CA2079796A1 - Nucleoside derivatives - Google Patents

Nucleoside derivatives

Info

Publication number
CA2079796A1
CA2079796A1 CA002079796A CA2079796A CA2079796A1 CA 2079796 A1 CA2079796 A1 CA 2079796A1 CA 002079796 A CA002079796 A CA 002079796A CA 2079796 A CA2079796 A CA 2079796A CA 2079796 A1 CA2079796 A1 CA 2079796A1
Authority
CA
Canada
Prior art keywords
group
groups
formula
compounds
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002079796A
Other languages
English (en)
French (fr)
Inventor
Jo Klaveness
Kjell Undheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27265029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2079796(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909007566A external-priority patent/GB9007566D0/en
Priority claimed from GB909007650A external-priority patent/GB9007650D0/en
Priority claimed from GB909007651A external-priority patent/GB9007651D0/en
Application filed by Nycomed AS filed Critical Nycomed AS
Publication of CA2079796A1 publication Critical patent/CA2079796A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA002079796A 1990-04-04 1991-04-04 Nucleoside derivatives Abandoned CA2079796A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9007651.4 1990-04-04
GB909007566A GB9007566D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB9007650.6 1990-04-04
GB909007650A GB9007650D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB909007651A GB9007651D0 (en) 1990-04-04 1990-04-04 Nucleoside derivatives
GB9007566.4 1990-04-04
PCT/EP1991/000639 WO1991015498A2 (en) 1990-04-04 1991-04-04 Nucleoside derivatives

Publications (1)

Publication Number Publication Date
CA2079796A1 true CA2079796A1 (en) 1991-10-05

Family

ID=27265029

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002079796A Abandoned CA2079796A1 (en) 1990-04-04 1991-04-04 Nucleoside derivatives

Country Status (6)

Country Link
EP (1) EP0523110A1 (de)
JP (1) JPH05505815A (de)
AU (1) AU7558491A (de)
CA (1) CA2079796A1 (de)
OA (1) OA09677A (de)
WO (1) WO1991015498A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991006554A1 (en) * 1989-11-06 1991-05-16 Nycomed As Nucleoside derivatives
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
YU43193A (sh) * 1992-06-22 1997-01-08 Eli Lilly And Company 2'-deoksi-2',2'-difluoro(4-supstituisani)pirimidinski nukleozidi antivirusnog i antikancerogenog dejstva i međuproizvodi
JPH0692987A (ja) * 1992-09-17 1994-04-05 Tanabe Seiyaku Co Ltd ウリジン誘導体およびその製法
JPH11217396A (ja) * 1998-01-30 1999-08-10 Ajinomoto Co Inc ヌクレオシド誘導体の製造方法
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
DK1465615T3 (da) 2002-01-15 2012-11-12 Dartmouth College Tricykliske bisenonderivater og fremgangsmåder til anvendelse heraf
US7265096B2 (en) 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
CN1693309A (zh) * 2005-04-18 2005-11-09 成都正开生物科技发展有限公司 N4－（取代的氧羰基）－2′，2′－二氟－2′－脱氧胞苷衍生物及其应用
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
CA2670099A1 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
CA2711834C (en) 2008-01-11 2017-03-14 Reata Pharmaceuticals, Inc. Synthetic triterpenoids and methods of use in the treatment of disease
EA019263B1 (ru) 2008-04-18 2014-02-28 Ритэ Фамэсутикл, Инк. Антиоксидативные модуляторы воспаления: производные олеанолевой кислоты с аминовыми и другими модификациями на с-17
CN104250280A (zh) 2008-04-18 2014-12-31 里亚塔医药公司 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US7915402B2 (en) 2008-04-18 2011-03-29 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
MX339476B (es) 2008-04-18 2016-05-27 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
EP2833905B1 (de) 2012-04-04 2018-05-02 Halozyme, Inc. Kombinationbehnadlung von hyaluronidase und einem tumor-gerichteten taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
WO2016078397A1 (zh) * 2014-11-17 2016-05-26 常州方圆制药有限公司 新型胞苷衍生物及其应用
WO2016078160A1 (zh) 2014-11-17 2016-05-26 常州方圆制药有限公司 胞苷衍生物及其应用
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
GR1009958B (el) * 2019-04-24 2021-03-18 ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." Παραγωγα γεμσιταβινης και μεθοδοι δημιουργιας παραγωγων γεμσιταβινης

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3651045A (en) * 1968-10-21 1972-03-21 Parke Davis & Co 9-(beta-d-arabinofuranosyl)adenine esters and methods for their production
NZ197458A (en) * 1980-06-23 1983-11-30 Univ Minnesota O-alkoxyalkanoyl derivatives of adenine nucleosides
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
EP0104857A1 (de) * 1982-09-28 1984-04-04 Beecham Group Plc Deoxyuridin-Derivate, Verfahren zu deren Herstellung und ihre Verwendung in der Medizin
WO1985000608A1 (en) * 1983-07-20 1985-02-14 Teijin Limited Antineoplastic agent
ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
US4780452A (en) * 1986-09-08 1988-10-25 Burroughs Wellcome Co. F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof
AU613026B2 (en) * 1987-03-24 1991-07-25 Nycomed As 2',3' dideoxyribofuranoxide derivatives
ES2075040T3 (es) * 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.
JPH02152976A (ja) * 1988-05-06 1990-06-12 Bristol Myers Co ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
EP0346108A3 (de) * 1988-06-09 1991-04-24 The Wellcome Foundation Limited Anti-infektiöse Nukleoside
EP0355031A3 (de) * 1988-08-17 1990-12-27 MATTHES, Eckart, Dr. Substituierte Pyrimidinnucleoside, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
GB8920534D0 (en) * 1989-09-11 1989-10-25 Wellcome Found Antiviral compounds

Also Published As

Publication number Publication date
WO1991015498A3 (en) 1992-06-11
AU7558491A (en) 1991-10-30
WO1991015498A2 (en) 1991-10-17
EP0523110A1 (de) 1993-01-20
JPH05505815A (ja) 1993-08-26
OA09677A (en) 1993-05-15

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