CA1246063B - 8-substituted-7-phenyl-[1,2,4]triazolo[2,3- c]pyrimidines-5-amines and amides - Google Patents

8-substituted-7-phenyl-[1,2,4]triazolo[2,3- c]pyrimidines-5-amines and amides

Info

Publication number
CA1246063B
CA1246063B CA000524601A CA524601A CA1246063B CA 1246063 B CA1246063 B CA 1246063B CA 000524601 A CA000524601 A CA 000524601A CA 524601 A CA524601 A CA 524601A CA 1246063 B CA1246063 B CA 1246063B
Authority
CA
Canada
Prior art keywords
formula
carbon atoms
ethoxyethyl
triazolo
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000524601A
Other languages
English (en)
French (fr)
Other versions
CA1246063A (en
Inventor
Hans A. Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of CA1246063A publication Critical patent/CA1246063A/en
Publication of CA1246063B publication Critical patent/CA1246063B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000524601A 1979-08-08 1986-12-04 8-substituted-7-phenyl-[1,2,4]triazolo[2,3- c]pyrimidines-5-amines and amides Expired CA1246063B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6470779A 1979-08-08 1979-08-08
US06/064,707 1979-08-08

Publications (2)

Publication Number Publication Date
CA1246063A CA1246063A (en) 1988-12-06
CA1246063B true CA1246063B (en) 1988-12-06

Family

ID=22057763

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000524601A Expired CA1246063B (en) 1979-08-08 1986-12-04 8-substituted-7-phenyl-[1,2,4]triazolo[2,3- c]pyrimidines-5-amines and amides
CA 524602 Expired CA1246064A (en) 1979-08-08 1986-12-04 8-substituted-7-phenyl-¬1,2,4|triazolo¬2,3- c|pyrimidines-5-amines and amides

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA 524602 Expired CA1246064A (en) 1979-08-08 1986-12-04 8-substituted-7-phenyl-¬1,2,4|triazolo¬2,3- c|pyrimidines-5-amines and amides

Country Status (7)

Country Link
JP (1) JPS5632479A (enExample)
AU (1) AU531507B2 (enExample)
CA (2) CA1246063B (enExample)
CH (1) CH645898A5 (enExample)
DE (1) DE3029871C2 (enExample)
FR (1) FR2463143A1 (enExample)
GB (1) GB2056449A (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3029871C2 (de) 1979-08-08 1987-01-15 G.D. Searle & Co., Skokie, Ill. 8-(2-Ethoxyethyl)-7-phenyl-1,2,4-triazolo[1,5-c]pyrimidin-5-amin, Verfahren zu dessen Herstellung und pharmazeutische Zubereitung, die diese Verbindung enthält
DK135184A (da) * 1983-03-03 1984-10-10 Riker Laboratories Inc Triazol(4,3-c)- og triazol(1,5-c)pyrimidiner
US4532242A (en) * 1983-05-02 1985-07-30 Riker Laboratories, Inc. Substituted triazolo[4,3-c]pyrimidines
US4528288A (en) * 1983-05-02 1985-07-09 Riker Laboratories, Inc. Substituted triazolo[1,5-c]pyrimidines
US4483987A (en) * 1983-06-20 1984-11-20 G. D. Searle & Co. 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
US4866063A (en) * 1988-12-22 1989-09-12 G. D. Searle & Co. Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines
US5958934A (en) * 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
US5952331A (en) * 1996-05-23 1999-09-14 Syntex (Usa) Inc. Aryl pyrimidine derivatives
AU2011328237A1 (en) 2010-11-09 2013-05-23 Cellzome Limited Pyridine compounds and aza analogues thereof as TYK2 inhibitors
JP7299307B2 (ja) * 2019-04-03 2023-06-27 テラ・ストーン株式会社 チミン核酸塩基をベースとするトリアゾロピリミジン類及びその製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1205144A (fr) * 1957-06-14 1960-01-29 Farmaceutici Italia Procédé pour la synthèse de 7-méthyl-s. triazol (4, 3-c) pyrimidines substituéesen position 5
US3284542A (en) 1963-03-22 1966-11-08 Rexall Drug Chemical Preparation of high impact compositions from vinyl aromatic monomers and rubbery diolefin polymers
US3244715A (en) 1964-10-30 1966-04-05 Smith Kline French Lab Phenylimidazo [4, 5-d] pyridazines
US3461123A (en) 1968-04-12 1969-08-12 Merck & Co Inc 1h-imidazo(4,5-b)pyrazin-2-ones and processes for their preparation
DE3029871C2 (de) 1979-08-08 1987-01-15 G.D. Searle & Co., Skokie, Ill. 8-(2-Ethoxyethyl)-7-phenyl-1,2,4-triazolo[1,5-c]pyrimidin-5-amin, Verfahren zu dessen Herstellung und pharmazeutische Zubereitung, die diese Verbindung enthält

Also Published As

Publication number Publication date
CA1246064B (en) 1988-12-06
AU531507B2 (en) 1983-08-25
CA1246063A (en) 1988-12-06
GB2056449A (en) 1981-03-18
CH645898A5 (de) 1984-10-31
JPH029592B2 (enExample) 1990-03-02
DE3029871C2 (de) 1987-01-15
CA1246064A (en) 1988-12-06
FR2463143B1 (enExample) 1983-12-16
JPS5632479A (en) 1981-04-01
DE3029871A1 (de) 1981-02-26
AU6115380A (en) 1981-02-12
FR2463143A1 (fr) 1981-02-20

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Legal Events

Date Code Title Description
NARE Reissued
MKEX Expiry
MKEC Expiry (correction)
MKEC Expiry (correction)

Effective date: 20050803