CA2130129A1 - Closure having an array of piercable places - Google Patents
Closure having an array of piercable placesInfo
- Publication number
- CA2130129A1 CA2130129A1 CA 2130129 CA2130129A CA2130129A1 CA 2130129 A1 CA2130129 A1 CA 2130129A1 CA 2130129 CA2130129 CA 2130129 CA 2130129 A CA2130129 A CA 2130129A CA 2130129 A1 CA2130129 A1 CA 2130129A1
- Authority
- CA
- Canada
- Prior art keywords
- closure
- pipetting
- top wall
- needle
- recesses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Closures For Containers (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Abstract
Abstract A closure (1) for a reagent container (3) for use in an analytical device in which an automatic pipetting means is used for transferring small quantities of reagent from reagent containers (3) to reaction cells, the pipetting means comprising a pipetting needle (13) automatically guided by a transfer device and having its free open end (19) in a plane at a first acute angle (.theta.) to the longitudinal axis of the pipetting needle, the disclosure (1) being a part moulded in one piece from a plastics and having a cylindrical side wall (4) and a top wall (5) adjacent the side wall.
To reduce the requirements on the accuracy of the device conveying the pipetting needle, the closure is characterised in that the central region of the top wall (5) has a perforation zone (16) formed by an arrangement of recesses (11) of equal depth and side by side, and adjacent recesses (11) are separated by a partition (15) forming a sharp edge (17) at its free top end, and the bottom (12) of each recess (11) is pierceable by the automatically guided needle (13) of the pipetting device.
Fig. 1
To reduce the requirements on the accuracy of the device conveying the pipetting needle, the closure is characterised in that the central region of the top wall (5) has a perforation zone (16) formed by an arrangement of recesses (11) of equal depth and side by side, and adjacent recesses (11) are separated by a partition (15) forming a sharp edge (17) at its free top end, and the bottom (12) of each recess (11) is pierceable by the automatically guided needle (13) of the pipetting device.
Fig. 1
Description
æ ~ 3 012 ~ RAN 4Q~0/241 The invention relates to a closure for a reagent container for use in an analytical device in which an automatic pipetting means is used for transferring small quantities of reagent from reagent containers to re~ction cells, the pipetting means comprising a s pipetting needle automatically guided by a transfer device and having its free open end in a plane at a first acute angle to the longitudinal axis of the pipetting needle, the closure being a Rart moulded in one piece from a plas~ics and having a cylindrical side wa}l and a top wall adjacent the side wall.
In previously-known analytical systems, e.g. for clinica!
chemical analysis of biological samples, open reagent containers are used. An automatic pipetting means takes a small amount of a liquid reagent from each container and supplies i~ to a reaction cell.
Ill each pipetting operation, an electromechanically driven arm 15 guides the needle of the pipet~ing device towards a reagent container, inserts it into the contaiiner to remove a volume of reagent, removes the needle from the contailler and guides it to the reaction vessel to be supplied with the volume of reagent. The con~ents of a conventional reagent container is norm~lly su~ficient for a relatively large number (about 20 ~o 2000) of such pipetting operations.
The use of open reagent containers has the follc>wing disadvantages:
- The laboratory staff have to take each new reagent container out of its packaging, remove the closure and insert the open reagent container in the analytical system in place of an empty container.
Often a number of different reagents are needed at different times in the same analytical system. Use of open reagen~ contain~s therefore considerably increases the wor~ of the laboratory staff.
- When open reagent containers are used in rooms with re~atively dry air, some of the reagent snlution is lost by Ve / 21.07.94 : , . , ,. : :
130t2S~ ~, evaporation and consequently the concentration of reagent gradually increases. When open reagent containers are used in rooms with relatively humid air or when water of condensation forms during use of cooled reagents, on the other hand, the volume -5 of the reagent solution increases and consequently the concentration of reagent gradually decreases. When open reagent containers are used, there is also an exchange of gas with the ambient air, thus altering or changing the reagent. All the aforementioned changes in the reagent, particular}y in its o con~entration, reduce the accuracy of analysis. To avoid this at least partly, relatively complicated packaging has hitherto been used around the entire reagent container.
