CA2011738A1 - Ligands recepteurs de la dopamine et agents pour l'imagerie medicale - Google Patents

Ligands recepteurs de la dopamine et agents pour l'imagerie medicale

Info

Publication number
CA2011738A1
CA2011738A1 CA2011738A CA2011738A CA2011738A1 CA 2011738 A1 CA2011738 A1 CA 2011738A1 CA 2011738 A CA2011738 A CA 2011738A CA 2011738 A CA2011738 A CA 2011738A CA 2011738 A1 CA2011738 A1 CA 2011738A1
Authority
CA
Canada
Prior art keywords
imaging agents
receptor ligands
dopamine receptor
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2011738A
Other languages
English (en)
Other versions
CA2011738C (fr
Inventor
Hank F. Kung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of CA2011738A1 publication Critical patent/CA2011738A1/fr
Application granted granted Critical
Publication of CA2011738C publication Critical patent/CA2011738C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • C07F7/081Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K51/047Benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22Tin compounds
    • C07F7/2208Compounds having tin linked only to carbon, hydrogen and/or halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CA002011738A 1989-04-03 1990-03-08 Ligands recepteurs de la dopamine et agents pour l'imagerie medicale Expired - Fee Related CA2011738C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US332,625 1989-04-03
US07/332,625 US5068326A (en) 1989-04-03 1989-04-03 Dopamine receptor ligands and imaging agents

Publications (2)

Publication Number Publication Date
CA2011738A1 true CA2011738A1 (fr) 1990-10-03
CA2011738C CA2011738C (fr) 1997-03-18

Family

ID=23299083

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002011738A Expired - Fee Related CA2011738C (fr) 1989-04-03 1990-03-08 Ligands recepteurs de la dopamine et agents pour l'imagerie medicale

Country Status (8)

Country Link
US (1) US5068326A (fr)
EP (1) EP0391554B1 (fr)
JP (1) JPH0660109B2 (fr)
KR (1) KR930000148B1 (fr)
AT (1) ATE157970T1 (fr)
AU (1) AU620704B2 (fr)
CA (1) CA2011738C (fr)
DE (1) DE69031399D1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320825A (en) * 1991-05-01 1994-06-14 Trustees Of The University Of Pennsylvania Serotonin reuptake inhibitors for S.P.E.C.T. imaging
US5446147A (en) * 1992-04-03 1995-08-29 Trustees Of The University Of Pennsylvania Fluorinated and iodinated dopamine agents
GB2271566A (en) * 1992-10-14 1994-04-20 Merck & Co Inc HIV integrase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561305A (en) * 1975-07-02 1980-02-20 Smithkline Corp Benzazepine derivatives and pharmeceutical compositions containing them
US4160765A (en) * 1976-11-17 1979-07-10 Smithkline Corporation Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4197297A (en) 1976-11-17 1980-04-08 Smithkline Corporation 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
CH637383A5 (en) * 1978-01-01 1983-07-29 Smithkline Beckman Corp Trisubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, and their salts
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPH02286662A (ja) 1990-11-26
EP0391554B1 (fr) 1997-09-10
ATE157970T1 (de) 1997-09-15
EP0391554A1 (fr) 1990-10-10
AU5229190A (en) 1990-10-04
KR930000148B1 (ko) 1993-01-09
US5068326A (en) 1991-11-26
JPH0660109B2 (ja) 1994-08-10
AU620704B2 (en) 1992-02-20
KR900016139A (ko) 1990-11-12
DE69031399D1 (de) 1997-10-16
CA2011738C (fr) 1997-03-18

Similar Documents

Publication Publication Date Title
GR3024008T3 (en) Dopamine receptor ligands and imaging agents
GB2234896B (en) Processes for the preparation of sustained release formulations of water soluble peptides
IL79559A0 (en) Contrast agents for nmr medical imaging
CA2278201A1 (fr) Nouvelles modifications du 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonyl-aminobenzene et procedes de preparation connexes
AU5791390A (en) Liners for ladies' panties
EP0456062A3 (en) Process for preparation of isocyanuratepolyisocyanates, the compounds prepared according to this process, and their use
EP0479306A3 (en) Preparation of polyamides from omega-aminonitriles
PT84662B (en) Process for the preparation of pharmaceutical compositions containing 7,alpha-]1(s)-hydroxy-1-methylbuthyl"-6,14-endoetheno-6,7,8,14-tetrahydro-oripavine (etorphine)
IL95946A0 (en) Preparation of tetrabromo-4,4'-alkylidenediphenols
HUP9900426A2 (hu) Amyloidmegkötő azoszármazékok, előállításuk, a vegyületek alkalmazása Alzheimer kór halál előtti diagnosztizálására és amyloid lerakódás in vivo kimutatására és megelőzésére
CA2011738A1 (fr) Ligands recepteurs de la dopamine et agents pour l'imagerie medicale
GB8726509D0 (en) Preparing 2 5-diphenyltetrahydrofurans & analogs
EP0692476A3 (fr) Procédé amélioré pour la préparation de N,N'-carbonyldiazoles, spécialement de N,N'-carbonyldiimidazole
IL89430A0 (en) Process for the preparation of 4,4'-dibromodiphenyl
EP0389110A3 (en) Process for the preparation of 2'-deoxy-5-trifluoromethyl-beta-uridine
ZA905932B (en) 14,17alpha-etheno-and-ethanoestratrienes,processes for the preparation of these compounds,as well as their use for the production of medicinal agents
EG19390A (en) Process for preparing compositions useful as contraceptives males
EP0297296A3 (en) Process for the preparation of 2,2'-oxybisûn,n-dimethyl-ethylamine¨
IL92465A0 (en) Process for the preparation of 4,4'-dibromodiphenylether
FR2522920B1 (fr) Machine agricole pour la preparation d'un lit de semence
HU895322D0 (en) Improved process for the preparation of 5-carbamoyl-5h-dibenz/b,f/ azepine
AU1807592A (en) New combination preparation for treatment of parkinson's disease
CS9002007A2 (en) Fastening element for reconstructed joint's articulated mechanism supporting
FR2596235B1 (fr) Combinaison d'outils pour la preparation du lit de semences
EP0486452A3 (en) Preparation of 2,2'-oxydisuccinate

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed