CA2012137A1 - Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase - Google Patents

Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase

Info

Publication number
CA2012137A1
CA2012137A1 CA2012137A CA2012137A CA2012137A1 CA 2012137 A1 CA2012137 A1 CA 2012137A1 CA 2012137 A CA2012137 A CA 2012137A CA 2012137 A CA2012137 A CA 2012137A CA 2012137 A1 CA2012137 A1 CA 2012137A1
Authority
CA
Canada
Prior art keywords
inhibitors
lipoxygenase
dibenzoheterocyclic
hydroxamic acids
hydroxy ureas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2012137A
Other languages
French (fr)
Other versions
CA2012137C (en
Inventor
Yves Girard
Pierre Hamel
Daniel Delorme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Priority to CA002012137A priority Critical patent/CA2012137C/en
Priority claimed from US07/493,527 external-priority patent/US5036067A/en
Publication of CA2012137A1 publication Critical patent/CA2012137A1/en
Application granted granted Critical
Publication of CA2012137C publication Critical patent/CA2012137C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds having the formula I:

(see formula I) are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
CA002012137A 1990-03-14 1990-03-14 Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase Expired - Fee Related CA2012137C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002012137A CA2012137C (en) 1990-03-14 1990-03-14 Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/493,527 US5036067A (en) 1990-03-14 1990-03-14 Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
CA002012137A CA2012137C (en) 1990-03-14 1990-03-14 Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase

Publications (2)

Publication Number Publication Date
CA2012137A1 true CA2012137A1 (en) 1991-09-14
CA2012137C CA2012137C (en) 2000-08-08

Family

ID=25674010

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002012137A Expired - Fee Related CA2012137C (en) 1990-03-14 1990-03-14 Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase

Country Status (1)

Country Link
CA (1) CA2012137C (en)

Also Published As

Publication number Publication date
CA2012137C (en) 2000-08-08

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