CA2032784A1 - Composition for cosmetic or pharmaceutical use - Google Patents
Composition for cosmetic or pharmaceutical useInfo
- Publication number
- CA2032784A1 CA2032784A1 CA002032784A CA2032784A CA2032784A1 CA 2032784 A1 CA2032784 A1 CA 2032784A1 CA 002032784 A CA002032784 A CA 002032784A CA 2032784 A CA2032784 A CA 2032784A CA 2032784 A1 CA2032784 A1 CA 2032784A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- vitamin
- glucose
- hydrogen peroxide
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
ABSTRACT
A composition for cosmetic or for pharmaceutical use is described, which is used for preventing the ageing of the skin or for treating benign disorders of the skin such as acne, and which contains vitamin A in the form of an ester or as the acid and glucose, in association with a stable aqueous emulsion of hydrogen peroxide.
A composition for cosmetic or for pharmaceutical use is described, which is used for preventing the ageing of the skin or for treating benign disorders of the skin such as acne, and which contains vitamin A in the form of an ester or as the acid and glucose, in association with a stable aqueous emulsion of hydrogen peroxide.
Description
3~
A CO~PO~ITION FOR COSMETIC OR PHARMACEUTICAL USE
Abstract of the disclosure r .._ _. ~
The object of the present invention is a new compo-sition for cosmetic or pharmaceutical use. The compo-sition is intended exclusively for external use and i5 capable of treating efEectively various skin disorders.
Background of the invention The therapeutic action of vitamin A in its acid (retinoic acid), aldehyde (retinal) or alcohol form (retinol) is well known in dermatology.
The use oE a composition including both an ester of vitamin A and a stable emulsion of hydrogen peroxide was proposed in patent CH-A-670 951. Such an emulsion has a particularly high capacity for releasing oxygen (paraosmotic pressure of about 10 atm), the effect of which is in particular to increase the movement of the vitamin A d~rivative across the outer layers of the skin, where the conversion of the vitamin A ester into retinoic acid may proceed.
Katzberg has reported in Anat. Rec. 112, 418 ~1952) and later H. Pinkus in Dermatologica, 106, 28 (1953), that the life span of a human epidermal cell is of 101 days during the ten first years of life and decreases subsequently to 46 days at the age of 80. This means that time causes an ageing which is evidenced by a decreased capacity of the cells to regenerate the epidermis. When the energy which can be used physiologically by the cells is no longer sufficient, for instance because of an inadequate permeability of the capillaries or becau~e of an inade~uate capillary circulation, there is then an increase in the disappearance rate of the cells, which is accompanied by a significant impairment of their vital functions.
A CO~PO~ITION FOR COSMETIC OR PHARMACEUTICAL USE
Abstract of the disclosure r .._ _. ~
The object of the present invention is a new compo-sition for cosmetic or pharmaceutical use. The compo-sition is intended exclusively for external use and i5 capable of treating efEectively various skin disorders.
Background of the invention The therapeutic action of vitamin A in its acid (retinoic acid), aldehyde (retinal) or alcohol form (retinol) is well known in dermatology.
The use oE a composition including both an ester of vitamin A and a stable emulsion of hydrogen peroxide was proposed in patent CH-A-670 951. Such an emulsion has a particularly high capacity for releasing oxygen (paraosmotic pressure of about 10 atm), the effect of which is in particular to increase the movement of the vitamin A d~rivative across the outer layers of the skin, where the conversion of the vitamin A ester into retinoic acid may proceed.
Katzberg has reported in Anat. Rec. 112, 418 ~1952) and later H. Pinkus in Dermatologica, 106, 28 (1953), that the life span of a human epidermal cell is of 101 days during the ten first years of life and decreases subsequently to 46 days at the age of 80. This means that time causes an ageing which is evidenced by a decreased capacity of the cells to regenerate the epidermis. When the energy which can be used physiologically by the cells is no longer sufficient, for instance because of an inadequate permeability of the capillaries or becau~e of an inade~uate capillary circulation, there is then an increase in the disappearance rate of the cells, which is accompanied by a significant impairment of their vital functions.
- 2 - ~03~
Whilst multiplication and growth of epidermal somatic cells require oxygen, the survival of cells is dependent upon glycolysis, which is an oxidative break-down of glucose. Actually, to keep its structure ready to function or to fulfil its functions, each individual cell of the body needs a large amount of energy.
Should the energy, or a part of the energy needed to keep the cell functioning, not be available, damages may occur which are reversible at the beginning, but which may lead to a loss of cell struct:ure and eventually to premature death, if not treated.
Up to now, no composition was available for cosmetic or for pharmaceutical use, which would associate the effects of vitamin A and of hydrogen peroxide and which could also supply the cell with the energy it needs.
The new composition according to the invention supplies this energy and, accordingly, is capable of restoring immediately the proper functioning of each individual cell, when the capillary insufficiency is due to an inadequate energy supply, which is particularly beneficial for cutaneous tissues.
The invention - Specifically, the object of the invention is a composition for cosmetic or for pharmaceutical use con taining vitamin A in the form of an ester, or as the acid and glucose, in association with a stable aqueous emul-sion of hydrogen peroxide.
Preferred emkodiments of the invention The energy is generated through the oxidative break-down of glucose, which is made possible due to an adequate oxygen supply from hydrogen peroxide.
Glucose is transported through the outer layers of the skin with vitamin A (ester or free acid) under the 2~3~
effect of the pressure exerted by nascent oxygen. The energy released through glycolysis can then be used under the skin.
Under in vivo conditions, t:he oxidative breakdown of 1 mole of glucose (C H 0 ~- 60 = 6C0 ~ 6H 0) results in the production of 690 kcal and is associated with the formation of 38 moles of adenosine triphosphate (ATP).
Specifically, glycolysis is the oxidative breakdown of glucose in a living organism under the effect of enzymes. ATP is an energy-rich phosphate donor in nume-rous phosphorylation reactions and also plays a role in the synthesis of ribonucleic acids.
The application of the composition according to the invention, for example as a cream, ensures that a rapid breakdown of ATP to adenosine diphosphate (ADP) is main-tained in the cutaneous tissues in contact with said composition, whereby the energy necessar~ for the metabo-lism of the cell is released : for example, for the synthesis of collagen, which is an important factor for preserving in particular the elasticity of the derm.
The hydrogen peroxide emulsions, which can be used within the scope of the present invention, can be either of the water-in-oil, or oil-in-water type.
A stable oil-in-water emulsion of hydrogen peroxide particularly well suited for preparing a composition according to the invention is described in patent US-A-3 954 974.
Since no toxic by-products are formed during the breakdown of hydrogen peroxide, such emulsions can include a high concentration of nascent oxygen which reinforces all the more the action of vitamin A, while at the same time ensuring a release of energy as a result of its reaction with glucose.
Amongst the esters of vitamin A which can be used, one can preferably choose an ester of a fatty acid, such as the palmitate of vitamin A, or equally its acetate.
:' - ' -.' . ' ' :
~3~
Such products are sold commercially under an appropriate form; the fatty acid esters of vitamin A have the further advantage of being well tolerated by the skin and the organism.
The relative concentrations of the ester of vitamin A or of the acid, and of glucose can vary considerably, depending upon the effects which are sought. The deriva-tive of vitamin A can be advantageously used at a concentration ranging from 1,000 to 10,000 international units tIU : expressed as vitamin A) per gram ~f the composition according to the invention.
As to the glucose, it is suitably included into the composition in an adequate molar proportion capable of producing through glycolysis, the amount of energy requi-red for the cell metabolism. Preferably, one can use glucose in an amount ranging from 0.5 to ~0 / in weight, based on the weight of the composition.
The concentrations of hydrogen peroxide in the com-position obviously vary according to the oxygenating effect which is sought. In the case of a composition for cosmetic use, hydrogen peroxide is used in an amount ranging from 0.5 to 4% in weight (expressed as 10~ H O ) and in the case of a composition for pharmaceutical use, from 0.1 to 6% in weight or more depending on circumstan-ces, based on the weight of the total composition.
Due to the well balanced nature of the emulsion composition, the excess oxygen generated not only produ-ces an immediate oxidative breakdown of glucose, but further ensures that the palmitate or the acetate of vitamin A are converted into retinoic acid and that the extracellular medium is enriched with oxygen and water, these two products resulting from the breakdown of hydro-gen peroxide.
Of course, the compositions according to the inven-tion, can also contain the usual stabilizers, thickeners, perfumes or colouring agents. They can also contain additional active components, for example other vitamins - 5 - ~ ~3.~7~
and vitamine derivatives such as vitamin E, or liposomes.
Being based on an aqueous emulsion with a high oxygenating capacity, the compositions according to the invention further display highly advantageous disinfec-ting and cicatrizing properties, which are useful for treating burns, open wounds such as ulcers or complica-tions arising from hemorrhoids.
The following examples are given for the purpose of illustrating the invention in more detail. These examples are in no way intended to be limiting.
Example 1 - A cosmetic composition A first phase of the "oil" type is prepared by mixing together the following components :
Petrolatum 450 g Liquid paraffin 325 g Cetyl alcohol 160 g Stearyl alcohol 160 g Monostearin 310 g Total 1405 g The following components are mixed together separa-tely, to prepare a "water" type phase :
H22' 30~400 g = 0.353 moles/kg of cream "Tween 80" 125 g Salicylic acid 9 g Vitamin A palmitate*63 g D,L-~-tocopherol acetate 200 g Glucose18 g = 0.01 moles/kg of cream Distilled water 7780 g Total 8595 g * 1.7 million IU/g ~3~7r~
The "oil" and the "water" phases thus prepared are then mixed together in an appropriate apparatus at a temperature comprised between 70 and 80 C, until a homogeneous emulsion is achieved. 10 kg of cream for cosmetic use are thus obtained, which contain 1.1~ active oxygen, 0.01 moles/kg of glucose and 10,000 IU of vitamin A palmitate/g of cream.
Example 2 - A cosmetic composition A first phase of the "oil" type is prepared by mixing together the following components :
Petrolatum 450 g Liquid paraffin 325 g Cetyl alcohol 160 g Stearyl alcohol 160 g Monostearin 310 g Vitamin A palmitate*63 g DrL-~-tocopherol acetate 200 g Total 1668 g The following components are mixed together separa-tely, to prepare a "water" type phase :
H 0 , 30%1167 g = 1.03 moles/kg of cream "Tween 80" 125 g Salicylic acid 9 g Glucose18 g = 0.01 moles/kg of cream Distilled water 7013 ~
Total 8332 g The "oil" and the "water" phases thus prepared are then mixed together in an appropriate apparatus at a temperature comprised between 70 and 80 C, until a * 1.7 million IU/g _ 7 _ ~ ~3 homogeneous emulsion is achieved. 10 kg of cream for cosmetic use are thus obtained, which contain 3.5% active oxygen, 0.01 moles/kg of glucose and 10,000 IU of vitamin A palmitate/g of cream.
Example 3 - ~ pharmaceutical composition A first phase of the "oil" type is prepared by mixing together the following components :
Petrolatum 475 g Liquid paraffin 350 g Cetyl alcohol 175 g Stearyl alcohol 175 g Monostearin 350 g D,L-~-tocopherol (vit. E) 250 g Total 1775 g The following components are mixed together separa-tely, to prepare a "water" type phase :
H2O2, 30% 1176 g "Tween 80" 150 g Salicylic acid 11 g Glucose 18 g Retinoic acid "Trétinoïne" 5 g Distilled water 6865 a Total 8225 g Tne "oil" and the "water" phases thus prepared are then mixed together in an appropriate apparatus at a temperature comprised between 70 and 80 C, until a homogeneous emulsion is achieved. 10 kg of cream for pharmaceutical use are thus obtained, which contain 3.5~
active oxygen (hydrogen peroxide), 0.01 moles/~g of glu-cose and 0.05~ of retinoic acid (Trétinoïne).
These compositions are perfectly well suited for numerous cosmetic or pharmaceutical uses and they proved to be particularly effective in cosmetic applications for ~13~
preventing skin ageing. They can also be used for the treatment of benign disorders of the skin, such as acne.
Further, these compositions have a disinfecting effect.
Whilst multiplication and growth of epidermal somatic cells require oxygen, the survival of cells is dependent upon glycolysis, which is an oxidative break-down of glucose. Actually, to keep its structure ready to function or to fulfil its functions, each individual cell of the body needs a large amount of energy.
Should the energy, or a part of the energy needed to keep the cell functioning, not be available, damages may occur which are reversible at the beginning, but which may lead to a loss of cell struct:ure and eventually to premature death, if not treated.
