ZA918074B - N-(2-alkyl-3-mercaptoglutaryl)-amino-diaza cycloakanone derivatives and their use as collage/nase inhibitors. - Google Patents

N-(2-alkyl-3-mercaptoglutaryl)-amino-diaza cycloakanone derivatives and their use as collage/nase inhibitors.

Info

Publication number
ZA918074B
ZA918074B ZA918074A ZA918074A ZA918074B ZA 918074 B ZA918074 B ZA 918074B ZA 918074 A ZA918074 A ZA 918074A ZA 918074 A ZA918074 A ZA 918074A ZA 918074 B ZA918074 B ZA 918074B
Authority
ZA
South Africa
Prior art keywords
mercaptoglutaryl
cycloakanone
collage
diaza
derivatives
Prior art date
Application number
ZA918074A
Inventor
Roger Edward Markwell
Robert William Ward
Shahzad Sharooq Rahman
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of ZA918074B publication Critical patent/ZA918074B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA918074A 1990-10-11 1991-10-09 N-(2-alkyl-3-mercaptoglutaryl)-amino-diaza cycloakanone derivatives and their use as collage/nase inhibitors. ZA918074B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909022117A GB9022117D0 (en) 1990-10-11 1990-10-11 Novel compounds

Publications (1)

Publication Number Publication Date
ZA918074B true ZA918074B (en) 1993-04-13

Family

ID=10683561

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA918074A ZA918074B (en) 1990-10-11 1991-10-09 N-(2-alkyl-3-mercaptoglutaryl)-amino-diaza cycloakanone derivatives and their use as collage/nase inhibitors.

Country Status (11)

Country Link
EP (1) EP0552264A1 (en)
JP (1) JPH06501944A (en)
AU (1) AU642046B2 (en)
CA (1) CA2092414A1 (en)
GB (1) GB9022117D0 (en)
IE (1) IE913572A1 (en)
MX (1) MX9101501A (en)
NZ (1) NZ240167A (en)
PT (1) PT99184A (en)
WO (1) WO1992006966A1 (en)
ZA (1) ZA918074B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
US5773428A (en) * 1993-08-05 1998-06-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
KR100347646B1 (en) * 1993-08-05 2002-12-05 신텍스(미국) 인크. Matrix metalloprotease inhibitor
US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
CN1542002A (en) * 1995-12-08 2004-11-03 ������ҩ�����޹�˾ Inhibitors of metalloproteinase, pharmaceutical compositions containing them, their pharmaceutical application and methods and intermediate compounds for their preparation
PT780386E (en) * 1995-12-20 2003-02-28 Hoffmann La Roche MATRIX METALOPROTEASE INHIBITORS
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ509241A (en) 1998-08-07 2003-08-29 Du Pont Pharm Co Succinoylamino lactams as inhibitors of alpha-beta protein production
US6331408B1 (en) * 1998-11-12 2001-12-18 Robert Zaczek Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
AU2003233154A1 (en) 2002-06-10 2003-12-22 Pfizer Inc. Metabolites of prinomastat and their sythesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3774858D1 (en) * 1986-12-24 1992-01-09 Beecham Group Plc DERIVATIVES OF N- (2-ALKYL-3-MERCAPTOGLUTARYL) ALPHA AMINOSAURS AND THE USE THEREOF AS COLLAGENASE INHIBITORS.
GB9000846D0 (en) * 1990-01-15 1990-03-14 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
WO1992006966A1 (en) 1992-04-30
IE913572A1 (en) 1992-04-22
CA2092414A1 (en) 1992-04-12
MX9101501A (en) 1992-06-05
AU642046B2 (en) 1993-10-07
AU8660491A (en) 1992-05-20
EP0552264A1 (en) 1993-07-28
JPH06501944A (en) 1994-03-03
NZ240167A (en) 1993-11-25
PT99184A (en) 1992-09-30
GB9022117D0 (en) 1990-11-21

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