CA2091977A1 - Process for the preparation of 3-substituted-2-azetidinones - Google Patents

Process for the preparation of 3-substituted-2-azetidinones

Info

Publication number
CA2091977A1
CA2091977A1 CA002091977A CA2091977A CA2091977A1 CA 2091977 A1 CA2091977 A1 CA 2091977A1 CA 002091977 A CA002091977 A CA 002091977A CA 2091977 A CA2091977 A CA 2091977A CA 2091977 A1 CA2091977 A1 CA 2091977A1
Authority
CA
Canada
Prior art keywords
alkyl
formula
group
phenyl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002091977A
Other languages
English (en)
French (fr)
Inventor
Catherine M. Gasparski
Marvin J. Miller
Min Teng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Notre Dame
Original Assignee
University of Notre Dame
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Notre Dame filed Critical University of Notre Dame
Publication of CA2091977A1 publication Critical patent/CA2091977A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/12—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002091977A 1992-03-23 1993-03-18 Process for the preparation of 3-substituted-2-azetidinones Abandoned CA2091977A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/855,402 US5250676A (en) 1992-03-23 1992-03-23 Process for the preparation of 3-substituted-2-azetidinones
US07/855,402 1992-03-23

Publications (1)

Publication Number Publication Date
CA2091977A1 true CA2091977A1 (en) 1993-09-24

Family

ID=25321177

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002091977A Abandoned CA2091977A1 (en) 1992-03-23 1993-03-18 Process for the preparation of 3-substituted-2-azetidinones

Country Status (4)

Country Link
US (1) US5250676A (show.php)
EP (1) EP0564129A2 (show.php)
JP (1) JPH06100532A (show.php)
CA (1) CA2091977A1 (show.php)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2590429B2 (ja) * 1994-03-08 1997-03-12 工業技術院長 β‐ラクタム誘導体及びその製造方法
US5750681A (en) * 1995-06-19 1998-05-12 University Of Notre Dame Du Lac Bicyclic beta-lactams and process therefor
KR20020087500A (ko) * 2000-12-23 2002-11-23 주식회사대웅제약 3-치환 아제티디논의 제조방법
WO2013007371A2 (en) * 2011-07-13 2013-01-17 Eth Zurich Kinetic resolution of chiral amines
US20170089915A1 (en) * 2015-09-30 2017-03-30 Agilent Technologies, Inc. Methods of analyte derivatization and enhanced soft ionization
US9862680B2 (en) * 2016-06-13 2018-01-09 University Of Notre Dame Du Lac Peripherally substituted monocyclic beta-lactams
WO2019070672A1 (en) * 2017-10-05 2019-04-11 University Of Notre Dame Du Lac ANTIBACTERIAL MONOBACTERAMES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ228600A (en) * 1988-04-11 1992-02-25 Merck & Co Inc 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives

Also Published As

Publication number Publication date
EP0564129A2 (en) 1993-10-06
US5250676A (en) 1993-10-05
JPH06100532A (ja) 1994-04-12
EP0564129A3 (show.php) 1994-04-13

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Legal Events

Date Code Title Description
FZDE Discontinued