CA2133998C - Treatment of macular degeneration - Google Patents
Treatment of macular degeneration Download PDFInfo
- Publication number
- CA2133998C CA2133998C CA002133998A CA2133998A CA2133998C CA 2133998 C CA2133998 C CA 2133998C CA 002133998 A CA002133998 A CA 002133998A CA 2133998 A CA2133998 A CA 2133998A CA 2133998 C CA2133998 C CA 2133998C
- Authority
- CA
- Canada
- Prior art keywords
- deprenyl
- macular degeneration
- salt
- use according
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000002780 macular degeneration Diseases 0.000 title claims abstract description 28
- 238000011282 treatment Methods 0.000 title claims description 17
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical group C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 claims abstract description 30
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 239000002253 acid Substances 0.000 claims abstract description 14
- 239000003814 drug Substances 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 210000004027 cell Anatomy 0.000 description 14
- 210000001525 retina Anatomy 0.000 description 12
- 229940079593 drug Drugs 0.000 description 7
- 230000004438 eyesight Effects 0.000 description 6
- 230000006872 improvement Effects 0.000 description 5
- 210000004379 membrane Anatomy 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000000049 pigment Substances 0.000 description 5
- 241000282414 Homo sapiens Species 0.000 description 4
- 102000010909 Monoamine Oxidase Human genes 0.000 description 4
- 108010062431 Monoamine oxidase Proteins 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 206010064930 age-related macular degeneration Diseases 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 230000007850 degeneration Effects 0.000 description 4
- 206010047531 Visual acuity reduced Diseases 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229920006267 polyester film Polymers 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000002207 retinal effect Effects 0.000 description 3
- 206010003694 Atrophy Diseases 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 208000003098 Ganglion Cysts Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 208000018737 Parkinson disease Diseases 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 208000005400 Synovial Cyst Diseases 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 210000001775 bruch membrane Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000005786 degenerative changes Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000002430 laser surgery Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 230000000649 photocoagulation Effects 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000004304 visual acuity Effects 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 108010082126 Alanine transaminase Proteins 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000010415 Low Vision Diseases 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 101000581498 Methylosinus trichosporium Methanobactin mb-OB3b Proteins 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 206010039729 Scotoma Diseases 0.000 description 1
- 229940124639 Selective inhibitor Drugs 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 239000007894 caplet Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940063628 catapres Drugs 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 210000003618 cortical neuron Anatomy 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000013534 fluorescein angiography Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002287 horizontal cell Anatomy 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 210000000627 locus coeruleus Anatomy 0.000 description 1
- 230000004303 low vision Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 210000004498 neuroglial cell Anatomy 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 230000004493 normal intraocular pressure Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 230000004431 optic radiations Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 210000000463 red nucleus Anatomy 0.000 description 1
- 239000000790 retinal pigment Substances 0.000 description 1
- 210000003583 retinal pigment epithelium Anatomy 0.000 description 1
- 230000002784 sclerotic effect Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000004911 serous fluid Anatomy 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 229940001089 sinemet Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Semiconductor Lasers (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/872,839 | 1992-04-23 | ||
| US07/872,839 US5242950A (en) | 1992-04-23 | 1992-04-23 | Treatment of macular degeneration |
| PCT/US1993/003862 WO1993021894A2 (en) | 1992-04-23 | 1993-04-23 | Treatment of macular degeneration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2133998A1 CA2133998A1 (en) | 1993-11-11 |
| CA2133998C true CA2133998C (en) | 2006-03-21 |
Family
ID=25360402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002133998A Expired - Lifetime CA2133998C (en) | 1992-04-23 | 1993-04-23 | Treatment of macular degeneration |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5242950A (no) |
| EP (1) | EP0637238B1 (no) |
| JP (1) | JP2669721B2 (no) |
| AT (1) | ATE175348T1 (no) |
| AU (1) | AU679679B2 (no) |
| BR (1) | BR9306283A (no) |
| CA (1) | CA2133998C (no) |
| DE (1) | DE69322957T2 (no) |
| DK (1) | DK0637238T3 (no) |
| ES (1) | ES2127819T3 (no) |
| GR (1) | GR3029670T3 (no) |
| HU (1) | HU224917B1 (no) |
| NO (1) | NO944018L (no) |
| WO (1) | WO1993021894A2 (no) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025380A (en) * | 1990-12-14 | 2000-02-15 | Smithkline Beecham Plc | Medicament |
| US5783606A (en) * | 1995-02-10 | 1998-07-21 | The University Of Toronto Innovations Foundation | Deprenyl compounds for treatment of glaucoma |
| US5462746A (en) * | 1992-11-02 | 1995-10-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
| US6033682A (en) * | 1995-01-13 | 2000-03-07 | Somerset Pharmaceuticals, Inc. | S(+) desmethylselegiline and its use in therapeutic methods and pharmaceutical compositions |
| US6319954B1 (en) | 1995-01-13 | 2001-11-20 | Somerset Pharmaceuticals, Inc. | S-(+)-desmethylselegiline and its use in the therapeutic methods and pharmaceutical compositions |
| US6348208B1 (en) | 1995-01-13 | 2002-02-19 | Somerset Pharmaceuticals, Inc. | Methods and pharmaceutical compositions employing desmethylselegiline |
| US6299901B1 (en) | 1995-01-13 | 2001-10-09 | Somerset Pharmaceuticals, Inc. | Methods and pharmaceutical compositions employing desmethylselegiline |
| WO1996024346A1 (en) * | 1995-02-10 | 1996-08-15 | The University Of Toronto Innovations Foundation | Deprenyl compounds for treatment of glaucoma |
| US6316022B1 (en) | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| CA2223588C (en) * | 1995-06-07 | 2004-01-06 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| US5827652A (en) | 1995-10-31 | 1998-10-27 | Applied Food Biotechnology, Inc. | Zeaxanthin formulations for human ingestion |
| CA2236368C (en) * | 1995-11-06 | 2001-10-23 | Somerset Pharmaceuticals, Inc. | Sublingual and buccal administration of selegiline |
| BR9908713A (pt) | 1998-03-16 | 2000-11-21 | Somerset Pharmaceuticals Inc | Uso de selegilina ou desmetil-selegilina para tratamento de feridas, queimaduras e danos dermatológicos |
| US7691406B2 (en) * | 2000-10-27 | 2010-04-06 | ZeaVision LLC. | Zeaxanthin formulations for human ingestion |
| DK1441708T3 (da) | 2001-11-05 | 2009-07-06 | Krele Pharmaceuticals Llc | Sammensætninger og fremgangsmåder til forögelse af föjelighed med terapier ved anvendelse af aldehyddehydrogenase-inhibitorer og behandling af alkoholisme |
| US8088363B2 (en) | 2002-10-28 | 2012-01-03 | Zeavision Llc | Protection against sunburn and skin problems with orally-ingested high-dosage zeaxanthin |
| AU2003282337B2 (en) * | 2002-11-07 | 2009-07-16 | Technion Research And Development Foundation Ltd. | Neuroprotective iron chelators and pharmaceutical compositions comprising them |
| US9192586B2 (en) | 2003-03-10 | 2015-11-24 | Zeavision Llc | Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders |
| US20040180090A1 (en) * | 2003-03-12 | 2004-09-16 | Demarco Peter | Treatment of macular degeneration |
| EP1622450A4 (en) * | 2003-04-25 | 2009-11-18 | Endo Pharmaceuticals Solutions | PROCESS FOR PROMOTING UNINTERRUPTED SLEEP BY ADMINISTERING TROPIUM CHLORIDE |
| US20070082066A1 (en) * | 2003-05-07 | 2007-04-12 | Gierhart Dennis L | Use of zeaxanthin to reduce light hyper-sensitivity, photophobia, and medical conditions relating to light hyper-sensitivity |
| US7941211B2 (en) * | 2003-11-17 | 2011-05-10 | Zeavision, Llc. | Preloading with macular pigment to improve photodynamic treatment of retinal vascular disorders |
| US8097608B2 (en) * | 2003-11-25 | 2012-01-17 | Technion Research And Development Foundation Ltd. | Methods for treatment of cardiovascular disorders and diseases |
| EP1686973A4 (en) * | 2003-11-25 | 2009-03-25 | Technion Res & Dev Foundation | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND DISEASES |
| JP2005232148A (ja) * | 2004-02-03 | 2005-09-02 | Technion Research & Development Foundation Ltd | 神経保護剤としてプロパルギルアミンの使用 |
| US20060089411A1 (en) * | 2004-08-07 | 2006-04-27 | Gierhart Dennis L | Treatment of Stargardt's disease and other lipofuscin disorders with combined retinaldehyde inhibitor and zeaxanthin |
| EP3381446A1 (en) * | 2004-10-29 | 2018-10-03 | The Regents of The University of California | Porous photonic crystals for drug delivery to the eye |
| US8263655B2 (en) * | 2005-10-06 | 2012-09-11 | Technion Research And Development Foundation Ltd | Methods for treatment of renal failure |
| KR20090034365A (ko) * | 2006-07-28 | 2009-04-07 | 알콘 리서치, 리미티드 | 외부 망막 질환을 치료하는데 유용한 모노아민 산화효소 저해제 |
| KR20100047258A (ko) | 2007-07-10 | 2010-05-07 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 선택된 조직에 조성물을 전달하는 물질 및 방법 |
| CN102791258B (zh) | 2010-02-03 | 2018-05-08 | 图必制药公司 | 雷沙吉兰的延长释放制剂及其用途 |
| US9394369B2 (en) | 2011-01-03 | 2016-07-19 | The Regents Of The University Of California | Luminescent porous silicon nanoparticles for targeted delivery and immunization |
| JP6894423B2 (ja) | 2015-07-09 | 2021-06-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 融合性リポソーム被覆多孔質ケイ素ナノ粒子 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU197510B (en) * | 1986-12-19 | 1989-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical composition containing phenyl-alkyl-amine derivatives, against motion-sick |
| US4861800A (en) * | 1987-08-18 | 1989-08-29 | Buyske Donald A | Method for administering the drug deprenyl so as to minimize the danger of side effects |
| US4868218A (en) * | 1987-08-18 | 1989-09-19 | Buyske Donald A | Method of treating depression |
| GB8807504D0 (en) * | 1988-03-29 | 1988-05-05 | Sandoz Ltd | Improvements in/relating to organic compounds |
| CA2039194C (en) * | 1990-08-31 | 1997-01-28 | Norton W. Milgram | Uses of l-deprenyl and compositions for same |
-
1992
- 1992-04-23 US US07/872,839 patent/US5242950A/en not_active Expired - Lifetime
-
1993
- 1993-04-23 ES ES93909617T patent/ES2127819T3/es not_active Expired - Lifetime
- 1993-04-23 AT AT93909617T patent/ATE175348T1/de not_active IP Right Cessation
- 1993-04-23 WO PCT/US1993/003862 patent/WO1993021894A2/en not_active Ceased
- 1993-04-23 BR BR9306283A patent/BR9306283A/pt not_active Application Discontinuation
- 1993-04-23 EP EP93909617A patent/EP0637238B1/en not_active Expired - Lifetime
- 1993-04-23 DK DK93909617T patent/DK0637238T3/da active
- 1993-04-23 DE DE69322957T patent/DE69322957T2/de not_active Expired - Fee Related
- 1993-04-23 HU HU9403052A patent/HU224917B1/hu not_active IP Right Cessation
- 1993-04-23 AU AU40339/93A patent/AU679679B2/en not_active Ceased
- 1993-04-23 CA CA002133998A patent/CA2133998C/en not_active Expired - Lifetime
- 1993-04-23 JP JP5519416A patent/JP2669721B2/ja not_active Expired - Fee Related
-
1994
- 1994-10-21 NO NO944018A patent/NO944018L/no unknown
-
1999
- 1999-03-12 GR GR990400754T patent/GR3029670T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO944018D0 (no) | 1994-10-21 |
| US5242950A (en) | 1993-09-07 |
| AU679679B2 (en) | 1997-07-10 |
| AU4033993A (en) | 1993-11-29 |
| CA2133998A1 (en) | 1993-11-11 |
| DK0637238T3 (da) | 1999-08-30 |
| HU224917B1 (en) | 2006-04-28 |
| DE69322957D1 (de) | 1999-02-18 |
| GR3029670T3 (en) | 1999-06-30 |
| EP0637238A1 (en) | 1995-02-08 |
| NO944018L (no) | 1994-10-21 |
| ES2127819T3 (es) | 1999-05-01 |
| HUT72295A (en) | 1996-04-29 |
| ATE175348T1 (de) | 1999-01-15 |
| EP0637238B1 (en) | 1999-01-07 |
| HU9403052D0 (en) | 1994-12-28 |
| JP2669721B2 (ja) | 1997-10-29 |
| BR9306283A (pt) | 1998-06-30 |
| JPH07505906A (ja) | 1995-06-29 |
| WO1993021894A2 (en) | 1993-11-11 |
| DE69322957T2 (de) | 1999-07-01 |
| WO1993021894A3 (en) | 1994-01-20 |
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