CA2050623A1 - Ointments containing tricyclic compound - Google Patents

Ointments containing tricyclic compound

Info

Publication number
CA2050623A1
CA2050623A1 CA002050623A CA2050623A CA2050623A1 CA 2050623 A1 CA2050623 A1 CA 2050623A1 CA 002050623 A CA002050623 A CA 002050623A CA 2050623 A CA2050623 A CA 2050623A CA 2050623 A1 CA2050623 A1 CA 2050623A1
Authority
CA
Canada
Prior art keywords
tricyclic compound
ointments containing
containing tricyclic
ointment
octavos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002050623A
Other languages
French (fr)
Other versions
CA2050623C (en
Inventor
Sotoo Asakura
Yoshio Murakami
Nobuto Kanagawa
Toshiomi Nakate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16982211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2050623(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2050623A1 publication Critical patent/CA2050623A1/en
Application granted granted Critical
Publication of CA2050623C publication Critical patent/CA2050623C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

An ointment comprising a tricyclic compound such as FK
506 substance which is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimet-hoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0 4,9)octavos-18-ene-2,3,10,16-tetraone, or the like, a solubilizing and/or absorption-promoting agent and an ointment base, which is useful for treating and preventing various skin diseases.
CA002050623A 1990-09-04 1991-09-04 Ointments containing tricyclic compound Expired - Lifetime CA2050623C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP235177/1990 1990-09-04
JP23517790 1990-09-04

Publications (2)

Publication Number Publication Date
CA2050623A1 true CA2050623A1 (en) 1992-03-05
CA2050623C CA2050623C (en) 2002-02-05

Family

ID=16982211

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002050623A Expired - Lifetime CA2050623C (en) 1990-09-04 1991-09-04 Ointments containing tricyclic compound

Country Status (20)

Country Link
US (1) US5385907A (en)
EP (1) EP0474126B1 (en)
JP (1) JP2526752B2 (en)
KR (1) KR100194240B1 (en)
CN (1) CN1069193C (en)
AT (1) ATE150304T1 (en)
AU (1) AU656145B2 (en)
CA (1) CA2050623C (en)
DE (1) DE69125230T2 (en)
DK (1) DK0474126T3 (en)
ES (1) ES2099112T3 (en)
GR (1) GR3022883T3 (en)
HK (1) HK1000006A1 (en)
HU (2) HUT59002A (en)
IE (1) IE913085A1 (en)
PH (1) PH31282A (en)
PT (1) PT98862B (en)
RU (1) RU2079303C1 (en)
SG (1) SG46547A1 (en)
ZA (1) ZA916983B (en)

Families Citing this family (54)

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DK0669127T3 (en) * 1992-11-18 1999-12-06 Fujisawa Pharmaceutical Co Prolonged action pharmaceutical preparation
JPH06345646A (en) * 1993-06-08 1994-12-20 Fujisawa Pharmaceut Co Ltd Lotion preparation
DE19549794B4 (en) * 1994-10-26 2009-07-30 Novartis Ag Microemulsion pre-concentrate of active agent with low solubility - with carrier medium comprising hydrophilic phase contg. di-methyl-isosorbide and/or alkanoic ester, lipophilic phase and surfactant
GB2327611B (en) * 1994-10-26 1999-06-02 Novartis Ag Macrolide compositions
AU735106B2 (en) * 1994-10-26 2001-06-28 Novartis Ag Pharmaceutical compositions
CZ289773B6 (en) * 1994-10-26 2002-04-17 Novartis Ag Pharmaceutical preparation for local application
GB2327610B (en) * 1994-11-04 1999-06-02 Novartis Ag Macrolide compositions
AR004480A1 (en) * 1995-04-06 1998-12-16 Amico Derin C D ASCOMICINE COMPOUNDS HAVING ANTI-INFLAMMATORY ACTIVITY, PROCEDURE TO PREPARE THEM, USE OF SUCH COMPOUNDS TO PREPARE PHARMACEUTICAL AGENTS AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM
US5993787A (en) * 1996-09-13 1999-11-30 Johnson & Johnson Consumer Products, Inc. Composition base for topical therapeutic and cosmetic preparations
AU5340298A (en) * 1996-12-27 1998-07-31 Takeda Chemical Industries Ltd. Stabilized tricyclic compound
TW450810B (en) 1997-02-20 2001-08-21 Fujisawa Pharmaceutical Co Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases
GB9723669D0 (en) * 1997-11-07 1998-01-07 Univ Aberdeen Skin penetration enhancing components
RU2149635C1 (en) * 1998-02-27 2000-05-27 Пермская государственная медицинская академия Method of treatment of patient with allergic dermatitis
TR200003108T2 (en) * 1998-04-27 2001-02-21 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical compositions
GB9817064D0 (en) * 1998-08-05 1998-10-07 Fujisawa Pharmaceutical Co New use
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
GB9826656D0 (en) * 1998-12-03 1999-01-27 Novartis Ag Organic compounds
AUPR529701A0 (en) * 2001-05-28 2001-06-21 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition
RU2183113C1 (en) * 2001-06-28 2002-06-10 Новицкий Юрий Алексеевич Graphite hydrosulfate preparation and method to treat patients with benign and malignant cutaneous tumors (versions)
WO2003004098A1 (en) 2001-07-06 2003-01-16 Sucampo Ag Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent
AR038628A1 (en) * 2002-03-04 2005-01-19 Novartis Ag OPHTHALM COMPOSITION
US20060115500A1 (en) * 2002-07-23 2006-06-01 Jithan Aukunuru Ophthalmic ointment composition comprising a drug, an ointment base and a solubilizing/dispersing agent
GB0218996D0 (en) * 2002-08-14 2002-09-25 Novartis Ag Organic compounds
RU2231359C1 (en) * 2002-12-11 2004-06-27 Государственное образовательное учреждение высшего профессионального образования Московская медицинская академия им. И.М.Сеченова Method for treatment of skin angiitis ulcerous forms
EP2377532A1 (en) * 2004-08-18 2011-10-19 Ace ApS Cosmetic and pharmaceutical compositions comprising ACE inhibitors and/or angiotensin II receptor antagonists for treating dermatological disorders
AU2005232248B2 (en) * 2005-01-04 2011-08-04 Texas United Chemical Company, Llc Compounded hydrocarbon oil and oil base drilling fluids prepared therefrom
US7888392B2 (en) * 2005-02-14 2011-02-15 Taisho Pharmaceutical Co., Ltd. Ointment
CA2601123A1 (en) * 2005-03-15 2006-09-21 Kyowa Hakko Kogyo Co., Ltd. External preparation
RU2414220C2 (en) * 2005-10-05 2011-03-20 Мицубиси Танабе Фарма Корпорейшн Medication for treating dermatitis
US7939540B2 (en) 2006-02-21 2011-05-10 Eisai R&D Management Co., Ltd. 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives
CA2678477A1 (en) 2007-02-16 2008-08-21 Eisai R&D Management Co., Ltd. Crystal, amorphous form and salt of methyl n-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
ATE538102T1 (en) 2007-08-17 2012-01-15 Eisai R&D Man Co Ltd METHOD FOR PRODUCING A QUINAZOLINE DERIVATIVE
KR20100042246A (en) 2007-08-17 2010-04-23 에자이 알앤드디 매니지먼트 가부시키가이샤 Novel preparation for external use
ES2478845T3 (en) 2008-10-08 2014-07-23 Takata Seiyaku Co., Ltd. Preparation of tacrolimus for external applications
JP2010132607A (en) * 2008-12-05 2010-06-17 Taisho Pharm Ind Ltd Ointment for use in cure for atopic dermatitis
JP2010202546A (en) * 2009-03-02 2010-09-16 Taisho Pharm Ind Ltd Ointment preparation for treating atopic dermatitis
AU2012211809A1 (en) * 2011-01-31 2013-09-05 Osaka University Externally-used drug for treating skin disorder and method for producing same
CN102885761B (en) * 2012-09-24 2015-08-05 浙江万晟药业有限公司 A kind of method preparing Tacrolimus paste
RU2538680C2 (en) * 2013-03-12 2015-01-10 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Pharmaceutical composition for treating atopic dermatitis and method for preparing it
RU2553600C2 (en) * 2013-05-16 2015-06-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Pharmaceutical composition for treating skin diseases
CN104127369A (en) * 2014-07-02 2014-11-05 人福医药集团股份公司 Tacrolimus ointment and preparation method thereof
EP3977995A1 (en) 2014-10-28 2022-04-06 Koushi Yamaguchi Tacrolimus for ameliorating pregnancy conditions
CN106309353A (en) * 2015-06-19 2017-01-11 江苏吉贝尔药业股份有限公司 Ointment used for treating psoriasis and preparation method thereof
RU2741504C2 (en) 2016-04-04 2021-01-26 Драг Деливери Солюшнз Лимитед Composition for local application containing tacrolimus
CN105769752B (en) * 2016-04-08 2018-12-11 湖北人福成田药业有限公司 Prepare the method and Tacrolimus paste of Tacrolimus paste
EP3542788A1 (en) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topical composition comprising calcipotriol and betamethasone dipropionate
JP7465806B2 (en) 2018-08-10 2024-04-11 晃史 山口 Drugs for treating humoral immune-related disorders in the mother and fetus
WO2020117134A1 (en) 2018-12-04 2020-06-11 İlko İlaç Sanayi̇ Ve Ti̇caret A.Ş. Stable tacrolimus ointment formulation for topical treatment of skin conditions
JPWO2020129348A1 (en) 2018-12-18 2021-11-04 晃史 山口 Drugs to improve infertility / recurrent pregnancy loss or pregnancy
CN114767688A (en) * 2019-09-04 2022-07-22 武汉科福新药有限责任公司 Transdermal penetration-promoting composition and application thereof in timolol preparation
EP4114357B1 (en) * 2020-03-02 2025-10-01 Shanghai Aucta Pharmaceuticals Co., Ltd. Topical formulations containing mtor inhibitors
CN112022798B (en) * 2020-08-11 2022-04-29 四川大学华西医院 A kind of quick-acting tacrolimus ointment, preparation method and application

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PH26083A (en) * 1987-11-09 1992-02-06 Sandoz Ltd 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
KR0159766B1 (en) * 1989-10-16 1998-12-01 후지사와 토모키치로 Hair revitalizing agent
US5061700A (en) * 1989-11-16 1991-10-29 Gordon Jay Dow Glyceryl acetate ointment vehicles

Also Published As

Publication number Publication date
ZA916983B (en) 1992-05-27
PT98862A (en) 1992-08-31
DK0474126T3 (en) 1997-04-07
PT98862B (en) 1999-02-26
RU2079303C1 (en) 1997-05-20
SG46547A1 (en) 1998-02-20
EP0474126A1 (en) 1992-03-11
HK1000006A1 (en) 1997-10-03
EP0474126B1 (en) 1997-03-19
US5385907A (en) 1995-01-31
AU8351591A (en) 1992-03-12
CA2050623C (en) 2002-02-05
AU656145B2 (en) 1995-01-27
DE69125230D1 (en) 1997-04-24
KR100194240B1 (en) 1999-06-15
ES2099112T3 (en) 1997-05-16
KR920005987A (en) 1992-04-27
CN1059468A (en) 1992-03-18
HU211470A9 (en) 1995-11-28
CN1069193C (en) 2001-08-08
DE69125230T2 (en) 1997-07-10
JP2526752B2 (en) 1996-08-21
IE913085A1 (en) 1992-03-11
PH31282A (en) 1998-07-06
HUT59002A (en) 1992-04-28
JPH0517481A (en) 1993-01-26
ATE150304T1 (en) 1997-04-15
GR3022883T3 (en) 1997-06-30

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Legal Events

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