CA2074081A1 - Molecules apparentees a une prothease cellulaire cytotoxique, et methodes - Google Patents

Molecules apparentees a une prothease cellulaire cytotoxique, et methodes

Info

Publication number
CA2074081A1
CA2074081A1 CA 2074081 CA2074081A CA2074081A1 CA 2074081 A1 CA2074081 A1 CA 2074081A1 CA 2074081 CA2074081 CA 2074081 CA 2074081 A CA2074081 A CA 2074081A CA 2074081 A1 CA2074081 A1 CA 2074081A1
Authority
CA
Canada
Prior art keywords
cells
cell
cytotoxic
protease
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2074081
Other languages
English (en)
Inventor
Robert C. Bleackley
Corrine G. Lobe
Verner H. Paetkau
Michael N. G. James
Michael Murphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seragen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2074081A1 publication Critical patent/CA2074081A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6467—Granzymes, e.g. granzyme A (3.4.21.78); granzyme B (3.4.21.79)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA 2074081 1990-01-19 1991-01-17 Molecules apparentees a une prothease cellulaire cytotoxique, et methodes Abandoned CA2074081A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46788090A 1990-01-19 1990-01-19
US467,880 1990-01-19

Publications (1)

Publication Number Publication Date
CA2074081A1 true CA2074081A1 (fr) 1991-07-20

Family

ID=23857533

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2074081 Abandoned CA2074081A1 (fr) 1990-01-19 1991-01-17 Molecules apparentees a une prothease cellulaire cytotoxique, et methodes

Country Status (4)

Country Link
EP (1) EP0511302A4 (fr)
JP (1) JPH05506569A (fr)
CA (1) CA2074081A1 (fr)
WO (1) WO1991010685A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858758A (en) * 1997-05-07 1999-01-12 Incyte Pharmaceuticals, Inc. Human serine protease precursor
CA2326827A1 (fr) * 1998-05-05 1999-11-11 Gene Logic, Inc. Procede pour etudier des modifications de l'expression genique dans des lymphocytes t
US7074911B2 (en) * 2002-09-25 2006-07-11 Board Of Regents, The University Of Texas System Endogenous granzyme B in non-immune cells
EP3066112A1 (fr) * 2013-11-04 2016-09-14 INSERM - Institut National de la Santé et de la Recherche Médicale Inhibiteurs sélectifs de la protéinase 3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4783410A (en) * 1985-06-28 1988-11-08 Massachusetts Institute Of Technology Cytotoxic t lymphocyte serine esterase and method for stimulation and inhibition
ATE114159T1 (de) * 1987-01-13 1994-12-15 Seragen Inc Protease-ähnliche zytotoxische lymphozyten- spezifische moleküle und verfahren.

Also Published As

Publication number Publication date
WO1991010685A1 (fr) 1991-07-25
EP0511302A1 (fr) 1992-11-04
EP0511302A4 (en) 1993-05-05
JPH05506569A (ja) 1993-09-30

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Legal Events

Date Code Title Description
FZDE Dead