method and composition for cancer detection in humans
US4311688A (en) * 1979-10-29 1982-01-19 Serono Laboratories Inc. Composition and method for cancer detection in humans
US4472371A (en) * 1979-10-29 1984-09-18 Summa Medical Corporation Radiolabeled antibody to anti-tumor associated antigen and process
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US5037630A (en) * 1985-01-14 1991-08-06 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4859449A (en) * 1987-09-14 1989-08-22 Center For Molecular Medicine And Immunology Modified antibodies for enhanced hepatocyte clearance

Also Published As

Publication number Publication date
AU4288493A (en) 1993-12-13
JPH07506830A (ja) 1995-07-27
WO1993023743A1 (fr) 1993-11-25
EP0640211A1 (fr) 1995-03-01

Similar Documents

Publication Publication Date Title
KR0178961B1 (ko) 단백질의 테크네튬/레늄 라벨링 방법
US5326778A (en) Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy
KR100235137B1 (ko) 모노아민, 다아민, 티올-함유 금속 킬레이트제
EP0354923B1 (fr) Procede de marquage d'anticorps a l'aide d'un ion metallique
JP2727074B2 (ja) 像形成組成物及び標的用ポリペプチド
EP0137457A2 (fr) Conjugués de métallothionéine et de molécules biologiquement actives chercheuses de cible, marqués par un traceur
JPH03504858A (ja) 蛋白質のラベリング方法
JPH08502075A (ja) 標識された単球走化性因子タンパク質材料およびその医学的使用
CA1222691A (fr) Methode de preparation de proteines marquees par un radionucleide, notamment des anticorps ou des fragments d'anticorps
US5130118A (en) Methods and materials for the preparation of metal labelled antibody solutions
EP0584256B1 (fr) Composes et compositions pour la detection et la loclisation de tissus comprenant des recepteurs de neurokinine 1
CA2135882A1 (fr) Mode de preparation d'un agent diagnostic ayant la capacite de detecter les inflammations
WO1997010854A1 (fr) Composes de biotine (radio) marques
JPH05502219A (ja) 安定な治療用放射性核種およびそれを調製する方法
USH735H (en) Lead-203 as a label for radioimaging
CA2069868A1 (fr) Methode pour preparer une proteine marquee par un traceur radioactif metallique
EP0485664A1 (fr) Procédé de préparation d'agent diagnostique pour la détection des inflammations
JPH01197445A (ja) 乳癌診断剤
EP0654043A1 (fr) Procede pour preparer une proteine marquee par un radionucleide de metal
JPH05178826A (ja) 二官能性キレート化剤、それと蛋白質との複合体及びその用途
JPH05239039A (ja) テクネチウムまたはレニウムで物質を標識する方法
JPH06509102A (ja) 体内造影抗イディオタイプ抗体を用いた組織特異的造影剤
WO1994012523A1 (fr) Complexe de steroide-21-phosphate de technetium-99m

Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 19951015