CA2022640A1 - Rotogranulations et enrobage masquant le gout pour la preparation de comprimes pharmaceutiques mastiquables - Google Patents

Rotogranulations et enrobage masquant le gout pour la preparation de comprimes pharmaceutiques mastiquables

Info

Publication number
CA2022640A1
CA2022640A1 CA2022640A CA2022640A CA2022640A1 CA 2022640 A1 CA2022640 A1 CA 2022640A1 CA 2022640 A CA2022640 A CA 2022640A CA 2022640 A CA2022640 A CA 2022640A CA 2022640 A1 CA2022640 A1 CA 2022640A1
Authority
CA
Canada
Prior art keywords
taste masking
rotogranulations
preparation
rotogranules
pharmaceutical tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2022640A
Other languages
English (en)
Other versions
CA2022640C (fr
Inventor
Edward J. Roche
Joseph P. Reo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson and Johnson Consumer Inc
Original Assignee
McNeil PPC Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeil PPC Inc filed Critical McNeil PPC Inc
Publication of CA2022640A1 publication Critical patent/CA2022640A1/fr
Application granted granted Critical
Publication of CA2022640C publication Critical patent/CA2022640C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • General Preparation And Processing Of Foods (AREA)
CA002022640A 1989-08-04 1990-08-03 Rotogranulations et enrobage masquant le gout pour la preparation de comprimes pharmaceutiques mastiquables Expired - Lifetime CA2022640C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38964589A 1989-08-04 1989-08-04
US389,645 1989-08-04

Publications (2)

Publication Number Publication Date
CA2022640A1 true CA2022640A1 (fr) 1991-02-05
CA2022640C CA2022640C (fr) 1997-02-11

Family

ID=23539113

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002022640A Expired - Lifetime CA2022640C (fr) 1989-08-04 1990-08-03 Rotogranulations et enrobage masquant le gout pour la preparation de comprimes pharmaceutiques mastiquables

Country Status (13)

Country Link
US (1) US5215755A (fr)
EP (1) EP0411952B1 (fr)
KR (1) KR0166064B1 (fr)
AT (1) ATE129406T1 (fr)
AU (1) AU646399B2 (fr)
CA (1) CA2022640C (fr)
DE (1) DE69023183T2 (fr)
ES (1) ES2081349T3 (fr)
GR (1) GR1001171B (fr)
IE (1) IE69042B1 (fr)
NZ (1) NZ234587A (fr)
PT (1) PT94898B (fr)
ZA (1) ZA906143B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460825A (en) * 1990-05-23 1995-10-24 Mcneil-Ppc, Inc. Taste mask coatings for preparing chewable pharmaceutical tablets
CA2085231C (fr) * 1990-07-02 1997-12-30 Berthold Stemmle Procede de preparation de formes de dosage unitaire moulees, comprimees, a liberation controlee et formes de dosage unitaire ainsi obtenues
JPH06506198A (ja) * 1991-03-04 1994-07-14 ワーナー−ランバート・コンパニー 種々な剤形の非ステロイド性抗炎症剤の新規な塩／イオン対
CA2079934C (fr) * 1991-10-15 2002-09-03 Edward J. Roche Enrobages permettant de masquer le gout de comprimes pharmaceutiques machables
US5429825A (en) * 1992-06-26 1995-07-04 Mcneil-Ppc, Inc. Rotomelt granulation
ZA945944B (en) * 1993-08-13 1996-02-08 Eurand America Inc Procedure for encapsulating nsaids
GB9405856D0 (en) * 1994-03-24 1994-05-11 Smithkline Beecham Plc Pharmaceutical formulation
US5399356A (en) * 1994-03-24 1995-03-21 The Procter & Gamble Company Process for making solid dose forms containing bismuth
AUPM814994A0 (en) * 1994-09-14 1994-10-06 Sterling Winthrop Inc. Codeine-containing formulations
US5529783A (en) * 1994-12-19 1996-06-25 Mcneil-Ppc, Inc. Rotor granulation and coating of acetaminophen, pseudoephedrine, chlorpheniramine, and, optionally dextromethorphan
US5639475A (en) * 1995-02-03 1997-06-17 Eurand America, Incorporated Effervescent microcapsules
US5518738A (en) * 1995-02-09 1996-05-21 Nanosystem L.L.C. Nanoparticulate nsaid compositions
US5560927A (en) * 1995-07-28 1996-10-01 Isp Investments Inc. Co-processing method for making a free-flowing compressible powder and tablet therefrom
FR2738833B1 (fr) * 1995-09-14 1997-12-05 Seppic Sa Composition filmogene pour le masquage de gout destinee a l'enrobage de formes solides ingerables telles qu'en particulier des comprimes pharmaceutiques
US6312724B1 (en) * 1997-04-04 2001-11-06 Isa Odidi Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof
NZ503086A (en) * 1997-08-29 2002-03-01 Upjohn Co An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
NZ333474A (en) * 1998-01-02 1999-06-29 Mcneil Ppc Inc A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
FR2785539B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Particules enrobees d'ibuprofene cristallin granule
FR2785538B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US6251945B1 (en) * 1999-01-14 2001-06-26 Knoll Aktiengesellschaft Pharmaceutical mixture comprising a combination of a profen and other active compounds
US6270807B1 (en) 1999-03-02 2001-08-07 L. Perrigo Company Taste-masked pharmaceutical composition
GB9910505D0 (en) * 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
US6211246B1 (en) 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6726922B1 (en) 1999-06-28 2004-04-27 Minu, L.L.C. Process and composition for temporarily suppressing pain
US6258381B1 (en) * 2000-02-11 2001-07-10 Mcneil-Ppc, Inc. Tablet and process for making the same
US20020119201A1 (en) * 2000-09-08 2002-08-29 Novozymes A/S Lubricated granules
WO2002020746A1 (fr) * 2000-09-08 2002-03-14 Novozymes A/S Granules lubrifiees
AU2002220248A1 (en) * 2000-11-06 2002-05-15 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
EP1368003A4 (fr) * 2001-02-05 2004-05-12 Scherer Technologies Inc R P Procedes et compositions reduisant le gout de principes actifs
CA2457100A1 (fr) * 2001-08-01 2003-02-13 Bristol-Myers Squibb Company Composition de masquage de gout
WO2003039516A1 (fr) * 2001-11-07 2003-05-15 Fujisawa Pharmaceuticla Co., Ltd. Procede pour ameliorer la dissolution de medicaments a faible pouvoir de dissolution
US20060068003A1 (en) 2002-11-06 2006-03-30 Herz Rachel S System for increasing compliance with medication regime
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
WO2004098571A1 (fr) * 2003-04-30 2004-11-18 Zicam, Llc Composition pour traiter les refroidissements comprenant des sels de zinc
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
US7165510B2 (en) 2003-11-04 2007-01-23 Dennis Lee Hakes Bovine germicide application device
ITMI20042356A1 (it) * 2004-12-10 2005-03-10 Acraf Composizione farmaceutica orodisperdibile e procedimento per prepararla
CN1883456B (zh) * 2005-06-20 2010-12-15 常州市第四制药厂有限公司 掩味药物颗粒及其制备方法和用途
KR101157267B1 (ko) * 2005-12-28 2012-07-03 두산인프라코어 주식회사 굴삭기의 주행복합제어용 유압시스템
EP1837020A1 (fr) * 2006-03-24 2007-09-26 Bioalliance Pharma Vehicule bioadhesif pour les muqueuses pour delivrer lentement des principes actifs
US20070286903A1 (en) * 2006-06-13 2007-12-13 Becicka Brian T Composition and method for taste masking
US20090060983A1 (en) * 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
AU2008318851B2 (en) * 2007-10-31 2014-04-17 Mcneil-Ppc, Inc. Orally disintegrated dosage form
CA2750196C (fr) * 2009-01-05 2017-06-20 Mcneil-Ppc, Inc. Comprime contenant des particules enrobees de cetirizine, de pseudoephedrine, et/ou de naproxene
WO2010078543A1 (fr) * 2009-01-05 2010-07-08 Mcneil-Ppc, Inc. Comprimé contenant de la pseudoéphédrine de cétirizine, et naproxène contenant une couche barrière
US8246988B2 (en) * 2009-01-05 2012-08-21 Mcneil-Ppc, Inc. Three layer tablet containing cetirizine, pseudoephedrine, and naproxen
US20110318411A1 (en) 2010-06-24 2011-12-29 Luber Joseph R Multi-layered orally disintegrating tablet and the manufacture thereof
US8784781B2 (en) 2009-09-24 2014-07-22 Mcneil-Ppc, Inc. Manufacture of chewing gum product with radiofrequency
US20110070286A1 (en) * 2009-09-24 2011-03-24 Andreas Hugerth Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
US9233491B2 (en) 2012-05-01 2016-01-12 Johnson & Johnson Consumer Inc. Machine for production of solid dosage forms
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
MX368159B (es) 2014-01-10 2019-09-20 Johnson & Johnson Consumer Inc Proceso para elaborar tabletas con el uso de radiofrecuencia y partículas disipativas revestidas.
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
CN110314150A (zh) * 2018-03-30 2019-10-11 洛阳惠中兽药有限公司 一种替米沙坦风味咀嚼片及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594470A (en) * 1968-02-19 1971-07-20 Abbott Lab Chewable tablets including coated particles of pseudoephedrine-weak cation exchange resin
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
GB8606762D0 (en) * 1986-03-19 1986-04-23 Boots Co Plc Therapeutic agents
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
US4835187A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US4837031A (en) * 1987-09-17 1989-06-06 Mallinckrodt, Inc. Compositions containing ibuprofen
US4851226A (en) * 1987-11-16 1989-07-25 Mcneil Consumer Products Company Chewable medicament tablet containing means for taste masking
NZ226822A (en) * 1987-11-16 1990-03-27 Mcneil Consumer Prod Chewable medicament tablet containing means for taste masking
US4835188A (en) * 1987-12-08 1989-05-30 American Home Products Corporation Spray dried ibuprofen

Also Published As

Publication number Publication date
US5215755A (en) 1993-06-01
GR1001171B (el) 1993-06-07
DE69023183T2 (de) 1996-04-18
IE69042B1 (en) 1996-08-07
ZA906143B (en) 1992-04-29
ATE129406T1 (de) 1995-11-15
CA2022640C (fr) 1997-02-11
PT94898B (pt) 1997-03-31
GR900100587A (en) 1991-12-30
AU646399B2 (en) 1994-02-24
PT94898A (pt) 1991-04-18
KR910004180A (ko) 1991-03-28
IE902823A1 (en) 1991-02-27
EP0411952B1 (fr) 1995-10-25
AU6018190A (en) 1991-02-07
EP0411952A2 (fr) 1991-02-06
KR0166064B1 (ko) 1999-01-15
ES2081349T3 (es) 1996-03-01
DE69023183D1 (de) 1995-11-30
NZ234587A (en) 1991-11-26
EP0411952A3 (en) 1991-10-23

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry