CA2097060A1 - Anticorps bifonctionnels et leur methode de preparation - Google Patents
Anticorps bifonctionnels et leur methode de preparationInfo
- Publication number
- CA2097060A1 CA2097060A1 CA 2097060 CA2097060A CA2097060A1 CA 2097060 A1 CA2097060 A1 CA 2097060A1 CA 2097060 CA2097060 CA 2097060 CA 2097060 A CA2097060 A CA 2097060A CA 2097060 A1 CA2097060 A1 CA 2097060A1
- Authority
- CA
- Canada
- Prior art keywords
- fab
- antibody
- binding
- sequence
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62298390A | 1990-12-04 | 1990-12-04 | |
US07/622,983 | 1990-12-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2097060A1 true CA2097060A1 (fr) | 1992-06-05 |
Family
ID=24496305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2097060 Abandoned CA2097060A1 (fr) | 1990-12-04 | 1991-12-03 | Anticorps bifonctionnels et leur methode de preparation |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0563214A4 (fr) |
CA (1) | CA2097060A1 (fr) |
WO (1) | WO1992010209A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5582996A (en) * | 1990-12-04 | 1996-12-10 | The Wistar Institute Of Anatomy & Biology | Bifunctional antibodies and method of preparing same |
EP0861893A3 (fr) * | 1991-09-19 | 1999-11-10 | Genentech, Inc. | Expression de haut niveau d'immunoglobulines |
US5932448A (en) * | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
US5693322A (en) * | 1993-03-11 | 1997-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Enhanced intercellular interaction by associational antibody molecules |
EP0787185A2 (fr) | 1994-10-20 | 1997-08-06 | MorphoSys AG | Hetero-association ciblee de proteines recombinees et de complexes fonctionnels |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
ES2246069T3 (es) | 1997-05-02 | 2006-02-01 | Genentech, Inc. | Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos. |
US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
US20020062010A1 (en) | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
RU2316337C2 (ru) | 2001-04-24 | 2008-02-10 | Мерк Патент Гмбх | КОМБИНИРОВАННАЯ ТЕРАПИЯ, ИСПОЛЬЗУЮЩАЯ АНТИАНГИОГЕННЫЕ СРЕДСТВА И TNF-α |
AU2016244273B2 (en) * | 2003-05-06 | 2018-10-18 | Bioverativ Therapeutics Inc. | Immunoglobulin Chimeric Monomer-Dimer Hybrids |
TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
DE602004031390D1 (de) | 2003-05-06 | 2011-03-24 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor VII-Fc chimäre Proteine zur Behandlung von hämostatischen Krankheiten |
EP1973569B1 (fr) | 2006-01-18 | 2013-05-22 | Merck Patent GmbH | Traitement specifique utilisant des ligands de integrine destine a traiter un cancer |
WO2008027236A2 (fr) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | Anticorps multispécifiques |
PL2101805T3 (pl) | 2007-01-18 | 2013-04-30 | Merck Patent Gmbh | Ligandy integryn do stosowania w leczeniu nowotworów |
AU2009288167B2 (en) | 2008-09-03 | 2015-10-22 | Genentech, Inc. | Multispecific antibodies |
WO2010136168A2 (fr) | 2009-05-25 | 2010-12-02 | Merck Patent Gmbh | Administration continue de ligands d'intégrines pour le traitement du cancer |
TWI586806B (zh) | 2010-04-23 | 2017-06-11 | 建南德克公司 | 異多聚體蛋白質之製造 |
CN103153328A (zh) | 2010-07-16 | 2013-06-12 | 默克专利股份有限公司 | 肽在乳腺癌和/或骨转移灶的治疗中的用途 |
BR112016024462B1 (pt) | 2014-05-06 | 2022-12-27 | Genentech, Inc | Métodos para a preparação de um anticorpo |
TW202016151A (zh) | 2018-06-09 | 2020-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL89491A0 (en) * | 1988-11-17 | 1989-09-10 | Hybritech Inc | Bifunctional chimeric antibodies |
DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5932448A (en) * | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
-
1991
- 1991-12-03 WO PCT/US1991/009019 patent/WO1992010209A1/fr not_active Application Discontinuation
- 1991-12-03 EP EP9292902137A patent/EP0563214A4/en not_active Withdrawn
- 1991-12-03 CA CA 2097060 patent/CA2097060A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0563214A4 (en) | 1994-08-17 |
EP0563214A1 (fr) | 1993-10-06 |
WO1992010209A1 (fr) | 1992-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |