CA2035603C - Methode pour deceler la presence de cellules exfoliees anormales au moyen de la spectroscopie a rayons infrarouges - Google Patents
Methode pour deceler la presence de cellules exfoliees anormales au moyen de la spectroscopie a rayons infrarougesInfo
- Publication number
- CA2035603C CA2035603C CA 2035603 CA2035603A CA2035603C CA 2035603 C CA2035603 C CA 2035603C CA 2035603 CA2035603 CA 2035603 CA 2035603 A CA2035603 A CA 2035603A CA 2035603 C CA2035603 C CA 2035603C
- Authority
- CA
- Canada
- Prior art keywords
- specimen
- cells
- exfoliated
- infrared
- functional group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 150000002632 lipids Chemical class 0.000 claims abstract description 13
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- 102000039446 nucleic acids Human genes 0.000 claims abstract description 12
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- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 9
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 9
- 150000004713 phosphodiesters Chemical group 0.000 claims abstract description 8
- 229910014033 C-OH Inorganic materials 0.000 claims description 7
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- 239000012528 membrane Substances 0.000 claims description 3
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- 238000012360 testing method Methods 0.000 description 12
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- 238000001228 spectrum Methods 0.000 description 8
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- 230000003595 spectral effect Effects 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000000232 Lipid Bilayer Substances 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 230000000112 colonic effect Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
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- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 208000031662 Noncommunicable disease Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 208000005448 Trichomonas Infections Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
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- 238000004458 analytical method Methods 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
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- 210000000621 bronchi Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 210000002726 cyst fluid Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
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- 230000008588 hemolysis Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
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- 230000003993 interaction Effects 0.000 description 1
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- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 108091005981 phosphorylated proteins Proteins 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 238000011121 vaginal smear Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2035603 CA2035603C (fr) | 1991-02-04 | 1991-02-04 | Methode pour deceler la presence de cellules exfoliees anormales au moyen de la spectroscopie a rayons infrarouges |
| US07/656,508 US5168162A (en) | 1991-02-04 | 1991-02-19 | Method of detecting the presence of anomalies in exfoliated cells using infrared spectroscopy |
| PCT/CA1992/000030 WO1992014134A1 (fr) | 1991-02-04 | 1992-01-31 | Procede permettant de detecter la presence d'anomalies dans des cellules exfoliees par spectroscopie a infrarouge |
| JP4503235A JPH06507237A (ja) | 1991-02-04 | 1992-01-31 | 赤外線分光分析を用いて剥落細胞における異常の存在を検出する方法 |
| AU11808/92A AU1180892A (en) | 1991-02-04 | 1992-01-31 | A method of detecting the presence of anomalies in exfoliated cells using infrared spectroscopy |
| EP92903692A EP0570418A1 (fr) | 1991-02-04 | 1992-01-31 | Procede permettant de detecter la presence d'anomalies dans des cellules exfoliees par spectroscopie a infrarouge |
| CN92101432A CN1067314A (zh) | 1991-02-04 | 1992-02-04 | 用红外光谱检测被剥离的细胞中存在异常的方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2035603 CA2035603C (fr) | 1991-02-04 | 1991-02-04 | Methode pour deceler la presence de cellules exfoliees anormales au moyen de la spectroscopie a rayons infrarouges |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2035603A1 CA2035603A1 (fr) | 1992-08-05 |
| CA2035603C true CA2035603C (fr) | 1998-08-04 |
Family
ID=4146947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2035603 Expired - Fee Related CA2035603C (fr) | 1991-02-04 | 1991-02-04 | Methode pour deceler la presence de cellules exfoliees anormales au moyen de la spectroscopie a rayons infrarouges |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0570418A1 (fr) |
| JP (1) | JPH06507237A (fr) |
| CN (1) | CN1067314A (fr) |
| AU (1) | AU1180892A (fr) |
| CA (1) | CA2035603C (fr) |
| WO (1) | WO1992014134A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733739A (en) * | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | System and method for diagnosis of disease by infrared analysis of human tissues and cells |
| WO1997014961A1 (fr) * | 1995-10-18 | 1997-04-24 | Aktsionernoe Obschestvo Zakrytogo Tipa 'ntf Intersvyaz' | Procede de diagnostic de troubles oncologiques |
| AUPN825796A0 (en) | 1996-02-26 | 1996-03-14 | Ashdown, Martin | The application of infrared (ir) spectrometry to the investigations of components of blood and other body fluids |
| AU8172998A (en) | 1997-06-27 | 1999-01-19 | Pacific Northwest Research Institute | Methods of differentiating metastatic and non-metastatic tumors |
| JP4403908B2 (ja) * | 2004-07-27 | 2010-01-27 | 住友電気工業株式会社 | ペプチドまたはタンパク質のリン酸化解析装置、リン酸化判別プログラム及びそのプログラムの記録媒体 |
| JP2013533960A (ja) | 2010-06-01 | 2013-08-29 | トドス メディカル リミテッド | がんの診断 |
| WO2012153326A1 (fr) | 2011-05-11 | 2012-11-15 | Todos Medical Ltd. | Diagnostic de cancer |
| US9804145B2 (en) | 2013-05-28 | 2017-10-31 | Todos Medical Ltd. | Infrared analysis of benign tumors |
| KR101735464B1 (ko) | 2014-12-17 | 2017-05-15 | 한밭대학교 산학협력단 | 유기물의 존재 또는 생물의 생사 측정 장치 및 방법 |
| GB2545877B (en) * | 2015-09-10 | 2021-09-15 | Sierra Medical Ltd | ATR-FTIR computational analysis of Barrett's esophagus and esophageal cancers |
| JP2017203637A (ja) * | 2016-05-09 | 2017-11-16 | 住友電気工業株式会社 | 腫瘍細胞検出方法及び腫瘍細胞検出装置 |
| CN110702720A (zh) * | 2019-10-09 | 2020-01-17 | 李俊菲 | 一种妇科分泌物分析仪用采样拭子及采集套装 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017192A (en) * | 1975-02-06 | 1977-04-12 | Neotec Corporation | Optical analysis of biomedical specimens |
| DE3903777A1 (de) * | 1989-02-09 | 1990-08-16 | Bruker Analytische Messtechnik | Verfahren zur schnellen detektion von mikroorganismen in proben und vorrichtung zur durchfuehrung des verfahrens |
| US4970396A (en) * | 1989-12-26 | 1990-11-13 | National Research Council Of Canada/Conseil National De Recherches Du Canada | Infrared spectra recording, high pressure sample holder |
| US4980551A (en) * | 1990-01-05 | 1990-12-25 | National Research Council Canada Conseil National De Recherches Canada | Non-pressure-dependancy infrared absorption spectra recording, sample cell |
| CA2008831C (fr) * | 1990-01-29 | 1996-03-26 | Patrick T.T. Wong | Methode de spectroscopie a infrarouge pour la detection de la presence d'anomalies dans les tissus biologiques et les cellules sous forme naturelle ou cultivees |
-
1991
- 1991-02-04 CA CA 2035603 patent/CA2035603C/fr not_active Expired - Fee Related
-
1992
- 1992-01-31 WO PCT/CA1992/000030 patent/WO1992014134A1/fr not_active Application Discontinuation
- 1992-01-31 EP EP92903692A patent/EP0570418A1/fr not_active Withdrawn
- 1992-01-31 JP JP4503235A patent/JPH06507237A/ja active Pending
- 1992-01-31 AU AU11808/92A patent/AU1180892A/en not_active Abandoned
- 1992-02-04 CN CN92101432A patent/CN1067314A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992014134A1 (fr) | 1992-08-20 |
| AU1180892A (en) | 1992-09-07 |
| JPH06507237A (ja) | 1994-08-11 |
| CA2035603A1 (fr) | 1992-08-05 |
| CN1067314A (zh) | 1992-12-23 |
| EP0570418A1 (fr) | 1993-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |