CA2071574A1 - Process for the glycosylation of avermectin compounds - Google Patents

Process for the glycosylation of avermectin compounds

Info

Publication number
CA2071574A1
CA2071574A1 CA002071574A CA2071574A CA2071574A1 CA 2071574 A1 CA2071574 A1 CA 2071574A1 CA 002071574 A CA002071574 A CA 002071574A CA 2071574 A CA2071574 A CA 2071574A CA 2071574 A1 CA2071574 A1 CA 2071574A1
Authority
CA
Canada
Prior art keywords
compound
broken line
compounds
plants
double bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002071574A
Other languages
English (en)
French (fr)
Inventor
Patrick J. Doherty
Marvin D. Schulman
Byron H. Arison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck & Co., Inc.
Patrick J. Doherty
Marvin D. Schulman
Byron H. Arison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc., Patrick J. Doherty, Marvin D. Schulman, Byron H. Arison filed Critical Merck & Co., Inc.
Publication of CA2071574A1 publication Critical patent/CA2071574A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pest Control & Pesticides (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Agronomy & Crop Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002071574A 1991-06-26 1992-06-18 Process for the glycosylation of avermectin compounds Abandoned CA2071574A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/721,744 US5192671A (en) 1991-06-26 1991-06-26 Process for the glycosylation of avermectin compounds
US721,744 1991-06-26

Publications (1)

Publication Number Publication Date
CA2071574A1 true CA2071574A1 (en) 1992-12-27

Family

ID=24899139

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002071574A Abandoned CA2071574A1 (en) 1991-06-26 1992-06-18 Process for the glycosylation of avermectin compounds

Country Status (7)

Country Link
US (1) US5192671A (ja)
EP (1) EP0520557A1 (ja)
JP (1) JPH06102675B2 (ja)
AU (1) AU657546B2 (ja)
CA (1) CA2071574A1 (ja)
NZ (1) NZ243202A (ja)
ZA (1) ZA924696B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
PT637244E (pt) * 1992-03-23 2001-04-30 Merck & Co Inc Estirpe de spretomyces avermitilis glicosilante de compostos de avermectina
US5478929A (en) * 1993-09-15 1995-12-26 Merck & Co., Inc. Bioconversion products of 27-hydroxy avermectin
US5554519A (en) * 1995-08-07 1996-09-10 Fermalogic, Inc. Process of preparing genistein
US5968540A (en) * 1997-06-30 1999-10-19 The United States Of America, As Represented By The Secretary Of Agriculture Method for controlling a target insect and hydrodynamic insect bait
CA2271448A1 (en) * 1999-05-12 2000-11-12 Stuart Energy Systems Inc. Energy distribution network
US7022684B2 (en) 2000-05-24 2006-04-04 Pfizer Inc. Treatment of rumen acidosis with α-amylase inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653899A (en) * 1952-04-14 1953-09-29 Lilly Co Eli Erythromycin, its salts, and method of preparation
US2834714A (en) * 1954-03-01 1958-05-13 Abbott Lab Culture process for erythromycin b
US3801465A (en) * 1971-01-18 1974-04-02 Abbott Lab Erythromycin e
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4203976A (en) * 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
NZ238521A (en) * 1990-06-22 1992-12-23 Merck & Co Inc Process for the conversion of avermectin glycone to avermectin mono- and disaccharides by fermentation with streptomyces avermitilis ma6078

Also Published As

Publication number Publication date
NZ243202A (en) 1993-08-26
US5192671A (en) 1993-03-09
EP0520557A1 (en) 1992-12-30
JPH06107677A (ja) 1994-04-19
ZA924696B (en) 1993-03-31
AU657546B2 (en) 1995-03-16
JPH06102675B2 (ja) 1994-12-14
AU1856392A (en) 1993-01-07

Similar Documents

Publication Publication Date Title
US4378353A (en) Novel C-076 compounds
US4285963A (en) Novel derivatives of C-076 compounds
US4666937A (en) Avermectin bioconversion products
US5192671A (en) Process for the glycosylation of avermectin compounds
EP0204421B1 (en) Antihelmintic macrocyclic lactones and their production by fermentation
US5070015A (en) Novel avermectins are produced from known microorganisms
US5015662A (en) Anthelmintic bioconversion products
EP0212867A2 (en) Antihelmintic avermectin derivatives produced by the fermentation of a microorganism
US4668696A (en) Novel averonectin fermentation product of a microorganism with anthelmintic activity
EP0637244B1 (en) A strain of streptomyces avermitilis glycosylates avermectin compounds
US5140042A (en) 28-hydroxy ivermectin aglycone
US5124258A (en) Fermentation process for the preparation of ivermectin aglycone
US5188944A (en) Process for the glycosylation of avermectin agylcones
AU646749B2 (en) A process for the glycosylation of avermectin compounds at the 14a-position
US4766112A (en) Anthelmintic fermentation products of a microorganism
NZ230948A (en) Avermectin derivatives, preparation by fermentation, pharmaceutical and insecticidal compositions thereof
US5312753A (en) Strain of streptomyces avermitilis capable of glycosylating avermectin compounds at the 13- and 14A positions
US5250422A (en) Biotransformation process for the production of invermectin derivatives
US5120646A (en) Process for the preparation of anthelmintive bioconversion products
CA2074328A1 (en) Process for the 14a-hydroxylation of avermectin compounds
US5478929A (en) Bioconversion products of 27-hydroxy avermectin
EP0463677A2 (en) Process for the glycosylation of avermectin aglycones
EP0481672A1 (en) 5Beta- and 13beta ivermectin monoglucopyranosides
EP0482795A1 (en) Preparation of novel invermectin compounds
EP0490474A2 (en) Novel avermectins are produced from known microorganisms

Legal Events

Date Code Title Description
FZDE Dead