CA2103062A1 - Oligo-2'-deoxynucleotides and their use as pharmaceutical agents with antiviral activity - Google Patents

Oligo-2'-deoxynucleotides and their use as pharmaceutical agents with antiviral activity

Info

Publication number
CA2103062A1
CA2103062A1 CA002103062A CA2103062A CA2103062A1 CA 2103062 A1 CA2103062 A1 CA 2103062A1 CA 002103062 A CA002103062 A CA 002103062A CA 2103062 A CA2103062 A CA 2103062A CA 2103062 A1 CA2103062 A1 CA 2103062A1
Authority
CA
Canada
Prior art keywords
deoxy
pharmaceutical agents
antiviral activity
deoxynucleotides
oligo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002103062A
Other languages
French (fr)
Other versions
CA2103062C (en
Inventor
Klaus Muhlegger
Herbert Von Der Eltz
Frank Seela
Helmut Rosemeyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2103062A1 publication Critical patent/CA2103062A1/en
Application granted granted Critical
Publication of CA2103062C publication Critical patent/CA2103062C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oligodeoxyribonucleotides in which at least two 2'-deoxy-B-D-erythro-pentofuranosoyl groups are replaced by 2'-deoxy-B-D-threo-pentofuranosyl groups at both the 5' end and 3' end, and oligodeoxyribonucleotides in which at least 20 % of the 2'-deoxy-B-D-erythro-pentofuranosyl groups in consecutive nucleotide building blocks are replaced by 2'-deoxy-B-D-threo-pentofuranosyl groups and which are composed of 6 to 100 nucleotide building blocks, are suitable for the inhibition of the expression of viral genes and oncogenes by the antisense principle and can be used for the production of pharmaceutical agents with antiviral activity.
CA002103062A 1991-05-25 1992-05-25 Oligo-2'-deoxynucleotides and their use as pharmaceutical agents with antiviral activity Expired - Fee Related CA2103062C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4117186.1 1991-05-25
DE4117186A DE4117186A1 (en) 1991-05-25 1991-05-25 OLIGO-2'-DESOXYNUCLEOTIDES AND THEIR USE AS MEDICINAL PRODUCTS WITH ANTIVIRAL EFFECTIVENESS
PCT/EP1992/001172 WO1992021692A1 (en) 1991-05-25 1992-05-25 Oligo-2'-deoxynucleotides and their use as drugs with an antiviral action

Publications (2)

Publication Number Publication Date
CA2103062A1 true CA2103062A1 (en) 1992-11-26
CA2103062C CA2103062C (en) 2004-11-30

Family

ID=6432469

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002103062A Expired - Fee Related CA2103062C (en) 1991-05-25 1992-05-25 Oligo-2'-deoxynucleotides and their use as pharmaceutical agents with antiviral activity

Country Status (8)

Country Link
EP (1) EP0611373B1 (en)
JP (1) JP2683296B2 (en)
AT (1) ATE150763T1 (en)
CA (1) CA2103062C (en)
DE (2) DE4117186A1 (en)
DK (1) DK0611373T3 (en)
ES (1) ES2102529T3 (en)
WO (1) WO1992021692A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues

Also Published As

Publication number Publication date
ES2102529T3 (en) 1997-08-01
JP2683296B2 (en) 1997-11-26
CA2103062C (en) 2004-11-30
ATE150763T1 (en) 1997-04-15
JPH06502655A (en) 1994-03-24
WO1992021692A1 (en) 1992-12-10
EP0611373B1 (en) 1997-03-26
DE4117186A1 (en) 1992-11-26
DK0611373T3 (en) 1997-10-06
DE59208280D1 (en) 1997-04-30
EP0611373A1 (en) 1994-08-24

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