CA2044172A1 - Oral and dental hygiene preparation - Google Patents
Oral and dental hygiene preparationInfo
- Publication number
- CA2044172A1 CA2044172A1 CA002044172A CA2044172A CA2044172A1 CA 2044172 A1 CA2044172 A1 CA 2044172A1 CA 002044172 A CA002044172 A CA 002044172A CA 2044172 A CA2044172 A CA 2044172A CA 2044172 A1 CA2044172 A1 CA 2044172A1
- Authority
- CA
- Canada
- Prior art keywords
- agents
- mouth
- mixture
- film
- care preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
Abstract Summary A mouth and tooth care preparation consists of tensides, polish-ing agents, aromatizing agents as well as additional usual addi-tives which are formulated in a binding agent or a mixture of binding agents consisting of water-soluble or water-swellable, physiologically acceptable film-forming agents. The mixture is formulated into a film which is pre-segmented into dosage units.
Description
2~ 172 Preparation for Mouth and Tooth Care Tooth care preparations have been prepared for many years in the form~of pastes, the so-called toothpastes. Herein the starting material is essentially a precipitated calcium carbonate which has been formulated with water, glycerol, surface-active sub-stances and thickening agents to obtain a paste and is filled into tubes or dispensers. The toothpaste has conquered the mar-ket while other tooth care preparations like drops, tooth soaps and powders or pellets scarcely play a role any more. The prepa-rations are proposed to remove the bacterial plaque, to serve for caries prophylaxis and for the careful cleaning of the teeth substantially supported by brushing, and to thoroughly clean the mouth cavity and refresh the same in a pleasant manner.
During recent years the picture of the toothpastes has not sub-stantially changed although the formulas have been modified in various aspects. The use of a rather coarse form of calcium carbonate for mechanically cleaning the teeth has more and more been replaced by modern, finer polishing agents on the basis of aluminum oxide or silicium dioxide (silica gel). Next to ten-sides structure-forming components and sophisticated taste cor-recting agents are used. Often active agents like particularly various fluoro derivatives or mineral salts are added. The volume could sometimes be reduced; certainly the introduction and general use of electric toothbrushes has had a strong in-fluence in this regard.
The handling of toothpastes is, however, accompanied by a number of disadvantages. Because the dosing from simple tubes is diffi-cult, dispensers have recently been developed which always de-liver a predetermined amount of toothpaste. These dispensers are, however, relatively big and therefore scarcely suitable for use when travelling. Tubes are pressure-sensitive and therefore also not ideal when travelling. In dispensers as well as in tubes toothpaste can dry out during longer interruptions of use, so that the used receptacles have to be discarded. In addition 2 ~
it is not possible to completely empty tubes as well as dispen-sers. After use the receptacles made from metal or plastic are retai~ned and cause pollution.
In contrast it is the object of the present invention to provide a new administration and dosage form for mouth and tooth care preparations which does not develop the aforementioned dis-advantages. In particular it is the ob~ect to make possible and secure exact dosage for the single toothcleaning procedure and to provide the possibility to completely use the preparation without remains staying in the package.
The mouth and tooth care preparation of the invention on the basis of tensides, polishing agents, aromatizing substances as well as additional usual additives is characterized in that the active agents and additives are formulated in a binding agent or a m~xture of binding agents which consists of water-soluble or water-swellable, physiologically acceptable film forming sub-stances and that this mixture is formulated into a film whereby the so formed film is pre-segmented in dosage units.
The mouth and tooth care preparations may comprise such compo-nents which are normally used for the preparation of tooth-pastes, with natural starting materials being particularly pre-ferred. In addition it is important for all components to be completely non-toxic and physiologically acceptable which, of course, also applies to the film forming substances to be used.
The following components are to be mentioned as the essential components of tooth care preparations:
- abrasives like calcium carbonate, calcium and sodium phos-phate, aluminum oxide or silicium dioxide, particularly silica gels - tensides (foaming agents) like sodiumlaurylsulfate, sodium-laurylsulfoacetate, sarcoside, monoglycerylsulfate and others 2 ~ 1 7 2 - aromatizing agents like peppermint oil, spearmint oil, aniseed oil, cinnamon oil, oil of cloves, menthol and the like - sweetening agents like saccharin, cyclamate, aspartame and the like.
The liquid components usually present in toothpastes like glyce-rol, propylene glykol or sorbite syrup do not have to be added to the preparations according to the invention in film-form, since the plasticity necessary for tubes or dispensers does not play a role in this regard. Additional usual additives like fluoro compounds, agents against the forming of tartar, anti-bacterial agents and the like, as normally used in mouth and tooth care preparations can also be used according to the invention.
As water-soluble or water-swellable film-forming agents starch, gelatines, glycerols and/or sorbite are particularly suitable as well as natural and synthetic resins and gums. The following basic formulation has proved suitable:
gelatine 8 - 10 g starch 3 - 8 g glycerol 1 - 2 g water 30 - 50 g.
In this basic material the components of the mouth and tooth care preparations are dissolved or dispersed to obtain a uniform distribution of the substances. The mixture so obtained can according to the invention be formulated in various manner into mouth and tooth care preparation in the form of a film:
a) It is in the first place possible to formulate the mass directly into a foil which generally will have a thickness of between 0.1 and 3 mm. Through predetermined fraction points this foil can be pre-segmented into dosage units by 4 2Q!1~1 7~
punching or perforation with the strip broadness and length preferably corresponding to about the size of the tooth-brush, i.e. of the surface formed by the free bristle ends of the bristle block or the surface of the longitudinal cross-cut of the bristle block in the bristle level.
b) Alternatively the mass can be applied onto a carrier film, the composition of which corresponds to the binding agent of the mass, as disclosed in detail in EP-OS 219 762. The films obtained in this manner can also be pre-segmented as indi-cated above.
c) In addition it is possible to apply the mass onto a release film or release paper as known from DE-PS 36 30 603. In this case the coating is pre-segmented in separate segments of the size as indicated above which prior to use can be peeled off the carrier film in a manner similar to adhesive stickers.
In all cases an administration and dosage form is obtained, the application of which is particularly convenient since the amount to be used is uniformly predetermined in each case. A dosage is separated or peeled off in a form of a film segment and is placed onto the moistened toothbrush or between the bristles where it adheres and swells through moisture contact. Through the insertion into the mouth cavity and in connection with the saliva and the intensive movement of the toothbrush the strip is pre-dissolved and dissolved so that the components can develop their full activity. After use and subsequent mouth washing with water no remains are retained in the mouth.
Optionally the foils can be printed, stamped or punched in various manners, with the possibility to apply designs particu-larly for children. The opening and closing of tube closures is not necessary, no toothpaste is spoiled and the administration form of the invention is particularly suitable for travelling, - 5 - 2~ 7 7 ~
since it is light of weight, no leaking has to be taken into account and it occupies extremely little space. Packaging is possible in non-polluting cardboard cases without the use of metals or plastics.
The preparations of the invention are suitable not only for tooth care in the mouth but also, given a suitable composition, for cleaning and care of artificial teeth and dentures. For the last mentioned purpose a multiple coating is particularly ad-vantageous, which comprises the cleaning, disinfecting and acidic components in one layer, while, optionally separated by an also water-soluble barrier layer, the second layer comprises the CO2 or 2 releasing substances.
Example A tooth care preparation according to the invention has the following composition:
amylogum 57.0 g honey 25.0 g citric acid 2.0 g titanium dioxide 1.0 g aromatizing agents 1.0 g silicium dioxide 3.0 g Ca-hydrog.-phos. 10.0 g Na-laurylsulfate 1.0 g A slurry is formed using the necessary amount of water which is formulated into a film having a thickness of about 0.5 mm. The film is segmented into segments of 8 x 35 mm by perforation.
