CA2026384A1 - A solid drug form with a high verapamil content - Google Patents

A solid drug form with a high verapamil content

Info

Publication number
CA2026384A1
CA2026384A1 CA002026384A CA2026384A CA2026384A1 CA 2026384 A1 CA2026384 A1 CA 2026384A1 CA 002026384 A CA002026384 A CA 002026384A CA 2026384 A CA2026384 A CA 2026384A CA 2026384 A1 CA2026384 A1 CA 2026384A1
Authority
CA
Canada
Prior art keywords
solid drug
drug form
verapamil
content
granulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002026384A
Other languages
French (fr)
Other versions
CA2026384C (en
Inventor
Helmut Fricke
Thomas Moest
Ernst Flaig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2026384A1 publication Critical patent/CA2026384A1/en
Application granted granted Critical
Publication of CA2026384C publication Critical patent/CA2026384C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

A solid drug form containing net less than 90 % by weight verapamil is produced by granulating at from 30 to 55°C with a little water, drying and, where appropriate, conventional tableting or by pelleting, in which case the granules obtained as described are, after cooling, moistened once again and compacted in a granulating mixer at from 30 to 55°C and are dried.
CA002026384A 1989-09-28 1990-09-27 A solid drug form with a high verapamil content Expired - Fee Related CA2026384C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3932378A DE3932378A1 (en) 1989-09-28 1989-09-28 SOLID MEDICAL FORM WITH A HIGH VERAPAMIL CONTENT
DEP3932378.1 1989-09-28

Publications (2)

Publication Number Publication Date
CA2026384A1 true CA2026384A1 (en) 1991-03-29
CA2026384C CA2026384C (en) 2002-04-09

Family

ID=6390380

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002026384A Expired - Fee Related CA2026384C (en) 1989-09-28 1990-09-27 A solid drug form with a high verapamil content

Country Status (8)

Country Link
EP (1) EP0420042B1 (en)
JP (1) JP3100615B2 (en)
AT (1) ATE78159T1 (en)
CA (1) CA2026384C (en)
DE (2) DE3932378A1 (en)
DK (1) DK0420042T3 (en)
ES (1) ES2043210T3 (en)
GR (1) GR3005754T3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013756A1 (en) * 1992-01-10 1993-07-22 Obschestvo S Ogranichennoy Otvetstvennostyu Meditsinsky Nauchno-Proizvodstvennoy Komplex 'biotiki' Granulated pharmaceutical composition and method of obtaining it

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3113901A1 (en) * 1981-04-07 1982-10-28 Basf Ag, 6700 Ludwigshafen ACTIVE SUBSTANCE PREPARATION FOR ORAL APPLICATION
LU86099A1 (en) * 1985-09-30 1987-04-02 Pharlyse EXTENDED RELEASE GALENIC FORMS OF VERAPAMIL, THEIR MANUFACTURE AND THE MEDICINAL PRODUCTS CONTAINING THEM
GB2209669B (en) * 1987-09-11 1992-02-12 Squibb & Sons Inc Pharmaceutical composition containing high drug load and method for preparing same

Also Published As

Publication number Publication date
DE3932378A1 (en) 1991-04-11
JP3100615B2 (en) 2000-10-16
EP0420042A3 (en) 1991-04-24
EP0420042B1 (en) 1992-07-15
DE59000209D1 (en) 1992-08-20
GR3005754T3 (en) 1993-06-07
DK0420042T3 (en) 1992-10-05
CA2026384C (en) 2002-04-09
JPH03167122A (en) 1991-07-19
EP0420042A2 (en) 1991-04-03
ATE78159T1 (en) 1992-08-15
ES2043210T3 (en) 1993-12-16

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Legal Events

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