CA2085520A1 - Hexahydrate stable d'etoposide-4'-phosphate, sel disodique - Google Patents

Hexahydrate stable d'etoposide-4'-phosphate, sel disodique

Info

Publication number
CA2085520A1
CA2085520A1 CA2085520A CA2085520A CA2085520A1 CA 2085520 A1 CA2085520 A1 CA 2085520A1 CA 2085520 A CA2085520 A CA 2085520A CA 2085520 A CA2085520 A CA 2085520A CA 2085520 A1 CA2085520 A1 CA 2085520A1
Authority
CA
Canada
Prior art keywords
etoposide
disodium salt
phosphate disodium
stable hexahydrate
hexahydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2085520A
Other languages
English (en)
Other versions
CA2085520C (fr
Inventor
Uday Shankar Gogate
William Francis Light
Shreeram Narahari Agharkar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CA2085520A1 publication Critical patent/CA2085520A1/fr
Application granted granted Critical
Publication of CA2085520C publication Critical patent/CA2085520C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
CA002085520A 1991-12-23 1992-12-16 Hexahydrate stable d'etoposide-4'-phosphate, sel disodique Expired - Fee Related CA2085520C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81259791A 1991-12-23 1991-12-23
US07/812,597 1991-12-23

Publications (2)

Publication Number Publication Date
CA2085520A1 true CA2085520A1 (fr) 1993-06-24
CA2085520C CA2085520C (fr) 1996-07-16

Family

ID=25210073

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002085520A Expired - Fee Related CA2085520C (fr) 1991-12-23 1992-12-16 Hexahydrate stable d'etoposide-4'-phosphate, sel disodique

Country Status (8)

Country Link
EP (1) EP0548834B1 (fr)
JP (1) JPH07632B2 (fr)
AT (1) ATE130616T1 (fr)
CA (1) CA2085520C (fr)
DE (1) DE69206246T2 (fr)
DK (1) DK0548834T3 (fr)
ES (1) ES2081551T3 (fr)
GR (1) GR3018198T3 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
DE68912721T2 (de) * 1988-11-16 1994-05-11 Nippon Kayaku Kk Kristallines Hydrochlorid von einer Etoposid-2-dimethylamino-Verbindung und Verfahren zur Herstellung davon.

Also Published As

Publication number Publication date
DE69206246D1 (de) 1996-01-04
JPH06206896A (ja) 1994-07-26
ES2081551T3 (es) 1996-03-16
DK0548834T3 (da) 1995-12-18
GR3018198T3 (en) 1996-02-29
ATE130616T1 (de) 1995-12-15
DE69206246T2 (de) 1996-05-15
EP0548834B1 (fr) 1995-11-22
CA2085520C (fr) 1996-07-16
JPH07632B2 (ja) 1995-01-11
EP0548834A1 (fr) 1993-06-30

Similar Documents

Publication Publication Date Title
CA2110693A1 (fr) Derive d'acide amine anticonvulsif
HU9501944D0 (en) Phosphonic acid derivatives
AU6124890A (en) Improved salt substitute granule
AU8341791A (en) Shoulder adjuster
PH31008A (en) Preparation of substituted guanidines.
AU8250491A (en) Shoulder adjuster
AU8612491A (en) Antiviral compounds
IL115793A0 (en) Process for the manufacture of n-phosphonomethylglycine or its salts
CA2170645A1 (fr) Procede de preparation du n-methyl-3-(1-methyl-4-piperidinyl)-14-indole-5-ethanesulfonamide
AU4089389A (en) N-phosphonomethylglycine + triazine compositions stabilized by surfactants
AU5584290A (en) Novel thiomethyl phosphonate derivatives
AU632380B2 (en) 13-epi-avermectin derivatives useful as antiparasitic agents
AU3377989A (en) Process for the preparation of N-phosphonomethylglycine
CA2085520A1 (fr) Hexahydrate stable d'etoposide-4'-phosphate, sel disodique
AU7266491A (en) Naphthotriazolium salts
ZA923437B (en) Preparation of organic salts or N-phosphonomethylglycine.
EP0523534A3 (en) Process for the preparation of polyenes
AU7507591A (en) Antiviral compounds
AU5151093A (en) Process for the preparation of alkylglycosides
AU2812692A (en) Processes for the preparation of substituted 1,2,4-triazolo- (1,5-a) (1,3,5)triazines
AU633399B2 (en) Multipass evaporator
EP0473020A3 (en) Process for the preparation of alkali metal salts of 2-phosphonobutane-1,2,4-tricarboxylic acid
AU647500B2 (en) Cyclopropylacetic acid derivatives
NZ240662A (en) Preparation of the anhydrous crystalline form of fenoxydim
EP0587533A3 (fr) Procédé pour la préparation de sels d'alpha-aminocétones.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20121217