Optionally the mass can be applied onto release paper as carrier and can be pre-segmented in segments of the size as indicated above by punching.
During recent years the picture of the toothpastes has not sub-stantially changed although the formulas have been modified in various aspects. The use of a rather coarse form of calcium carbonate for mechanically cleaning the teeth has more and more been replaced by modern, finer polishing agents on the basis of aluminum oxide or silicium dioxide (silica gel). Next to ten-sides structure-forming components and sophisticated taste cor-recting agents are used. Often active agents like particularly various fluoro derivatives or mineral salts are added. The volume could sometimes be reduced; certainly the introduction and general use of electric toothbrushes has had a strong in-fluence in this regard.
The handling of toothpastes is, however, accompanied by a number of disadvantages. Because the dosing from simple tubes is diffi-cult, dispensers have recently been developed which always de-liver a predetermined amount of toothpaste. These dispensers are, however, relatively big and therefore scarcely suitable for use when travelling. Tubes are pressure-sensitive and therefore also not ideal when travelling. In dispensers as well as in tubes toothpaste can dry out during longer interruptions of use, so that the used receptacles have to be discarded. In addition 2 ~
it is not possible to completely empty tubes as well as dispen-sers. After use the receptacles made from metal or plastic are retai~ned and cause pollution.
In contrast it is the object of the present invention to provide a new administration and dosage form for mouth and tooth care preparations which does not develop the aforementioned dis-advantages. In particular it is the ob~ect to make possible and secure exact dosage for the single toothcleaning procedure and to provide the possibility to completely use the preparation without remains staying in the package.
The mouth and tooth care preparation of the invention on the basis of tensides, polishing agents, aromatizing substances as well as additional usual additives is characterized in that the active agents and additives are formulated in a binding agent or a m~xture of binding agents which consists of water-soluble or water-swellable, physiologically acceptable film forming sub-stances and that this mixture is formulated into a film whereby the so formed film is pre-segmented in dosage units.
The mouth and tooth care preparations may comprise such compo-nents which are normally used for the preparation of tooth-pastes, with natural starting materials being particularly pre-ferred. In addition it is important for all components to be completely non-toxic and physiologically acceptable which, of course, also applies to the film forming substances to be used.
The following components are to be mentioned as the essential components of tooth care preparations:
- abrasives like calcium carbonate, calcium and sodium phos-phate, aluminum oxide or silicium dioxide, particularly silica gels - tensides (foaming agents) like sodiumlaurylsulfate, sodium-laurylsulfoacetate, sarcoside, monoglycerylsulfate and others 2 ~ 1 7 2 - aromatizing agents like peppermint oil, spearmint oil, aniseed oil, cinnamon oil, oil of cloves, menthol and the like - sweetening agents like saccharin, cyclamate, aspartame and the like.
The liquid components usually present in toothpastes like glyce-rol, propylene glykol or sorbite syrup do not have to be added to the preparations according to the invention in film-form, since the plasticity necessary for tubes or dispensers does not play a role in this regard. Additional usual additives like fluoro compounds, agents against the forming of tartar, anti-bacterial agents and the like, as normally used in mouth and tooth care preparations can also be used according to the invention.
As water-soluble or water-swellable film-forming agents starch, gelatines, glycerols and/or sorbite are particularly suitable as well as natural and synthetic resins and gums. The following basic formulation has proved suitable:
gelatine 8 - 10 g starch 3 - 8 g glycerol 1 - 2 g water 30 - 50 g.
