CA2130828C - Non-azo naphthalimide dyes and uses for same - Google Patents

Non-azo naphthalimide dyes and uses for same Download PDF

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Publication number
CA2130828C
CA2130828C CA002130828A CA2130828A CA2130828C CA 2130828 C CA2130828 C CA 2130828C CA 002130828 A CA002130828 A CA 002130828A CA 2130828 A CA2130828 A CA 2130828A CA 2130828 C CA2130828 C CA 2130828C
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CA
Canada
Prior art keywords
alkyl
group
substituted
chain
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002130828A
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English (en)
French (fr)
Other versions
CA2130828A1 (en
Inventor
David E. Lewis
Ronald E. Utecht
Millard M. Judy
J. Lester Matthews
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHOTOBIOMED
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PHOTOBIOMED
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PHOTOBIOMED filed Critical PHOTOBIOMED
Publication of CA2130828A1 publication Critical patent/CA2130828A1/en
Application granted granted Critical
Publication of CA2130828C publication Critical patent/CA2130828C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/08—Naphthalimide dyes; Phthalimide dyes
    • A61L2103/05—

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
CA002130828A 1992-03-19 1993-03-18 Non-azo naphthalimide dyes and uses for same Expired - Lifetime CA2130828C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/854,416 US5235045A (en) 1992-03-19 1992-03-19 Non-azo naphthalimide dyes
US854,416 1992-03-19
PCT/US1993/002509 WO1993018789A1 (en) 1992-03-19 1993-03-18 Non-azo naphthalimide dyes and uses for same

Publications (2)

Publication Number Publication Date
CA2130828A1 CA2130828A1 (en) 1993-09-30
CA2130828C true CA2130828C (en) 2007-06-12

Family

ID=25318632

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002130828A Expired - Lifetime CA2130828C (en) 1992-03-19 1993-03-18 Non-azo naphthalimide dyes and uses for same

Country Status (8)

Country Link
US (3) US5235045A (OSRAM)
EP (1) EP0639080B1 (OSRAM)
JP (1) JPH07505366A (OSRAM)
KR (1) KR950700910A (OSRAM)
AU (1) AU3924693A (OSRAM)
CA (1) CA2130828C (OSRAM)
DE (1) DE69331384T2 (OSRAM)
WO (1) WO1993018789A1 (OSRAM)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
GB2306496A (en) * 1992-11-16 1997-05-07 Microbiomed Corp Non-azo 4-((2-amino- and 2-hydroxy-ethyl)amino)-N-alkyl-1,8-naphthalimide dyes
US5308773A (en) * 1992-11-16 1994-05-03 Microbiomed Corp. Non-azo 1,8-naphthalimide dyes for the detection and quantitation of a paramagnetic metal cation in a non-aqueous medium
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
US5561042A (en) * 1994-07-22 1996-10-01 Cancer Therapy And Research Center Diamine platinum naphthalimide complexes as antitumor agents
US5604095A (en) * 1994-07-22 1997-02-18 Cancer Therapy & Research Center Unsymmetrically linked bisnaphthalimides as antitumor agents
DE19505941A1 (de) * 1995-02-21 1996-08-22 Bayer Ag 1,8-Naphthalimid-Derivate, Verfahren zur Herstellung und ihre Verwendung als Zwischenprodukte
DE19505942A1 (de) 1995-02-21 1996-08-22 Bayer Ag (Co)Polymerisate auf Basis von Vinyl-Einheiten und ihre Verwendung in elektrolumineszierenden Anordnungen
DE19511484A1 (de) * 1995-03-29 1996-10-02 Bayer Ag (Co)Polymerisate auf Basis von Vinyl-Einheiten und ihre Verwendung in elektrolumineszierenden Anordnungen
US6075106A (en) * 1995-03-29 2000-06-13 D-51368 Bayer Ag (Co)polymers based on vinyl units and use thereof in electroluminescent devices
DE59501555D1 (de) * 1995-04-20 1998-04-09 Fuba Automotive Gmbh Flachantennen-Anordnung
US5917045A (en) * 1995-06-07 1999-06-29 Microbiomed Corporation Dimeric non-azo naphthalimides and uses for same
US6410505B1 (en) 1999-06-28 2002-06-25 Microbiomed Corp. Dimeric non-azo naphthalimides and uses for the same
DE19536843A1 (de) * 1995-10-02 1997-04-03 Bayer Ag (Co)Polymerisate auf Basis von Vinyl-Einheiten und ihre Verwendung in elektrolumineszierenden Anordnungen
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
AU3897397A (en) * 1996-07-29 1998-02-20 Regents Of The University Of California, The Polymeric assemblies for sensitive colorimetric assays
DE19632949A1 (de) * 1996-08-16 1998-02-19 Bayer Ag (Co)Polymerisate auf Basis von Vinyl-Einheiten und ihre Verwendung in elektrolumineszierenden Anordnungen
AU5818498A (en) * 1997-01-15 1998-08-07 Microbiomed Corporation Naphthalimide dyes and their use as fluid visualizing agents
US5858930A (en) * 1997-05-30 1999-01-12 United Color Manufacturing, Inc. Liquid Benz-iso-Quinoline derivatives
CA2298526A1 (en) * 1997-07-28 1999-02-04 Dermatolazer Technologies Ltd Phototherapy based method for treating pathogens and composition for effecting same
US6121278A (en) * 1997-09-03 2000-09-19 Guilford Pharmaceuticals, Inc. Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6346536B1 (en) 1997-09-03 2002-02-12 Guilford Pharmaceuticals Inc. Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US5918269A (en) * 1998-02-18 1999-06-29 Milliken & Company Naphthalimide colorants with improved compatibility in refrigeration and air conditioning lubricants
JP2002515488A (ja) * 1998-05-15 2002-05-28 ギルフォード ファーマシューティカルズ インコーポレイテッド カルボキサミド化合物、組成物、及びｐａｒｐ活性の抑制方法
US6380193B1 (en) 1998-05-15 2002-04-30 Guilford Pharmaceuticals Inc. Fused tricyclic compounds, methods and compositions for inhibiting PARP activity
US6395749B1 (en) 1998-05-15 2002-05-28 Guilford Pharmaceuticals Inc. Carboxamide compounds, methods, and compositions for inhibiting PARP activity
JP2002515490A (ja) * 1998-05-15 2002-05-28 ギルフォード ファーマシューティカルズ インコーポレイテッド Ｐａｒｐ活性を抑制する縮合三環化合物
US6387902B1 (en) 1998-12-31 2002-05-14 Guilford Pharmaceuticals, Inc. Phenazine compounds, methods and pharmaceutical compositions for inhibiting PARP
US5935272A (en) * 1999-02-02 1999-08-10 Milliken & Company Compositions comprising aryloxypolyoxyalkylene naphthalimide derivative colorants
JP3993747B2 (ja) * 1999-02-02 2007-10-17 ミリケン・アンド・カンパニー アリールオキシ−ポリ（オキシアルキレン）ナフタルイミド誘導体着色剤
US5998621A (en) * 1999-02-02 1999-12-07 Milliken & Company Aryloxy-poly(oxyalkylene) naphthalimide derivative colorants
US6150306A (en) * 1999-03-04 2000-11-21 Morton Internatioanl Inc. Fluorescent tracer dyes
GB9920774D0 (en) 1999-09-03 1999-11-03 Avecia Ltd Polymer
US6682938B1 (en) 1999-09-15 2004-01-27 The Regents Of The University Of California Glucose sensing molecules having selected fluorescent properties
US6673625B2 (en) 1999-09-15 2004-01-06 The Regents Of The University Of California Saccharide sensing molecules having enhanced fluorescent properties
US7331350B2 (en) * 2000-02-11 2008-02-19 The General Hospital Corporation Photochemical tissue bonding
US8215314B2 (en) * 2000-02-11 2012-07-10 The General Hospital Corporation Photochemical tissue bonding
US7073510B2 (en) * 2000-02-11 2006-07-11 The General Hospital Corporation Photochemical tissue bonding
US6607522B1 (en) * 2000-03-16 2003-08-19 General Hospital Corporation Methods for tissue welding using laser-activated protein solders
AU2001251210A1 (en) * 2000-04-04 2001-10-15 Medtronic Minimed, Inc. Saccharide sensing molecules having enhanced fluorescent properties
US6723733B2 (en) 2000-05-19 2004-04-20 Guilford Pharmaceuticals, Inc. Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses
AU2001275085A1 (en) 2000-06-01 2001-12-11 Guilford Pharmaceuticals Inc. Methods, compounds and compositions for treating gout
US6843961B2 (en) 2000-06-15 2005-01-18 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
AU2001273099A1 (en) 2000-07-13 2002-01-30 Guilford Pharmaceuticals Inc. Substituted 4,9-dihydrocyclopenta(imn) phenanthridine-5-ones, derivatives thereof and their uses
WO2002026270A2 (en) * 2000-09-27 2002-04-04 Gambro, Inc. Inactivation of contaminants using photosensitizers and pulsed light
GB2368843A (en) * 2000-11-08 2002-05-15 Leuven K U Res & Dev Non-porphyrin multipurpose contrast agents
AU2002251944A1 (en) * 2001-02-15 2002-09-04 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
HU224941B1 (en) * 2001-08-10 2006-04-28 Bgi Innovacios Kft Phototerapy apparatus
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
CA2586320A1 (en) * 2003-11-05 2005-05-19 Photobiomed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
GB0419850D0 (en) * 2004-09-07 2004-10-13 Angeletti P Ist Richerche Bio Therapeutic agents
US7528144B2 (en) * 2005-03-14 2009-05-05 Wisys Technology Foundation, Inc. Molecules and methods for fluorescence microscopy
FR2898902B1 (fr) * 2006-03-24 2010-09-10 Oreal Colorants particuliers de type naphtalimide, composition tinctoriale comprenant au moins un tel colorant, procede de mise en oeuvre et utilisations
EP2232243B1 (en) 2007-12-20 2015-12-16 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Real-time method for the detection of viable micro-organisms
US8420665B2 (en) * 2008-01-11 2013-04-16 Northwestern University Anti-cancer compounds
WO2014015274A1 (en) 2012-07-20 2014-01-23 The General Hospital Corporation Methods for tissue passivation
US10549112B2 (en) 2012-07-20 2020-02-04 The General Hospital Corporation Apparatus for tissue irradiation and methods and kits utilizing the same
CN103848786B (zh) * 2012-12-04 2017-03-29 湖北文理学院 一种1,8‑萘酰亚胺类衍生物荧光探针制备方法及利用该生物探针检测酪蛋白的方法
WO2014090364A1 (de) 2012-12-13 2014-06-19 Merck Patent Gmbh Substituierte chinone oder analoga als farbstoffe
EP3013354B1 (en) 2013-01-16 2020-08-19 Alumend, LLC Composition for decreasing inflammatory response in a blood vessel
EP2976081B1 (en) 2013-03-15 2020-06-17 Alumend, LLC Methods of acute restoration of vascular compliance
EP2970227B1 (en) 2013-03-15 2018-01-10 Alumend, LLC Compositions and methods of using the compositions for plaque softening
CA3278502A1 (en) 2013-07-18 2025-10-31 The General Hospital Corporation Vessel treatment systems, methods, and kits
KR101662385B1 (ko) * 2014-07-22 2016-10-14 충남대학교산학협력단 나프탈이미드-비스인돌말레이미드 염료 화합물 및 이를 포함하는 염료 조성물
CN106867271A (zh) * 2015-12-11 2017-06-20 中国科学院大连化学物理研究所 一种大斯托克斯位移和长发射波长的萘酰亚胺类荧光染料及其合成方法和应用
CN107459988B (zh) * 2017-08-30 2018-11-13 新乡医学院 有机萘与无机银的复合材料
CN108752594B (zh) * 2018-05-03 2020-09-25 苏州大学张家港工业技术研究院 基于偶氮还原酶响应的两亲性嵌段聚合物及其制备方法与应用
CN114989236B (zh) * 2022-06-02 2024-03-15 苏州大学 单一分子量两亲性主链含偶氮苯侧链含糖齐聚物及其制备方法与应用
US12295949B2 (en) 2022-08-07 2025-05-13 Alumend, Llc Treatment of the gastrointestinal tract with dimeric naphthalimide compounds
WO2025138295A1 (zh) * 2023-12-30 2025-07-03 中国医学科学院基础医学研究所 hnRNPA2B1激动剂化合物及其抗感染应用
CN119409633A (zh) * 2024-10-31 2025-02-11 河南大学 一种肼基修饰天然多胺-萘酰亚胺缀合物、其制备方法及应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1836529A (en) * 1928-01-25 1931-12-15 Gen Aniline Works Inc Dyed cellulose esters or ethers and process of producing the dyeings
CH140716A (de) * 1928-01-25 1930-06-30 Ig Farbenindustrie Ag Verfahren zur Darstellung eines Acetatseidenfarbstoffes.
US1796012A (en) * 1928-04-12 1931-03-10 Gen Aniline Works Inc Amino-naphthalimido-sulphonic acid compounds and process of preparing same
US1886797A (en) * 1928-05-18 1932-11-08 Gen Aniline Works Inc Naphthalimide dyestuffs and process of preparing them
US1918461A (en) * 1929-12-10 1933-07-18 Gen Aniline Works Inc Dyestuff derived from 1-8-naphthalic acid anhydride
FR753104A (fr) * 1932-03-24 1933-10-07 Ig Farbenindustrie Ag Procédé de préparation de l'imide de l'acide 4-amino-1, 8-naphtalène-dicarboxylique et de ses dérivés
CH175865A (de) * 1932-03-24 1935-03-15 Ig Farbenindustrie Ag Verfahren zur Darstellung einer 1.8-Naphthalindicarbonsäureimidverbindung.
US2006017A (en) * 1932-03-24 1935-06-25 Gen Aniline Works Inc 4-amino-1.8-naphthalene-dicarboxylic acid imides and 4-alkylamino1.8-naphthalene-dicarboxylic acid alkylimides and a process of preparing them
US2385106A (en) * 1942-09-05 1945-09-18 American Cyanamid Co Long chain alkyl substituted 4-amino-1, 8-naphthalic acid imides
US2415373A (en) * 1942-09-05 1947-02-04 American Cyanamid Co Substituted 4-hydroxyalkylamino-1, 8-naphthalic acid imides
US2455095A (en) * 1945-02-20 1948-11-30 American Cyanamid Co 4-amino-1, 8-naphthalic imide disulfonic acids
DE1445775A1 (de) * 1964-08-31 1969-03-20 Bayer Ag Verfahren zur Herstellung basisch alkylierter Bisnaphthalimide
US3371092A (en) * 1965-07-22 1968-02-27 Allied Chem 4-amino-n-polyalkylphenyl-1, 8-naphthalic imides
CH560235A5 (OSRAM) * 1972-02-18 1975-03-27 Ciba Geigy Ag
US4081446A (en) * 1974-05-15 1978-03-28 Hoechst Aktiengesellschaft Process for the preparation of 4-amino-1,8-naphthalic acid-N-arylimides
DE2423546C2 (de) * 1974-05-15 1983-01-27 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von 4-Amino-1,8- naphthalsäure-N-arylimid-Verbindungen
US3940398A (en) * 1975-01-23 1976-02-24 E. R. Squibb & Sons, Inc. 2-[[4-(Azine or diazine or triazine)-1-piperazinyl]alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
US3947452A (en) * 1975-01-06 1976-03-30 E. R. Squibb & Sons, Inc. 2-[(Dihydroisoquinolinyl or dihydroisoindol-2-yl)alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
US3959286A (en) * 1975-01-06 1976-05-25 E. R. Squibb & Sons, Inc. N-(1-(1,3-Dihydro-1,3-dioxo-2H-benz(de)-isoquinolin-2-yl)alkyl)-4-N-piperidinyl)-n-phenylalkylamides
US4172202A (en) * 1975-04-29 1979-10-23 Hoechst Aktiengesellschaft Process for the preparation of 4-amino-1,8-naphthalimides
US4006238A (en) * 1975-08-28 1977-02-01 E. R. Squibb & Sons, Inc. Use of 2-(hydroxyalkyl)-1H-benz[de]isoquinoline-1,3(2H)-diones as anti-allergy agents
US4062953A (en) * 1976-06-24 1977-12-13 E. R. Squibb & Sons, Inc. Various 2-substituted-1H-benz[de]isoquinoline-1,3(2H)-diones
DE2748758A1 (de) * 1977-10-31 1979-05-10 Basf Ag Azofarbstoffe
US4200752A (en) * 1978-02-16 1980-04-29 Bertelson Robert C 4-Disubstituted amino, N-substituted naphthalimide dyestuffs
US4207107A (en) * 1978-08-23 1980-06-10 Rca Corporation Novel ortho-quinone diazide photoresist sensitizers
US5183821A (en) * 1983-09-19 1993-02-02 Laboratories Knoll, S.A. Method for treating leukemias using N-(2-dimethylaminoethyl)-3-amino-1,8-naphthalimide for treating leukemias and solid tumors
US4594346A (en) * 1984-02-21 1986-06-10 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
US5177083A (en) * 1986-07-03 1993-01-05 The Scripps Clinic And Research Foundation Drugs effective against retroviruses
DE3635711A1 (de) * 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
AU8325987A (en) * 1986-12-11 1988-06-30 Upjohn Company, The Antipsychotic amino-polyhydro-benz-(iso)quinolines and intermediates
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US4878891A (en) * 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
US5091385A (en) * 1988-09-30 1992-02-25 Baylor Research Institute Pre-activated therapeutic agents derived from photoactive compounds
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
US5206250A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amide and thioamide linkers as anticancer agents

Also Published As

Publication number Publication date
EP0639080A4 (OSRAM) 1995-03-29
WO1993018789A1 (en) 1993-09-30
EP0639080A1 (en) 1995-02-22
EP0639080B1 (en) 2001-12-19
US5420136A (en) 1995-05-30
KR950700910A (ko) 1995-02-20
DE69331384D1 (de) 2002-01-31
AU3924693A (en) 1993-10-21
US5235045A (en) 1993-08-10
DE69331384T2 (de) 2002-08-14
JPH07505366A (ja) 1995-06-15
CA2130828A1 (en) 1993-09-30
US5565551A (en) 1996-10-15

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