CN1198092A - Cosmetic method for treating and preventing signs of skin ageing - Google Patents

Cosmetic method for treating and preventing signs of skin ageing Download PDF

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Publication number
CN1198092A
CN1198092A CN97190973A CN97190973A CN1198092A CN 1198092 A CN1198092 A CN 1198092A CN 97190973 A CN97190973 A CN 97190973A CN 97190973 A CN97190973 A CN 97190973A CN 1198092 A CN1198092 A CN 1198092A
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China
Prior art keywords
retinoid
compositions
concentration
skin
arbitrary
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CN97190973A
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Chinese (zh)
Inventor
D·卡斯特利
G·里斯
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Roc SA
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Roc SA
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Publication of CN1198092A publication Critical patent/CN1198092A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a cosmetic method for treating and preventing the signs of skin aging and in particular wrinkles, characterized in that: a) a composition containing at least one retinoid at a sub-irritant dose which is effective for combating skin aging, in a support which is suitable for topical administration, is applied to the skin once a day; b) a composition containing a higher dose of at least one retinoid, in a cosmetologically acceptable support which is suitable for topical administration, is applied about 10 to 16 hours after the composition mentioned in a). The invention also relates to a combination product containing such compositions.

Description

Nurse and prevent the beauty method of skin ageing phenomenon
The present invention relates to adopt the compositions that contains retinoid that skin is nursed, form to prevent skin aging and wrinkle.The present invention be more particularly directed to a kind of retinoid compositions nursing skin, particularly method of nursing face, cervical region or hand of adopting, this method is lower than known method zest, and compared with former method, in when nursing and phase before use, the individual can adopt higher and effective dosage.
Retinoid type chemical compound known in the state of the art can be used for treating skin aging, and can prevent formation and pachylosis and other abnormal conditions of wrinkle, uneven excessive mottle and freckle effectively.For example in United States Patent (USP) 4603146,4887805 and 4888342, Kligman has described retinoid in the purposes that reduces and prevent aspect the skin injury that illumination causes.But find that also use in first week of retinoid, it is chafe extremely.This can make user stop to proceed the skin protection process with retinoid at the use initial stage, and especially in the cosmetology field, the user is reluctant to accept this class inconvenience.
Attempted adopting some method and prescription to reduce the stimulation that this retinoid causes.For example proposing in United States Patent (USP) 5401517 increases the dosage of retinoid in the compositions again at the retinoid that begins to use earlier in a couple of days than low dosage after skin adapts to this chemical compound gradually after this.But the shortcoming of this method is: require to adjust operational version, adopt the higher different formulations of retinoid dosage.This causes burden to the user, requires the user to remember to change product, and also will buy another kind of product before first kind of product uses up.
By comparison, but the lower present composition of retinoid dosage use daytime, but the individual can apply before going to bed at night more and the prescription of effective dose more.In the nursing process, every pipe product all can use up, thereby has avoided product loss and unnecessary cost.
In addition, coating method is identical from maintenance in initial day of nursing, forms suitable custom thereby help the individual, and keeps these customs in first day from using.The individual just applies the retinoid of high dose from the nursing beginning, thereby just can obtain the benefit of high dose at once.
Therefore, one of purpose of the present invention provides a kind of skin protection method, and this method is that the retinoid with effective dose is coated on the skin daytime, to prevent skin aging.
Another object of the present invention provides a kind of method with the retinoid skin protection, and can reduce the stimulation that retinoid causes.
Another object of the present invention provides a kind of skin protection method, and this method allows from using the retinoid that just can apply high dose in first day.
Another object of the present invention provides a kind of skin protection method, but this method is just used the retinoid base product every day when allowing personal nursing to begin.
Therefore, the present invention relates to a kind of skin protection method, the step of this method is as follows:
(a) coating once a day contains the compositions of the low quantity of stimulus of low dosage retinoid, and described retinoid comprises the retinoid type chemical compound that can effectively prevent skin aging; With
(b) behind the initial dose about 10-16 hour, preferred 12 hours, coating contained the compositions of higher dosage retinoid.
In addition, but the special once or twice preparation of every day coating is used for the facial compositions that goes up certain part as be exclusively used in the low stimulating dose of eye.
In the methods of the invention can be according to the specific (special) requirements of skin protection mode and user and identical or different as the prescription of every kind of coating goods support.For example, can use basic recipe or lighter prescription daytime, and can use more condensed moist Emulsion night, so that make user skin when rest more comfortable.
Problem solved by the invention is can adapt to retinoid quickly when making the individual use the retinoid based composition and use thereof in packaging.Usually, user skin rubefaction, pruritus, twinge, burning sensation and decortication phenomenon can occur when using retinoid.But when adopting the retinoid in the coating method of the present invention, user can adapt to this chemical compound that applies effective dose quickly, even the therefore product of stimulating dose also can be used for coating every day at once.
In order to understand the present invention, term " retinoid " is understood to include tretinoin or retinoic acid, retinol, retinal and salt thereof and ester.Typical salt has alkali metal salt, ammonium salt and C 2-30Ammonium salt.Special particular certain cancers, potassium salt, tri ethanol ammonium salt and ammonium salt.More than the combination of all chemical compounds also can be present in the compositions of the present invention.In addition, term " retinol ' and " tretinoin " are understood to include its hydrogenation and unhydrided isomer, as 9-cis-retinol, two dehydroretinols, 13-cis-tretinoin, 13-trans-tretinoin and two dehydrogenation tretinoins.Can treat the retinoid of skin aging, wrinkle and other abnormal conditions effectively and see United States Patent (USP) 4603146,4887805 and 4888342, its disclosure is incorporated herein by reference.The concentration of these chemical compounds in the compositions that the present invention uses is about 0.0001%-about 5%.Preferred its consumption is 0.0001%-about 0.3%.More preferably its consumption is about 0.01%-about 0.075%.Even more preferably its consumption is about 0.015%-about 0.04%.
Those skilled in the art can determine its concentration according to the character that is present in the retinoid in the said composition specially.They also should adapt with the ability that the function of excipient and prescription discharge the active retinoid molecule that can be utilized by skin.
The present invention can adopt various medicines can accept and/or the cosmetics acceptable carrier.The consumption of carrier can account for about 1-99.9% of composition weight, is preferably about 80-98%, advantageously is about 95-about 99.950%.
As the carrier of product of the present invention or the compositions of substrate can be emulsion form, as oil-in-water type or water-in-oil emulsion.They also can be lipid build emulsion or other emulsion well known by persons skilled in the art, and they are physics and chemically stable.For example, the compositions that can be used in the inventive method comprises the water-in-oil emulsion of describing among the EP91 9137059, and this patent is incorporated herein by reference.The oil-in-water type prescription that can be used in the inventive method is seen WO/US 95/11750, and it is incorporated herein by reference.The liposome composition that is used as carrier in the retinoid compositions of the inventive method is seen WO/US 96/04557, and it is incorporated herein by reference.
Said composition can be mixed with gel or lotion form with the excipient of cosmetics that is applicable to well known by persons skilled in the art.
Also can add other in the present composition to the activated reagent of skin protection.These compositions specifically comprise sunscreen and screening agent, help and shine agent, anti-acne agents (particularly salicylic acid), antiinflammatory (particularly pantothenylol, Gingko biloba, glycyrrhetinic acid etc.), anti-freckle agent, hydrating agents, plant extract and other anti-wrinkle agent.