Up to now, no composition was available for cosmetic or for pharmaceutical use, which would associate the effects of vitamin A and of hydrogen peroxide and which could also supply the cell with the energy it needs.
The new composition according to the invention supplies this energy and, accordingly, is capable of restoring immediately the proper functioning of each individual cell, when the capillary insufficiency is due to an inadequate energy supply, which is particularly beneficial for cutaneous tissues.
The invention - Specifically, the object of the invention is a composition for cosmetic or for pharmaceutical use con taining vitamin A in the form of an ester, or as the acid and glucose, in association with a stable aqueous emul-sion of hydrogen peroxide.
Preferred emkodiments of the invention The energy is generated through the oxidative break-down of glucose, which is made possible due to an adequate oxygen supply from hydrogen peroxide.
Glucose is transported through the outer layers of the skin with vitamin A (ester or free acid) under the 2~3~
effect of the pressure exerted by nascent oxygen. The energy released through glycolysis can then be used under the skin.
Under in vivo conditions, t:he oxidative breakdown of 1 mole of glucose (C H 0 ~- 60 = 6C0 ~ 6H 0) results in the production of 690 kcal and is associated with the formation of 38 moles of adenosine triphosphate (ATP).
Specifically, glycolysis is the oxidative breakdown of glucose in a living organism under the effect of enzymes. ATP is an energy-rich phosphate donor in nume-rous phosphorylation reactions and also plays a role in the synthesis of ribonucleic acids.
The application of the composition according to the invention, for example as a cream, ensures that a rapid breakdown of ATP to adenosine diphosphate (ADP) is main-tained in the cutaneous tissues in contact with said composition, whereby the energy necessar~ for the metabo-lism of the cell is released : for example, for the synthesis of collagen, which is an important factor for preserving in particular the elasticity of the derm.
The hydrogen peroxide emulsions, which can be used within the scope of the present invention, can be either of the water-in-oil, or oil-in-water type.
A stable oil-in-water emulsion of hydrogen peroxide particularly well suited for preparing a composition according to the invention is described in patent US-A-3 954 974.
Since no toxic by-products are formed during the breakdown of hydrogen peroxide, such emulsions can include a high concentration of nascent oxygen which reinforces all the more the action of vitamin A, while at the same time ensuring a release of energy as a result of its reaction with glucose.
Amongst the esters of vitamin A which can be used, one can preferably choose an ester of a fatty acid, such as the palmitate of vitamin A, or equally its acetate.
:' - ' -.' . ' ' :
~3~
Such products are sold commercially under an appropriate form; the fatty acid esters of vitamin A have the further advantage of being well tolerated by the skin and the organism.
The relative concentrations of the ester of vitamin A or of the acid, and of glucose can vary considerably, depending upon the effects which are sought. The deriva-tive of vitamin A can be advantageously used at a concentration ranging from 1,000 to 10,000 international units tIU : expressed as vitamin A) per gram ~f the composition according to the invention.
As to the glucose, it is suitably included into the composition in an adequate molar proportion capable of producing through glycolysis, the amount of energy requi-red for the cell metabolism. Preferably, one can use glucose in an amount ranging from 0.5 to ~0 / in weight, based on the weight of the composition.
The concentrations of hydrogen peroxide in the com-position obviously vary according to the oxygenating effect which is sought. In the case of a composition for cosmetic use, hydrogen peroxide is used in an amount ranging from 0.5 to 4% in weight (expressed as 10~ H O ) and in the case of a composition for pharmaceutical use, from 0.1 to 6% in weight or more depending on circumstan-ces, based on the weight of the total composition.
Due to the well balanced nature of the emulsion composition, the excess oxygen generated not only produ-ces an immediate oxidative breakdown of glucose, but further ensures that the palmitate or the acetate of vitamin A are converted into retinoic acid and that the extracellular medium is enriched with oxygen and water, these two products resulting from the breakdown of hydro-gen peroxide.
Of course, the compositions according to the inven-tion, can also contain the usual stabilizers, thickeners, perfumes or colouring agents. They can also contain additional active components, for example other vitamins - 5 - ~ ~3.~7~
and vitamine derivatives such as vitamin E, or liposomes.
Being based on an aqueous emulsion with a high oxygenating capacity, the compositions according to the invention further display highly advantageous disinfec-ting and cicatrizing properties, which are useful for treating burns, open wounds such as ulcers or complica-tions arising from hemorrhoids.
