CA2002860A1 - Anticorps specifiques de l'elam-1 et application - Google Patents
Anticorps specifiques de l'elam-1 et applicationInfo
- Publication number
- CA2002860A1 CA2002860A1 CA002002860A CA2002860A CA2002860A1 CA 2002860 A1 CA2002860 A1 CA 2002860A1 CA 002002860 A CA002002860 A CA 002002860A CA 2002860 A CA2002860 A CA 2002860A CA 2002860 A1 CA2002860 A1 CA 2002860A1
- Authority
- CA
- Canada
- Prior art keywords
- elam
- antibody
- patient
- specific antibody
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27086088A | 1988-11-14 | 1988-11-14 | |
| US270,860 | 1988-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2002860A1 true CA2002860A1 (fr) | 1990-05-14 |
Family
ID=23033111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002002860A Abandoned CA2002860A1 (fr) | 1988-11-14 | 1989-11-14 | Anticorps specifiques de l'elam-1 et application |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5403713A (fr) |
| EP (1) | EP0534944B1 (fr) |
| JP (1) | JPH04501565A (fr) |
| AT (1) | ATE142505T1 (fr) |
| AU (1) | AU636589B2 (fr) |
| CA (1) | CA2002860A1 (fr) |
| DE (1) | DE68927188T2 (fr) |
| WO (1) | WO1990005539A1 (fr) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5632991A (en) * | 1988-11-14 | 1997-05-27 | Brigham & Women's Hospital | Antibodies specific for E-selectin and the uses thereof |
| US5776775A (en) * | 1989-02-21 | 1998-07-07 | Dana-Farber Cancer Institute | Anti-LAM 1-3 antibody and hybridoma |
| EP0585963A1 (fr) * | 1989-05-23 | 1994-03-09 | Otsuka Pharmaceutical Co., Ltd. | Anticorps monoclonaux contre l'antigène CMP-170 sur les cellules endothétiales activées |
| WO1992008489A1 (fr) * | 1990-11-08 | 1992-05-29 | Biogen, Inc. | Traitement d'affections intestinales inflammatoires |
| HUT64476A (en) | 1990-11-23 | 1994-01-28 | Gen Hospital Corp | Process for inhibiting interacton between proteins and carbohydrate causing cell-adhesion |
| CA2100681A1 (fr) * | 1991-01-24 | 1992-07-25 | Elisabeth Wayner | Anticorps monoclonaux anti-elam-1 et leur utilisation |
| EP0668871A1 (fr) * | 1991-05-03 | 1995-08-30 | The Rockefeller University | Homologies au niveau de la sequence en acides amines entre les selectines et la toxine de b. pertussis-peptides en derivant et anticorps contre ces peptides et compositions pharmaceutiques |
| US5891841A (en) * | 1991-06-11 | 1999-04-06 | The Center For Blood Research, Inc. | Methods of using intercellular adhesion molecule-3 (ICAM-3), antibodies thereto, and soluble fragments thereof |
| ATE173503T1 (de) * | 1991-07-31 | 1998-12-15 | Boehringer Ingelheim Pharma | Die verwendung des leukozyten adhäsionsmolekül-1- aus endothelzellen und antikörper dagegen in der behandlung von asthma |
| GB9120768D0 (en) * | 1991-09-30 | 1991-11-13 | British Bio Technology | Diagnostic and prognastic materials and methods |
| HUT69725A (en) * | 1991-10-01 | 1995-09-28 | Gen Hospital Corp | Process for producing compositions for preventing allograft rejection |
| US5837822A (en) * | 1992-01-27 | 1998-11-17 | Icos Corporation | Humanized antibodies specific for ICAM related protein |
| US6153395A (en) * | 1992-01-27 | 2000-11-28 | Icos Corporation | ICAM-related protein |
| US6100383A (en) * | 1992-01-27 | 2000-08-08 | Icos Corporation | Fusion proteins comprising ICAM-R polypeptides and immunoglobulin constant regions |
| US6818743B1 (en) | 1992-01-27 | 2004-11-16 | Icos Corporation | I-CAM related protein |
| US5773218A (en) * | 1992-01-27 | 1998-06-30 | Icos Corporation | Method to identify compounds which modulate ICAM-related protein interactions |
| US5532127A (en) * | 1992-01-27 | 1996-07-02 | Icos Corporation | Assay for 1-CAM related protein expression |
| US5525487A (en) * | 1992-01-27 | 1996-06-11 | Icos Corporation | DNA encoding I-CAM related protein |
| JP3616090B2 (ja) * | 1992-01-27 | 2005-02-02 | イコス コーポレイション | 細胞間接着分子関連タンパク質 |
| US5989843A (en) * | 1992-01-27 | 1999-11-23 | Icos Corporation | Methods for identifying modulators of protein kinase C phosphorylation of ICAM-related protein |
| US6093399A (en) * | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US5877289A (en) * | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
| US6004555A (en) * | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| PT627940E (pt) * | 1992-03-05 | 2003-07-31 | Univ Texas | Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados |
| US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
| US5660827A (en) * | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| US6036955A (en) * | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
| US5648458A (en) * | 1992-05-06 | 1997-07-15 | Affymax Technologies N.V. | Peptides and compounds that bind to ELAM-1 |
| US5728802A (en) * | 1992-05-06 | 1998-03-17 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) |
| US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
| WO1994017828A2 (fr) * | 1993-02-09 | 1994-08-18 | Biogen, Inc. | Traitement du diabete insulino-dependant |
| AU1280695A (en) * | 1993-12-27 | 1995-07-17 | Nisshin Oil Mills, Ltd., The | Method of assaying complex formed between secretin and ligand thereof and use of said complex |
| US6001356A (en) * | 1995-09-29 | 1999-12-14 | Rush-Presbyterian-St. Luke's Medical Center | Method of inhibiting tissue destruction in autoimmune disease using anti-CD44 antibodies |
| US6416960B1 (en) | 1996-08-08 | 2002-07-09 | Prolume, Ltd. | Detection and visualization of neoplastic tissues and other tissues |
| EP1015872B1 (fr) | 1996-12-12 | 2005-03-02 | Prolume, Ltd. | Appareil permettant de detecter et d'identifier des agents infectieux et procede correspondant |
| US6096511A (en) * | 1997-06-10 | 2000-08-01 | Merck & Co., Inc. | Protein elongation factor 2 as a target for antifungal and antiparasitic agents |
| EP0995120A1 (fr) * | 1997-06-10 | 2000-04-26 | Merck & Co., Inc. | Proteine facteur d'elongation 2 en tant que cible pour des antifongiques et des antiparasitaires |
| KR20010042288A (ko) | 1998-03-31 | 2001-05-25 | 블레어 큐. 퍼거슨 | 신생혈관 형성 질환의 영상화용 약제 |
| US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| US6524553B2 (en) * | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
| US20020160441A1 (en) * | 1998-06-02 | 2002-10-31 | Merck & Co., Inc. | Protein elongation factor 2 as a target for antifungal and antiparasitic agents |
| US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
| IL142958A0 (en) | 1998-12-18 | 2002-04-21 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals |
| US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| TR200101757T2 (tr) | 1998-12-18 | 2001-12-21 | Dupont Pharmaceuticais Company | Vitronektin reseptör antagonisti farmasötikler |
| CA2461905A1 (fr) * | 2001-09-27 | 2003-04-10 | Board Of Regents, The University Of Texas System | Compositions et methodes combinees pour la coagulation et le traitement du reseau vasculaire tumoral |
| EP4093508A1 (fr) | 2020-01-24 | 2022-11-30 | Pfizer Inc. | Anticorps anti-e-sélectine, compositions et procédés d'utilisation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4468464A (en) * | 1974-11-04 | 1984-08-28 | The Board Of Trustees Of The Leland Stanford Junior University | Biologically functional molecular chimeras |
| US4727028A (en) * | 1981-06-22 | 1988-02-23 | Eli Lilly And Company | Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof |
| US4840793A (en) * | 1987-06-11 | 1989-06-20 | Dana-Farber Cancer Institute | Method of reducing tissue damage at an inflammatory site using a monoclonal antibody |
| US4797277A (en) * | 1987-09-22 | 1989-01-10 | Pharmacia Ab | Method for reperfusion therapy |
| US5081034A (en) * | 1988-11-14 | 1992-01-14 | Brigham & Women's Hospital | Cloned genes which encode elam-1 |
-
1989
- 1989-11-14 DE DE68927188T patent/DE68927188T2/de not_active Expired - Fee Related
- 1989-11-14 CA CA002002860A patent/CA2002860A1/fr not_active Abandoned
- 1989-11-14 AT AT89912817T patent/ATE142505T1/de not_active IP Right Cessation
- 1989-11-14 WO PCT/US1989/005075 patent/WO1990005539A1/fr active IP Right Grant
- 1989-11-14 AU AU46217/89A patent/AU636589B2/en not_active Ceased
- 1989-11-14 EP EP89912817A patent/EP0534944B1/fr not_active Expired - Lifetime
- 1989-11-14 JP JP2500666A patent/JPH04501565A/ja active Pending
-
1993
- 1993-08-05 US US08/102,510 patent/US5403713A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0534944B1 (fr) | 1996-09-11 |
| AU4621789A (en) | 1990-06-12 |
| EP0534944A1 (fr) | 1993-04-07 |
| AU636589B2 (en) | 1993-05-06 |
| JPH04501565A (ja) | 1992-03-19 |
| DE68927188D1 (de) | 1996-10-17 |
| WO1990005539A1 (fr) | 1990-05-31 |
| EP0534944A4 (fr) | 1991-09-23 |
| DE68927188T2 (de) | 1997-04-24 |
| US5403713A (en) | 1995-04-04 |
| ATE142505T1 (de) | 1996-09-15 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |