CA2060557A1 - (quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes - Google Patents

(quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes

Info

Publication number
CA2060557A1
CA2060557A1 CA002060557A CA2060557A CA2060557A1 CA 2060557 A1 CA2060557 A1 CA 2060557A1 CA 002060557 A CA002060557 A CA 002060557A CA 2060557 A CA2060557 A CA 2060557A CA 2060557 A1 CA2060557 A1 CA 2060557A1
Authority
CA
Canada
Prior art keywords
inhibitors
biosynthesis
leukotrienes
ylmethoxy
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002060557A
Other languages
French (fr)
Other versions
CA2060557C (en
Inventor
Petpiboon Prasit
Rejean Fortin
John H. Hutchinson
Michel L. Belley
Serge Leger
John Gillard
Richard Frenette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/650,825 external-priority patent/US5204344A/en
Application filed by Individual filed Critical Individual
Priority to US07/903,051 priority Critical patent/US5252585A/en
Priority claimed from US07/903,051 external-priority patent/US5252585A/en
Publication of CA2060557A1 publication Critical patent/CA2060557A1/en
Application granted granted Critical
Publication of CA2060557C publication Critical patent/CA2060557C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds having the formula I:
are inhibitors of leukotriene biosynthesis.
These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
CA002060557A 1991-02-05 1992-02-03 (quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes Expired - Fee Related CA2060557C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US07/903,051 US5252585A (en) 1992-02-03 1992-06-22 Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/650,825 US5204344A (en) 1989-08-22 1991-02-05 (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US650,825 1991-02-05
US07/903,051 US5252585A (en) 1992-02-03 1992-06-22 Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes

Publications (2)

Publication Number Publication Date
CA2060557A1 true CA2060557A1 (en) 1992-08-06
CA2060557C CA2060557C (en) 2002-06-04

Family

ID=27095945

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002060557A Expired - Fee Related CA2060557C (en) 1991-02-05 1992-02-03 (quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes

Country Status (2)

Country Link
CA (1) CA2060557C (en)
MX (1) MX9203486A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013293A3 (en) * 1992-12-14 1994-08-18 Merck Frosst Canada Inc (quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
JP2009514959A (en) * 2005-11-04 2009-04-09 アミラ ファーマシューティカルス，インコーポレーテッド 5-Lipoxygenase activating protein (FLAP) inhibitor
US7741326B2 (en) 2006-11-09 2010-06-22 Roche Palo Alto Llc Indole and benzofuran 2-carboxamide derivatives and uses thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013293A3 (en) * 1992-12-14 1994-08-18 Merck Frosst Canada Inc (quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
JP2009514959A (en) * 2005-11-04 2009-04-09 アミラ ファーマシューティカルス，インコーポレーテッド 5-Lipoxygenase activating protein (FLAP) inhibitor
US7741326B2 (en) 2006-11-09 2010-06-22 Roche Palo Alto Llc Indole and benzofuran 2-carboxamide derivatives and uses thereof

Also Published As

Publication number Publication date
MX9203486A (en) 1992-08-01
CA2060557C (en) 2002-06-04

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Legal Events

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