The following examples are given for the purpose of illustrating the invention in more detail. These examples are in no way intended to be limiting.
Example 1 - A cosmetic composition A first phase of the "oil" type is prepared by mixing together the following components :
Petrolatum 450 g Liquid paraffin 325 g Cetyl alcohol 160 g Stearyl alcohol 160 g Monostearin 310 g Total 1405 g The following components are mixed together separa-tely, to prepare a "water" type phase :
H22' 30~400 g = 0.353 moles/kg of cream "Tween 80" 125 g Salicylic acid 9 g Vitamin A palmitate*63 g D,L-~-tocopherol acetate 200 g Glucose18 g = 0.01 moles/kg of cream Distilled water 7780 g Total 8595 g * 1.7 million IU/g ~3~7r~
The "oil" and the "water" phases thus prepared are then mixed together in an appropriate apparatus at a temperature comprised between 70 and 80 C, until a homogeneous emulsion is achieved. 10 kg of cream for cosmetic use are thus obtained, which contain 1.1~ active oxygen, 0.01 moles/kg of glucose and 10,000 IU of vitamin A palmitate/g of cream.
Example 2 - A cosmetic composition A first phase of the "oil" type is prepared by mixing together the following components :
Petrolatum 450 g Liquid paraffin 325 g Cetyl alcohol 160 g Stearyl alcohol 160 g Monostearin 310 g Vitamin A palmitate*63 g DrL-~-tocopherol acetate 200 g Total 1668 g The following components are mixed together separa-tely, to prepare a "water" type phase :
H 0 , 30%1167 g = 1.03 moles/kg of cream "Tween 80" 125 g Salicylic acid 9 g Glucose18 g = 0.01 moles/kg of cream Distilled water 7013 ~
Total 8332 g The "oil" and the "water" phases thus prepared are then mixed together in an appropriate apparatus at a temperature comprised between 70 and 80 C, until a * 1.7 million IU/g _ 7 _ ~ ~3 homogeneous emulsion is achieved. 10 kg of cream for cosmetic use are thus obtained, which contain 3.5% active oxygen, 0.01 moles/kg of glucose and 10,000 IU of vitamin A palmitate/g of cream.
Example 3 - ~ pharmaceutical composition A first phase of the "oil" type is prepared by mixing together the following components :
Petrolatum 475 g Liquid paraffin 350 g Cetyl alcohol 175 g Stearyl alcohol 175 g Monostearin 350 g D,L-~-tocopherol (vit. E) 250 g Total 1775 g The following components are mixed together separa-tely, to prepare a "water" type phase :
H2O2, 30% 1176 g "Tween 80" 150 g Salicylic acid 11 g Glucose 18 g Retinoic acid "Trétinoïne" 5 g Distilled water 6865 a Total 8225 g Tne "oil" and the "water" phases thus prepared are then mixed together in an appropriate apparatus at a temperature comprised between 70 and 80 C, until a homogeneous emulsion is achieved. 10 kg of cream for pharmaceutical use are thus obtained, which contain 3.5~
active oxygen (hydrogen peroxide), 0.01 moles/~g of glu-cose and 0.05~ of retinoic acid (Trétinoïne).
These compositions are perfectly well suited for numerous cosmetic or pharmaceutical uses and they proved to be particularly effective in cosmetic applications for ~13~
preventing skin ageing. They can also be used for the treatment of benign disorders of the skin, such as acne.
Further, these compositions have a disinfecting effect.
Claims (8)
1. A composition for cosmetic use containing vitamin A
in the form of an ester or as the free acid and glucose, in association with a stable aqueous emulsion of hydrogen peroxide.
in the form of an ester or as the free acid and glucose, in association with a stable aqueous emulsion of hydrogen peroxide.
2. A composition for pharmaceutical use containing vitamin A in the form of an ester or as the free acid and glucose, in association with a stable aqueous emulsion of hydrogen peroxide.
3. A composition according to one of claims 1 and 2, characterized in that the ester of vitamin A is selected from the palmitate and the acetate.
4. A composition according to one of claims 1 to 3, characterized in that vitamin A is included in the form of an ester or as the free acid, in an amount ranging from 1,000 to 10,000 IU/g of composition.