In this basic material the components of the mouth and tooth care preparations are dissolved or dispersed to obtain a uniform distribution of the substances. The mixture so obtained can according to the invention be formulated in various manner into mouth and tooth care preparation in the form of a film:
a) It is in the first place possible to formulate the mass directly into a foil which generally will have a thickness of between 0.1 and 3 mm. Through predetermined fraction points this foil can be pre-segmented into dosage units by 4 2Q!1~1 7~
punching or perforation with the strip broadness and length preferably corresponding to about the size of the tooth-brush, i.e. of the surface formed by the free bristle ends of the bristle block or the surface of the longitudinal cross-cut of the bristle block in the bristle level.
b) Alternatively the mass can be applied onto a carrier film, the composition of which corresponds to the binding agent of the mass, as disclosed in detail in EP-OS 219 762. The films obtained in this manner can also be pre-segmented as indi-cated above.
c) In addition it is possible to apply the mass onto a release film or release paper as known from DE-PS 36 30 603. In this case the coating is pre-segmented in separate segments of the size as indicated above which prior to use can be peeled off the carrier film in a manner similar to adhesive stickers.
In all cases an administration and dosage form is obtained, the application of which is particularly convenient since the amount to be used is uniformly predetermined in each case. A dosage is separated or peeled off in a form of a film segment and is placed onto the moistened toothbrush or between the bristles where it adheres and swells through moisture contact. Through the insertion into the mouth cavity and in connection with the saliva and the intensive movement of the toothbrush the strip is pre-dissolved and dissolved so that the components can develop their full activity. After use and subsequent mouth washing with water no remains are retained in the mouth.
Optionally the foils can be printed, stamped or punched in various manners, with the possibility to apply designs particu-larly for children. The opening and closing of tube closures is not necessary, no toothpaste is spoiled and the administration form of the invention is particularly suitable for travelling, - 5 - 2~ 7 7 ~
since it is light of weight, no leaking has to be taken into account and it occupies extremely little space. Packaging is possible in non-polluting cardboard cases without the use of metals or plastics.
The preparations of the invention are suitable not only for tooth care in the mouth but also, given a suitable composition, for cleaning and care of artificial teeth and dentures. For the last mentioned purpose a multiple coating is particularly ad-vantageous, which comprises the cleaning, disinfecting and acidic components in one layer, while, optionally separated by an also water-soluble barrier layer, the second layer comprises the CO2 or 2 releasing substances.
Example A tooth care preparation according to the invention has the following composition:
amylogum 57.0 g honey 25.0 g citric acid 2.0 g titanium dioxide 1.0 g aromatizing agents 1.0 g silicium dioxide 3.0 g Ca-hydrog.-phos. 10.0 g Na-laurylsulfate 1.0 g A slurry is formed using the necessary amount of water which is formulated into a film having a thickness of about 0.5 mm. The film is segmented into segments of 8 x 35 mm by perforation.
Optionally the mass can be applied onto release paper as carrier and can be pre-segmented in segments of the size as indicated above by punching.
Claims (6)
1. Mouth and tooth care preparation on the basis of tensides, polishing agents, aromatizing agents as well as additional usual additives, characterized in that the active agents and additives are formulated in a binding agent or a mixture of binding agents, which consist of water-soluble or water-swallable, physiologically acceptable film forming agents, and that this mixture is formulated into a film, the so formed film being pre-segmented in dosage units.
2. Mouth and tooth care preparation according to Claim 1, characterized in that it contains as film forming agents starches, gelatines, glycerol and/or sobitol or natural and/or synthetic resins and gums.
3. Mouth and tooth care preparation according to Claim 1, characterized in that it contains amylogum as film forming agent.
4. Mouth and tooth care preparation according to Claims 1 to 3, characterized in that it comprises as film forming agent a mixture containing 8 to 10 parts per weight gelatine, 4 to 8 parts per weight starch and 1 to 2 parts per weight glycerol.
5. Mouth and tooth care preparation according to Claims 1 to 4, characterized in that it consist of a carrier film comprising the binding agent or the mixture of binding agents, onto which a layer has been applied, which contains the components of the care preparation together with binding agent or the mixture of binding agents, the binding agent or the mixture of binding agents in the carrier film and in the coating having substantially the same qualitative composition.
6. Mouth and tooth care agent according to Claims 1 to 4, characterized in that a coating comprising the components of the care preparation and the binding agent or the mixture of the binding agent has been applied to a carrier film in the form of a release paper, a release film or a release foil, whereby the coating can be peeled off the carrier material dosiswise after pre-segmenting in dosis units.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3934416 | 1989-10-14 | ||
| DEP3934416.9 | 1989-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2044172A1 true CA2044172A1 (en) | 1991-04-15 |
Family
ID=6391526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002044172A Abandoned CA2044172A1 (en) | 1989-10-14 | 1990-10-15 | Oral and dental hygiene preparation |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0452446B1 (en) |
| JP (1) | JP3043804B2 (en) |
| AT (1) | ATE99165T1 (en) |
| AU (1) | AU627950B2 (en) |
| BR (1) | BR9006965A (en) |
| CA (1) | CA2044172A1 (en) |
| DE (1) | DE59004042D1 (en) |
| DK (1) | DK0452446T3 (en) |
| ES (1) | ES2062562T3 (en) |
| FI (1) | FI95346C (en) |
| NO (1) | NO179891C (en) |
| WO (1) | WO1991005540A1 (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19646392A1 (en) | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Preparation for use in the oral cavity with a layer containing pressure-sensitive adhesive, pharmaceuticals or cosmetics for dosed delivery |
| DE19652257A1 (en) | 1996-12-16 | 1998-06-18 | Lohmann Therapie Syst Lts | Individually dosed, film-like dosage form that quickly disintegrates on contact with liquid and contains active ingredients and especially flavorings |
| US6231957B1 (en) | 1999-05-06 | 2001-05-15 | Horst G. Zerbe | Rapidly disintegrating flavor wafer for flavor enrichment |
| US6660292B2 (en) | 2001-06-19 | 2003-12-09 | Hf Flavoring Technology Llp | Rapidly disintegrating flavored film for precooked foods |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US8663687B2 (en) | 2001-10-12 | 2014-03-04 | Monosol Rx, Llc | Film compositions for delivery of actives |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US7910641B2 (en) | 2001-10-12 | 2011-03-22 | Monosol Rx, Llc | PH modulated films for delivery of actives |
| US7666337B2 (en) | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US7425292B2 (en) | 2001-10-12 | 2008-09-16 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US8017150B2 (en) | 2002-04-11 | 2011-09-13 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| FR2840221B1 (en) * | 2002-06-04 | 2006-01-13 | Backert Marie Elisabeth Cuine | POLYMERIC FILM CONTAINING "ACTIVE" TO BE RELEASED IN A LIQUID |
| JP2009514597A (en) | 2005-11-04 | 2009-04-09 | ライフサイエンス・プラス・インコーポレイテッド | Bioabsorbable hemostatic gauze |
| FR2916635B1 (en) * | 2007-05-30 | 2009-08-07 | Backert Marie Elisabeth Cuine | SOLID FORMULATIONS FOR ADMINISTRATION, PARENTLY PARENTAL, OF ACTI (S), IN THE FORM OF A FILM INTENDED TO BE DISSOLVED AND / OR DISPERSED IN A LIQUID PRODUCT |
| US8765155B2 (en) * | 2007-08-30 | 2014-07-01 | Colgate-Palmolive Company | Oral care strip or tape and methods of use and manufacture thereof |
| US9265779B2 (en) | 2008-05-13 | 2016-02-23 | Lts Lohmann Therapie-Systeme Ag | Method of using a film-shaped preparation comprising oily substances for oral administration |
| DE102008023345B4 (en) | 2008-05-13 | 2014-12-04 | Lts Lohmann Therapie-Systeme Ag | Film-like preparation with oily substances for oral administration |
| US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| CA2807271C (en) | 2010-06-10 | 2018-07-31 | Midatech Limited | Nanoparticle film delivery systems |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| JPWO2013108384A1 (en) * | 2012-01-19 | 2015-05-11 | ツキオカフィルム製薬株式会社 | Film-like dentifrice |
| WO2013108384A1 (en) * | 2012-01-19 | 2013-07-25 | 株式会社ツキオカ | Film-shaped dentifrices |
| WO2017192921A1 (en) | 2016-05-05 | 2017-11-09 | Monosol Rx, Llc | Enhanced delivery epinephrine compositions |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476057A (en) * | 1975-03-20 | 1977-06-10 | Unicliffe Ltd | Throat pastilles |
| GB8421226D0 (en) * | 1984-08-21 | 1984-09-26 | Int Conferences Ab | Tooth cleaning tablet |
| ATE59289T1 (en) * | 1985-10-09 | 1991-01-15 | Desitin Arzneimittel Gmbh | PROCESS FOR PREPARING A PHARMACEUTICAL AND DOSAGE FORM FOR MEDICINAL INGREDIENTS, REAGENTS OR OTHER INGREDIENTS. |
| US4765984A (en) * | 1986-01-22 | 1988-08-23 | Colgate-Palmolive Company | Stable single unit dose oral product |
| DE3630603A1 (en) * | 1986-09-09 | 1988-03-10 | Desitin Arzneimittel Gmbh | PHARMACEUTICAL AND DOSAGE FORM FOR MEDICINAL ACTIVE SUBSTANCES, REAGENTS OR THE LIKE, AND METHOD FOR THE PRODUCTION THEREOF |
-
1990
- 1990-10-15 CA CA002044172A patent/CA2044172A1/en not_active Abandoned
- 1990-10-15 DK DK90915758.8T patent/DK0452446T3/en active
- 1990-10-15 WO PCT/EP1990/001936 patent/WO1991005540A1/en active IP Right Grant
- 1990-10-15 AU AU66094/90A patent/AU627950B2/en not_active Ceased
- 1990-10-15 BR BR909006965A patent/BR9006965A/en not_active IP Right Cessation
- 1990-10-15 JP JP2514619A patent/JP3043804B2/en not_active Expired - Fee Related
- 1990-10-15 DE DE90915758T patent/DE59004042D1/en not_active Expired - Fee Related
- 1990-10-15 ES ES90915758T patent/ES2062562T3/en not_active Expired - Lifetime
- 1990-10-15 EP EP90915758A patent/EP0452446B1/en not_active Expired - Lifetime
- 1990-10-15 AT AT90915758T patent/ATE99165T1/en not_active IP Right Cessation
-
1991
- 1991-06-12 NO NO912267A patent/NO179891C/en not_active IP Right Cessation
- 1991-06-13 FI FI912849A patent/FI95346C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| AU6609490A (en) | 1991-05-16 |
| EP0452446B1 (en) | 1993-12-29 |
| JPH04502332A (en) | 1992-04-23 |
| ATE99165T1 (en) | 1994-01-15 |
| FI912849A0 (en) | 1991-06-13 |
| NO179891C (en) | 1997-01-08 |
| AU627950B2 (en) | 1992-09-03 |
| JP3043804B2 (en) | 2000-05-22 |
| NO912267L (en) | 1991-06-12 |
| EP0452446A1 (en) | 1991-10-23 |
| ES2062562T3 (en) | 1994-12-16 |
| DE59004042D1 (en) | 1994-02-10 |
| BR9006965A (en) | 1991-11-12 |
| DK0452446T3 (en) | 1994-01-24 |
| FI95346C (en) | 1996-01-25 |
| NO179891B (en) | 1996-09-30 |
| NO912267D0 (en) | 1991-06-12 |
| FI95346B (en) | 1995-10-13 |
| WO1991005540A1 (en) | 1991-05-02 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |