CA2088996A1 - Alpha-substituted tryptophane dipeptoid derivatives - Google Patents

Alpha-substituted tryptophane dipeptoid derivatives

Info

Publication number
CA2088996A1
CA2088996A1 CA002088996A CA2088996A CA2088996A1 CA 2088996 A1 CA2088996 A1 CA 2088996A1 CA 002088996 A CA002088996 A CA 002088996A CA 2088996 A CA2088996 A CA 2088996A CA 2088996 A1 CA2088996 A1 CA 2088996A1
Authority
CA
Canada
Prior art keywords
compound according
methyl
amino
indol
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002088996A
Other languages
English (en)
French (fr)
Inventor
David C. Horwell
Martyn C. Pritchard
Reginald S. Richardson
Edward Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2088996A1 publication Critical patent/CA2088996A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002088996A 1990-08-31 1991-08-29 Alpha-substituted tryptophane dipeptoid derivatives Abandoned CA2088996A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57629690A 1990-08-31 1990-08-31
US576,296 1990-08-31
US07/726,654 US5244915A (en) 1990-08-31 1991-07-12 Amico acid derivatives cyclized at the c-terminal
US726,654 1991-07-12

Publications (1)

Publication Number Publication Date
CA2088996A1 true CA2088996A1 (en) 1992-03-01

Family

ID=27076919

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002088996A Abandoned CA2088996A1 (en) 1990-08-31 1991-08-29 Alpha-substituted tryptophane dipeptoid derivatives

Country Status (11)

Country Link
US (3) US5244915A (https=)
EP (1) EP0546123A1 (https=)
JP (1) JPH06502850A (https=)
KR (1) KR930702296A (https=)
AU (1) AU658377B2 (https=)
CA (1) CA2088996A1 (https=)
FI (1) FI930878L (https=)
IE (1) IE913078A1 (https=)
NZ (1) NZ239612A (https=)
PT (1) PT98828A (https=)
WO (1) WO1992004322A1 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631281A (en) * 1989-06-29 1997-05-20 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
NZ239595A (en) * 1990-08-31 1994-06-27 Warner Lambert Co Cholecystokinin antagonistic compounds ; pharmaceutical compositions and use thereof
WO1993000897A1 (en) * 1991-07-12 1993-01-21 Warner-Lambert Company Cholecystokinin antagonists useful in the treatment of panic attacks
US5217957A (en) * 1991-08-20 1993-06-08 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
US5380872A (en) * 1992-07-14 1995-01-10 Glaxo Inc. Modulators of cholecystokinin
FR2700540B1 (fr) * 1993-01-15 1995-02-17 Irj alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique.
US6129685A (en) * 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US7077822B1 (en) 1994-02-09 2006-07-18 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
JP3361100B2 (ja) * 1994-03-10 2003-01-07 ワーナー−ランバート・コンパニー Ｃｃｋ受容体アンタゴニストとしてのインドール誘導体
US5420353A (en) * 1994-03-11 1995-05-30 Merck & Co., Inc. Regiospecific process to make cis-1-amino-2-alkanol from epoxide
JP2000506141A (ja) * 1996-02-27 2000-05-23 マリンクロッド・インコーポレイテッド 標識化ｃｃｋ―ｂ受容体リガンドによるヒト悪性腫瘍の検出および位置特定
WO2002026104A2 (en) * 2000-09-27 2002-04-04 Niazi Sarfaraz K A combination of appetite controlling agents which create a synergy and produce a satiating result
US20060062864A1 (en) * 2000-12-28 2006-03-23 Mccleary Edward L Weight loss composition and method
CA2502209A1 (en) * 2002-10-15 2004-04-29 University Of Tennessee Research Foundation Methylene-bridged selective androgen receptor modulators and methods of use thereof
CN101214249A (zh) * 2003-11-25 2008-07-09 纽约大学西奈山医学院 尼曼-皮克病的基于陪伴分子的治疗
CA2555594A1 (en) * 2004-02-10 2005-08-25 Janssen Pharmaceutica N.V. Pyridazinones as antagonists of a4 integrins
US20050245534A1 (en) * 2004-04-29 2005-11-03 Link James T Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US7880001B2 (en) * 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US8415354B2 (en) * 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US20050261302A1 (en) * 2004-04-29 2005-11-24 Hoff Ethan D Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their therapeutic application
US20100222316A1 (en) * 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8198331B2 (en) * 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
MX2007008238A (es) 2005-01-05 2007-08-17 Abbott Lab Derivados de adamantilo como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1.
CN101142172A (zh) * 2005-01-05 2008-03-12 艾博特公司 11-β-羟甾类脱氢酶1型酶的抑制剂
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
JP5736098B2 (ja) * 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4757151A (en) * 1985-11-14 1988-07-12 Warner-Lambert Company 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
JPH0761992B2 (ja) * 1987-02-06 1995-07-05 武田薬品工業株式会社 置換アミン誘導体
US4888427A (en) * 1987-04-07 1989-12-19 University Of Florida Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain
US4877785A (en) * 1987-10-01 1989-10-31 G. D. Searle & Co. Non-peptidyl beta-succinamidoacyl aminodiols as anti-hypertensive agents
EP0442878A4 (en) * 1988-04-05 1991-10-23 Abbott Laboratories Derivatives of tryptophan as cck antagonists
NZ234264A (en) * 1989-06-29 1993-05-26 Warner Lambert Co N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives, and pharmaceutical compositions
FR2700540B1 (fr) * 1993-01-15 1995-02-17 Irj alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique.

Also Published As

Publication number Publication date
US5523306A (en) 1996-06-04
IE913078A1 (en) 1992-03-11
JPH06502850A (ja) 1994-03-31
EP0546123A1 (en) 1993-06-16
US5244915A (en) 1993-09-14
FI930878A0 (fi) 1993-02-26
KR930702296A (ko) 1993-09-08
AU658377B2 (en) 1995-04-13
US5397788A (en) 1995-03-14
PT98828A (pt) 1992-07-31
FI930878A7 (fi) 1993-04-16
FI930878L (fi) 1993-04-16
EP0546123A4 (https=) 1994-04-27
NZ239612A (en) 1994-02-25
WO1992004322A1 (en) 1992-03-19
AU8866191A (en) 1992-03-30

Similar Documents

Publication Publication Date Title
CA2088996A1 (en) Alpha-substituted tryptophane dipeptoid derivatives
CA2344707C (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives
US5622983A (en) N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
CA2088980C (en) Pro-drugs for cck antagonists
US5846942A (en) Cholecystokinin antagonists, their preparation and therapeutic use
WO1992004045A1 (en) Novel cholecystokinin antagonists, their preparation and therapeutic use
US5278316A (en) N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives
US5264419A (en) N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
US5244905A (en) N-substituted cycloalkyl and polycycloalkyl polyhydro-β-carboline-phenylalanine- and phenethylamine derivatives
US5218123A (en) Didehydrotryptophan derivatives and pharmaceutical use thereof
AU651390C (en) Novel cholecystokinin antagonists, their preparation and therapeutic use

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued