CA1198365A - Method composition and kit for stabilizing radiolabeled compounds - Google Patents

Method composition and kit for stabilizing radiolabeled compounds

Info

Publication number
CA1198365A
CA1198365A CA000366336A CA366336A CA1198365A CA 1198365 A CA1198365 A CA 1198365A CA 000366336 A CA000366336 A CA 000366336A CA 366336 A CA366336 A CA 366336A CA 1198365 A CA1198365 A CA 1198365A
Authority
CA
Canada
Prior art keywords
compound
kit
stabilizing
radiolabeled
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000366336A
Other languages
English (en)
French (fr)
Inventor
Robert E. O'brien
Nathan R. Tzodikov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Revvity Health Sciences Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/105,272 external-priority patent/US4358434A/en
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Priority to CA000460499A priority Critical patent/CA1198549A/en
Application granted granted Critical
Publication of CA1198365A publication Critical patent/CA1198365A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA000366336A 1979-12-19 1980-12-08 Method composition and kit for stabilizing radiolabeled compounds Expired CA1198365A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000460499A CA1198549A (en) 1979-12-19 1984-08-07 Stabilization of radiolabeled organic compound

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US105,272 1979-12-19
US06/105,272 US4358434A (en) 1979-12-19 1979-12-19 Method, composition and kit for stabilizing radiolabeled compounds
US178,609 1980-08-15
US06/178,609 US4390517A (en) 1979-12-19 1980-08-15 Method, composition and kit for stabilizing radiolabeled compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000460499A Division CA1198549A (en) 1979-12-19 1984-08-07 Stabilization of radiolabeled organic compound

Publications (1)

Publication Number Publication Date
CA1198365A true CA1198365A (en) 1985-12-24

Family

ID=26802419

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000366336A Expired CA1198365A (en) 1979-12-19 1980-12-08 Method composition and kit for stabilizing radiolabeled compounds

Country Status (5)

Country Link
US (1) US4390517A (enExample)
EP (1) EP0031121B1 (enExample)
JP (1) JPH02110113A (enExample)
CA (1) CA1198365A (enExample)
DE (1) DE3070719D1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411881A (en) * 1982-07-12 1983-10-25 New England Nuclear Corporation Composition and method for stabilizing radiolabeled compounds using thiocarbonylated diethylenetriamines
DE3331159A1 (de) * 1983-08-30 1985-03-14 Hoechst Ag, 6230 Frankfurt N-(4-aminobenzoyl)-aminodicarbonsaeuren zur stabilisierung von technetium-99m-praeparaten, stabilisierte injektionspraeparate und verfahren zu ihrer herstellung
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
EP0513510A1 (en) * 1991-05-01 1992-11-19 E.R. SQUIBB & SONS, INC. Method for stabilizing radiolabeled biological molecules using ion exchange resins
CA2105402C (en) * 1992-04-30 2000-04-04 Roger M. Price Radiolabelled compound formulations
US5686058A (en) * 1992-04-30 1997-11-11 Amersham International Plc Radiolabelled nucleotide formulations stored in an unfrozen state
US5942210A (en) * 1994-11-15 1999-08-24 Cytogen Corporation Methods for lyoprotecting a macromolecule using tricine
FR2727687B1 (fr) * 1994-12-02 1997-01-24 Isotopchim Sarl Stabilisation de composes radiomarques
WO1997001520A1 (en) * 1995-06-28 1997-01-16 E.I. Du Pont De Nemours And Company Composition and method for stabilizing radiolabeled organic compounds
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
FR2763505B1 (fr) * 1997-05-22 2000-10-06 Oreal Utilisation en cosmetique de certains polymeres polyamines comme agents anti-oxydants
AU2985100A (en) 1999-02-08 2000-08-25 Checkpoint Genetics, Inc. (n)-substituted amino acids, antioxidant pharmaceutical compositions containing same and methods using same
HUP0101921A2 (hu) * 2001-05-10 2004-01-28 Izotóp Intézet Kft Radioaktívan jelzett nukleotido/ka/t tartalmazó preparátumok és eljárás azok előállítására
JP4611017B2 (ja) * 2002-04-30 2011-01-12 エモリー ユニバーシティー 腫瘍画像化化合物
JP5139678B2 (ja) * 2003-07-24 2013-02-06 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 安定な放射性医薬品組成物およびその製法
AU2006262502A1 (en) 2005-06-23 2007-01-04 Emory Univerisity Imaging agents
CA2612187C (en) * 2005-06-23 2013-05-07 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
GB201007353D0 (en) 2010-04-30 2010-06-16 Algeta Asa Method
GB201007354D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method
GB201600153D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD88780A (enExample) *
BE759895R (fr) * 1969-12-04 1971-06-04 Squibb & Sons Inc Appareil et procede pour determiner la fonction
SU432218A1 (ru) * 1972-11-14 1974-06-15 Способ извлечения и концентрирования цветных металлов
US3928293A (en) * 1974-04-01 1975-12-23 Dynapol Corp Polymeric reagent
US4029706A (en) * 1974-04-01 1977-06-14 Dynapol Reduction with polymeric reagent
SE420733B (sv) * 1974-05-30 1981-10-26 Exploaterings Ab Tbf Gelprodukt, innehallande tiosulfatgrupper samt sett for framstellning derav
US4048296A (en) * 1975-05-27 1977-09-13 Mallinckrodt, Inc. Radiopharmaceutical scanning agents
US4062933A (en) * 1975-05-27 1977-12-13 Mallinckrodt, Inc. Colloidal compositions with protective agents suitable for radioactive labeling
US4107867A (en) * 1975-10-16 1978-08-22 Kennedy Benton B Catfish trap
US4107284A (en) * 1975-10-28 1978-08-15 Sultanian Ishkhan V Radioimmunoassay procedure using a stabilized complex
CA1083508A (fr) * 1975-11-13 1980-08-12 Jacques Grange Supports porteurs de chaines laterales, procedes d'obtention de ces supports, procedes de fixation de composes organiques comportant un residu glucidique sur lesdits supports, produits et reactifs resultant de ladite fixation chimique
US4115540A (en) * 1976-06-16 1978-09-19 The University Of Kentucky Research Foundation Radiodiagnostic agent
US4107283A (en) * 1976-07-19 1978-08-15 New England Nuclear Corporation Tracer for circulation determinations
US4112064A (en) * 1977-02-22 1978-09-05 Hoffmann-La Roche Inc. Stabilized angiotensin I solutions
JPS5489019A (en) * 1977-11-29 1979-07-14 Mochida Pharm Co Ltd Immunochemical measuring reagent
US4229427A (en) * 1978-06-28 1980-10-21 The Procter & Gamble Company Radioactive scanning agents with hydroquinone stabilizer

Also Published As

Publication number Publication date
EP0031121B1 (en) 1985-05-29
US4390517A (en) 1983-06-28
JPH0515987B2 (enExample) 1993-03-03
JPH02110113A (ja) 1990-04-23
DE3070719D1 (en) 1985-07-04
EP0031121A1 (en) 1981-07-01

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