CA2065842A1 - Process for inactivating viruses in blood and blood products - Google Patents

Process for inactivating viruses in blood and blood products

Info

Publication number
CA2065842A1
CA2065842A1 CA 2065842 CA2065842A CA2065842A1 CA 2065842 A1 CA2065842 A1 CA 2065842A1 CA 2065842 CA2065842 CA 2065842 CA 2065842 A CA2065842 A CA 2065842A CA 2065842 A1 CA2065842 A1 CA 2065842A1
Authority
CA
Grant status
Application
Patent type
Prior art keywords
blood
process
dyes
inactivating viruses
phenothiazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2065842
Other languages
French (fr)
Other versions
CA2065842C (en )
Inventor
Harald Mohr
Bernd Lambrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blutspendedienst Der Landesverbande Des Deutschen Roten Kreuzes Niedersachsen Oldenburg und Bremen Ggmbh
Original Assignee
Harald Mohr
Bernd Lambrecht
Blutspendedienst Der Landesverbande Des Deutschen Roten Kreuzes Niedersachsen, Oldenburg Und Bremen G.G.M.B.H.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08Radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02Blood transfusion apparatus
    • A61M1/0209Multiple bag systems for separating or storing blood components
    • A61M1/0218Multiple bag systems for separating or storing blood components with filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • A61M1/3686Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents by removing photoactive agents after irradiation

Abstract

The invention is directed to a process for inactivating viruses in blood and blood products, comprising adding phenothiazine dyes to the solutions or suspensions to be treated and subsequently irradiating said phenothiazine dye-containing solutions or suspensions with light. The use of a very small concentration of phenothiazine dyes prevents any adverse effects on the plasma proteins. Inactivation is effected by direct irradiation of the blood bags.
After irradiation the dyes may be removed from the blood. To this end the blood is passed over adsorbing agents.
CA 2065842 1989-09-13 1990-09-08 Process for inactivating viruses in blood and blood products Expired - Lifetime CA2065842C (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DEP3930510.4 1989-09-13
DE19893930510 DE3930510A1 (en) 1989-09-13 1989-09-13 A process for inactivating viruses in blood and blood products
PCT/DE1990/000691 WO1991003933A1 (en) 1989-09-13 1990-09-08 Process for inactivating viruses in blood and blood products

Publications (2)

Publication Number Publication Date
CA2065842A1 true true CA2065842A1 (en) 1991-03-14
CA2065842C CA2065842C (en) 1999-12-21

Family

ID=6389298

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2065842 Expired - Lifetime CA2065842C (en) 1989-09-13 1990-09-08 Process for inactivating viruses in blood and blood products

Country Status (9)

Country Link
EP (2) EP0491757B2 (en)
JP (1) JP2965695B2 (en)
CA (1) CA2065842C (en)
DE (3) DE3930510A1 (en)
DK (1) DK0491757T4 (en)
ES (1) ES2113347T5 (en)
FI (1) FI99192C (en)
RU (1) RU2036235C1 (en)
WO (1) WO1991003933A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951713B2 (en) 1997-01-06 2005-10-04 Cerus Corporation Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US7037642B2 (en) 1997-01-06 2006-05-02 Cerus Corporation Removing compounds from blood products with porous particles immobilized in a matrix
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571666A (en) * 1988-10-28 1996-11-05 Oklahoma Medical Research Foundation Thiazine dyes used to inactivate HIV in biological fluids
US6348309B1 (en) * 1989-09-13 2002-02-19 Blutspendedienst Der Landesverbaende Des Deutschen Roten Kreuzes Niedersachsen, Oldenburg Und Bremen G.G.M.B.H. Process for inactivating viruses in blood and blood products
US6251644B1 (en) 1990-04-16 2001-06-26 Baxter International, Inc. Method for inactivating non-enveloped viral contaminants with a photosensitizer by increasing viral permeability to the photosensitizer
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5120649A (en) * 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
DE9102709U1 (en) * 1991-03-07 1991-07-04 Blutspendedienst Der Landesverbaende Des Deutschen Roten Kreuzes Niedersachsen, Oldenburg Und Bremen Gemeinnuetzige Gmbh, 3257 Springe, De
US6433343B1 (en) 1992-03-02 2002-08-13 Cerus Corporation Device and method for photoactivation
US6207107B1 (en) * 1992-10-05 2001-03-27 Baxter International Inc. Steam sterilizable system for inactivating viral contaminants in body fluids
WO1995000631A1 (en) * 1993-06-23 1995-01-05 New York Blood Center, Inc. System for viral inactivation of blood
US6420570B1 (en) 1993-06-28 2002-07-16 Cerus Corporation Psoralen compounds
US5399719A (en) 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5712085A (en) 1993-06-28 1998-01-27 Cerus Corporation 5'-(4-amino-2-oxa)butye-4,4', 8-trinethylpsoralen in synthetic medium
US6319662B1 (en) * 1993-12-17 2001-11-20 Baxter International Inc. Method and apparatus for removing viral contaminants from a body fluid
EP0739232A1 (en) * 1994-01-10 1996-10-30 Hemasure, Inc. Device and process for removing leukocytes and viral inactivating agents from blood
US5639376A (en) * 1994-01-10 1997-06-17 Hemasure, Inc. Process for simultaneously removing leukocytes and methylene blue from plasma
DE4444045C2 (en) * 1994-12-10 1997-04-17 Behringwerke Ag Method of inactivating viruses by means of acridine or acridine
US6544727B1 (en) 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
DE19781229T1 (en) * 1996-06-17 1999-01-28 Mercury Diagnostics Inc The electrochemical test device and related method
US6190609B1 (en) 1996-11-19 2001-02-20 Baxter International Inc. Methods and apparatus for inactivating contaminants in biological fluid
US5922278A (en) * 1996-11-19 1999-07-13 Baxter International Inc. Method and apparatus for inactivating contaminants in biological fluid
US6610436B1 (en) 1998-09-11 2003-08-26 Gore Enterprise Holdings Catalytic coatings and fuel cell electrodes and membrane electrode assemblies made therefrom
DE69819360T2 (en) 1997-11-20 2004-08-19 Cerus Corp., Concord New psoralens for inactivation of pathogenic
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
DE19904088A1 (en) 1999-02-02 2000-09-07 Fressenius Hemocare Gmbh Hose for a cell separator for separating blood into its components and methods for separating blood into its components
DE19914850A1 (en) * 1999-04-01 2000-10-05 Gerhard Saalmann Device for inactivating viruses, especially human immunodeficiency virus (HIV) from blood products, uses coloring agents and radiation
US6565802B1 (en) 1999-06-03 2003-05-20 Baxter International Inc. Apparatus, systems and methods for processing and treating a biological fluid with light
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
DE10031851B4 (en) * 2000-07-04 2005-10-13 Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH Photodynamic treatment and UV-B irradiation of a platelet suspension
CA2474242C (en) * 2002-02-01 2011-05-17 Gambro, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2516920B2 (en) * 1975-04-17 1977-02-10 A process for recovering thiazine
DE2827109C2 (en) * 1977-06-24 1986-10-30 Asahi Kasei Kogyo K.K., Osaka, Jp
JPS5665071A (en) * 1979-11-01 1981-06-02 Asahi Chem Ind Co Ltd Photo-oxidation treating agent
US4748120A (en) * 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4727027A (en) * 1983-05-02 1988-02-23 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
JPS61275228A (en) 1985-03-14 1986-12-05 Baxter Travenol Lab Photodynamic inactivity of virus in therapeutical protein composition
US4775625A (en) * 1986-11-21 1988-10-04 The Medical College Of Wisconsin, Inc. Inactivating enveloped viruses with a merocyanine dye
DE3717951C1 (en) * 1987-05-25 1988-11-24 Shanmugam Murugavel Using silica gel for the detoxification of blood
US4878891A (en) * 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
DE3805459A1 (en) * 1988-02-22 1989-08-31 Biotest Pharma Gmbh A process for the sterilization of blood, plasma, blood and plasma derivatives, cell suspensions or the like.
US5149718A (en) * 1989-01-19 1992-09-22 New York University Biological fluid purification system
EP0471794B1 (en) * 1989-05-11 1996-10-02 Oklahoma Medical Research Foundation Antiviral therapy using thiazine and xanthene dyes

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6951713B2 (en) 1997-01-06 2005-10-04 Cerus Corporation Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US7037642B2 (en) 1997-01-06 2006-05-02 Cerus Corporation Removing compounds from blood products with porous particles immobilized in a matrix
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US9259525B2 (en) 1998-01-06 2016-02-16 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix

Also Published As

Publication number Publication date Type
DK0491757T4 (en) 2002-04-22 grant
JP2965695B2 (en) 1999-10-18 grant
CA2065842C (en) 1999-12-21 grant
ES2113347T3 (en) 1998-05-01 grant
JPH05500366A (en) 1993-01-28 application
DE122008000026I2 (en) 2011-05-05 grant
FI920981A0 (en) 1992-03-05 application
ES2113347T5 (en) 2002-09-16 grant
WO1991003933A1 (en) 1991-04-04 application
DK0491757T3 (en) 1998-09-07 grant
DE3930510A1 (en) 1991-03-21 application
FI920981D0 (en) grant
FI99192C (en) 1997-10-27 grant
EP0491757B1 (en) 1998-01-07 grant
EP0593098A2 (en) 1994-04-20 application
EP0491757B2 (en) 2002-01-09 grant
FI99192B (en) 1997-07-15 application
EP0491757A1 (en) 1992-07-01 application
RU2036235C1 (en) 1995-05-27 grant
DE122008000026I1 (en) 2008-08-21 grant
EP0593098A3 (en) 1994-04-27 application
DE59010793D1 (en) 1998-02-12 grant

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