CA2057558A1 - Methode et appareil de mesure en deux dimensions de la concentration de macromolecules biologiques en solution - Google Patents

Methode et appareil de mesure en deux dimensions de la concentration de macromolecules biologiques en solution

Info

Publication number
CA2057558A1
CA2057558A1 CA2057558A CA2057558A CA2057558A1 CA 2057558 A1 CA2057558 A1 CA 2057558A1 CA 2057558 A CA2057558 A CA 2057558A CA 2057558 A CA2057558 A CA 2057558A CA 2057558 A1 CA2057558 A1 CA 2057558A1
Authority
CA
Canada
Prior art keywords
biological macromolecule
concentration
dimensional measurement
crystallizing
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2057558A
Other languages
English (en)
Other versions
CA2057558C (fr
Inventor
Kotaro Oka
Koji Asano
Shozo Fujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujitsu Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2057558A1 publication Critical patent/CA2057558A1/fr
Application granted granted Critical
Publication of CA2057558C publication Critical patent/CA2057558C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G01N21/5907—Densitometers
    • G01N21/5911—Densitometers of the scanning type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/14—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation
    • G01N25/147—Investigating or analyzing materials by the use of thermal means by using distillation, extraction, sublimation, condensation, freezing, or crystallisation by cristallisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G01N21/5907—Densitometers
    • G01N2021/5957—Densitometers using an image detector type detector, e.g. CCD
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light

Landscapes

  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CA002057558A 1990-12-18 1991-12-17 Methode et appareil de mesure en deux dimensions de la concentration de macromolecules biologiques en solution Expired - Fee Related CA2057558C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP02-403315 1990-12-18
JP2403315A JP2914758B2 (ja) 1990-12-18 1990-12-18 タンパク質溶液濃度の２次元測定方法および装置

Publications (2)

Publication Number Publication Date
CA2057558A1 true CA2057558A1 (fr) 1992-06-19
CA2057558C CA2057558C (fr) 1995-01-03

Family

ID=18513063

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002057558A Expired - Fee Related CA2057558C (fr) 1990-12-18 1991-12-17 Methode et appareil de mesure en deux dimensions de la concentration de macromolecules biologiques en solution

Country Status (5)

Country Link
US (1) US5214288A (fr)
EP (1) EP0491558B1 (fr)
JP (1) JP2914758B2 (fr)
CA (1) CA2057558C (fr)
DE (1) DE69119568T2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3094880B2 (ja) * 1995-03-01 2000-10-03 住友金属工業株式会社 有機化合物の結晶化制御方法およびそれに用いる結晶化制御用固体素子
GB9509410D0 (en) 1995-05-10 1995-07-05 Imperial College Molecular imaging
JP4020539B2 (ja) * 1999-06-29 2007-12-12 ジーイーヘルスケア バイオサイエンス株式会社 水晶発振子を用いた液滴中の溶質濃度測定方法
DE10036880A1 (de) * 2000-07-28 2002-02-07 Basf Ag Regelung einer Waschkolonne in einem Schmelzkristallisationsprozess
WO2002097404A1 (fr) * 2001-05-30 2002-12-05 Sciperio, Inc. Systeme, procede et appareil pour determiner de maniere non intrusive la concentration d'un solute dans une solution
US20040007672A1 (en) * 2002-07-10 2004-01-15 Delucas Lawrence J. Method for distinguishing between biomolecule and non-biomolecule crystals
JP4458513B2 (ja) 2003-08-18 2010-04-28 株式会社リガク 特定高分子結晶の評価装置
JP4113063B2 (ja) * 2003-08-18 2008-07-02 株式会社リガク 特定高分子結晶の検出方法
DE102004005878A1 (de) * 2004-02-05 2005-09-01 Rina-Netzwerk Rna Technologien Gmbh Verfahren zur Überwachung der Herstellung von Biomolekülkristallen
US7545495B2 (en) * 2004-04-27 2009-06-09 Abbott Laboratories Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
US20050237522A1 (en) * 2004-04-27 2005-10-27 Swift Kerry M Methods for visualizing crystals and distinguishing crystals from other matter within a biological sample
US20070088508A1 (en) * 2005-09-28 2007-04-19 Scott Childs Cocrystallization methods
KR101400173B1 (ko) * 2006-09-12 2014-05-27 술저 켐테크 악티엔게젤샤프트 이온성 액체의 정제 방법
US20080225265A1 (en) * 2007-03-17 2008-09-18 Mi Research, Inc. Method and apparatus for finding macromolecule crystallization conditions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751167A (en) * 1971-02-23 1973-08-07 G Claus Method and apparatus for continuous monitoring of dissolved organics
DE2741068A1 (de) * 1977-09-13 1979-03-22 Arnold Dipl Phys Dr Binder Verfahren und vorrichtung zur diagnose an gewebeproben
US4192996A (en) * 1978-07-12 1980-03-11 Hewlett-Packard Company Measurement of oxygen by differential absorption of UV radiation
US4587428A (en) * 1980-09-29 1986-05-06 Arnold Binder Method and apparatus for the diagnosis of tissue samples
JPS5892841A (ja) * 1981-11-28 1983-06-02 Shimadzu Corp 濃度計
JPS62106000A (ja) * 1985-10-30 1987-05-16 Fujitsu Ltd 生体高分子結晶自動作製装置
US4845552A (en) * 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US4919899A (en) * 1988-02-29 1990-04-24 Herrmann Frederick T Crystal growth apparatus

Also Published As

Publication number Publication date
US5214288A (en) 1993-05-25
JP2914758B2 (ja) 1999-07-05
DE69119568D1 (de) 1996-06-20
EP0491558A2 (fr) 1992-06-24
EP0491558B1 (fr) 1996-05-15
CA2057558C (fr) 1995-01-03
JPH04216441A (ja) 1992-08-06
EP0491558A3 (en) 1992-11-19
DE69119568T2 (de) 1996-09-19

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Effective date: 20051219