CA2095152A1 - Sample pipetting method - Google Patents
Sample pipetting methodInfo
- Publication number
- CA2095152A1 CA2095152A1 CA002095152A CA2095152A CA2095152A1 CA 2095152 A1 CA2095152 A1 CA 2095152A1 CA 002095152 A CA002095152 A CA 002095152A CA 2095152 A CA2095152 A CA 2095152A CA 2095152 A1 CA2095152 A1 CA 2095152A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- sample pipetting
- pipetting method
- level
- fluid present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/14—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measurement of pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/146—Employing pressure sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/025—Displaying results or values with integrated means
- B01L2300/027—Digital display, e.g. LCD, LED
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
- G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
Abstract
A non-invasive method of determining the level of fluid present in a test sample. The level of fluid present in a test sample in a container (22) is determined by moving a pipettor (10) toward the sample surface while aspirating air and monitoring the pressure change produced with a sensor (18). Non-homogeneity of the sample can be detected during the aspiration of the sample using the invention.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61216090A | 1990-11-09 | 1990-11-09 | |
US612,160 | 1990-11-09 | ||
PCT/US1991/008375 WO1992008545A1 (en) | 1990-11-09 | 1991-11-08 | Sample pipetting method |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2095152A1 true CA2095152A1 (en) | 1992-05-10 |
CA2095152C CA2095152C (en) | 2003-02-18 |
Family
ID=24451979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002095152A Expired - Lifetime CA2095152C (en) | 1990-11-09 | 1991-11-08 | Sample pipetting method |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0556336A1 (en) |
JP (1) | JP3065100B2 (en) |
KR (1) | KR930702072A (en) |
AU (1) | AU652014B2 (en) |
CA (1) | CA2095152C (en) |
WO (1) | WO1992008545A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2148248C (en) * | 1993-08-31 | 2000-04-04 | Masaaki Takeda | Pipetting apparatus with clot detection |
US5503036A (en) * | 1994-05-09 | 1996-04-02 | Ciba Corning Diagnostics Corp. | Obstruction detection circuit for sample probe |
US5537880A (en) * | 1995-06-07 | 1996-07-23 | Abbott Laboratories | Automatic pipetting apparatus with leak detection and method of detecting a leak |
US5750881A (en) * | 1995-07-13 | 1998-05-12 | Chiron Diagnostics Corporation | Method and apparatus for aspirating and dispensing sample fluids |
US6158269A (en) * | 1995-07-13 | 2000-12-12 | Bayer Corporation | Method and apparatus for aspirating and dispensing sample fluids |
US5723795A (en) * | 1995-12-14 | 1998-03-03 | Abbott Laboratories | Fluid handler and method of handling a fluid |
US5915282A (en) * | 1995-12-14 | 1999-06-22 | Abbott Laboratories | Fluid handler and method of handling a fluid |
US5965828A (en) * | 1995-12-14 | 1999-10-12 | Abbott Laboratories | Fluid handler and method of handling a fluid |
JP3343038B2 (en) * | 1996-10-03 | 2002-11-11 | ダイナボット株式会社 | Dispensing method in automatic sample analyzer |
US20020009392A1 (en) * | 2000-03-28 | 2002-01-24 | Wolk Jeffrey A. | Methods of reducing fluid carryover in microfluidic devices |
JP4677076B2 (en) * | 2000-04-19 | 2011-04-27 | アークレイ株式会社 | Liquid level detector |
EP1306675A4 (en) * | 2000-06-30 | 2010-07-28 | Hitachi Ltd | Liquid dispensing method and device |
JP4328531B2 (en) * | 2001-03-09 | 2009-09-09 | ハミルトン・ボナドゥーツ・アーゲー | Method and apparatus for evaluating process of dispensing predetermined amount of liquid |
CN1653338A (en) | 2002-05-17 | 2005-08-10 | 贝克顿·迪金森公司 | Automated system for isolating, amplifying and detecting a target nucleic acid sequence |
US8307722B2 (en) | 2005-05-19 | 2012-11-13 | Universal Bio Research Co., Ltd. | Method of detecting dispensed quantity, and liquid suction monitoring dispensing apparatus |
EP2031403B1 (en) | 2007-08-27 | 2016-02-17 | Roche Diagnostics GmbH | Method for monitoring a fluid transfer process |
US20100047898A1 (en) * | 2008-08-19 | 2010-02-25 | Biomerieux, Inc. | Mixing pipette |
FR2977317B1 (en) * | 2011-06-28 | 2013-08-02 | Gilson Sas | METHOD FOR DETECTING ANOMALIES WHEN FILLING A LIQUID ASSAY DEVICE AND LIQUID ASSAY DEVICE |
DE102011081186A1 (en) * | 2011-08-18 | 2013-02-21 | Hamilton Bonaduz Ag | A method of detecting the surface of a liquid sample in a sample container |
JP5761753B2 (en) | 2011-09-20 | 2015-08-12 | 株式会社日立ハイテクノロジーズ | Automatic analyzer and its operation failure judgment method |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4794085A (en) * | 1984-07-19 | 1988-12-27 | Eastman Kodak Company | Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid |
JPS6375565A (en) * | 1986-09-18 | 1988-04-05 | Toshiba Corp | Sampling monitor |
JPS63109330A (en) * | 1986-10-27 | 1988-05-14 | Kyoto Daiichi Kagaku:Kk | Method and apparatus for detecting liquid level |
EP0341438A3 (en) * | 1988-05-13 | 1990-11-28 | Abbott Laboratories | Pneumatic sensing system |
JPH087222B2 (en) * | 1990-01-18 | 1996-01-29 | 持田製薬株式会社 | Automatic dispensing dilution device |
-
1991
- 1991-11-08 JP JP4501066A patent/JP3065100B2/en not_active Expired - Lifetime
- 1991-11-08 KR KR1019930701367A patent/KR930702072A/en not_active Application Discontinuation
- 1991-11-08 EP EP92902011A patent/EP0556336A1/en not_active Ceased
- 1991-11-08 WO PCT/US1991/008375 patent/WO1992008545A1/en not_active Application Discontinuation
- 1991-11-08 CA CA002095152A patent/CA2095152C/en not_active Expired - Lifetime
- 1991-11-08 AU AU90758/91A patent/AU652014B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
KR930702072A (en) | 1993-09-08 |
EP0556336A4 (en) | 1994-02-23 |
AU652014B2 (en) | 1994-08-11 |
CA2095152C (en) | 2003-02-18 |
EP0556336A1 (en) | 1993-08-25 |
JPH06501558A (en) | 1994-02-17 |
AU9075891A (en) | 1992-06-11 |
WO1992008545A1 (en) | 1992-05-29 |
JP3065100B2 (en) | 2000-07-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |