CA1283103C - Substituted 2,3-dihydro-6-hydroxy-pyrimido ¬2,1-f|-purine- 4,8(1h,9h)-diones - Google Patents

Substituted 2,3-dihydro-6-hydroxy-pyrimido ¬2,1-f|-purine- 4,8(1h,9h)-diones

Info

Publication number
CA1283103C
CA1283103C CA000508913A CA508913A CA1283103C CA 1283103 C CA1283103 C CA 1283103C CA 000508913 A CA000508913 A CA 000508913A CA 508913 A CA508913 A CA 508913A CA 1283103 C CA1283103 C CA 1283103C
Authority
CA
Canada
Prior art keywords
carbon atoms
hydroxy
compound
purine
pyrimido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000508913A
Other languages
English (en)
French (fr)
Inventor
Daniel M. Solomon
James J. Kaminski
David J. Conn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of CA1283103C publication Critical patent/CA1283103C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000508913A 1985-05-13 1986-05-12 Substituted 2,3-dihydro-6-hydroxy-pyrimido ¬2,1-f|-purine- 4,8(1h,9h)-diones Expired - Lifetime CA1283103C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US732,994 1985-05-13
US06/732,994 US4666914A (en) 1985-05-13 1985-05-13 Anti-inflammatory and anti-allergic substituted-2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]-purine-4,8(1H,9H)-diones

Publications (1)

Publication Number Publication Date
CA1283103C true CA1283103C (en) 1991-04-16

Family

ID=24945768

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000508913A Expired - Lifetime CA1283103C (en) 1985-05-13 1986-05-12 Substituted 2,3-dihydro-6-hydroxy-pyrimido ¬2,1-f|-purine- 4,8(1h,9h)-diones

Country Status (11)

Country Link
US (2) US4666914A (OSRAM)
EP (1) EP0221996B1 (OSRAM)
JP (1) JPS62502842A (OSRAM)
KR (1) KR900004834B1 (OSRAM)
AU (1) AU592088B2 (OSRAM)
CA (1) CA1283103C (OSRAM)
DE (1) DE3673759D1 (OSRAM)
DK (1) DK13487A (OSRAM)
FI (1) FI870079L (OSRAM)
HU (1) HU195221B (OSRAM)
WO (1) WO1986006724A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666914A (en) * 1985-05-13 1987-05-19 Schering Corporation Anti-inflammatory and anti-allergic substituted-2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]-purine-4,8(1H,9H)-diones
US4847377A (en) * 1985-05-13 1989-07-11 Schering Corporation Substituted-2,3-dihydro-6-substituted-pyrimido[2,1-F]-purine-4,8(1H,9H)-diones
GB8906792D0 (en) * 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
CN102452750B (zh) * 2010-10-15 2013-05-01 中国石油化工股份有限公司 炼油污水分类控制分级处理方法
EP4161903A4 (en) * 2020-06-04 2024-05-22 London Pharmaceuticals and Research Corporation Rigid cannabidiol analogues as potent modulators of cannabinoid receptors and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
US4457919A (en) * 1980-03-14 1984-07-03 Newport Pharmaceutical International, Inc. Method of imparting immunomodulating, antiviral or antitumor activity
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
DE3370961D1 (en) * 1982-10-25 1987-05-21 Schering Corp Substituted 9h-8-oxo-pyrimido(2,1-f)purine-2,4-diones, process for their production and pharmaceutical compositions containing them
US4569936A (en) * 1982-10-25 1986-02-11 Schering Corporation Anti-inflammatory substituted 9H-8-oxo-pyrimido[2,1-f]purine-2,4-diones
US4666914A (en) * 1985-05-13 1987-05-19 Schering Corporation Anti-inflammatory and anti-allergic substituted-2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]-purine-4,8(1H,9H)-diones

Also Published As

Publication number Publication date
AU5816686A (en) 1986-12-04
EP0221996B1 (en) 1990-08-29
JPS62502842A (ja) 1987-11-12
KR870700624A (ko) 1987-12-30
JPH0513953B2 (OSRAM) 1993-02-23
US4666914A (en) 1987-05-19
KR900004834B1 (ko) 1990-07-07
EP0221996A1 (en) 1987-05-20
HU195221B (en) 1988-04-28
AU592088B2 (en) 1990-01-04
FI870079A7 (fi) 1987-01-09
HUT41794A (en) 1987-05-28
DE3673759D1 (de) 1990-10-04
WO1986006724A1 (en) 1986-11-20
FI870079A0 (fi) 1987-01-09
DK13487D0 (da) 1987-01-12
US4816458A (en) 1989-03-28
DK13487A (da) 1987-03-12
FI870079L (fi) 1987-01-09

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