5. A composition according to one of claims 1 to 4, characterized in that glucose is included in an amount ranging from 0.5 to 10°/?? in weight, based on the weight of the composition.
6. A composition according to one of claims 1 to 5, characterized in that the stable aqueous emulsion of hydrogen peroxide is an emulsion of the oil-in-water type.
7. A composition for cosmetic use according to one of claims 1 or 3 to 6, characterized in that it contains from 0.5 to 4% in weight of hydrogen peroxide, based on the weight of the composition.
8. A composition for pharmaceutical use according to one of claims 2 to 6, characterized in that it contains from 0.1 to 10% in weight of hydrogen peroxide, based on the weight of the composition.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4582/89-4 | 1989-12-21 | ||
| CH4582/89A CH679981A5 (en) | 1989-12-21 | 1989-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2032784A1 true CA2032784A1 (en) | 1991-06-22 |
Family
ID=4278786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002032784A Abandoned CA2032784A1 (en) | 1989-12-21 | 1990-12-20 | Composition for cosmetic or pharmaceutical use |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0434628B1 (en) |
| JP (1) | JPH06227956A (en) |
| AT (1) | ATE102019T1 (en) |
| CA (1) | CA2032784A1 (en) |
| CH (1) | CH679981A5 (en) |
| DE (1) | DE69007051D1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2122923C (en) * | 1991-11-25 | 1999-01-19 | Roy L. Blank | Compositions for regulating skin wrinkles and/or skin atrophy |
| ES2195461T3 (en) * | 1991-11-25 | 2003-12-01 | Richardson Vicks Inc | USE OF SALICILIC ACID TO REGULATE SKIN WRINKLES AND / OR SKIN ATROPHY. |
| DE4328871A1 (en) * | 1993-08-27 | 1995-03-02 | Beiersdorf Ag | Means against sensitive, hyper-reactive skin conditions, atopic dermatitis, pruritus, psoriasis prurigo, photodermatoses and ichthyosis |
| JPH09509403A (en) * | 1993-12-15 | 1997-09-22 | エイボン プロダクツ インコーポレイテッド | Novel retinoid conjugate compounds and methods for treating skin aging |
| DE4444237C2 (en) * | 1994-12-13 | 2000-08-24 | Beiersdorf Ag | Use of combinations of active ingredients to combat blemished skin caused by Propionibacterium acnes and mild forms of acne |
| US6180670B1 (en) | 1995-07-20 | 2001-01-30 | Avon Products, Inc. | Retinoid conjugate compounds useful for the treatment of aging skin |
| KR100760167B1 (en) * | 1998-02-10 | 2007-09-20 | 가부시키가이샤 시세이도 | Oil-in-water type emulsified compositions |
| JP3634139B2 (en) * | 1998-02-10 | 2005-03-30 | 株式会社資生堂 | Oil-in-water emulsion composition |
| KR20000065305A (en) * | 1999-04-01 | 2000-11-15 | 유상옥 | Skin care composition containing stabilized retinol, phytosphingosine, and Castaneae crenata extracts |
| JP2007505093A (en) * | 2003-09-13 | 2007-03-08 | ブーツ ヘルスケア インターナショナル リミテッド | Skin care compositions and methods |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH670951A5 (en) * | 1988-06-13 | 1989-07-31 | Paul Dr Med Herzog | Cosmetic, cicatrising and disinfectant emulsions - contain vitamin=A ester and hydrogen peroxide |
-
1989
- 1989-12-21 CH CH4582/89A patent/CH679981A5/fr not_active IP Right Cessation
-
1990
- 1990-12-17 DE DE90810992T patent/DE69007051D1/en not_active Expired - Lifetime
- 1990-12-17 AT AT90810992T patent/ATE102019T1/en not_active IP Right Cessation
- 1990-12-17 EP EP90810992A patent/EP0434628B1/en not_active Expired - Lifetime
- 1990-12-20 CA CA002032784A patent/CA2032784A1/en not_active Abandoned
- 1990-12-21 JP JP2404689A patent/JPH06227956A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH679981A5 (en) | 1992-05-29 |
| EP0434628B1 (en) | 1994-03-02 |
| JPH06227956A (en) | 1994-08-16 |
| EP0434628A1 (en) | 1991-06-26 |
| ATE102019T1 (en) | 1994-03-15 |
| DE69007051D1 (en) | 1994-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |