CA1264760C - Intermediate for nonapeptide and decapeptide analogs of lhrh useful as lhrh antagonists - Google Patents

Intermediate for nonapeptide and decapeptide analogs of lhrh useful as lhrh antagonists

Info

Publication number
CA1264760C
CA1264760C CA 430081 CA430081A CA1264760C CA 1264760 C CA1264760 C CA 1264760C CA 430081 CA430081 CA 430081 CA 430081 A CA430081 A CA 430081A CA 1264760 C CA1264760 C CA 1264760C
Authority
CA
Canada
Prior art keywords
phe
pro
alanyl
arg
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 430081
Other languages
English (en)
French (fr)
Inventor
Brian H. Vickery
John J. Nestor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/451,671 external-priority patent/US4481190A/en
Priority claimed from US06/472,692 external-priority patent/US4581169A/en
Priority claimed from US06/495,226 external-priority patent/US4667014A/en
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Priority to CA000566251A priority Critical patent/CA1264760A/en
Application granted granted Critical
Publication of CA1264760C publication Critical patent/CA1264760C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA 430081 1982-06-10 1983-06-09 Intermediate for nonapeptide and decapeptide analogs of lhrh useful as lhrh antagonists Expired - Lifetime CA1264760C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000566251A CA1264760A (en) 1982-06-10 1988-05-06 Intermediate for nonapeptide and decapeptide analogs of lhrh useful as lhrh antagonists

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US38710182A 1982-06-10 1982-06-10
US387,101 1982-06-10
US451,671 1982-12-21
US06/451,671 US4481190A (en) 1982-12-21 1982-12-21 Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US06/472,692 US4581169A (en) 1982-12-21 1983-03-07 Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US472,692 1983-03-07
US06/495,226 US4667014A (en) 1983-03-07 1983-05-20 Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US495,226 1983-05-20

Publications (1)

Publication Number Publication Date
CA1264760C true CA1264760C (en) 1990-01-23

Family

ID=27503273

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 430081 Expired - Lifetime CA1264760C (en) 1982-06-10 1983-06-09 Intermediate for nonapeptide and decapeptide analogs of lhrh useful as lhrh antagonists

Country Status (12)

Country Link
EP (1) EP0097031B1 (fi)
JP (1) JPH0610184B2 (fi)
KR (1) KR910002550B1 (fi)
AU (2) AU569036B2 (fi)
CA (1) CA1264760C (fi)
DE (1) DE3378053D1 (fi)
DK (1) DK171483B1 (fi)
ES (2) ES523128A0 (fi)
FI (1) FI832053L (fi)
IE (1) IE55164B1 (fi)
IL (2) IL78380A (fi)
NO (2) NO832098L (fi)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them
ZA846154B (en) * 1983-08-16 1985-03-27 Akzo Nv Lh-rh antagonists
EP0145032B1 (en) * 1983-08-16 1987-11-04 Akzo N.V. Lh- rh antagonists
US4530920A (en) * 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4647653A (en) * 1984-08-23 1987-03-03 Tulane Educational Fund Therapeutic peptides
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
ZA862570B (en) * 1985-04-09 1986-12-30 Univ Tulane Therapeutic decapeptides
HU194280B (en) * 1985-10-22 1988-01-28 Richter Gedeon Vegyeszet Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them
US4761398A (en) * 1986-08-18 1988-08-02 Embrex, Inc. Method of inducing birds to molt
EP0268066A3 (en) * 1986-10-17 1990-07-11 Syntex (U.S.A.) Inc. Fertility control and uterine therapy in dogs with luteinizing hormone releasing hormone antagonists
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
DE3842010A1 (de) * 1988-12-14 1990-06-21 Hoechst Ag Kompetitive gonadoliberin-antagonisten
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
JPH0628601U (ja) * 1992-09-02 1994-04-15 京都度器株式会社 巻 尺
US5656727A (en) * 1992-09-15 1997-08-12 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US6620848B2 (en) 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
JP4328625B2 (ja) * 2001-11-05 2009-09-09 アイアールエム エルエルシー 標識試薬とその使用方法
WO2006051314A2 (en) * 2004-11-12 2006-05-18 Ucl Business Plc Guanidine derivatives as inhibitors of ddah
FR3020810B1 (fr) * 2014-05-06 2016-05-06 Servier Lab Nouveau sel de l'ivabradine et son procede de preparation.
TW202328059A (zh) * 2021-09-01 2023-07-16 日商積水醫療股份有限公司 精胺酸衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835108A (en) * 1972-02-15 1974-09-10 American Home Prod Process for preparing the releasing hormone of luteinizing hormone(lh)and of follicle stimulating hormone(fsh),salts and compositions thereof,and intermediates therefor
US3929759A (en) * 1974-11-04 1975-12-30 American Home Prod P-Glu-D-Phe-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates
NZ181036A (en) * 1975-06-12 1978-12-18 A Schally Luteinising hormone releasing hormone analogues and intermediates therefor
ZA829041B (en) * 1981-12-10 1983-09-28 David Howard Coy Lh-rh antagonists

Also Published As

Publication number Publication date
ES8504110A1 (es) 1985-04-16
IL68938A0 (en) 1983-10-31
JPH0610184B2 (ja) 1994-02-09
ES523128A0 (es) 1985-04-16
IL68938A (en) 1986-08-31
DE3378053D1 (en) 1988-10-27
AU613878B2 (en) 1991-08-15
NO832098L (no) 1983-12-12
ES537653A0 (es) 1985-12-16
IE55164B1 (en) 1990-06-20
AU7941887A (en) 1988-01-21
IE831359L (en) 1983-12-10
FI832053A0 (fi) 1983-06-08
EP0097031A2 (en) 1983-12-28
EP0097031A3 (en) 1984-11-07
AU1567483A (en) 1983-12-15
DK171483B1 (da) 1996-11-25
EP0097031B1 (en) 1988-09-21
JPS5962556A (ja) 1984-04-10
FI832053L (fi) 1983-12-11
AU569036B2 (en) 1988-01-21
KR840005081A (ko) 1984-11-03
ES8603194A1 (es) 1985-12-16
KR910002550B1 (ko) 1991-04-24
NO834404L (no) 1983-12-12
DK264683A (da) 1983-12-11
DK264683D0 (da) 1983-06-09
IL78380A (en) 1986-08-31

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CA1264760C (en) Intermediate for nonapeptide and decapeptide analogs of lhrh useful as lhrh antagonists
US4667014A (en) Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4481190A (en) Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
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