CA2072871A1 - Preservation of blood, tissues and biological fluids - Google Patents
Preservation of blood, tissues and biological fluidsInfo
- Publication number
- CA2072871A1 CA2072871A1 CA002072871A CA2072871A CA2072871A1 CA 2072871 A1 CA2072871 A1 CA 2072871A1 CA 002072871 A CA002072871 A CA 002072871A CA 2072871 A CA2072871 A CA 2072871A CA 2072871 A1 CA2072871 A1 CA 2072871A1
- Authority
- CA
- Canada
- Prior art keywords
- iodine
- povidone
- blood
- plasma
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 111
- 239000008280 blood Substances 0.000 title claims abstract description 111
- 238000004321 preservation Methods 0.000 title abstract description 5
- 239000013060 biological fluid Substances 0.000 title 1
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims abstract description 185
- 229920000153 Povidone-iodine Polymers 0.000 claims abstract description 159
- 229960001621 povidone-iodine Drugs 0.000 claims abstract description 159
- 238000011282 treatment Methods 0.000 claims abstract description 29
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 14
- 210000004027 cell Anatomy 0.000 claims description 104
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 103
- 229910052740 iodine Inorganic materials 0.000 claims description 99
- 239000011630 iodine Substances 0.000 claims description 99
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 74
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 74
- 238000000034 method Methods 0.000 claims description 56
- 229940069328 povidone Drugs 0.000 claims description 56
- 210000001519 tissue Anatomy 0.000 claims description 55
- 210000002381 plasma Anatomy 0.000 claims description 46
- 239000007788 liquid Substances 0.000 claims description 33
- 239000012620 biological material Substances 0.000 claims description 31
- 210000000601 blood cell Anatomy 0.000 claims description 31
- 241000700605 Viruses Species 0.000 claims description 24
- 210000003743 erythrocyte Anatomy 0.000 claims description 21
- 239000012141 concentrate Substances 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 17
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- 244000000010 microbial pathogen Species 0.000 claims description 13
- 241000894006 Bacteria Species 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 230000006872 improvement Effects 0.000 claims description 11
- 230000001524 infective effect Effects 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 11
- 239000002245 particle Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 210000002421 cell wall Anatomy 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 235000015097 nutrients Nutrition 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 7
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 5
- 230000004069 differentiation Effects 0.000 claims description 4
- 230000000249 desinfective effect Effects 0.000 claims description 3
- 238000012377 drug delivery Methods 0.000 claims description 3
- 238000005194 fractionation Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 230000007102 metabolic function Effects 0.000 claims description 2
- 230000035935 pregnancy Effects 0.000 claims description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 33
- 239000003638 chemical reducing agent Substances 0.000 claims 15
- 230000001590 oxidative effect Effects 0.000 claims 4
- 239000013618 particulate matter Substances 0.000 claims 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000002791 soaking Methods 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 abstract description 19
- 239000003914 blood derivative Substances 0.000 abstract description 12
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 103
- 239000000243 solution Substances 0.000 description 37
- 208000015181 infectious disease Diseases 0.000 description 20
- 238000002360 preparation method Methods 0.000 description 19
- 238000007792 addition Methods 0.000 description 18
- 238000012360 testing method Methods 0.000 description 16
- 210000002966 serum Anatomy 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 210000000056 organ Anatomy 0.000 description 14
- 244000052769 pathogen Species 0.000 description 13
- 239000010836 blood and blood product Substances 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 238000012545 processing Methods 0.000 description 10
- 210000001124 body fluid Anatomy 0.000 description 9
- 239000010839 body fluid Substances 0.000 description 9
- 238000005070 sampling Methods 0.000 description 9
- 239000007787 solid Substances 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 239000000306 component Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 102000009027 Albumins Human genes 0.000 description 7
- 108010088751 Albumins Proteins 0.000 description 7
- 102000001554 Hemoglobins Human genes 0.000 description 7
- 108010054147 Hemoglobins Proteins 0.000 description 7
- 229940125691 blood product Drugs 0.000 description 7
- 208000006454 hepatitis Diseases 0.000 description 7
- 231100000283 hepatitis Toxicity 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 230000027455 binding Effects 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 230000002421 anti-septic effect Effects 0.000 description 5
- 238000004113 cell culture Methods 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 239000002510 pyrogen Substances 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 241000283690 Bos taurus Species 0.000 description 4
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 4
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 230000009027 insemination Effects 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- -1 povidone-iodine Chemical compound 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 150000003648 triterpenes Chemical class 0.000 description 4
- 241001529453 unidentified herpesvirus Species 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- 241000701083 Bovine alphaherpesvirus 1 Species 0.000 description 3
- 206010018910 Haemolysis Diseases 0.000 description 3
- 208000007514 Herpes zoster Diseases 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 239000003633 blood substitute Substances 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000008588 hemolysis Effects 0.000 description 3
- 208000002672 hepatitis B Diseases 0.000 description 3
- 230000000415 inactivating effect Effects 0.000 description 3
- 230000002458 infectious effect Effects 0.000 description 3
- 150000002497 iodine compounds Chemical class 0.000 description 3
- 229940035535 iodophors Drugs 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 229940063718 lodine Drugs 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 230000001603 reducing effect Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- WRTMQOHKMFDUKX-UHFFFAOYSA-N triiodide Chemical compound I[I-]I WRTMQOHKMFDUKX-UHFFFAOYSA-N 0.000 description 3
- 230000003253 viricidal effect Effects 0.000 description 3
- 241001222053 Akabane virus Species 0.000 description 2
- 241000120506 Bluetongue virus Species 0.000 description 2
- 241000701922 Bovine parvovirus Species 0.000 description 2
- 241000606161 Chlamydia Species 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 2
- 239000004378 Glycyrrhizin Substances 0.000 description 2
- 241000700721 Hepatitis B virus Species 0.000 description 2
- 241000204031 Mycoplasma Species 0.000 description 2
- 206010067152 Oral herpes Diseases 0.000 description 2
- 241000606701 Rickettsia Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 239000012503 blood component Substances 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- OBZHEBDUNPOCJG-SZTGPWMUSA-N carbenoxolone Chemical compound C([C@H]1C2=CC(=O)[C@@H]34)[C@](C)(C(O)=O)CC[C@@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@H]1[C@@]3(C)CC[C@@H](OC(=O)CCC(O)=O)C1(C)C OBZHEBDUNPOCJG-SZTGPWMUSA-N 0.000 description 2
- 229960000530 carbenoxolone Drugs 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 208000005562 infectious bovine rhinotracheitis Diseases 0.000 description 2
- 201000006747 infectious mononucleosis Diseases 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 230000003641 microbiacidal effect Effects 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000010257 thawing Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- XOILGBPDXMVFIP-UHFFFAOYSA-N 1-(diiodomethylsulfonyl)-4-methylbenzene Chemical compound CC1=CC=C(S(=O)(=O)C(I)I)C=C1 XOILGBPDXMVFIP-UHFFFAOYSA-N 0.000 description 1
- GASOXIRLBJILKE-UHFFFAOYSA-N 1-chloro-4-(diiodomethylsulfonyl)benzene Chemical compound ClC1=CC=C(S(=O)(=O)C(I)I)C=C1 GASOXIRLBJILKE-UHFFFAOYSA-N 0.000 description 1
- BALXAMAFSGBZFN-UHFFFAOYSA-N 1-nonyl-2-(2-nonylphenoxy)benzene Chemical compound CCCCCCCCCC1=CC=CC=C1OC1=CC=CC=C1CCCCCCCCC BALXAMAFSGBZFN-UHFFFAOYSA-N 0.000 description 1
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 229910001316 Ag alloy Inorganic materials 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 241000589876 Campylobacter Species 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 241000518994 Conta Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 208000001860 Eye Infections Diseases 0.000 description 1
- 229910000640 Fe alloy Inorganic materials 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010061166 Gastroenteritis bacterial Diseases 0.000 description 1
- 206010018180 Genital ulceration Diseases 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000004898 Herpes Labialis Diseases 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000969106 Megalaima haemacephala Species 0.000 description 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 description 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000223960 Plasmodium falciparum Species 0.000 description 1
- 241000223821 Plasmodium malariae Species 0.000 description 1
- 206010035501 Plasmodium malariae infection Diseases 0.000 description 1
- 241001505293 Plasmodium ovale Species 0.000 description 1
- 206010035502 Plasmodium ovale infection Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 229910019026 PtCr Inorganic materials 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 102100035115 Testin Human genes 0.000 description 1
- 101710070533 Testin Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 206010051511 Viral diarrhoea Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 241000607447 Yersinia enterocolitica Species 0.000 description 1
- 241001428384 Zamora Species 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000003567 ascitic fluid Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 230000002599 biostatic effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229960000182 blood factors Drugs 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 235000012206 bottled water Nutrition 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000001461 cytolytic effect Effects 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 229940059082 douche Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 208000011323 eye infectious disease Diseases 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000012977 glove powder Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- 229940006461 iodide ion Drugs 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 150000002496 iodine Chemical class 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- LVQPBIMCRZQQBC-UHFFFAOYSA-N methoxymethyl 2-methylprop-2-enoate Chemical compound COCOC(=O)C(C)=C LVQPBIMCRZQQBC-UHFFFAOYSA-N 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 230000009972 noncorrosive effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000000934 spermatocidal agent Substances 0.000 description 1
- 230000001150 spermicidal effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000005570 vertical transmission Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0215—Disinfecting agents, e.g. antimicrobials for preserving living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0289—Pressure processes, i.e. using a designated change in pressure over time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Charge And Discharge Circuits For Batteries Or The Like (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57720490A | 1990-09-04 | 1990-09-04 | |
| US577,204 | 1990-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2072871A1 true CA2072871A1 (en) | 1992-03-05 |
Family
ID=24307713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002072871A Abandoned CA2072871A1 (en) | 1990-09-04 | 1991-09-03 | Preservation of blood, tissues and biological fluids |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0500893A4 (ja) |
| JP (1) | JPH05502183A (ja) |
| AU (1) | AU644216B2 (ja) |
| CA (1) | CA2072871A1 (ja) |
| WO (1) | WO1992004031A1 (ja) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5370869A (en) * | 1990-09-04 | 1994-12-06 | Shanbrom; Edward | Antimicrobial preservation of platelets and blood factors |
| US5333626A (en) * | 1991-12-31 | 1994-08-02 | Cryolife, Inc. | Preparation of bone for transplantation |
| US5513662A (en) * | 1991-12-31 | 1996-05-07 | Osteotech, Inc. | Preparation of bone for transplantation |
| JPH06509118A (ja) * | 1992-05-04 | 1994-10-13 | シャンブロム、エドワード | 安全な生物流体 |
| EP0605704A4 (en) * | 1992-06-29 | 1994-11-17 | Edward Shanbrom | PRESERVATION OF BLOOD, TISSUE AND BIOLOGICAL LIQUIDS BY STRENGTH IODINE PEROXIDE. |
| JPH06510798A (ja) * | 1992-06-29 | 1994-12-01 | シャンブロム、エドワード | 血液、組織および生物流体のポビドン過酸化水素による保存 |
| DE4343226A1 (de) * | 1993-12-17 | 1995-06-22 | Schenk Filterbau Gmbh | Tiefenfilter zur Abtötung von Mikroorganismen und Inaktivierung von Viren und dessen Anwendung |
| US5591350A (en) * | 1994-04-15 | 1997-01-07 | Pall Corporation | Iodine disinfection method using a gaseous iodine treated porous medium |
| US6096216A (en) * | 1994-06-09 | 2000-08-01 | American National Red Cross | Iodinated matrices for disinfecting biological fluids |
| US6114108A (en) * | 1995-08-29 | 2000-09-05 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of viral nucleic acids |
| US5741894A (en) * | 1995-09-22 | 1998-04-21 | Baxter International, Inc. | Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form |
| DE19544449A1 (de) | 1995-11-29 | 1997-06-05 | Basf Ag | Pulverförmige Iod-Komplexe |
| US6352695B1 (en) | 1997-10-03 | 2002-03-05 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
| US6093564A (en) * | 1997-10-03 | 2000-07-25 | V.I. Technologies, Inc. | Methods and compositions for the selective modification of nucleic acids |
| US6106773A (en) * | 1998-09-24 | 2000-08-22 | American National Red Cross | Pathogen inactivating compositions for disinfecting biological fluids |
| US6617100B2 (en) | 1998-09-25 | 2003-09-09 | V.I. Technologies, Inc. | Solid phase quenching systems |
| US6403359B1 (en) | 1998-09-25 | 2002-06-11 | V. I. TECHNOLOGIES, Inc. | Solid phase quenching systems |
| US6881731B1 (en) * | 2000-10-23 | 2005-04-19 | Shanbrom Technologies, Llc | Enhancers for microbiological disinfection |
| WO2006093314A1 (ja) * | 2005-03-04 | 2006-09-08 | National University Corporation, Tokyo Medical And Dental University | 臓器機能維持改善液 |
| GB0707275D0 (en) * | 2007-04-16 | 2007-05-23 | Safemed Ltd | Preservation composition |
| JP5379192B2 (ja) * | 2011-07-01 | 2013-12-25 | エヌディー パートナーズ，リミティド ライアビリティー カンパニー | 殺生物剤ロック |
| FR3072246B1 (fr) | 2017-10-13 | 2020-06-12 | Biodesiv Efnium | Polymere antimicrobien pour semences animales |
| CN109938008A (zh) * | 2019-03-20 | 2019-06-28 | 上海创宏生物科技有限公司 | 一种动物精液处理剂及其应用方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2675341A (en) * | 1949-12-28 | 1954-04-13 | Gen Aniline & Film Corp | Protein hydrolysate detoxified by polyvinyl pyrrolidone |
| US3169905A (en) * | 1961-05-15 | 1965-02-16 | William H Lambert | Sanitizing composition and method of use |
| US3216579A (en) * | 1961-05-25 | 1965-11-09 | Ind Biology Lab Inc | Water-insoluble polyvinylpyrrolidone composition |
| US3177117A (en) * | 1961-12-26 | 1965-04-06 | Joseph F Saunders | Process for freezing blood |
| US3155590A (en) * | 1962-08-02 | 1964-11-03 | Ncr Co | Encapsulation process and its product |
| EP0079782B1 (en) * | 1981-11-16 | 1987-02-04 | Euroceltique S.A. | Stabilized iodine-containing germicidal preparation |
| FR2529463B1 (fr) * | 1982-07-05 | 1986-01-10 | Centre Nat Rech Scient | Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus |
| GB8622012D0 (en) * | 1986-09-12 | 1986-10-22 | Euro Celtique Sa | Solid iodophor composition |
| US4996048A (en) * | 1988-11-30 | 1991-02-26 | Euroceltique, S.A. | Stabilizing packaged iodophor and minimizing leaching of iodine through packaging |
| US5149718A (en) * | 1989-01-19 | 1992-09-22 | New York University | Biological fluid purification system |
| AU639227B2 (en) * | 1989-03-14 | 1993-07-22 | David James Batten | Improved method of treating footrot |
-
1991
- 1991-09-03 AU AU85037/91A patent/AU644216B2/en not_active Ceased
- 1991-09-03 WO PCT/US1991/006240 patent/WO1992004031A1/en not_active Application Discontinuation
- 1991-09-03 EP EP19910916527 patent/EP0500893A4/en not_active Withdrawn
- 1991-09-03 CA CA002072871A patent/CA2072871A1/en not_active Abandoned
- 1991-09-03 JP JP3515148A patent/JPH05502183A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU8503791A (en) | 1992-03-30 |
| WO1992004031A1 (en) | 1992-03-19 |
| JPH05502183A (ja) | 1993-04-22 |
| EP0500893A1 (en) | 1992-09-02 |
| EP0500893A4 (en) | 1993-03-10 |
| AU644216B2 (en) | 1993-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU644216B2 (en) | Preservation of blood, tissues and biological fluids | |
| US5360605A (en) | Preservation of blood, tissues and biological fluids | |
| US5370869A (en) | Antimicrobial preservation of platelets and blood factors | |
| US7381521B2 (en) | Anti-pathogenic composition useful in blood preservation | |
| US5211912A (en) | Method for disinfecting red blood cells, blood products, and corneas | |
| AU648823B2 (en) | Antimicrobial preservation of plasma | |
| WO1993017693A1 (en) | Albumin-iodine preservation of blood, tissues and biological fluids | |
| EP0614368A4 (en) | SAFE BLOOD FOR HUMAN TRANSFUSION. | |
| US5985260A (en) | Disinfection of blood and biologicals with active albumin-iodine complex | |
| EP0598896A1 (en) | Starch-iodine used as a preservative | |
| EP0622989A1 (en) | A method of inactivating microbes in blood using iodine | |
| WO1994000161A1 (en) | Povidone hydrogen peroxide preservation of blood, tissues and biological fluids | |
| WO1994000011A1 (en) | Starch-iodine-peroxide preservation of blood, tissues and biological fluids | |
| WO1993004731A1 (en) | Iodine-iodide treatment of red blood cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |