CA1202193A - Use of haloacetic acids at homeopathic doses, in human and veterinary medicine, in personal hygiene products and in phytopharmaceutical products - Google Patents
Use of haloacetic acids at homeopathic doses, in human and veterinary medicine, in personal hygiene products and in phytopharmaceutical productsInfo
- Publication number
- CA1202193A CA1202193A CA000397579A CA397579A CA1202193A CA 1202193 A CA1202193 A CA 1202193A CA 000397579 A CA000397579 A CA 000397579A CA 397579 A CA397579 A CA 397579A CA 1202193 A CA1202193 A CA 1202193A
- Authority
- CA
- Canada
- Prior art keywords
- compositions
- homeopathic
- haloacetic
- products
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
- C07C53/18—Halogenated acetic acids containing fluorine
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
ABSTRACT
Compositions for pharmaceutical and personal hygiene use containing halogenoacetic acid of the formula:
Compositions for pharmaceutical and personal hygiene use containing halogenoacetic acid of the formula:
Description
USE OF HALOACETIC ACXDS AT EIOMEOPATHIC DOSES, IN HUMAN AND
VETERINARY MEDICINE, IN PERSONAL HYGIENE PRODUCTS AND IN
PHYTOPHARMACEUTICAL PRODUCTS
_ ~ _ The invention relates to the use of homeopathic doses in human and veterinary medicine, in phytopharmacy and in personal hygiene products, of haloacetic acids of the formulao R2--C COOH ( I
in which RL, R~l R3 each represent hydrogen or (F, Cl, Br/ I) atom/ one at least of the radicals Rl, R2, R3 representing a halogen, and, when two or three of these radicals represent a halogen, they may be identical or different.
One of the important routes of cell metabolism is that which is covered by the coenzyme A, which regulates, among other things, the entrance of the acetate into the Krebs cycle, the synthesis and degradation of lipid, the synthesis of certain amino acids: alanine, valine, leucine, phospho-amino-lipids, and chemicaL mediators such as acetylcholine.
The unaided acetate ion, as well as its higher homologs, has difficulty undergoing cell metabolism due to a resonance phenomenon:
C~3 - C / ~ C~13 - C
and must be activated by the CoA (work of Ingraham-Green)~
According to the invention it has been found that, if an inductomeric effect is made to take part through one or 30 several halogens,: F-Cl-Br-I on CH3 - COOH, the molecule L'33 is polarized and, thus activated, behavesS on the one hand, like coenzyme A and, on the other hand, like a carrier of the atom or atoms which have modified the resonance, when it is used at homeopathic doses.
Furthermore, the inductomeric efEect can be modified by playing, on the one hand, on the nature of the halogens where the electronic charge fractions are established as follows:
F = 0.27, Cl = 0.22, ~r = 0.20 1 = 0.16, and, on the other hand, on their distribution, thus enabling the therapeutic or metabolism regulating effects to be modiEied.
Clinical experiments on the products at homeopathic doses according to the invention has shown that:
1) Substitution of 1, 2 or 3 hydrogen atoms of acetic acid by 1, 2 or 3 atoms of Cl enables a generally beneficial action to be produced on a fatigued organism.
VETERINARY MEDICINE, IN PERSONAL HYGIENE PRODUCTS AND IN
PHYTOPHARMACEUTICAL PRODUCTS
_ ~ _ The invention relates to the use of homeopathic doses in human and veterinary medicine, in phytopharmacy and in personal hygiene products, of haloacetic acids of the formulao R2--C COOH ( I
in which RL, R~l R3 each represent hydrogen or (F, Cl, Br/ I) atom/ one at least of the radicals Rl, R2, R3 representing a halogen, and, when two or three of these radicals represent a halogen, they may be identical or different.
One of the important routes of cell metabolism is that which is covered by the coenzyme A, which regulates, among other things, the entrance of the acetate into the Krebs cycle, the synthesis and degradation of lipid, the synthesis of certain amino acids: alanine, valine, leucine, phospho-amino-lipids, and chemicaL mediators such as acetylcholine.
The unaided acetate ion, as well as its higher homologs, has difficulty undergoing cell metabolism due to a resonance phenomenon:
C~3 - C / ~ C~13 - C
and must be activated by the CoA (work of Ingraham-Green)~
According to the invention it has been found that, if an inductomeric effect is made to take part through one or 30 several halogens,: F-Cl-Br-I on CH3 - COOH, the molecule L'33 is polarized and, thus activated, behavesS on the one hand, like coenzyme A and, on the other hand, like a carrier of the atom or atoms which have modified the resonance, when it is used at homeopathic doses.
Furthermore, the inductomeric efEect can be modified by playing, on the one hand, on the nature of the halogens where the electronic charge fractions are established as follows:
F = 0.27, Cl = 0.22, ~r = 0.20 1 = 0.16, and, on the other hand, on their distribution, thus enabling the therapeutic or metabolism regulating effects to be modiEied.
Clinical experiments on the products at homeopathic doses according to the invention has shown that:
1) Substitution of 1, 2 or 3 hydrogen atoms of acetic acid by 1, 2 or 3 atoms of Cl enables a generally beneficial action to be produced on a fatigued organism.
2) The substitution of 1, 2 or 3 hydroqen atoms by 1, 2 or 3 atoms of F orients the therapeutic effect on to bone lesions in general, dental lesions and the integuments (nails, hair);
3) The substitution oE 1, 2 or 3 hydrogen atoms by 1, 2 or 3 Br atoms confers Oll the molecule a particular protective action on the capillary circulation system;
4) The substitution of 1, 2 or 3 hydrogen atoms by 1, 2 or 3 I atoms causes stimulation of the thyroid and through this regulation of the general metabolism, particularly at the level of the skin, integuments and dental dystrophies.
The present invention provides pharmaceutical compositions for homeopathic medicine, including phytopharmacy, and personal hygiene products, characterized in that they contain a haloacetic acid of above formula I, at dilutions comprised within the range normally used in homeophathy.
Homeopathy, as defined in Webster's New Encyclopedic Dictionary, is "the system of treating disease by administering in minute quantities drugs which would, if given in larger doses to a healthy person, produce symptoms similar to those of the disease, opposed to allopathy".
Homeopathic doses of medicine thus use minute quantities, and are measured by number of C~, meaning Hahnemannil Centesimal units, one CH unit meaning a dilution of l/lO0, 2 CH units meaning a dilution of l/10,000, 6 CH meaning a dilution of l/10l2, etc~ Homeopathic doses are made by means of a dilution step followed by a dynamization step.
The compositions useful in medicine are designed either for the oral route and are then offered in the form of granules or of drinkable solutions prepared according to current methods in homeopathy, or for the parenteral route in the form of injectable liquids in ampoules, or for the local route and are prepared in the form of lotions, creams, pomades, aerosols, collyria, suppositories, oils, etc. in a pharmaceutical vehicle.
In personal hygiene products, the haloacetic acids according to the invention are introduced at homeopathic dilutions into dentifrices, mouth washes, shampoos, creams and sun oils, in a physiologically suitable vehicle.
Below are given examples of use of the haloacetic acids at homeopathic doses.
Phytopharmaceutical field.
A mimosa underwent the effect of the 78-79 winter freeze and, through this fact, lost all-its leaves.
It was sprinkled with a solution containing ten - 3a -granules per liter of haloacetic acid at 5 CH according to the invention.
Fifteen days later, the tree grew green again and was again covered with leaves~ It is moreover still alive at the date of this application.
~'0;~3;~
_eterinary medicine A small mongrel dog found in the street was 14 years old and had all the signs of advanced senescence: eczema, thin hair, wrinkles and rasping of an old dog. It dragged and had difficulty in moving.
It was made to take morning and night two granules of haloacetic acid at 5CH.
The week had not ended when the eczema had entirely disappeared, the hair had again become smooth and silky and the animal ran.
At the date of this application the dog is more than 18 years old and, when it is tired, its master administers to it the treatment that had saved it four years earlier, with the same success.
Human medicine The healing of a necrosis of the hip in less than four months following a treatment by taking three granules of haloacetic acid at 5CH is reported, plus one dose at 30CH
every eight days.
_XAMPIE 4 A patient received a burn from a hot iron (the cord was connected to 220 V) on the palm of the right hand. The pain was unbearable and phlyctena appeared.
An application of the following pomade:
haloacetic acid at 4CH + 5CH aa-10% excipient Q.S. was made.
~h~Vf,J~L~
The application eased the pain in some moments and permitted scar formation of the skin in 24 hours, the same time taken for the patient to recover the use of the hand.
Numerous experiments carried out over 4 years on people afflicted with sun burn showed that, even in the case of severe burns, the painful sensations disappeared very rapidly under the effect of light massage carried out with an oil containing:
haloacetic acid at 5CH + 9CH + 15CH
EXAMPLE _ Capillary system a) Alopecia The use of a shampoo containing the following formula stopped the fall of hair in a period of 10 to 15 days in more than 80% of the cases:
haloacetic acid at 5CH
9CH aâ 10 excipient Q.S.
used three times per week.
b) Baldness Where baldness is concerned, the use twice daily of the following promade:
haloacetic acid at 5CH
9CH aa 20%
excipient for pomade Q~S.
enabled the scalp to be restored. Subsequently there was seen to appear, after a certain time and to varying degrees, initially some fine fragile hair, which fell out, regrew and became stronger and stronger. The density of the new hair growth generally was a function of the age of the subject and of his temperament.
F X fl M P
E~?~- 7 _ Odontostomatology Buccal pathology is connected with more than 90 of cases concerning a dental condition and, consequently, with the dental hygiene.
It is perhaps here that the qualities of this halogenated formula as defined above, is manifested more spectacularly. The general formula:
haloacetic acid at SCH
6CH ~a 20%
excipient Q.S.P. a tube of dentifrice, gave spectacular results.
a) Dail~ dental hygiene A study group of 50 people who regularly brushed tn ~? "- 1S
morning and evening after ~e~s with a composition according to this invention was compared to a control group who regularly brushed with a common dentifrice. At the end of a year of experiments it was found that the dental decay of the study group was 47.5% less than that of the control group.
b) Parodontolyses In the case of parodontolyses, one of the symptoms, gingival congestion with bleeding, disappears within a period of one and two weeks, if brushing with the S composition of this invention is carried out after each meal.
Moreover, in numerous cases, after a variable time, restarting of alveolar osseous regenerescence with consolidation of the dental mobility is seen to appear.
In the compositions according to the invention the vehicle can be a customary physiologically acceptable substance such as water, alcohol or an oil, and the vehicles currently used in homeopathic compositions.
It is to be understood that the embodiments given above are purely by way of illustrative example and that the invention is not limited thereto.
The present invention provides pharmaceutical compositions for homeopathic medicine, including phytopharmacy, and personal hygiene products, characterized in that they contain a haloacetic acid of above formula I, at dilutions comprised within the range normally used in homeophathy.
Homeopathy, as defined in Webster's New Encyclopedic Dictionary, is "the system of treating disease by administering in minute quantities drugs which would, if given in larger doses to a healthy person, produce symptoms similar to those of the disease, opposed to allopathy".
Homeopathic doses of medicine thus use minute quantities, and are measured by number of C~, meaning Hahnemannil Centesimal units, one CH unit meaning a dilution of l/lO0, 2 CH units meaning a dilution of l/10,000, 6 CH meaning a dilution of l/10l2, etc~ Homeopathic doses are made by means of a dilution step followed by a dynamization step.
The compositions useful in medicine are designed either for the oral route and are then offered in the form of granules or of drinkable solutions prepared according to current methods in homeopathy, or for the parenteral route in the form of injectable liquids in ampoules, or for the local route and are prepared in the form of lotions, creams, pomades, aerosols, collyria, suppositories, oils, etc. in a pharmaceutical vehicle.
In personal hygiene products, the haloacetic acids according to the invention are introduced at homeopathic dilutions into dentifrices, mouth washes, shampoos, creams and sun oils, in a physiologically suitable vehicle.
Below are given examples of use of the haloacetic acids at homeopathic doses.
Phytopharmaceutical field.
A mimosa underwent the effect of the 78-79 winter freeze and, through this fact, lost all-its leaves.
It was sprinkled with a solution containing ten - 3a -granules per liter of haloacetic acid at 5 CH according to the invention.
Fifteen days later, the tree grew green again and was again covered with leaves~ It is moreover still alive at the date of this application.
~'0;~3;~
_eterinary medicine A small mongrel dog found in the street was 14 years old and had all the signs of advanced senescence: eczema, thin hair, wrinkles and rasping of an old dog. It dragged and had difficulty in moving.
It was made to take morning and night two granules of haloacetic acid at 5CH.
The week had not ended when the eczema had entirely disappeared, the hair had again become smooth and silky and the animal ran.
At the date of this application the dog is more than 18 years old and, when it is tired, its master administers to it the treatment that had saved it four years earlier, with the same success.
Human medicine The healing of a necrosis of the hip in less than four months following a treatment by taking three granules of haloacetic acid at 5CH is reported, plus one dose at 30CH
every eight days.
_XAMPIE 4 A patient received a burn from a hot iron (the cord was connected to 220 V) on the palm of the right hand. The pain was unbearable and phlyctena appeared.
An application of the following pomade:
haloacetic acid at 4CH + 5CH aa-10% excipient Q.S. was made.
~h~Vf,J~L~
The application eased the pain in some moments and permitted scar formation of the skin in 24 hours, the same time taken for the patient to recover the use of the hand.
Numerous experiments carried out over 4 years on people afflicted with sun burn showed that, even in the case of severe burns, the painful sensations disappeared very rapidly under the effect of light massage carried out with an oil containing:
haloacetic acid at 5CH + 9CH + 15CH
EXAMPLE _ Capillary system a) Alopecia The use of a shampoo containing the following formula stopped the fall of hair in a period of 10 to 15 days in more than 80% of the cases:
haloacetic acid at 5CH
9CH aâ 10 excipient Q.S.
used three times per week.
b) Baldness Where baldness is concerned, the use twice daily of the following promade:
haloacetic acid at 5CH
9CH aa 20%
excipient for pomade Q~S.
enabled the scalp to be restored. Subsequently there was seen to appear, after a certain time and to varying degrees, initially some fine fragile hair, which fell out, regrew and became stronger and stronger. The density of the new hair growth generally was a function of the age of the subject and of his temperament.
F X fl M P
E~?~- 7 _ Odontostomatology Buccal pathology is connected with more than 90 of cases concerning a dental condition and, consequently, with the dental hygiene.
It is perhaps here that the qualities of this halogenated formula as defined above, is manifested more spectacularly. The general formula:
haloacetic acid at SCH
6CH ~a 20%
excipient Q.S.P. a tube of dentifrice, gave spectacular results.
a) Dail~ dental hygiene A study group of 50 people who regularly brushed tn ~? "- 1S
morning and evening after ~e~s with a composition according to this invention was compared to a control group who regularly brushed with a common dentifrice. At the end of a year of experiments it was found that the dental decay of the study group was 47.5% less than that of the control group.
b) Parodontolyses In the case of parodontolyses, one of the symptoms, gingival congestion with bleeding, disappears within a period of one and two weeks, if brushing with the S composition of this invention is carried out after each meal.
Moreover, in numerous cases, after a variable time, restarting of alveolar osseous regenerescence with consolidation of the dental mobility is seen to appear.
In the compositions according to the invention the vehicle can be a customary physiologically acceptable substance such as water, alcohol or an oil, and the vehicles currently used in homeopathic compositions.
It is to be understood that the embodiments given above are purely by way of illustrative example and that the invention is not limited thereto.
Claims (9)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. Compositions for homeopathic medicine comprising one at least of the haloacetic acids of the formula:
in which R1, R2, R3 represent a hydrogen or halogen atom, one at least of these radicals representing a halogen atom and, when two or three of them each represent a halogen, they can be identical or different,and a physiologically acceptable vehicle, said acids being at dilutions comprised within the range normally used in homeopathy.
in which R1, R2, R3 represent a hydrogen or halogen atom, one at least of these radicals representing a halogen atom and, when two or three of them each represent a halogen, they can be identical or different,and a physiologically acceptable vehicle, said acids being at dilutions comprised within the range normally used in homeopathy.
2. Compositions for homeopathic medicine according to claim 1, in a parenterally administrable form as injectable ampoules.
3. Compositions for homeopathic medicine according to claim 1, in an orally administrable form.
4. Compositions for homeopathic medicine according to claim 1, in a topically administrable form including creams, pomades, lotions, aerosols, collyria or oils.
5. Personal hygiene products containing at least one of the haloacetic acids recited in claim 1, at dilutions equal to or higher than 4 CH.
6. Veterinary compositions according to claim 1, in orally, parenterally or topically administrable form.
7. Phytopharmaceutical compositions according to claim 1, in a form suitable for application to plants, including a solution, suspension or aerosol.
8. Compositions according to claim 1, wherein the haloacetic acid is present at a dilution in said vehicle of from 4 CH to 30 CH.
9. A process of treating plants to effect improved biological conditions therein, which comprises applying to the plant a homeopathic dosage of a haloacetic acid of the formula defined in claim 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8104434A FR2501043A1 (en) | 1981-03-05 | 1981-03-05 | APPLICATION OF HALOGENOACETIC ACID TO HOMEOPATHIC DOSE, HUMAN AND VETERINARY MEDICINE IN BODY HYGIENE PRODUCTS AND PHYTOPHARMACEUTICAL PRODUCTS |
| FR8104434 | 1981-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1202193A true CA1202193A (en) | 1986-03-25 |
Family
ID=9255901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000397579A Expired CA1202193A (en) | 1981-03-05 | 1982-03-04 | Use of haloacetic acids at homeopathic doses, in human and veterinary medicine, in personal hygiene products and in phytopharmaceutical products |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0060195B1 (en) |
| JP (1) | JPS57176909A (en) |
| AT (1) | ATE17647T1 (en) |
| CA (1) | CA1202193A (en) |
| DE (1) | DE3268737D1 (en) |
| FR (1) | FR2501043A1 (en) |
| ZA (1) | ZA821447B (en) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1061239A (en) * | 1952-08-05 | 1954-04-09 | Products intended for hygiene | |
| FR1295338A (en) * | 1959-06-02 | 1962-06-08 | Italseber S P A | New ammonium salts of chlorinated carboxylic acids and their preparation |
| US3179562A (en) * | 1961-08-23 | 1965-04-20 | Du Pont | Treatment of diabetes with alpha, alpha substituted acetic acid derivatives |
| FR2293M (en) * | 1962-07-02 | 1964-01-27 | Jean Meyer | Product for the treatment of dental pulpitis. |
| FR6070M (en) * | 1966-12-23 | 1968-05-27 | ||
| US4122188A (en) * | 1976-12-28 | 1978-10-24 | Vanderbilt University | Treatment of hyperlipoproteinemia with a dichloroacetate salt |
| JPS53136528A (en) * | 1977-04-30 | 1978-11-29 | Kanebo Ltd | Cosmetics |
-
1981
- 1981-03-05 FR FR8104434A patent/FR2501043A1/en active Granted
-
1982
- 1982-03-04 DE DE8282400378T patent/DE3268737D1/en not_active Expired
- 1982-03-04 ZA ZA821447A patent/ZA821447B/en unknown
- 1982-03-04 EP EP82400378A patent/EP0060195B1/en not_active Expired
- 1982-03-04 CA CA000397579A patent/CA1202193A/en not_active Expired
- 1982-03-04 AT AT82400378T patent/ATE17647T1/en not_active IP Right Cessation
- 1982-03-05 JP JP57034127A patent/JPS57176909A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA821447B (en) | 1983-01-26 |
| FR2501043A1 (en) | 1982-09-10 |
| JPS57176909A (en) | 1982-10-30 |
| DE3268737D1 (en) | 1986-03-13 |
| FR2501043B1 (en) | 1984-11-16 |
| ATE17647T1 (en) | 1986-02-15 |
| EP0060195B1 (en) | 1986-01-29 |
| EP0060195A1 (en) | 1982-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |