CA1341566C - Reponse immune a des tumeurs induite par des anticorps anti-idiotypes
- Google Patents
Reponse immune a des tumeurs induite par des anticorps anti-idiotypes
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Publication number
CA1341566C
CA1341566CCA000616029ACA1341566ACA1341566CCA 1341566 CCA1341566 CCA 1341566CCA 000616029 ACA000616029 ACA 000616029ACA 1341566 ACA1341566 ACA 1341566ACA 1341566 CCA1341566 CCA 1341566C
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CA
Canada
Prior art keywords
antibody
idiotype
antibodies
mab
epitope
Prior art date
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Wistar Institute of Anatomy and Biology
Original Assignee
Wistar Institute of Anatomy and Biology
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Publication date
Application filed by Wistar Institute of Anatomy and BiologyfiledCriticalWistar Institute of Anatomy and Biology
Application grantedgrantedCritical
Publication of CA1341566CpublicationCriticalpatent/CA1341566C/fr
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Abstract
Des anticorps anti-idiotypes, leur production et leur utilisation pour l'induction de réponse immunologique aux tumeurs sont décrits. Les anticorps supportent une image interne d'un épitope présent dans une cellule tumorale solide, dans laquelle ledit anticorps anti-idiotype : (a) immuno-réagit à travers son parotope avec un anticorps monoclonal spécifique audit épitope de cellule tumorale solide, et (b) va induire la formation d'anticorps anti-idiotypes spécifiques audit épitope de cellule tumorale solide lors de l'administration à un humain.
CA000616029A1983-11-071984-11-06Reponse immune a des tumeurs induite par des anticorps anti-idiotypes
ActiveCA1341566C
(fr)
Patients treated with a monoclonal antibody (ab1) to the colorectal carcinoma antigen 17–1A develop a cellular response (DTH) to the “internal image of the antigen”(ab2)