Available screening agent can be made by titanium dioxide, zinc oxide and Talcum; Sunscreen specifically comprises 4-amino benzoic Acid and derivant thereof, dibenzoyl methane, camphor derivatives, homosalicylic acid ester, oxybenzene, cinnamate, 3-imidazol-4 yl acrylic acid and benzimidizole derivatives such as 2-Phenylbenzimidazole-5-sulfonic acid and sodium salt and triethanolamine salt.
The coating first of every day preferably should be waken up in the morning and be carried out behind the clean skin.Should apply the retinoid of low stimulating dose first, for example about 0.04% for about 0.0001%-, preferably be lower than 0.04%, preferably at 0.01%-0.02%.The concentration of particularly suitable is 0.015% (weight).Preferably emulsion oil-in-water is adopted in coating first, and it is lighter, is easy to coating and wearing and tearing.
Before for the second time coating is preferably gone to bed at night just, and carried out in about 10-16 hour in coating back first.For the second time should apply the higher retinoid of content, current coating is suitable for using relatively large retinoid on skin.Because the prescription of this higher concentration contains the active component of higher dosage, so it can more effectively treat the skin abnormality situation.Coating for the second time can be adopted emulsion oil-in-water.But also can adopt water-in-oil emulsion.Water-in-oil emulsion than emulsion oil-in-water more moist and " oils and fats " some.But these prescriptions more are applicable to night, and can give skin to moisten fully.When using for the second time, the content of retinoid is preferably about 0.04%-0.3%, although if the patient can tolerate, dosage can also be higher.
In addition, except that other compositions, the compositions that special preparation is used for around upper body part special area such as cervical region and circumference of eyes or the mouth can be used with the prescription of lower retinoid dosage with other, so that these zones are provided assisted care and can not cause any other stimulation.
Following examples are used to illustrate the present invention, but scope of the present invention be there is no any qualification.Embodiment 1
After cleaning suitable skin part morning every day, in facial and a kind of compositions that contains retinol of cervical region coating, said composition has prescription A and contains the retinol of 0.015% (weight).Clean cervical region and face every night once more, at same area coating retinol prescription, this prescription has the retinol of forming B and containing 0.075% (weight).Stimulate phenomenon lower than applying the prescription that contains 0.04% retinol for twice approximately every day.
Preparation and prescription A, B, C and D corresponding compositions.Prescription A % water 70.085 octyl methoxycinnamates, 6.000 tristerins and PEG100 stearate 5.000 glycerol 5.000 benzoate C 12-15Alkyl 4.000 denatured alcohol 2.780 vaseline 1.500 hexadecanoic acid hexadecyl esters 1.000 hexadecanol 1.000 stearyl alcohols, 0.500 lauroyl lysine, 0.500 retinol solution (10%, be dissolved in suitable solvent) 0.150 panthenol 0.500 allantoin 0.150 carbopol 0.300 Tocopherol acetate ester, 0.100 phenoxetol, 0.730 methylparoban, 0.200 propylparaben, the 0.070 NaOH 0.135EDTA disodium 0.200BHT 0.100 that fills a prescription
100.000 prescription B % water 49.952 saualanes 15.000 glycerine 10.000 nut oils 7.000 pentaerythrites four caprylates 5.000 butanediols 4.000 vaseline 3.000 Quaternium-18 hectorites 2.200 poly-two glyceryl isostearates-2 2.000PEG-150,1.000 retinol solution (45%, be dissolved in suitable solvent), 0.198 Tocopherol acetate ester, 0.100 ascorbic acid, 0.100 natrium citricum 0.100EDTA disodium, 0.100 oxybenzene Ethyl formate, 0.100 oxybenzene butyl formate 0.100BHT 0.050
100.000 prescription C % water 69.775 octyl methoxycinnamates, 6.000 tristerins and PEG100 stearate 5.000 glycerol 5.000 benzoic acid C 12-15Arrcostab 4.000 denatured alcohol 2.780 vaseline 1.500 hexadecanoic acid hexadecyl esters 1.000 hexadecanol 1.000 stearyl alcohols, 0.500 lauroyl lysine, 0.500 retinol solution (10%, be dissolved in suitable solvent) 0.460 panthenol 0.500 allantoin 0.150 carbopol 0.300 Tocopherol acetate ester, 0.100 phenoxetol, 0.730 methylparoban, 0.200 propylparaben, the 0.070 NaOH 0.135EDTA disodium 0.200BHT 0.100 that fills a prescription
100.000 prescription D % water 83.908 benzoic acid C 12-15Arrcostab 4.000 glycerine 3.000 hexadecanols, 2.500 cetyl stearyl alcohols and cetyl stearyl glucosides 1.400 SEN CHA extract 1.000 octyl hydroxystearates, 1.000 dimethyl polysiloxanes, 1.000 retinol solution (45%, be dissolved in suitable solvent) 0.102 panthenol 0.500 tocopherol 0.050 carbopol 0.350 chlohexidine didextrose acid esters, 0.030 methylparoban, 0.300 propylparaben, 0.050 NaOH, the 0.110 EDETATE SODIUM 0.100BHT 0.100 that fills a prescription
100.000
Two groups of user are adopted different application process nursing 15 days and 1 month respectively, and the result compares with toleration.
As mentioned above, the 1st group of coating formulation A, coating formulation B at night in the morning.Under the same terms, the 2nd group of coating formulation C, coating formulation D at night in the morning.
Write down possible local response, it may be slight fever sense, twinge, perhaps temporary transient or secular rubescent phenomenon.
The results are shown in following table:
Toleration result in the time of 15 days
15 days
The number of results dermoreaction is stopped using because of dermoreaction
N=% n=% prescription A+ prescription B 104 22 21.1 4 3.84
Toleration result in the time of one month
One month
Stopping because of dermoreaction of dermoreaction appears in number of results
Other user ends use
N=% n=% prescription A+ prescription B 98 3 3.1 22
Toleration result in the time of 15 days
15 days
The number of results dermoreaction is stopped using because of dermoreaction
N=% n=% prescription C+ prescription D 99 26 26 99
Toleration result in the time of one month
One month
Stopping because of dermoreaction of dermoreaction appears in number of results
Other user ends use
N=% n=% prescription C+ prescription D 84 7 8.3 45
The 2nd group observation is found 26% user complaint skin after nursing 15 days is impatient at, thereby has 9% people to abandon nursing.
The 1st group toleration is better, wherein only is lower than 4% user and stops to use after 15 days.
After 1 month nursing, confirm these results, wherein only had other 3 (3.1%) user to have the reaction that can not tolerate in the group of coating formulation A and B; On the other hand, in the 2nd group, also do not observe the philtrum of dermoreaction in the time of 15 days, have 8% Crinis Carbonisatus existing again, and have 5% people in nursing process, to stop to apply this product again at dermoreaction.
Therefore find that toleration is obviously better, nursing process can be carried out, and can use the retinol of effective daily dose regularly in the group of coating prescription of the present invention A and B.
Although this dosage is low slightly in the group of using prescription C and D, in most cases, incidence rate that can not tolerance response is higher, and causes stopping the nursing rate and will exceed 2 times.Embodiment 2
Be the effect of assessment coating formulation A in morning, only nurse matched group once a day with prescription B, preferably it carries out after carefully cleaning facial and cervical region at night.Toleration when 15 days and 1 month the results are shown in following table:
Toleration result in the time of 15 days
15 days
The number of results dermoreaction is stopped using because of dermoreaction
The n=% n=% B 100 15 15 55 that fills a prescription
Toleration result in the time of one month
One month
Stopping because of dermoreaction of dermoreaction appears in number of results
Other user ends use
The n=% n=% B 95 4 4.21 2 2.1 that fills a prescription
The incidence rate of finding irritative response is lower, and the incidence rate of viewed irritative response when being similar to coating formulation A and B.
Therefore coating formulation A does not in fact cause other stimulation in the morning, but makes the skin that will be nursed adapt to the dosage that exists among the prescription B, and adjusts total daily dose of being used.Embodiment 3
Need comprise that the satisfaction of coating that preparation is used for enclosing near the eyes the compositions of specific part assesses to nursing.
Require one group of women's user to apply the prescription that contains 0.01% retinol once a day regularly, provide its composition below.Prescription E % water 83.910 benzoic acid C 12-15Arrcostab 4.000 glycerine 3.000 hexadecanols, 2.500 cetyl stearyl alcohols and cetyl stearyl glucosides 1.400 SEN CHA extract 1.000 octyl hydroxystearates, 1.000 dimethyl polysiloxanes, 1.000 retinol solution (10%, be dissolved in suitable solvent) 0.100 panthenol 0.500 Tocopherol acetate ester 0.500 tocopherol 0.050 carbopol 0.350 NaOH, 0.110 methylparoban, 0.300 propylparaben, the 0.050 chlohexidine didextrose acid esters 0.030EDTA disodium 0.100BHT 0.100 that fills a prescription
100.000
Write down the irritative response that after nursing in 15 days and 1 month, may occur respectively.
Toleration result in the time of 15 days
15 days
The number of results dermoreaction is stopped using because of dermoreaction
n＝ ％ n＝ ％
100 11 11 5 5
Toleration result in the time of one month
Month number of results dermoreaction appears and its stop using because of dermoreaction
Its user
n＝ ％ n＝ ％
94 3 3.2 1 1
Discovery is good to the toleration of this product, and makes user can cooperate nursing process well.
Therefore on entire face, the prescription that applies high dose in morning coating formulation E and evening can be combined as prescription B.

Claims (14)

  1. The nursing and prevent the particularly beauty method of wrinkle of skin ageing phenomenon, it is characterized in that:
    (a) once a day on skin coating contain at least a compositions that is in the low stimulating dose retinoid in the carrier that is fit to local application, this retinoid can prevent skin aging effectively,
    (b) coating (a) described compositions is after about 10-16 hour, and coating contains at least a compositions that is in the higher dosage retinoid in the cosmetics acceptable carrier that is fit to topical application.
  2. 2. according to the method for claim 1, it is characterized in that (a) and (b) described in compositions in, the concentration of retinoid is respectively 0.0001% and 5% of composition total weight.
  3. 3. according to the method for one of claim 1 and 2, it is characterized in that: in the compositions described in (a), the total concentration of retinoid is more than or equal to about 0.0001%, and less than 0.04% (weight), and in the compositions described in (b), the total concentration of retinoid is about 0.04%-5% (weight).
  4. 4. according to the method for arbitrary claim among the claim 1-3, it is characterized in that: in the compositions (a), the concentration of retinoid is about 0.02% (weight) of about 0.01%-.
  5. 5. according to the method for arbitrary claim among the claim 1-4, it is characterized in that: in the compositions (b), the concentration of retinoid is about 0.3% (weight) of about 0.04%-.
  6. 6. according to the method for claim 5, it is characterized in that: in the compositions (b), the concentration of retinoid is about 0.075% (weight).
  7. 7. according to the method for arbitrary claim among the claim 1-6, it is characterized in that: retinoid is selected from various isomeric forms, retinoic acid, retinol, retinal and salt thereof and the ester of tretinoin.
  8. 8. according to the method for claim 7, it is characterized in that: the salt of retinoid is selected from sodium salt, potassium salt, ammonium salt and C 2-C 30Alkanol amine salt.
  9. 9. according to the method for arbitrary claim among the claim 1-8, it is characterized in that: (a) or at least a compositions (b) be emulsion oil-in-water.
  10. 10. according to the method for arbitrary claim among the claim 1-9, it is characterized in that: (a) or at least a compositions (b) contain at least a other active component.
  11. 11. the method according to claim 10 is characterized in that: this additional active component is selected from sunscreen and screening agent except that retinoid, helps and shine agent, anti-acne agents, antiinflammatory, anti-freckle agent and anti-wrinkle agent.
  12. 12. the method according to arbitrary claim among the claim 1-11 is characterized in that: it is a kind of beautifying nursing method that is used for face and/or skin of neck.
  13. 13. method according to claim 12, it is characterized in that: in step (a), apply specific compositions around eye and/or mouth, the concentration of contained retinoid is lower than this concentration of the compositions that is used for face and/or all the other positions of cervical region in the said composition.
  14. 14. can be used for separately or smear and open the combination product that is used for the nursing of wrinkle and skin ageing phenomenon, it comprises:
    (a) contain at least a compositions that is in the low stimulating dose retinoid in the carrier that is fit to local application, this retinoid can prevent skin aging effectively.
    (b) contain at least a compositions that is in the higher dosage retinoid in the carrier that is fit to local application.
CN97190973A 1996-06-07 1997-06-05 Cosmetic method for treating and preventing signs of skin ageing Pending CN1198092A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR96/07110 1996-06-07
FR9607110A FR2749511B1 (en) 1996-06-07 1996-06-07 COSMETIC METHOD OF TREATMENT AND PREVENTION OF SIGNS OF AGING SKIN

Publications (1)

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CN1198092A true CN1198092A (en) 1998-11-04

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CN97190973A Pending CN1198092A (en) 1996-06-07 1997-06-05 Cosmetic method for treating and preventing signs of skin ageing

Country Status (13)

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EP (1) EP0845979A1 (en)
JP (1) JPH11510824A (en)
KR (1) KR19990036233A (en)
CN (1) CN1198092A (en)
AU (1) AU2786197A (en)
BR (1) BR9702284A (en)
CA (1) CA2228750A1 (en)
CZ (1) CZ31798A3 (en)
EA (1) EA199800194A1 (en)
FR (1) FR2749511B1 (en)
HU (1) HUP9802916A3 (en)
PL (1) PL324929A1 (en)
WO (1) WO1997046221A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102256666A (en) * 2008-12-22 2011-11-23 法国强生及强生消费者控股公司 A composition and method of treating skin conditions

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017549A (en) * 1997-09-30 2000-01-25 E-L Management Corp. Non-irritating cosmetic and pharmaceutical compositions
KR100404868B1 (en) * 2000-03-28 2003-11-15 김삼 Stable retinol palmitate and cosmetic composition containing the same
FR2817475B1 (en) * 2000-12-04 2005-06-17 Rocher Yves Biolog Vegetale USE OF A RETINOL PROTEASE-SOURCE ASSOCIATION TO PREVENT SKIN AGING
WO2003053327A2 (en) * 2001-12-20 2003-07-03 Johnson & Johnson Consumer France S.A.S. Compositions containing a retinoid and malt extract
US20050019356A1 (en) * 2003-07-25 2005-01-27 The Procter & Gamble Company Regulation of mammalian keratinous tissue using N-acyl amino acid compositions
JP2013056867A (en) * 2011-09-09 2013-03-28 Pias Arise Kk Kit for adjusting circadian rhythm and method for adjusting circadian rhythm
US10639252B2 (en) * 2011-09-23 2020-05-05 Allergan, Inc. Compositions for skin exfoliation and use thereof
FR3006191B1 (en) * 2013-06-03 2016-04-29 Pierre Fabre Dermo-Cosmetique COSMETIC OR DERMATOLOGICAL COMPOSITIONS ASSOCIATED WITH RETINALDEHYDE AND GLYCYLGLYCINE OLEAMIDE, AND USES THEREOF IN COSMETICS OR DERMATOLOGY

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Publication number Priority date Publication date Assignee Title
CA945068A (en) * 1967-10-25 1974-04-09 Albert M. Kligman Composition and method of treating acne
US5401517A (en) * 1993-11-15 1995-03-28 Elizabeth Arden Company, Division Of Conopco, Inc. Cosmetic method for treatment of skin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102256666A (en) * 2008-12-22 2011-11-23 法国强生及强生消费者控股公司 A composition and method of treating skin conditions
CN102256666B (en) * 2008-12-22 2015-05-20 法国强生及强生消费者控股公司 A composition and method of treating skin conditions

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FR2749511B1 (en) 1998-08-28
AU2786197A (en) 1998-01-05
EP0845979A1 (en) 1998-06-10
WO1997046221A1 (en) 1997-12-11
CA2228750A1 (en) 1997-12-11
BR9702284A (en) 1999-12-28
EA199800194A1 (en) 1998-08-27
CZ31798A3 (en) 1998-06-17
FR2749511A1 (en) 1997-12-12
HUP9802916A2 (en) 1999-03-29
JPH11510824A (en) 1999-09-21
KR19990036233A (en) 1999-05-25
PL324929A1 (en) 1998-06-22
HUP9802916A3 (en) 1999-08-30

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