WO1993017651A3 - Antiviral nucleoside analogues, their production and use - Google Patents

Antiviral nucleoside analogues, their production and use Download PDF

Info

Publication number
WO1993017651A3
WO1993017651A3 PCT/DE1993/000213 DE9300213W WO9317651A3 WO 1993017651 A3 WO1993017651 A3 WO 1993017651A3 DE 9300213 W DE9300213 W DE 9300213W WO 9317651 A3 WO9317651 A3 WO 9317651A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
nucleoside analogues
antiviral nucleoside
antiviral
disclosed
Prior art date
Application number
PCT/DE1993/000213
Other languages
German (de)
French (fr)
Other versions
WO1993017651A2 (en
Inventor
Eckart Matthes
Janta-Lipinski Martin Von
Original Assignee
Max Delbrueck Centrum
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Delbrueck Centrum filed Critical Max Delbrueck Centrum
Publication of WO1993017651A2 publication Critical patent/WO1993017651A2/en
Publication of WO1993017651A3 publication Critical patent/WO1993017651A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New and known nucleoside analogues particularly effective against hepatitis B and HIV infections are disclosed, as well as their production and use.
PCT/DE1993/000213 1992-03-04 1993-03-03 Antiviral nucleoside analogues, their production and use WO1993017651A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4207363.4 1992-03-04
DE19924207363 DE4207363A1 (en) 1992-03-04 1992-03-04 ANTIVIRAL NUCLEOSIDE ANALOGS, THEIR PRODUCTION AND THEIR PHARMACEUTICAL USE

Publications (2)

Publication Number Publication Date
WO1993017651A2 WO1993017651A2 (en) 1993-09-16
WO1993017651A3 true WO1993017651A3 (en) 1993-11-25

Family

ID=6453548

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1993/000213 WO1993017651A2 (en) 1992-03-04 1993-03-03 Antiviral nucleoside analogues, their production and use

Country Status (2)

Country Link
DE (1) DE4207363A1 (en)
WO (1) WO1993017651A2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022330A1 (en) * 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
JP5230052B2 (en) 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド Methods and compositions for the treatment of flaviviruses and pestiviruses
GB0114286D0 (en) 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
CA2506129C (en) 2002-11-15 2015-02-17 Idenix (Cayman) Limited 2'-branched nucleosides and flaviviridae mutation
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
CN100351264C (en) * 2002-11-19 2007-11-28 霍夫曼-拉罗奇有限公司 Antiviral nucleoside derivatives
ES2617582T3 (en) 2005-09-26 2017-06-19 Gilead Pharmasset Llc 4'-Nucleosides modified as antiviral agents
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
WO2013017853A2 (en) * 2011-07-29 2013-02-07 Cambridge Epigenetix Limited Methods for detection of nucleotide modification
AU2013266393B2 (en) 2012-05-22 2017-09-28 Idenix Pharmaceuticals Llc D-amino acid compounds for liver disease
EA027929B1 (en) 2012-05-25 2017-09-29 Янссен Сайенсиз Айрлэнд Юси Uracyl spirooxetane nucleosides
US10513534B2 (en) 2012-10-08 2019-12-24 Idenix Pharmaceuticals Llc 2′-chloro nucleoside analogs for HCV infection
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
EP2970357A1 (en) 2013-03-13 2016-01-20 IDENIX Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
WO2015017713A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
EP3131914B1 (en) 2014-04-16 2023-05-10 Idenix Pharmaceuticals LLC 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
CN104193801A (en) * 2014-08-12 2014-12-10 苏州维泰生物技术有限公司 Guanine peptide nucleic acid monomer and synthetic method thereof
AU2019231725B2 (en) * 2018-03-07 2024-06-20 Emory University 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277599A2 (en) * 1987-01-30 1988-08-10 Asahi Glass Company Ltd. Fluorine containing cyclopentane derivatives and processes for their production
EP0322384A1 (en) * 1987-11-03 1989-06-28 Medivir Aktiebolag Nucleosides for use in therapy
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
WO1991019727A1 (en) * 1990-06-19 1991-12-26 Sloan-Kettering Institute For Cancer Research 5'-hydrogenphosphonates and 5'-methylphosphonates of sugar modified nucleosides, compositions and uses thereof
EP0464642A1 (en) * 1990-07-02 1992-01-08 Hoechst Aktiengesellschaft Pyrimidine derivatives, their preparation and use as well as medicaments containing them
EP0302760B1 (en) * 1987-08-07 1992-07-29 The Governors of the University of Alberta Antiviral therapy for hepatitis b using 2',3'-dideoxynucleosides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0277599A2 (en) * 1987-01-30 1988-08-10 Asahi Glass Company Ltd. Fluorine containing cyclopentane derivatives and processes for their production
EP0302760B1 (en) * 1987-08-07 1992-07-29 The Governors of the University of Alberta Antiviral therapy for hepatitis b using 2',3'-dideoxynucleosides
EP0322384A1 (en) * 1987-11-03 1989-06-28 Medivir Aktiebolag Nucleosides for use in therapy
EP0375183A1 (en) * 1988-12-05 1990-06-27 Schering Corporation Antiviral dimers and trimers
WO1991019727A1 (en) * 1990-06-19 1991-12-26 Sloan-Kettering Institute For Cancer Research 5'-hydrogenphosphonates and 5'-methylphosphonates of sugar modified nucleosides, compositions and uses thereof
EP0464642A1 (en) * 1990-07-02 1992-01-08 Hoechst Aktiengesellschaft Pyrimidine derivatives, their preparation and use as well as medicaments containing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF ORGANIC CHEMISTRY. Bd. 41, Nr. 18, 3. September 1976, EASTON US Seiten 3010 - 3017 G.R.OWEN ET AL. '4'-Substituted Nucleosides. 3.Synthesis of Some 4'-Fluorouridine Derivatives.' *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Bd. 98, Nr. 11, 26. Mai 1976, GASTON, PA US Seiten 3346 - 3357 I.D.JENKINS ET AL. '4'-Substituted Nucleosides. 2. Synthesis of the Nucleoside Antibiotic Nucleocidin.' *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV

Also Published As

Publication number Publication date
WO1993017651A2 (en) 1993-09-16
DE4207363A1 (en) 1993-09-09

Similar Documents

Publication Publication Date Title
WO1993017651A3 (en) Antiviral nucleoside analogues, their production and use
CA2068943A1 (en) 1,3-oxathiolanes useful in the treatment of hepatitis
NL960025I2 (en) Substituted 1,3-oxathiolanes with antiviral activity.
MA22919A1 (en) 1,3 - OXATHIOLANE NUCLEOSIDE ANALOGUES.
AU6924796A (en) 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis c
AU3453993A (en) New liponucleotides, their preparation and their use as antiviral medicaments
FI906212A0 (en) INHIBITORER FOER HIV PROTEAS, VILKA AER ANVAENDBARA VID AV AIDS.
EP0334368A3 (en) Production of 2',3'-dideoxy-2',3'-didehydronucleosides
AU9125991A (en) Enantiomerically pure beta -l-(-)-1,3-oxathiolane nucleosides
CA2143204A1 (en) Use of Dideoxy Nucleoside Analogues in the Treatment of Viral Infections
AU626726B2 (en) Uracil derivatives, and their production and use
ZA949151B (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents.
CA2120743A1 (en) Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
HUP0100087A3 (en) Nucleosides analogues, the use thereof for producing medicaments useful against retroviral infections and hepatitis b virus and the same medicaments
DE69000743D1 (en) ANTIVIRAL TETRAHYDROIMIDAZO (1,4) BENZODIAZEPINE-2-THIONE.
DE68902695D1 (en) BODY PROTECTIVE SUIT AGAINST ACCELERATING FORCES.
FI935780A0 (en) HIV proteasinhibitorer, vilka aer anvaendbara vid behandling av AIDS
DE68918215D1 (en) 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives.
EP0317128A3 (en) Anti-HIV Pyrimidine Nucleosides
AU642751B2 (en) New embodiments of the HIV principal neutralizing determinant
AU3170193A (en) Therapeutic nucleosides
CA2285463A1 (en) A combination therapy for hiv infections
AU6401490A (en) 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents
AU9179891A (en) Hiv reverse transcriptase vaccine
EP0453247A3 (en) Anti-viral compounds

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase