CA2030525A1 - Method and means for inducing, resp., preventing constriction of the pupil in the eye - Google Patents
Method and means for inducing, resp., preventing constriction of the pupil in the eyeInfo
- Publication number
- CA2030525A1 CA2030525A1 CA002030525A CA2030525A CA2030525A1 CA 2030525 A1 CA2030525 A1 CA 2030525A1 CA 002030525 A CA002030525 A CA 002030525A CA 2030525 A CA2030525 A CA 2030525A CA 2030525 A1 CA2030525 A1 CA 2030525A1
- Authority
- CA
- Canada
- Prior art keywords
- cck
- cholecystokinin
- eye
- derivatives
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 210000001747 pupil Anatomy 0.000 title description 24
- 238000000034 method Methods 0.000 title description 5
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 claims abstract description 94
- 101800001982 Cholecystokinin Proteins 0.000 claims abstract description 75
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- 239000000203 mixture Substances 0.000 claims abstract description 12
- 230000004478 pupil constriction Effects 0.000 claims abstract 6
- IEKOTSCYBBDIJC-UHFFFAOYSA-N N(2)-(3,4-dichlorobenzoyl)-N,N-dipentyl-alpha-glutamine Chemical compound CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)C1=CC=C(Cl)C(Cl)=C1 IEKOTSCYBBDIJC-UHFFFAOYSA-N 0.000 claims description 21
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- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 7
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 4
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- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
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- VWOZTYAWDCUDEH-UHFFFAOYSA-N 5-(dipentylamino)-5-oxopentanoic acid Chemical class CCCCCN(CCCCC)C(=O)CCCC(O)=O VWOZTYAWDCUDEH-UHFFFAOYSA-N 0.000 description 1
- KOVRZNUMIKACTB-UHFFFAOYSA-N 9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester Chemical compound N1C2=CC=CC=C2C2=C1C=NC(C(=O)OCC)=C2 KOVRZNUMIKACTB-UHFFFAOYSA-N 0.000 description 1
- 241001261360 Aspergillus alliaceus Species 0.000 description 1
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- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2207—Gastrins; Cholecystokinins [CCK]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8901149A SE8901149D0 (sv) | 1989-04-03 | 1989-04-03 | Medel foer inducering respektive foerhindrande av pupillkonstriktion i oegat |
| SE8901149-8 | 1989-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2030525A1 true CA2030525A1 (en) | 1990-10-04 |
Family
ID=20375526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002030525A Abandoned CA2030525A1 (en) | 1989-04-03 | 1990-04-03 | Method and means for inducing, resp., preventing constriction of the pupil in the eye |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0422181A1 (bg) |
| JP (1) | JPH03505224A (bg) |
| KR (1) | KR920700044A (bg) |
| AU (1) | AU627570B2 (bg) |
| BG (1) | BG93398A (bg) |
| CA (1) | CA2030525A1 (bg) |
| FI (1) | FI905952A0 (bg) |
| HU (1) | HU206185B (bg) |
| SE (1) | SE8901149D0 (bg) |
| WO (1) | WO1990011773A1 (bg) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206237A (en) * | 1991-05-14 | 1993-04-27 | Merck & Co., Inc. | Benzodiazepine analogs |
| US5185331A (en) * | 1991-05-14 | 1993-02-09 | Merck & Co., Inc. | Triazolobenzodiazepines |
| US5210082A (en) * | 1991-05-16 | 1993-05-11 | Merck & Co., Inc. | 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders |
| US5189050A (en) * | 1991-06-03 | 1993-02-23 | Merck & Co., Inc. | Fermentation analogs of virginiamycin m1 to treat panic and anxiety disorder |
| US5177071A (en) * | 1991-06-17 | 1993-01-05 | Merck & Co., Inc. | 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder |
| SE9201425D0 (sv) * | 1992-05-06 | 1992-05-06 | Kabi Pharmacia Ab | Method and means for preventing constriction of the pupil in the eye |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4400377A (en) * | 1980-09-26 | 1983-08-23 | Farmitalia Carlo Erba, S.P.A. | Use of polypeptides as analgesic drugs |
| DK489683A (da) * | 1982-10-27 | 1984-04-28 | Amano Pharma Co Ltd | Fremgangsmaade til fremstilling af peptider |
| IT1179866B (it) * | 1984-12-12 | 1987-09-16 | Rotta Research Lab | Derivati del triptofano farmaceuticamente attivi e composizioni farmaceutiche che li contengono |
| IT1179894B (it) * | 1984-12-27 | 1987-09-16 | Rotta Research Lab | Proglumide e composizioni farmaceutiche che la contengono per l impiego nella terapia di affezioni neoplastiche |
| IT1204430B (it) * | 1986-01-10 | 1989-03-01 | Alfio Bertolini | Composizioni farmaceutiche comprendenti peptidi del gruppo colecistochinina-cerulina per il trattamento terapeutico degli stati di shock e dell'insufficienza respiratoria e cardiocircolatoria |
| DD272653A1 (de) * | 1987-02-09 | 1989-10-18 | Akad Wissenschaften Ddr | Verfahren zur herstellung neuer antagonisten des cholecystokinins |
-
1989
- 1989-04-03 SE SE8901149A patent/SE8901149D0/xx unknown
-
1990
- 1990-04-03 AU AU54282/90A patent/AU627570B2/en not_active Ceased
- 1990-04-03 HU HU903583A patent/HU206185B/hu not_active IP Right Cessation
- 1990-04-03 JP JP2506058A patent/JPH03505224A/ja active Pending
- 1990-04-03 EP EP90906391A patent/EP0422181A1/en not_active Withdrawn
- 1990-04-03 WO PCT/SE1990/000219 patent/WO1990011773A1/en not_active Application Discontinuation
- 1990-04-03 CA CA002030525A patent/CA2030525A1/en not_active Abandoned
- 1990-11-23 KR KR1019900702506A patent/KR920700044A/ko not_active Application Discontinuation
- 1990-12-03 FI FI905952A patent/FI905952A0/fi not_active IP Right Cessation
- 1990-12-06 BG BG093398A patent/BG93398A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU627570B2 (en) | 1992-08-27 |
| HUT55994A (en) | 1991-07-29 |
| FI905952A0 (fi) | 1990-12-03 |
| WO1990011773A1 (en) | 1990-10-18 |
| KR920700044A (ko) | 1992-02-19 |
| SE8901149D0 (sv) | 1989-04-03 |
| HU903583D0 (en) | 1991-05-28 |
| HU206185B (en) | 1992-09-28 |
| JPH03505224A (ja) | 1991-11-14 |
| EP0422181A1 (en) | 1991-04-17 |
| AU5428290A (en) | 1990-11-05 |
| BG93398A (bg) | 1993-12-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |