CA2092414A1 - Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase - Google Patents

Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase

Info

Publication number
CA2092414A1
CA2092414A1 CA002092414A CA2092414A CA2092414A1 CA 2092414 A1 CA2092414 A1 CA 2092414A1 CA 002092414 A CA002092414 A CA 002092414A CA 2092414 A CA2092414 A CA 2092414A CA 2092414 A1 CA2092414 A1 CA 2092414A1
Authority
CA
Canada
Prior art keywords
methyl
formula
aminocarbonyl
group
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002092414A
Other languages
English (en)
Inventor
Roger E. Markwell
Robert W. Ward
Shahzad S. Rahman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2092414A1 publication Critical patent/CA2092414A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
CA002092414A 1990-10-11 1991-10-09 Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase Abandoned CA2092414A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909022117A GB9022117D0 (en) 1990-10-11 1990-10-11 Novel compounds
GB9022117.7 1990-10-11

Publications (1)

Publication Number Publication Date
CA2092414A1 true CA2092414A1 (fr) 1992-04-12

Family

ID=10683561

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002092414A Abandoned CA2092414A1 (fr) 1990-10-11 1991-10-09 Derives n-(2-alkyl-3-mercaptoglutaryl)-amino-diazacycloalcanone et leur utilisation comme inhibiteurs de la collagenase

Country Status (11)

Country Link
EP (1) EP0552264A1 (fr)
JP (1) JPH06501944A (fr)
AU (1) AU642046B2 (fr)
CA (1) CA2092414A1 (fr)
GB (1) GB9022117D0 (fr)
IE (1) IE913572A1 (fr)
MX (1) MX9101501A (fr)
NZ (1) NZ240167A (fr)
PT (1) PT99184A (fr)
WO (1) WO1992006966A1 (fr)
ZA (1) ZA918074B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773428A (en) * 1993-08-05 1998-06-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
DE69405572T2 (de) * 1993-08-05 1998-02-12 Syntex Inc Matrix-metalloprotease inhibitoren
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
ATE234291T1 (de) * 1995-12-08 2003-03-15 Agouron Pharma Metallproteinasehemmer, diesen enthaltende pharmazeutische zusammensetzung und dessen pharmazeutische verwendung und verfahren zu ihrer herstellung
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
EP0780386B1 (fr) * 1995-12-20 2002-10-02 F. Hoffmann-La Roche Ag Inhibiteurs de métalloprotéases matricielles
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
WO2000028331A1 (fr) * 1998-11-12 2000-05-18 Du Pont Pharmaceuticals Company Utilisation de radioligands pour detecter des inhibiteurs de la production de peptides beta-amyloides
WO2001092235A1 (fr) 2000-06-01 2001-12-06 Bristol-Myers Squibb Pharma Company Lactames substitues par des succinates cycliques en tant qu'inhibiteurs de la production de la proteine beta
AU2003233154A1 (en) 2002-06-10 2003-12-22 Pfizer Inc. Metabolites of prinomastat and their sythesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937243A (en) * 1986-12-24 1990-06-26 Beecham Group P.L.C. Thiol carboxylic acid derivatives and their use as colagenase inhibitors
GB9000846D0 (en) * 1990-01-15 1990-03-14 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
NZ240167A (en) 1993-11-25
AU642046B2 (en) 1993-10-07
GB9022117D0 (en) 1990-11-21
WO1992006966A1 (fr) 1992-04-30
ZA918074B (en) 1993-04-13
IE913572A1 (en) 1992-04-22
JPH06501944A (ja) 1994-03-03
AU8660491A (en) 1992-05-20
MX9101501A (es) 1992-06-05
PT99184A (pt) 1992-09-30
EP0552264A1 (fr) 1993-07-28

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Legal Events

Date Code Title Description
FZDE Dead