CA2026384A1 - A solid drug form with a high verapamil content - Google Patents
A solid drug form with a high verapamil contentInfo
- Publication number
- CA2026384A1 CA2026384A1 CA002026384A CA2026384A CA2026384A1 CA 2026384 A1 CA2026384 A1 CA 2026384A1 CA 002026384 A CA002026384 A CA 002026384A CA 2026384 A CA2026384 A CA 2026384A CA 2026384 A1 CA2026384 A1 CA 2026384A1
- Authority
- CA
- Canada
- Prior art keywords
- solid drug
- drug form
- verapamil
- content
- granulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- 229960001722 verapamil Drugs 0.000 title abstract 2
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
A solid drug form containing net less than 90 % by weight verapamil is produced by granulating at from 30 to 55°C with a little water, drying and, where appropriate, conventional tableting or by pelleting, in which case the granules obtained as described are, after cooling, moistened once again and compacted in a granulating mixer at from 30 to 55°C and are dried.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3932378.1 | 1989-09-28 | ||
| DE3932378A DE3932378A1 (en) | 1989-09-28 | 1989-09-28 | SOLID MEDICAL FORM WITH A HIGH VERAPAMIL CONTENT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2026384A1 true CA2026384A1 (en) | 1991-03-29 |
| CA2026384C CA2026384C (en) | 2002-04-09 |
Family
ID=6390380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002026384A Expired - Fee Related CA2026384C (en) | 1989-09-28 | 1990-09-27 | A solid drug form with a high verapamil content |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0420042B1 (en) |
| JP (1) | JP3100615B2 (en) |
| AT (1) | ATE78159T1 (en) |
| CA (1) | CA2026384C (en) |
| DE (2) | DE3932378A1 (en) |
| DK (1) | DK0420042T3 (en) |
| ES (1) | ES2043210T3 (en) |
| GR (1) | GR3005754T3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534262A (en) * | 1992-01-10 | 1996-07-09 | Dobrotvorsky; Anatoly E. | Pharmaceutical granulated composition and method for preparing same |
| RU2145214C1 (en) * | 1999-07-08 | 2000-02-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Pharmaceutical composition exhibiting cardiovascular effect |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3113901A1 (en) * | 1981-04-07 | 1982-10-28 | Basf Ag, 6700 Ludwigshafen | ACTIVE SUBSTANCE PREPARATION FOR ORAL APPLICATION |
| LU86099A1 (en) * | 1985-09-30 | 1987-04-02 | Pharlyse | EXTENDED RELEASE GALENIC FORMS OF VERAPAMIL, THEIR MANUFACTURE AND THE MEDICINAL PRODUCTS CONTAINING THEM |
| JP2804048B2 (en) * | 1987-09-11 | 1998-09-24 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | High drug content pharmaceutical composition and method for producing the same |
-
1989
- 1989-09-28 DE DE3932378A patent/DE3932378A1/en not_active Withdrawn
-
1990
- 1990-09-20 AT AT90118101T patent/ATE78159T1/en not_active IP Right Cessation
- 1990-09-20 DK DK90118101.6T patent/DK0420042T3/en active
- 1990-09-20 DE DE9090118101T patent/DE59000209D1/en not_active Expired - Lifetime
- 1990-09-20 ES ES90118101T patent/ES2043210T3/en not_active Expired - Lifetime
- 1990-09-20 EP EP90118101A patent/EP0420042B1/en not_active Expired - Lifetime
- 1990-09-27 CA CA002026384A patent/CA2026384C/en not_active Expired - Fee Related
- 1990-09-28 JP JP02257614A patent/JP3100615B2/en not_active Expired - Fee Related
-
1992
- 1992-09-23 GR GR920402085T patent/GR3005754T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59000209D1 (en) | 1992-08-20 |
| EP0420042B1 (en) | 1992-07-15 |
| CA2026384C (en) | 2002-04-09 |
| ES2043210T3 (en) | 1993-12-16 |
| EP0420042A2 (en) | 1991-04-03 |
| GR3005754T3 (en) | 1993-06-07 |
| EP0420042A3 (en) | 1991-04-24 |
| ATE78159T1 (en) | 1992-08-15 |
| DK0420042T3 (en) | 1992-10-05 |
| JP3100615B2 (en) | 2000-10-16 |
| DE3932378A1 (en) | 1991-04-11 |
| JPH03167122A (en) | 1991-07-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUT65527A (en) | Process for production of tablets, granulates and pellets with high drug contents | |
| ES8500739A1 (en) | Extended action controlled release compositions. | |
| JPS56144055A (en) | Tablet confectionery containing bifidus bacterium and its production | |
| KR910014120A (en) | Oral Pharmaceutical Formulations of Fimovevenan | |
| CA2208441A1 (en) | Animal excrement treating material and method of manufacturing same | |
| CA2026384A1 (en) | A solid drug form with a high verapamil content | |
| FR2787811B1 (en) | POWDER DEXTROSE AND PROCESS FOR THE PREPARATION THEREOF | |
| JPS5299217A (en) | Vermin attractants | |
| JPS5315425A (en) | Blend-type resticide granules | |
| EP0181153A3 (en) | Process for the utilisation of solid paper mill waste | |
| RU96113711A (en) | METHOD FOR PREPARING PEAT FOR BRIQUETTING | |
| JPS55165144A (en) | Deodorant | |
| JPS53118526A (en) | Preparation of granular pesticide for agricultural and horticultural use | |
| JPS57125666A (en) | Storing method of raw rice flour | |
| JPS57204227A (en) | Uranium adsorbing material molded into fibrous form | |
| TH13475A (en) | Pharmaceutical formulas | |
| JPS5721315A (en) | Stable solid preparation of cytochrome c and its preparation | |
| JPS5594315A (en) | Antibacterial drug | |
| Lohoar et al. | Production and marketing handbook for horticultural crops in Barbados | |
| JPS52125118A (en) | Manufacture of sorbic acid granules | |
| JPS56106563A (en) | Granulated gum guaiac and its preparation | |
| JPS5237262A (en) | Movable drier for pastures and other grasses | |
| Novikov | A Theoretical Analysis of the Structure of the Ionic Subsystem of Sn sub 30 Au sub 70 and Sn sub 90 Au sub 10 Alloys in the Liquid and Solid Amorphous States | |
| RU98118896A (en) | MEDICAL-PROPHYLACTIC MEDICINE | |
| JPS52128351A (en) | Preparation of alpha-elemene and delta-elemene |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |