CA1270827C - Les 3-amino-3,4,6-tridesoxyglycals, procede pour leur preparation et anthracyclines preparees a l'aide de ces glycals - Google Patents

Les 3-amino-3,4,6-tridesoxyglycals, procede pour leur preparation et anthracyclines preparees a l'aide de ces glycals

Info

Publication number
CA1270827C
CA1270827C CA 484086 CA484086A CA1270827C CA 1270827 C CA1270827 C CA 1270827C CA 484086 CA484086 CA 484086 CA 484086 A CA484086 A CA 484086A CA 1270827 C CA1270827 C CA 1270827C
Authority
CA
Canada
Prior art keywords
group
cocf3
amino
denote
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 484086
Other languages
English (en)
Inventor
Claude Monneret
Martine Mondon
Jean-Claude Jacquesy
Jean-Pierre Gesson
Jean-Claude Florent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Laboratoires Hoechst SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Hoechst SA filed Critical Laboratoires Hoechst SA
Priority to CA000572361A priority Critical patent/CA1270827A/fr
Application granted granted Critical
Publication of CA1270827C publication Critical patent/CA1270827C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
CA 484086 1984-06-15 1985-06-14 Les 3-amino-3,4,6-tridesoxyglycals, procede pour leur preparation et anthracyclines preparees a l'aide de ces glycals Expired - Lifetime CA1270827C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000572361A CA1270827A (fr) 1984-06-15 1988-07-18 Les 3-amino-3,4,6-tridesoxyglycals, procede pour leur preparation et anthracyclines preparees a l'aide de ces glycals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8409405A FR2565982B1 (fr) 1984-06-15 1984-06-15 Nouveaux amino-3-tridesoxy-3,4,6-glycals, leurs procedes de preparation et anthracyclines obtenues a l'aide de ces glycals
FR84.09405 1984-06-15

Publications (1)

Publication Number Publication Date
CA1270827C true CA1270827C (fr) 1990-06-26

Family

ID=9305069

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 484086 Expired - Lifetime CA1270827C (fr) 1984-06-15 1985-06-14 Les 3-amino-3,4,6-tridesoxyglycals, procede pour leur preparation et anthracyclines preparees a l'aide de ces glycals

Country Status (5)

Country Link
EP (3) EP0272735A3 (fr)
JP (1) JPS6110572A (fr)
CA (1) CA1270827C (fr)
FR (1) FR2565982B1 (fr)
MA (1) MA20454A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058543A1 (fr) * 1998-05-13 1999-11-18 Instytut Farmaceutyczny Nouveaux derives n-alkyloxycarbonyliques de monosaccharides l-acosamine et l-daunosamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1462387A (en) * 1974-05-02 1977-01-26 Farmaceutici Italia Aminoglycosides
US4322482A (en) * 1980-06-09 1982-03-30 United Technologies Corporation Electrolyte matrix for molten carbonate fuel cells
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
GB2091243B (en) * 1981-01-21 1984-06-20 Erba Farmitalia Anthracycline glycosides
US4325947A (en) * 1981-05-12 1982-04-20 Farmitalia Carlo Erba S.P.A. 4-Demethoxy-4'-deoxydoxorubicin
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
CA1248944A (fr) * 1982-09-28 1989-01-17 Gareth J. Thomas Glycosides d'anthracycline
GB2140006A (en) * 1983-05-17 1984-11-21 Erba Farmitalia Anthracycline derivatives

Also Published As

Publication number Publication date
EP0170820A2 (fr) 1986-02-12
EP0272735A2 (fr) 1988-06-29
EP0272734A3 (fr) 1989-11-02
EP0170820A3 (fr) 1987-07-01
MA20454A1 (fr) 1985-12-31
JPS6110572A (ja) 1986-01-18
FR2565982B1 (fr) 1988-01-15
EP0272735A3 (fr) 1989-11-02
FR2565982A1 (fr) 1985-12-20
EP0272734A2 (fr) 1988-06-29

Similar Documents

Publication Publication Date Title
CA1061335A (fr) Procede de preparation de glycosides oncolytiques
US4039663A (en) Daunomycins, process for their uses and intermediates
JP4066389B2 (ja) モルホリニルアントラサイクリン誘導体
US5304687A (en) Morpholinyl derivatives of doxorubicin and process for their preparation
US4025623A (en) 4'-Epi-6'-hydroxyadriamycin and method of use
US4465671A (en) Anthracycline glycosides use and compositions containing same
US5036055A (en) Acylated derivatives of etoposide
US4188377A (en) Carminomycin derivatives, their preparation and use
US4366149A (en) Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
US4418192A (en) Anthracyclinone trisaccharide compounds
US5532218A (en) 3'-aziridino-anthracycline derivatives
CA1270827C (fr) Les 3-amino-3,4,6-tridesoxyglycals, procede pour leur preparation et anthracyclines preparees a l'aide de ces glycals
US4183919A (en) Antitumor glycosides, process for their preparation including intermediates therefor and their use
US4351937A (en) N-Glycosyl derivatives of anthracycline antibiotics and the method of their preparation
US4393052A (en) Antitumor anthracycline glycosides, their preparation, intermediates therefor, and compositions and use thereof
US4322412A (en) Anthracycline glycosides, their preparation, use and compositions thereof
US4216157A (en) Substituted antitumor anthracyclines
US4965352A (en) Anthracycline derivatives having cytostatic activity
KR950004897B1 (ko) 안트라사이클린 글리코사이드 유도체의 제조방법
US4749693A (en) Nitro anthracyclines, process for their preparation and use thereof
US4265885A (en) Anthracyclines containing branched-chain amino-deoxy sugars
CA1091225A (fr) Anthracyclines
Pelyvás et al. Synthesis of N-trifluoroacetyl-l-acosamine, N-trifluoroacetyl-l-daunosamine, and their 1-thio analogs
US4562177A (en) 3'-Amino-2' halo-anthracycline antibiotics
RU2065863C1 (ru) Производные дезацетилколхицина, способ их получения и противоопухолевая композиция