IT1270122B - 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- IT1270122B IT1270122B ITMI942023A ITMI942023A IT1270122B IT 1270122 B IT1270122 B IT 1270122B IT MI942023 A ITMI942023 A IT MI942023A IT MI942023 A ITMI942023 A IT MI942023A IT 1270122 B IT1270122 B IT 1270122B
- Authority
- IT
- Italy
- Prior art keywords
- preparation
- benzyl
- pharmaceutical compositions
- oxypyrimidin
- replaced
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
- JCPZGLWRQNPRGS-UHFFFAOYSA-N 6-benzyl-1h-pyrimidin-4-one Chemical class N1C=NC(=O)C=C1CC1=CC=CC=C1 JCPZGLWRQNPRGS-UHFFFAOYSA-N 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Sono descritte 6-benzil-4-ossopirimidine sostituite di formula (I) (FORMULA I) in cui:X è scelto nel gruppo costituito da O, S;R è scelto nel gruppo costituito da C1-4 alchile, C5-6 cicloalchile;R', R" e Z, uguali o diversi fra loro indicano H, C1-4 alchile considerando che quando X = O R ed R' non possono essere entrambi uguali a H;loro sali farmaceuticamente accettabili e loro derivati solubili;un loro processo di preparazione ed il loro uso per la preparazione di composizioni farmaceutiche utili per il trattamento di infezioni virali.Substituted 6-benzyl-4-oxopyrimidines of formula (I) (FORMULA I) are described wherein: X is selected from the group consisting of O, S; R is selected from the group consisting of C1-4 alkyl, C5-6 cycloalkyl; R ', R "and Z, equal or different from each other, indicate H, C1-4 alkyl considering that when X = OR and R' cannot both be equal to H; their pharmaceutically acceptable salts and their soluble derivatives; a process of their preparation and their use for the preparation of pharmaceutical compositions useful for the treatment of viral infections.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI942023A IT1270122B (en) | 1994-10-04 | 1994-10-04 | 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
AU38036/95A AU3803695A (en) | 1994-10-04 | 1995-10-04 | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them |
PCT/EP1995/003912 WO1996010565A1 (en) | 1994-10-04 | 1995-10-04 | Substituted 6-benzyl-4-oxopyrimidines, process for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI942023A IT1270122B (en) | 1994-10-04 | 1994-10-04 | 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI942023A0 ITMI942023A0 (en) | 1994-10-04 |
ITMI942023A1 ITMI942023A1 (en) | 1996-04-04 |
IT1270122B true IT1270122B (en) | 1997-04-28 |
Family
ID=11369647
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI942023A IT1270122B (en) | 1994-10-04 | 1994-10-04 | 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU3803695A (en) |
IT (1) | IT1270122B (en) |
WO (1) | WO1996010565A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001007027A2 (en) * | 1999-07-22 | 2001-02-01 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives for the treatment of viral diseases |
CN100439343C (en) * | 2006-08-04 | 2008-12-03 | 复旦大学 | 2-alkylsulfide-5-alkyl-6-(1-cyano aromethyl) substituted uracil kind compound, its preparation method and use |
CN100519540C (en) * | 2007-01-09 | 2009-07-29 | 云南大学 | S-DABO compound, synthesizing method and usage |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
GB9012592D0 (en) * | 1990-06-06 | 1990-07-25 | Smithkline Beecham Intercredit | Compounds |
-
1994
- 1994-10-04 IT ITMI942023A patent/IT1270122B/en active IP Right Grant
-
1995
- 1995-10-04 WO PCT/EP1995/003912 patent/WO1996010565A1/en active Application Filing
- 1995-10-04 AU AU38036/95A patent/AU3803695A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ITMI942023A1 (en) | 1996-04-04 |
ITMI942023A0 (en) | 1994-10-04 |
AU3803695A (en) | 1996-04-26 |
WO1996010565A1 (en) | 1996-04-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUT61989A (en) | Process for producing 2-deoxy-2,3-didehydro-n-acetylneuraminic acid derivatives and analogs, as well as pharmaceutical compositions comprising same as active ingredient | |
MD1233B1 (en) | Erythromycin derivatives, process for their preparation and pharmaceutical composition on base thereof | |
AP9801378A0 (en) | 9-amino-3- keto erythromycin derivatives. | |
CA2081068A1 (en) | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-d-neuraminic acid | |
BG103945A (en) | Derivatives of 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a | |
ATE36699T1 (en) | QUINONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AND PHARMACEUTICAL COMPOSITION. | |
FI954898A0 (en) | Water-soluble camptothecin derivatives, process for their preparation and their use as anti-tumor agents | |
ES2160949T3 (en) | DERIVATIVES OF PHENYLENE-SULFONAMIDE REPLACED IN META. | |
TR199902995T2 (en) | 9-Oxime erythromycin derivatives | |
IL95956A0 (en) | Benzoic acid derivatives and pharmaceutical compositions containing the same | |
ES2108129T3 (en) | NEW DERIVATIVES OF PIRAZINE, ITS PREPARATION AND USE. | |
HUP0004282A2 (en) | 2-halo-6-0-substituted ketolide derivatives | |
CA2286511A1 (en) | Novel macrolide derivatives | |
AU3860893A (en) | New benzimidazole compounds, a process for their preparation and pharmaceutical compositions containing them | |
NO933611L (en) | ANTI-TUMOR AND ANTI-PSORIATIC AGENTS | |
BR9611871A (en) | Diaminopyrimidines pharmaceutical compositions containing them and their use as antibacterials | |
CA2127472A1 (en) | New adenosine derivatives, preparation methods and pharmaceutical compositions containing them | |
ATE259369T1 (en) | NEW GERANYLGERANYL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND CORRESPONDING PHARMACEUTICAL COMPOSITIONS | |
DE69302829T2 (en) | BICYCLIC PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | |
UA48958C2 (en) | 9-0-oxime derivatives of erythromycine and pharmaceutical composition thereof | |
MX9806229A (en) | BENZO[C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5'alpha'-REDUCTASES INHIBITORS. | |
IT1270122B (en) | 6-BENZYL-4-OXYPYRIMIDIN REPLACED, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
MY110004A (en) | Biologically active ureido derivatives useful as antimetastatic agents. | |
AU614204B2 (en) | 16-hydroxymethyl amphotericin b derivatives | |
TW252979B (en) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |