CA2012137A1 - Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase - Google Patents
Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenaseInfo
- Publication number
- CA2012137A1 CA2012137A1 CA2012137A CA2012137A CA2012137A1 CA 2012137 A1 CA2012137 A1 CA 2012137A1 CA 2012137 A CA2012137 A CA 2012137A CA 2012137 A CA2012137 A CA 2012137A CA 2012137 A1 CA2012137 A1 CA 2012137A1
- Authority
- CA
- Canada
- Prior art keywords
- inhibitors
- lipoxygenase
- dibenzoheterocyclic
- hydroxamic acids
- hydroxy ureas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 title abstract 2
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 title 1
- -1 hydroxy ureas Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010000234 Abortion spontaneous Diseases 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
- 206010036600 Premature labour Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000026440 premature labor Diseases 0.000 abstract 1
- 208000000995 spontaneous abortion Diseases 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds having the formula I:
(see formula I) are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
(see formula I) are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002012137A CA2012137C (en) | 1990-03-14 | 1990-03-14 | Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/493,527 US5036067A (en) | 1990-03-14 | 1990-03-14 | Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
| CA002012137A CA2012137C (en) | 1990-03-14 | 1990-03-14 | Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2012137A1 true CA2012137A1 (en) | 1991-09-14 |
| CA2012137C CA2012137C (en) | 2000-08-08 |
Family
ID=25674010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002012137A Expired - Fee Related CA2012137C (en) | 1990-03-14 | 1990-03-14 | Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2012137C (en) |
-
1990
- 1990-03-14 CA CA002012137A patent/CA2012137C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2012137C (en) | 2000-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |