CA1262904C - - Google Patents

Info

Publication number
CA1262904C
CA1262904C CA 485960 CA485960A CA1262904C CA 1262904 C CA1262904 C CA 1262904C CA 485960 CA485960 CA 485960 CA 485960 A CA485960 A CA 485960A CA 1262904 C CA1262904 C CA 1262904C
Authority
CA
Canada
Prior art keywords
hydrogen
compounds
loweralkyl
halogen
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA 485960
Other languages
English (en)
Other versions
CA1251790A (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000574704A priority Critical patent/CA1262904A/en
Application granted granted Critical
Publication of CA1251790A publication Critical patent/CA1251790A/en
Publication of CA1262904C publication Critical patent/CA1262904C/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA000485960A 1984-07-02 1985-06-28 PYRROLE[1,2-B][1,2,5] TRIAZEPINES, METHOD AND INTERMEDIATES FOR THEIR PREPARATION AND USE AS MEDICINES Expired CA1251790A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000574704A CA1262904A (en) 1984-07-02 1988-08-12 Pyrrolo ¬1,2-b| ¬1,2,5|triazepines, a process and intermediates for their preparation and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/627,329 US4517195A (en) 1984-07-02 1984-07-02 Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000574704A Division CA1262904A (en) 1984-07-02 1988-08-12 Pyrrolo ¬1,2-b| ¬1,2,5|triazepines, a process and intermediates for their preparation and their use as medicaments

Publications (2)

Publication Number Publication Date
CA1251790A CA1251790A (en) 1989-03-28
CA1262904C true CA1262904C (it) 1989-11-14

Family

ID=24514226

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000485960A Expired CA1251790A (en) 1984-07-02 1985-06-28 PYRROLE[1,2-B][1,2,5] TRIAZEPINES, METHOD AND INTERMEDIATES FOR THEIR PREPARATION AND USE AS MEDICINES

Country Status (13)

Country Link
US (1) US4517195A (it)
EP (1) EP0167922B1 (it)
JP (1) JPS6118781A (it)
KR (1) KR860001113A (it)
AT (1) ATE51401T1 (it)
AU (2) AU593771B2 (it)
CA (1) CA1251790A (it)
DE (1) DE3576822D1 (it)
DK (1) DK298085A (it)
ES (5) ES8702913A1 (it)
GR (1) GR851599B (it)
PT (1) PT80746B (it)
ZA (1) ZA854946B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800203A (en) * 1987-09-24 1989-01-24 Hoechst-Roussel Pharmaceuticals, Inc. Pyrrolo(1,2-b)cinnolines
US5274116A (en) * 1992-07-30 1993-12-28 Hoechst-Roussel Pharmaceuticals Inc. 1-aminoacetamidopyrroles and 1-aminoacetamido-2-(substituted)pyrroles and related compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3121081A (en) * 1961-08-18 1964-02-11 Du Pont 6-amino-7, 8-dicyanopyrrolo [b]-as-triazines and 7-amino-8, 9-dicyanopyrrolo [b]-[1.2.4]triazepines and their preparation
US3116203A (en) * 1962-03-14 1963-12-31 Hoffmann La Roche Oleaginous systems
GB1433103A (en) * 1974-03-20 1976-04-22 Lepetit Spa Pharmacologically active pyrrolodiazepines
US4201712A (en) * 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
FI803908L (fi) * 1979-12-21 1981-06-22 Sandoz Ag Nya pyrrolobenszotriazepiner deras framstaellning och dessa innehaollande farmaceutiska foereningar
GR76455B (it) * 1981-06-04 1984-08-10 Lepetit Spa

Also Published As

Publication number Publication date
ES552023A0 (es) 1987-03-01
AU4722889A (en) 1990-05-17
ES544746A0 (es) 1987-01-16
GR851599B (it) 1985-11-25
EP0167922A2 (en) 1986-01-15
DK298085D0 (da) 1985-07-01
ES552022A0 (es) 1987-02-16
US4517195A (en) 1985-05-14
JPS6118781A (ja) 1986-01-27
ZA854946B (en) 1986-02-26
DE3576822D1 (de) 1990-05-03
PT80746B (en) 1987-02-13
EP0167922B1 (en) 1990-03-28
ES8703422A1 (es) 1987-02-16
ATE51401T1 (de) 1990-04-15
KR860001113A (ko) 1986-02-22
EP0167922A3 (en) 1987-01-21
ES8703837A1 (es) 1987-03-01
CA1251790A (en) 1989-03-28
ES552024A0 (es) 1987-03-01
ES8707536A1 (es) 1987-08-01
ES8702913A1 (es) 1987-01-16
AU4451485A (en) 1986-01-09
ES557083A0 (es) 1987-08-01
ES8703836A1 (es) 1987-03-01
DK298085A (da) 1986-01-03
AU593771B2 (en) 1990-02-22
PT80746A (en) 1985-08-01

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Legal Events

Date Code Title Description
MKEX Expiry