These disadvantages of open reagen~ containers are eliminated by the reagent container according to EP-A-0 192 96B A2, which is 15 provided with a pierceable closure. The pierceable part of the closure is a diaphragm in the central region of the top wall of the closure. This known closure has the following disadYantages:
When a number of pipetting operations (e.g. 200 to 1000) are made through the same diaphragm, it becomes increasingly 20 darnaged by the pipetting needle, because the needle pierces the diaphragm at closely adjacent places and gradually cuts out small ~agments of the diaphragm which fall into the reagent underneath.
The result is a gradually increasing opening in the middle of the diaphragm, so that the reagent container is no longer reliably sealed 2S as required. Also, fragments of the diaphragm suspended in the reagent can clog up the needle and thus impair operation of the analytical device.
The aforementioned disadvantages are obviated by a closure ;
for reagent containers according to EP-A-û 504 697 Al, comprising 30 a single pierceable place in the middle of the top wall of the closure, through which the pipetting needle is inserted during all pipetting operations. In order to use this closure, however, the device conveying the pipetting needle must be able to position it very accurately relative to the pierceable place on the closure. Such 3S precise positioning of the pipetting needle is very expensive, and is impracticable for other reasons in many applications, e.g. if the reagent container is automatically shaken before the pipetting operation. At the end of the shaking operation, the positions of the reagent container and the colTesponding closure are no longer defined as accurately as when a permanently stationary reagent container is used.
s The aim of the invention therefore is to provide a closure of the initially-mentioned kind which obviates the aforementioned disadvantages .
According to the invention, the problem is solved by a closure characterised in that the middle region of the top wall has an arrangement of-equal-sized recesses close to one another, adjacent recess being separated by a partition forming a sharp edge at its ~ree top end, and the bottom of each recess is pierceable by the needle of the pipetting device.
The main advantages of the closure according to the invention are as follows:
In order to pipette a reagent from the reagent container into the cells, the pipetting needle can be introduced through the closure into the reagent container. Consequently the closure does not have to be removed in order to use the reagent container in the analytical system.
In each pipetting operation, ~he needle is inserted th~ough the bottom of one of the recesses in the central region of the top wall of the closure. It does not matter which recess is pierced through the bottom by the pipetting needle. When there are a number of 2s pipetting operations through the same closure, it may happen that a needle is inserted ~hrough a recess, the bottom of which has already been pierced during an earlier pipetting operation. This also is permissible according to the invention. The closure according to the inven~ion therefore can be used to reduce the requ;rements on the 3 o accuracy of automatic positioning of the pipetting needle. Another result of the construction of the closure according to ~he invention is that even when a large number of pipet~ing operations (e.g. 200 to 1000) are made through the same closure, there can be no damage to the closure and no resulting clogging of the pipetting needle (by .
~13012~
.
In previously-known analytical systems, e.g. for clinica!
chemical analysis of biological samples, open reagent containers are used. An automatic pipetting means takes a small amount of a liquid reagent from each container and supplies i~ to a reaction cell.
Ill each pipetting operation, an electromechanically driven arm 15 guides the needle of the pipet~ing device towards a reagent container, inserts it into the contaiiner to remove a volume of reagent, removes the needle from the contailler and guides it to the reaction vessel to be supplied with the volume of reagent. The con~ents of a conventional reagent container is norm~lly su~ficient for a relatively large number (about 20 ~o 2000) of such pipetting operations.
The use of open reagent containers has the follc>wing disadvantages:
- The laboratory staff have to take each new reagent container out of its packaging, remove the closure and insert the open reagent container in the analytical system in place of an empty container.
Often a number of different reagents are needed at different times in the same analytical system. Use of open reagen~ contain~s therefore considerably increases the wor~ of the laboratory staff.
- When open reagent containers are used in rooms with re~atively dry air, some of the reagent snlution is lost by Ve / 21.07.94 : , . , ,. : :
130t2S~ ~, evaporation and consequently the concentration of reagent gradually increases. When open reagent containers are used in rooms with relatively humid air or when water of condensation forms during use of cooled reagents, on the other hand, the volume -5 of the reagent solution increases and consequently the concentration of reagent gradually decreases. When open reagent containers are used, there is also an exchange of gas with the ambient air, thus altering or changing the reagent. All the aforementioned changes in the reagent, particular}y in its o con~entration, reduce the accuracy of analysis. To avoid this at least partly, relatively complicated packaging has hitherto been used around the entire reagent container.
These disadvantages of open reagen~ containers are eliminated by the reagent container according to EP-A-0 192 96B A2, which is 15 provided with a pierceable closure. The pierceable part of the closure is a diaphragm in the central region of the top wall of the closure. This known closure has the following disadYantages:
When a number of pipetting operations (e.g. 200 to 1000) are made through the same diaphragm, it becomes increasingly 20 darnaged by the pipetting needle, because the needle pierces the diaphragm at closely adjacent places and gradually cuts out small ~agments of the diaphragm which fall into the reagent underneath.
The result is a gradually increasing opening in the middle of the diaphragm, so that the reagent container is no longer reliably sealed 2S as required. Also, fragments of the diaphragm suspended in the reagent can clog up the needle and thus impair operation of the analytical device.
The aforementioned disadvantages are obviated by a closure ;
for reagent containers according to EP-A-û 504 697 Al, comprising 30 a single pierceable place in the middle of the top wall of the closure, through which the pipetting needle is inserted during all pipetting operations. In order to use this closure, however, the device conveying the pipetting needle must be able to position it very accurately relative to the pierceable place on the closure. Such 3S precise positioning of the pipetting needle is very expensive, and is impracticable for other reasons in many applications, e.g. if the reagent container is automatically shaken before the pipetting operation. At the end of the shaking operation, the positions of the reagent container and the colTesponding closure are no longer defined as accurately as when a permanently stationary reagent container is used.
s The aim of the invention therefore is to provide a closure of the initially-mentioned kind which obviates the aforementioned disadvantages .
According to the invention, the problem is solved by a closure characterised in that the middle region of the top wall has an arrangement of-equal-sized recesses close to one another, adjacent recess being separated by a partition forming a sharp edge at its ~ree top end, and the bottom of each recess is pierceable by the needle of the pipetting device.
The main advantages of the closure according to the invention are as follows:
In order to pipette a reagent from the reagent container into the cells, the pipetting needle can be introduced through the closure into the reagent container. Consequently the closure does not have to be removed in order to use the reagent container in the analytical system.
In each pipetting operation, ~he needle is inserted th~ough the bottom of one of the recesses in the central region of the top wall of the closure. It does not matter which recess is pierced through the bottom by the pipetting needle. When there are a number of 2s pipetting operations through the same closure, it may happen that a needle is inserted ~hrough a recess, the bottom of which has already been pierced during an earlier pipetting operation. This also is permissible according to the invention. The closure according to the inven~ion therefore can be used to reduce the requ;rements on the 3 o accuracy of automatic positioning of the pipetting needle. Another result of the construction of the closure according to ~he invention is that even when a large number of pipet~ing operations (e.g. 200 to 1000) are made through the same closure, there can be no damage to the closure and no resulting clogging of the pipetting needle (by .
~13012~
.
fragments of the closure). Such clogging occurs e.g. when using an ordinary stopper or a closure with a pierceable diaphragm.
Apart from the small punctures in the pierced bottoms of the recesses used in the pipetting operations, the reagent container 5 provided with the closure according to the invention remains substantially sealed during its entire period of use in the analy~ical system. This substantially prevents evaporation of the reagent solution, exchange of gas with the ambient air, and resulting prem~ture ageing of the reagent. The dimensions of the recesses l o and the bottoms thereof are chosen so that the pipetting needle is wiped off when inserted or extracted~ thus largely preventing contamination between differen~ reagents.
Because of the aforementioned advantages, the closure according to the invention can be used for ~utomatic treatment of 5 ~he reagent container in an analytical system, i.e. the laboratory staff are relieved from the previously required manual work and the processing is also made more reliable.
The closure according to the invention is preferably a screw closure, a simple means of reliably sealing the reagent container.
In a pre~erred embodiment of the closure according to the invention, the outer surface of the partition includes a second acute angle with a straight line at right angles to ~he bottom. By this means, the partition pushes ~he tip of the needle towards the middle of the recess, if the device conveying the needle does not 2s guide it exactly towards the middle of ~he recess.
An embodiment of the invention will now be described with reference to the accompanying drawings, in which:
Fig. 1 is a perspective view of a container provided with a closure according to the invention and a pipetting needle positioned above it; Fig. la shows the ~ip region of a prefelTed embodimen~ of the pipetting needle 13 in Fig. 1, on a larger scale and in section;
Fig. 2 shows the tip region of a second embodimenlt of the pipe~ting needle 13 in Fig. 1, on a larger scale and in sec~ion;
012~
Fig. 3 is a larger-scale partial section through a container comprising a closure according to the invention;
Fig. 4 is a larger-scale partial view of the bottom of a closure according to the invention as per F;g. 1;
s Fig. S is a plan view of the central region of the bottom of a closure according to the invention as in Fig 1, and Fig. 6 is a section through line VI-VI in Fig. 5 showing an inserted pipetting needle, the motion and force componen~s for guiding or centring the pipetting needle being diagrammatically indicated.
Figs. 1 and 3 show a closure cap 1 according to the inven~ion secured in conventional manner ~y a threaded connection to the neck 2 of a container 3.
The cap 1 substantially comprises a cylindrical wall 4, closed at 5 the top end face by a basically flat plate 5. Structures 6 for increasing the grip are visible on the ou~side of the cylindrical wall 4. On the inside of the cylindrical wall 4, an internal thread 7 is formed to colTespond with the outer thread 8 on the container neck 2. A sealing tube matching the inner diameter of the container neck 20 2 is integrally formed on the top cover plate S and extends coaxially with the cylindrical wall 4 in~o the contairler neck 2. The side of the cover plate 5 remote from the container inte~ior is formed with recesses 11 having bases or bot~oms 12 defining possible places for perforating with a pipetting needle 13.
2S The cap is preferably moulded in one pieoe from a suitable plastics, e.g. polyethylene, such as LDPE (low dens;ty polyethylene) ar HDPE (high density polyethylene).
The base surfaces or bottoms 12 of the recesses 11 for perforating by the needle 13 are of reduced thickness compared with the cover plate 5 and their area is adapted to the cross-section of the pipetting needle and is advantageously circular.
Advantageously the recesses 11 have the shape of a circular truncated cone, the smaller circular area cons~itu~ing the base ~13012~3 :
surface or bottom 12 or a piercing place. A number of base surfaces 12 or recesses 11 are disposed in the central region of the end plate 5 and form a perforation zone 16, so as to obtain a maximum density, i.e. a maximum number of perforation places per unit area.
s The wall parts 15 remaining between the base surfaces or bo~toms 12 and stabilising the entire perforation zone 16 are made of material of adequate quality.
Advantageously the recesses 11 are arranged in rows offset from one another, so as to obtain a perforation zone 16 having a o sub~stantially hexagonal outer contour. In a special embodiment, the recesses 11 are separated from one another so that the intersection between the conical surfaces 18 of the recesses 11 results in sharp edges 17 which, considered from above (Fig. 5), have a hexagonal configuration round each bottom 12, or have the shape of a hyperbola when considered from the side (Figs. 4 and 6).
The boundary walls 15 of the bottom or perforation surfaces 12 thus have a roof shape, so that a pipetting needle 13 positioned relath~ely roughly over the perforation zone 16 is reliably and automatically guided to a corresponding perforation place. ~ ~;
The acute angle ~ at the tip of the pipetting needle 13 is about 30 . To avnid cutting the bottom 12 or boundary walls 1~ during perforation, the tip 14 of the needle 13 is rounded (~ig. 2). The ;~
inclination angle ~ (relative to the longitudinal axis of the pipetting needle) of the conical surface 18 of the recesses 11 is adapted to the 2s angle a of the tip of the pipetting needle 13 ~nd is pre~erably of about the same value. The inclination angle (p is preferably between 20 and 40 . -~
The aligning and centring forces which may act on the pipetting needle 13 or cap 1 are diagrammatically indicated by arrows in Fig.
30 6. If for example a pipetting needle 13 (shown chain-dotted in Fig.
S) is guided towards the perforation zone 16 on a boundary wall 15 (arrow Pfl), the pipetting needle 13 may give way through its own elasticity (arrow Pf2) or the closure cap 1 and container 3 (arrow Pf3) may give way in a horizontal plane, if the holder of container 3 35 has limited mobility, so that the needle 13 finally reaches the bottom 12 and pierces it.
Apart from the small punctures in the pierced bottoms of the recesses used in the pipetting operations, the reagent container 5 provided with the closure according to the invention remains substantially sealed during its entire period of use in the analy~ical system. This substantially prevents evaporation of the reagent solution, exchange of gas with the ambient air, and resulting prem~ture ageing of the reagent. The dimensions of the recesses l o and the bottoms thereof are chosen so that the pipetting needle is wiped off when inserted or extracted~ thus largely preventing contamination between differen~ reagents.
Because of the aforementioned advantages, the closure according to the invention can be used for ~utomatic treatment of 5 ~he reagent container in an analytical system, i.e. the laboratory staff are relieved from the previously required manual work and the processing is also made more reliable.
The closure according to the invention is preferably a screw closure, a simple means of reliably sealing the reagent container.
In a pre~erred embodiment of the closure according to the invention, the outer surface of the partition includes a second acute angle with a straight line at right angles to ~he bottom. By this means, the partition pushes ~he tip of the needle towards the middle of the recess, if the device conveying the needle does not 2s guide it exactly towards the middle of ~he recess.
An embodiment of the invention will now be described with reference to the accompanying drawings, in which:
Fig. 1 is a perspective view of a container provided with a closure according to the invention and a pipetting needle positioned above it; Fig. la shows the ~ip region of a prefelTed embodimen~ of the pipetting needle 13 in Fig. 1, on a larger scale and in section;
Fig. 2 shows the tip region of a second embodimenlt of the pipe~ting needle 13 in Fig. 1, on a larger scale and in sec~ion;
012~
Fig. 3 is a larger-scale partial section through a container comprising a closure according to the invention;
Fig. 4 is a larger-scale partial view of the bottom of a closure according to the invention as per F;g. 1;
s Fig. S is a plan view of the central region of the bottom of a closure according to the invention as in Fig 1, and Fig. 6 is a section through line VI-VI in Fig. 5 showing an inserted pipetting needle, the motion and force componen~s for guiding or centring the pipetting needle being diagrammatically indicated.
Figs. 1 and 3 show a closure cap 1 according to the inven~ion secured in conventional manner ~y a threaded connection to the neck 2 of a container 3.
The cap 1 substantially comprises a cylindrical wall 4, closed at 5 the top end face by a basically flat plate 5. Structures 6 for increasing the grip are visible on the ou~side of the cylindrical wall 4. On the inside of the cylindrical wall 4, an internal thread 7 is formed to colTespond with the outer thread 8 on the container neck 2. A sealing tube matching the inner diameter of the container neck 20 2 is integrally formed on the top cover plate S and extends coaxially with the cylindrical wall 4 in~o the contairler neck 2. The side of the cover plate 5 remote from the container inte~ior is formed with recesses 11 having bases or bot~oms 12 defining possible places for perforating with a pipetting needle 13.
2S The cap is preferably moulded in one pieoe from a suitable plastics, e.g. polyethylene, such as LDPE (low dens;ty polyethylene) ar HDPE (high density polyethylene).
The base surfaces or bottoms 12 of the recesses 11 for perforating by the needle 13 are of reduced thickness compared with the cover plate 5 and their area is adapted to the cross-section of the pipetting needle and is advantageously circular.
Advantageously the recesses 11 have the shape of a circular truncated cone, the smaller circular area cons~itu~ing the base ~13012~3 :
surface or bottom 12 or a piercing place. A number of base surfaces 12 or recesses 11 are disposed in the central region of the end plate 5 and form a perforation zone 16, so as to obtain a maximum density, i.e. a maximum number of perforation places per unit area.
s The wall parts 15 remaining between the base surfaces or bo~toms 12 and stabilising the entire perforation zone 16 are made of material of adequate quality.
Advantageously the recesses 11 are arranged in rows offset from one another, so as to obtain a perforation zone 16 having a o sub~stantially hexagonal outer contour. In a special embodiment, the recesses 11 are separated from one another so that the intersection between the conical surfaces 18 of the recesses 11 results in sharp edges 17 which, considered from above (Fig. 5), have a hexagonal configuration round each bottom 12, or have the shape of a hyperbola when considered from the side (Figs. 4 and 6).
The boundary walls 15 of the bottom or perforation surfaces 12 thus have a roof shape, so that a pipetting needle 13 positioned relath~ely roughly over the perforation zone 16 is reliably and automatically guided to a corresponding perforation place. ~ ~;
The acute angle ~ at the tip of the pipetting needle 13 is about 30 . To avnid cutting the bottom 12 or boundary walls 1~ during perforation, the tip 14 of the needle 13 is rounded (~ig. 2). The ;~
inclination angle ~ (relative to the longitudinal axis of the pipetting needle) of the conical surface 18 of the recesses 11 is adapted to the 2s angle a of the tip of the pipetting needle 13 ~nd is pre~erably of about the same value. The inclination angle (p is preferably between 20 and 40 . -~
The aligning and centring forces which may act on the pipetting needle 13 or cap 1 are diagrammatically indicated by arrows in Fig.
30 6. If for example a pipetting needle 13 (shown chain-dotted in Fig.
S) is guided towards the perforation zone 16 on a boundary wall 15 (arrow Pfl), the pipetting needle 13 may give way through its own elasticity (arrow Pf2) or the closure cap 1 and container 3 (arrow Pf3) may give way in a horizontal plane, if the holder of container 3 35 has limited mobility, so that the needle 13 finally reaches the bottom 12 and pierces it.
Claims (9)
1. A closure for a reagent container for use in an analytical device in which an automatic pipetting means is used for transferring small quantities of reagent from reagent containers to reaction cells, the pipetting means comprising a pipetting needle automatically guided by a transfer device and having its free open end in a plane at a first acute angle (.theta.) to the longitudinal axis of the pipetting needle, the closure being a part moulded in one piece from a plastics and having a cylindrical side wall and a top wall adjacent the side wall, characterised in that the central region of the top wall has a perforation zone formed by an arrangement of recesses of equal depth and side by side, said adjacent recesses are separated by a partition forming a sharp edge at its free top end, and the bottom of each recess is pierceable by the automatically guided needle of the pipetting device.
2. A closure according to claim 1, characterised in that it is a screw closure.
3. A closure according to claim 1, characterised in that the outer surface of the partition includes a second acute angle (?) with a straight line at right angles to the bottom.
4. A closure according to claim 3, characterised in that the second acute angle (?) is in a range between 20 and 40 °.
5. A closure according to claim 1, characterised in that each recess is in the shape of a right circular truncated cone, the width of which decreases with distance from the top wall.
6. A closure according to claim 1, characterised in that the boundary between each recess and the outer surface of the top wall is a polygon.
7. A closure according to claim 1, characterised in that the arrangement of recesses lies within a polygonal region of the top wall, the middle of the region coinciding with the middle of the top wall.
8. A closure according to claim 1, characterised in that the recesses are arranged in rows, the recesses in adjacent rows being offset from one another.
9. A closure according to claim 1, characterised in that it has a cylindrical wall adjacent the top wall and extending inwards from the top wall and concentric with the side wall.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH271993 | 1993-09-10 | ||
| CH2719/93 | 1993-09-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2130129A1 true CA2130129A1 (en) | 1995-03-11 |
Family
ID=4240065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2130129 Abandoned CA2130129A1 (en) | 1993-09-10 | 1994-08-15 | Closure having an array of piercable places |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0642830A1 (en) |
| JP (1) | JPH07191040A (en) |
| CA (1) | CA2130129A1 (en) |
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| WO2019018911A1 (en) * | 2017-07-26 | 2019-01-31 | Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein | Sealing film and method of pipetting using a sealing film |
| CN114555231A (en) * | 2019-10-28 | 2022-05-27 | 美国西门子医学诊断股份有限公司 | Vibrating pipette tip and method for preventing viscous forces in pipette tip |
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| CA2397688C (en) * | 2001-08-17 | 2012-01-17 | Becton Dickinson And Company | Liquid specimen collection system |
| FR2835616B1 (en) * | 2002-02-01 | 2005-02-11 | Junior Instruments | DEVICE FOR THE AUTOMATED ANALYSIS OF A LIQUID SAMPLE |
| CA2556772A1 (en) * | 2004-03-02 | 2005-09-15 | Dako Denmark A/S | Reagent delivery system, dispensing device and container for a biological staining apparatus |
| JP2006001600A (en) * | 2004-06-18 | 2006-01-05 | Toppan Printing Co Ltd | Plastic cap with temper-resistant function |
| ITPD20080334A1 (en) * | 2008-11-14 | 2010-05-15 | Holos Sro | ANTI-TAMPER CLOSING CAP FOR TUBES |
| JP5545233B2 (en) * | 2011-01-31 | 2014-07-09 | コニカミノルタ株式会社 | Inspection system |
| CN103071556B (en) * | 2012-06-15 | 2014-11-26 | 郑州安图生物工程股份有限公司 | Reagent bottle and holder for medical analyzer |
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| CN214585470U (en) * | 2020-06-19 | 2021-11-02 | 上海快灵生物科技有限公司 | Biochemical test paper tube |
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| JPS56137072U (en) * | 1980-03-17 | 1981-10-17 | ||
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| JPH0350451Y2 (en) * | 1987-07-16 | 1991-10-28 | ||
| CA2046813A1 (en) * | 1990-10-02 | 1992-04-03 | Ueli Stettler | Apparatus for introducing pipetting inserts through sample cup closures |
| SG46491A1 (en) * | 1991-03-19 | 1998-02-20 | Hoffmann La Roche | Closure for reagent container |
-
1994
- 1994-08-15 CA CA 2130129 patent/CA2130129A1/en not_active Abandoned
- 1994-08-29 EP EP94113449A patent/EP0642830A1/en not_active Ceased
- 1994-09-09 JP JP6216274A patent/JPH07191040A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107003330A (en) * | 2014-12-18 | 2017-08-01 | 株式会社日立高新技术 | The manufacture method of sample nozzle, the automatic analysing apparatus using the sample nozzle and sample nozzle |
| EP3236269A4 (en) * | 2014-12-18 | 2018-08-08 | Hitachi High-Technologies Corporation | Sampling nozzle, automated analyzer using same, and sampling nozzle manufacturing method |
| CN107003330B (en) * | 2014-12-18 | 2018-08-28 | 株式会社日立高新技术 | Sample nozzle uses the automatic analysing apparatus of the sample nozzle and the manufacturing method of sample nozzle |
| US10539584B2 (en) | 2014-12-18 | 2020-01-21 | Hitachi High-Technologies Corporation | Sampling nozzle, automatic analyzer using the same, and method of manufacturing sampling nozzle |
| WO2019018911A1 (en) * | 2017-07-26 | 2019-01-31 | Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein | Sealing film and method of pipetting using a sealing film |
| CN114555231A (en) * | 2019-10-28 | 2022-05-27 | 美国西门子医学诊断股份有限公司 | Vibrating pipette tip and method for preventing viscous forces in pipette tip |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07191040A (en) | 1995-07-28 |
| EP0642830A1 (en) | 1995-03-15 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Dead |