CA2095152A1 - Sample pipetting method - Google Patents

Sample pipetting method

Info

Publication number
CA2095152A1
CA2095152A1 CA002095152A CA2095152A CA2095152A1 CA 2095152 A1 CA2095152 A1 CA 2095152A1 CA 002095152 A CA002095152 A CA 002095152A CA 2095152 A CA2095152 A CA 2095152A CA 2095152 A1 CA2095152 A1 CA 2095152A1
Authority
CA
Canada
Prior art keywords
sample
sample pipetting
pipetting method
level
fluid present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002095152A
Other languages
French (fr)
Other versions
CA2095152C (en
Inventor
Charles W. Brentz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2095152A1 publication Critical patent/CA2095152A1/en
Application granted granted Critical
Publication of CA2095152C publication Critical patent/CA2095152C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • G01F23/14—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measurement of pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/027—Digital display, e.g. LCD, LED
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

A non-invasive method of determining the level of fluid present in a test sample. The level of fluid present in a test sample in a container (22) is determined by moving a pipettor (10) toward the sample surface while aspirating air and monitoring the pressure change produced with a sensor (18). Non-homogeneity of the sample can be detected during the aspiration of the sample using the invention.
CA002095152A 1990-11-09 1991-11-08 Sample pipetting method Expired - Lifetime CA2095152C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61216090A 1990-11-09 1990-11-09
US612,160 1990-11-09
PCT/US1991/008375 WO1992008545A1 (en) 1990-11-09 1991-11-08 Sample pipetting method

Publications (2)

Publication Number Publication Date
CA2095152A1 true CA2095152A1 (en) 1992-05-10
CA2095152C CA2095152C (en) 2003-02-18

Family

ID=24451979

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002095152A Expired - Lifetime CA2095152C (en) 1990-11-09 1991-11-08 Sample pipetting method

Country Status (6)

Country Link
EP (1) EP0556336A1 (en)
JP (1) JP3065100B2 (en)
KR (1) KR930702072A (en)
AU (1) AU652014B2 (en)
CA (1) CA2095152C (en)
WO (1) WO1992008545A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0726466B1 (en) * 1993-08-31 2002-04-24 Aloka Co. Ltd. Pipetting apparatus equipped with closure detection function
US5503036A (en) * 1994-05-09 1996-04-02 Ciba Corning Diagnostics Corp. Obstruction detection circuit for sample probe
US5537880A (en) * 1995-06-07 1996-07-23 Abbott Laboratories Automatic pipetting apparatus with leak detection and method of detecting a leak
US5750881A (en) * 1995-07-13 1998-05-12 Chiron Diagnostics Corporation Method and apparatus for aspirating and dispensing sample fluids
US6158269A (en) * 1995-07-13 2000-12-12 Bayer Corporation Method and apparatus for aspirating and dispensing sample fluids
US5965828A (en) * 1995-12-14 1999-10-12 Abbott Laboratories Fluid handler and method of handling a fluid
US5915282A (en) * 1995-12-14 1999-06-22 Abbott Laboratories Fluid handler and method of handling a fluid
US5723795A (en) * 1995-12-14 1998-03-03 Abbott Laboratories Fluid handler and method of handling a fluid
JP3343038B2 (en) * 1996-10-03 2002-11-11 ダイナボット株式会社 Dispensing method in automatic sample analyzer
WO2001073396A1 (en) * 2000-03-28 2001-10-04 Caliper Technologies, Corp. Methods of reducing fluid carryover in microfluidic devices
JP4677076B2 (en) * 2000-04-19 2011-04-27 アークレイ株式会社 Liquid level detector
US7439076B1 (en) * 2000-06-30 2008-10-21 Hitachi, Ltd. Liquid dispensing method and device
JP4328531B2 (en) * 2001-03-09 2009-09-09 ハミルトン・ボナドゥーツ・アーゲー Method and apparatus for evaluating process of dispensing predetermined amount of liquid
WO2003097808A2 (en) 2002-05-17 2003-11-27 Becton, Dickinson And Company Automated system for isolating, amplyifying and detecting a target nucleic acid sequence
US8307722B2 (en) 2005-05-19 2012-11-13 Universal Bio Research Co., Ltd. Method of detecting dispensed quantity, and liquid suction monitoring dispensing apparatus
EP2031403B1 (en) 2007-08-27 2016-02-17 Roche Diagnostics GmbH Method for monitoring a fluid transfer process
US20100047898A1 (en) * 2008-08-19 2010-02-25 Biomerieux, Inc. Mixing pipette
FR2977317B1 (en) 2011-06-28 2013-08-02 Gilson Sas METHOD FOR DETECTING ANOMALIES WHEN FILLING A LIQUID ASSAY DEVICE AND LIQUID ASSAY DEVICE
DE102011081186A1 (en) * 2011-08-18 2013-02-21 Hamilton Bonaduz Ag A method of detecting the surface of a liquid sample in a sample container
JP5761753B2 (en) * 2011-09-20 2015-08-12 株式会社日立ハイテクノロジーズ Automatic analyzer and its operation failure judgment method
JP7181821B2 (en) * 2019-03-15 2022-12-01 株式会社日立ハイテク automatic analyzer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4794085A (en) * 1984-07-19 1988-12-27 Eastman Kodak Company Apparatus and method for detecting liquid penetration by a container used for aspirating and dispensing the liquid
JPS6375565A (en) * 1986-09-18 1988-04-05 Toshiba Corp Sampling monitor
JPS63109330A (en) * 1986-10-27 1988-05-14 Kyoto Daiichi Kagaku:Kk Method and apparatus for detecting liquid level
EP0341438A3 (en) * 1988-05-13 1990-11-28 Abbott Laboratories Pneumatic sensing system
JPH087222B2 (en) * 1990-01-18 1996-01-29 持田製薬株式会社 Automatic dispensing dilution device

Also Published As

Publication number Publication date
EP0556336A1 (en) 1993-08-25
KR930702072A (en) 1993-09-08
EP0556336A4 (en) 1994-02-23
WO1992008545A1 (en) 1992-05-29
AU652014B2 (en) 1994-08-11
JP3065100B2 (en) 2000-07-12
CA2095152C (en) 2003-02-18
JPH06501558A (en) 1994-02-17
AU9075891A (en) 1992-06-11

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Legal Events

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