IL78380A - Omega-guanidino-and omega-amidino-substituted alpha-amino acid derivatives - Google Patents

Omega-guanidino-and omega-amidino-substituted alpha-amino acid derivatives

Info

Publication number
IL78380A
IL78380A IL78380A IL7838083A IL78380A IL 78380 A IL78380 A IL 78380A IL 78380 A IL78380 A IL 78380A IL 7838083 A IL7838083 A IL 7838083A IL 78380 A IL78380 A IL 78380A
Authority
IL
Israel
Prior art keywords
omega
guanidino
amidino
amino acid
acid derivatives
Prior art date
Application number
IL78380A
Other languages
English (en)
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/451,671 external-priority patent/US4481190A/en
Priority claimed from US06/472,692 external-priority patent/US4581169A/en
Priority claimed from US06/495,226 external-priority patent/US4667014A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IL78380A publication Critical patent/IL78380A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL78380A 1982-06-10 1983-06-09 Omega-guanidino-and omega-amidino-substituted alpha-amino acid derivatives IL78380A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38710182A 1982-06-10 1982-06-10
US06/451,671 US4481190A (en) 1982-12-21 1982-12-21 Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US06/472,692 US4581169A (en) 1982-12-21 1983-03-07 Nona-peptide and deca-peptide analogs of LHRH, useful as LHRH antagonists
US06/495,226 US4667014A (en) 1983-03-07 1983-05-20 Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists

Publications (1)

Publication Number Publication Date
IL78380A true IL78380A (en) 1986-08-31

Family

ID=27503273

Family Applications (2)

Application Number Title Priority Date Filing Date
IL78380A IL78380A (en) 1982-06-10 1983-06-09 Omega-guanidino-and omega-amidino-substituted alpha-amino acid derivatives
IL68938A IL68938A (en) 1982-06-10 1983-06-09 Nonapeptide and decapeptide analogs of lhrh,their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL68938A IL68938A (en) 1982-06-10 1983-06-09 Nonapeptide and decapeptide analogs of lhrh,their preparation and pharmaceutical compositions containing them

Country Status (12)

Country Link
EP (1) EP0097031B1 (xx)
JP (1) JPH0610184B2 (xx)
KR (1) KR910002550B1 (xx)
AU (2) AU569036B2 (xx)
CA (1) CA1264760C (xx)
DE (1) DE3378053D1 (xx)
DK (1) DK171483B1 (xx)
ES (2) ES8504110A1 (xx)
FI (1) FI832053L (xx)
IE (1) IE55164B1 (xx)
IL (2) IL78380A (xx)
NO (2) NO832098L (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL70888A0 (en) * 1983-03-10 1984-05-31 Salk Inst For Biological Studi Gn rh antagonist peptides and pharmaceutical compositions containing them
ZA846154B (en) * 1983-08-16 1985-03-27 Akzo Nv Lh-rh antagonists
DE3467173D1 (en) * 1983-08-16 1987-12-10 Akzo Nv Lh- rh antagonists
US4530920A (en) * 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4647653A (en) * 1984-08-23 1987-03-03 Tulane Educational Fund Therapeutic peptides
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4677193A (en) * 1985-02-22 1987-06-30 The Salk Institute For Biological Studies Peptides containing an aliphatic-aromatic ketone side chain
ZA862570B (en) * 1985-04-09 1986-12-30 Univ Tulane Therapeutic decapeptides
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
HU194280B (en) * 1985-10-22 1988-01-28 Richter Gedeon Vegyeszet Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them
US4761398A (en) * 1986-08-18 1988-08-02 Embrex, Inc. Method of inducing birds to molt
EP0268066A3 (en) * 1986-10-17 1990-07-11 Syntex (U.S.A.) Inc. Fertility control and uterine therapy in dogs with luteinizing hormone releasing hormone antagonists
US4801577A (en) * 1987-02-05 1989-01-31 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
DE3842010A1 (de) * 1988-12-14 1990-06-21 Hoechst Ag Kompetitive gonadoliberin-antagonisten
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
JPH0628601U (ja) * 1992-09-02 1994-04-15 京都度器株式会社 巻 尺
US5656727A (en) * 1992-09-15 1997-08-12 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US5480969A (en) * 1992-09-15 1996-01-02 The Administrators Of The Tulane Educational Fund Antagonists of LHRH
US6620848B2 (en) 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
US6369272B1 (en) 1997-01-13 2002-04-09 Glaxosmithkline Nitric oxide synthase inhibitors
GB9811599D0 (en) 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
AU2002365152A1 (en) * 2001-11-05 2003-07-15 Irm Llc Labeling reagent and methods of use
JP5274838B2 (ja) * 2004-11-12 2013-08-28 ユーシーエル ビジネス ピーエルシー 化合物
FR3020810B1 (fr) * 2014-05-06 2016-05-06 Servier Lab Nouveau sel de l'ivabradine et son procede de preparation.
TW202328059A (zh) * 2021-09-01 2023-07-16 日商積水醫療股份有限公司 精胺酸衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835108A (en) * 1972-02-15 1974-09-10 American Home Prod Process for preparing the releasing hormone of luteinizing hormone(lh)and of follicle stimulating hormone(fsh),salts and compositions thereof,and intermediates therefor
US3929759A (en) * 1974-11-04 1975-12-30 American Home Prod P-Glu-D-Phe-Trp-Ser-Tyr-D-Arg-Leu-Arg-Pro-Gly-NH{HD 2 {B and intermediates
NZ181036A (en) * 1975-06-12 1978-12-18 A Schally Luteinising hormone releasing hormone analogues and intermediates therefor
ZA829041B (en) * 1981-12-10 1983-09-28 David Howard Coy Lh-rh antagonists

Also Published As

Publication number Publication date
KR840005081A (ko) 1984-11-03
AU1567483A (en) 1983-12-15
AU613878B2 (en) 1991-08-15
DE3378053D1 (en) 1988-10-27
EP0097031A3 (en) 1984-11-07
IE55164B1 (en) 1990-06-20
JPS5962556A (ja) 1984-04-10
ES8603194A1 (es) 1985-12-16
DK264683A (da) 1983-12-11
NO832098L (no) 1983-12-12
DK171483B1 (da) 1996-11-25
JPH0610184B2 (ja) 1994-02-09
EP0097031A2 (en) 1983-12-28
IL68938A0 (en) 1983-10-31
EP0097031B1 (en) 1988-09-21
ES537653A0 (es) 1985-12-16
CA1264760C (en) 1990-01-23
AU569036B2 (en) 1988-01-21
IL68938A (en) 1986-08-31
ES523128A0 (es) 1985-04-16
NO834404L (no) 1983-12-12
KR910002550B1 (ko) 1991-04-24
AU7941887A (en) 1988-01-21
FI832053L (fi) 1983-12-11
IE831359L (en) 1983-12-10
DK264683D0 (da) 1983-06-09
FI832053A0 (fi) 1983-06-08
ES8504110A1 (es) 1985-04-16

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